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  1. Lysophosphatidic acid (LPA) and sphingosine 1-phosphate (S1P) are bioactive lipid signaling molecules implicated in tumor dissemination. Membrane-type matrix metalloproteinase 1 (MT1-MMP) is a membrane-tethere...

    Authors: Kevin E Fisher, Andreia Pop, Wonshill Koh, Nicholas J Anthis, W Brian Saunders and George E Davis

    Citation: Molecular Cancer 2006 5:69

    Content type: Research

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  2. Recently, a small population of cancer stem cells in adult and pediatric brain tumors has been identified. Some evidence has suggested that CD133 is a marker for a subset of leukemia and glioblastoma cancer st...

    Authors: Gentao Liu, Xiangpeng Yuan, Zhaohui Zeng, Patrizia Tunici, Hiushan Ng, Iman R Abdulkadir, Lizhi Lu, Dwain Irvin, Keith L Black and John S Yu

    Citation: Molecular Cancer 2006 5:67

    Content type: Research

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  3. Metastatic renal cell carcinoma (RCC) remains the leading cause of mortality in patients with clear cell RCC arising from mutations in the von Hippel Lindau (VHL) tumor suppressor. Successful RCC tumor suppres...

    Authors: Brenda L Petrella and Constance E Brinckerhoff

    Citation: Molecular Cancer 2006 5:66

    Content type: Research

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  4. Renal cell carcinoma (RCC) is the sixth leading cause of cancer death and is responsible for 11,000 deaths per year in the US. Approximately one-third of patients present with disease which is already metastat...

    Authors: Bertrand Perroud, Jinoo Lee, Nelly Valkova, Amy Dhirapong, Pei-Yin Lin, Oliver Fiehn, Dietmar Kültz and Robert H Weiss

    Citation: Molecular Cancer 2006 5:64

    Content type: Research

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  5. Constitutive activation of MEK1 (caMEK) can induce the oncogenic transformation of normal intestinal epithelial cells. To define the genetic changes that occur during this process, we used oligonucleotide micr...

    Authors: Koga Komatsu, F Gregory Buchanan, Michiro Otaka, Mario Jin, Masaru Odashima, Yohei Horikawa, Sumio Watanabe and Raymond N DuBois

    Citation: Molecular Cancer 2006 5:63

    Content type: Research

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  6. The involvement of the cyclooxygenases (COX), in particular COX-2, is well documented for many tumours, e.g. colon, breast and prostate cancer, by both experimental and clinical studies. There are epidemiologi...

    Authors: Katarina Rask, Yihong Zhu, Wanzhong Wang, Lars Hedin and Karin Sundfeldt

    Citation: Molecular Cancer 2006 5:62

    Content type: Research

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  7. Pituitary tumor transforming gene (PTTG) is a novel oncogene that is expressed at higher level in most of the tumors analyzed to date compared to normal tissues. Existence of a relationship between PTTG levels...

    Authors: Mohammad T Malik and Sham S Kakar

    Citation: Molecular Cancer 2006 5:61

    Content type: Research

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  8. The correlation between epigenetic aberrations and disease underscores the importance of epigenetic mechanisms. Here, we review recent findings regarding chromatin modifications and their relevance to cancer.

    Authors: Miryam Ducasse and Mark A Brown

    Citation: Molecular Cancer 2006 5:60

    Content type: Review

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  9. Metabolic transformations of malignant cells are essential to the development and progression of all cancers. The understanding of the pathogenesis and progression of cancer requires the establishment of the a...

    Authors: Leslie C Costello and Renty B Franklin

    Citation: Molecular Cancer 2006 5:59

    Content type: Commentary

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  10. Changes in the structure of commercial scholarly publishing have led to spiraling subscription prices. This has resulted in a "serials crisis" that has eroded library budgets and threatened the system of scien...

    Authors: Edwin V Sperr Jr

    Citation: Molecular Cancer 2006 5:58

    Content type: Commentary

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  11. The MUC1 gene encodes a mucin glycoprotein(s) which is basally expressed in most epithelial cells. In breast adenocarcinoma and a variety of epithelial tumors its transcription is dramatically upregulated. Of ...

    Authors: Joseph Z Zaretsky, Itay Barnea, Yael Aylon, Marat Gorivodsky, Daniel H Wreschner and Iafa Keydar

    Citation: Molecular Cancer 2006 5:57

    Content type: Research

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  12. Renal cell carcinoma (RCC) is characterized by organ-specific metastases. The chemokine stromal derived factor-1 (SDF-1/CXCL12) and its receptor CXCR4 have been suggested to regulate organ-specific metastasis ...

    Authors: Judong Pan, Javier Mestas, Marie D Burdick, Roderick J Phillips, George V Thomas, Karen Reckamp, John A Belperio and Robert M Strieter

    Citation: Molecular Cancer 2006 5:56

    Content type: Research

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  13. Genes that cause cancer have been divided into two general classes – oncogenes that act in a dominant fashion to transform normal cells into a malignant state, and tumor suppressor genes that act in a dominant...

    Authors: Shu-ling Fu, Brigitte Ganter and Joseph S Lipsick

    Citation: Molecular Cancer 2006 5:54

    Content type: Research

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  14. Deregulated expression of oncogenes such as MYC and PAX3-FKHR often occurs in rhabdomyosarcomas. MYC can enhance cell proliferation and apoptosis under specific conditions, whereas PAX3-FKHR has only been describ...

    Authors: Alan C Taylor, Katja Schuster, Pamela P McKenzie and Linda C Harris

    Citation: Molecular Cancer 2006 5:53

    Content type: Research

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  15. The Calcium-Sensing Receptor is a key component of Calcium/Parathyroid hormone homeostatic system that helps maintain appropriate plasma Ca2+ concentrations. It also has a number of non-homeostatic functions, inc...

    Authors: Richard Morgan, Benjamin Fairfax and Hardev S Pandha

    Citation: Molecular Cancer 2006 5:51

    Content type: Research

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  16. The mucin MUC16 and the glycosylphosphatidylinositol anchored glycoprotein mesothelin likely facilitate the peritoneal metastasis of ovarian tumors. The biochemical basis and the kinetics of the binding betwee...

    Authors: Jennifer AA Gubbels, Jennifer Belisle, Masanori Onda, Claudine Rancourt, Martine Migneault, Mitchell Ho, Tapan K Bera, Joseph Connor, Bangalore K Sathyanarayana, Byungkook Lee, Ira Pastan and Manish S Patankar

    Citation: Molecular Cancer 2006 5:50

    Content type: Research

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  17. Cervical cancer is the second most common gynecological cancer amongst women world-wide. Despite optimized protocols, standard treatments still face several disadvantages. Therefore, research aims at the devel...

    Authors: Nathalie Cools, Peter Ponsaerts, Marc Lenjou, Griet Nijs, Dirk R Van Bockstaele, Viggo FI Van Tendeloo and Zwi N Berneman

    Citation: Molecular Cancer 2006 5:49

    Content type: Research

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  18. Barrett's esophagus, a risk factor for esophageal adenocarcinoma, is associated with reflux disease. The aim of this study was to assess the expression of bile acid receptors in the esophagus (normal, esophagi...

    Authors: Andrea De Gottardi, Jean-Marc Dumonceau, Fabien Bruttin, Alain Vonlaufen, Isabelle Morard, Laurent Spahr, Laura Rubbia-Brandt, Jean-Louis Frossard, Winand NM Dinjens, Peter S Rabinovitch and Antoine Hadengue

    Citation: Molecular Cancer 2006 5:48

    Content type: Research

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  19. The tumor suppressor gene p53 (TP53) controls numerous signaling pathways and is frequently mutated in human cancers. Novel p53 isoforms suggest alternative splicing as a regulatory feature of p53 activity.

    Authors: Lars O Baumbusch, Simen Myhre, Anita Langerød, Anna Bergamaschi, Stephanie B Geisler, Per E Lønning, Wolfgang Deppert, Irene Dornreiter and Anne-Lise Børresen-Dale

    Citation: Molecular Cancer 2006 5:47

    Content type: Research

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  20. The transmembrane protein c-kit is a receptor tyrosine kinase (KIT) and KIT is expressed in solid tumors and hematological malignancies such as gastrointestinal stromal tumor (GIST), small-cell lung cancer and ch...

    Authors: Akira Yasuda, Hirozumi Sawai, Hiroki Takahashi, Nobuo Ochi, Yoichi Matsuo, Hitoshi Funahashi, Mikinori Sato, Yuji Okada, Hiromitsu Takeyama and Tadao Manabe

    Citation: Molecular Cancer 2006 5:46

    Content type: Research

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  21. Endometrial cancer is the fourth most prominent cancer among all feminine cancers in the Western world. Resveratrol, a natural anti-oxidant found in red wine emerging as a novel anticancer agent, exerts antipr...

    Authors: Émilie Sexton, Céline Van Themsche, Kim Leblanc, Sophie Parent, Pascal Lemoine and Eric Asselin

    Citation: Molecular Cancer 2006 5:45

    Content type: Research

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  22. Cancer research has mainly focused on alterations of genes and proteins in cancer cells themselves that result in either gain-of-function in oncogenes or loss-of-function in tumour-suppressor genes. However, s...

    Authors: Xiao-Feng Sun and Hong Zhang

    Citation: Molecular Cancer 2006 5:43

    Content type: Review

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  23. Certain types of potassium channels (known as Eag1, KCNH1, Kv10.1) are associated with the production of tumours in patients and in animals. We have now studied the expression pattern of the Eag1 channel in a ...

    Authors: Bernhard Hemmerlein, Rüdiger M Weseloh, Fernanda Mello de Queiroz, Hendrik Knötgen, Araceli Sánchez, María E Rubio, Sabine Martin, Tessa Schliephacke, Marc Jenke, Heinz-Joachim-Radzun, Walter Stühmer and Luis A Pardo

    Citation: Molecular Cancer 2006 5:41

    Content type: Research

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  24. Histone deacetylase inhibitors (HDACIs) have been shown to induce apoptotic and autophagic cell death in vitro and in vivo. The molecular mechanisms that underlie these cytotoxic effects are not yet clearly under...

    Authors: John P Alao, Alexandra V Stavropoulou, Eric W-F Lam and R Charles Coombes

    Citation: Molecular Cancer 2006 5:40

    Content type: Short communication

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  25. Conventional cytogenetic and comparative genomic hybridization (CGH) studies in brain malignancies have shown that glioblastoma multiforme (GBM) is characterized by complex structural and numerical alterations...

    Authors: Yolanda Ruano, Manuela Mollejo, Teresa Ribalta, Concepción Fiaño, Francisca I Camacho, Elena Gómez, Angel Rodríguez de Lope, Jose-Luis Hernández-Moneo, Pedro Martínez and Bárbara Meléndez

    Citation: Molecular Cancer 2006 5:39

    Content type: Research

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  26. Cancer development is accompanied by genetic phenomena like deletion and amplification of chromosome parts or alterations of chromatin structure. It is expected that these mechanisms have a strong effect on re...

    Authors: Eike Staub, Jörn Gröne, Detlev Mennerich, Stefan Röpcke, Irina Klamann, Bernd Hinzmann, Esmeralda Castanos-Velez, Benno Mann, Christian Pilarsky, Thomas Brümmendorf, Birgit Weber, Heinz-Johannes Buhr and André Rosenthal

    Citation: Molecular Cancer 2006 5:37

    Content type: Research

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  27. Neurofibromatosis type 1 (NF1) is the most common hereditary neurocutaneous disorder and it is associated with an elevated risk for malignant tumors of tissues derived from neural crest cells. The NF1 gene is con...

    Authors: Albert Rübben, Birke Bausch and Arjen Nikkels

    Citation: Molecular Cancer 2006 5:36

    Content type: Research

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  28. Uncensored exchange of scientific results hastens progress. Open Access does not stop at the removal of price and permission barriers; still, censorship and reading disabilities, to name a few, hamper access t...

    Authors: Shawn Mathur, Christian Schmidt, Chhaya Das and Philip W Tucker

    Citation: Molecular Cancer 2006 5:35

    Content type: Editorial

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  29. Apoptosis resistance occurs in various tumors. The anti-apoptotic XIAP protein is responsible for inhibiting apoptosis by reducing caspase-3 activation. Our aim is to evaluate whether RNA inhibition against XI...

    Authors: Bart Spee, Martijn DB Jonkers, Brigitte Arends, Gerard R Rutteman, Jan Rothuizen and Louis C Penning

    Citation: Molecular Cancer 2006 5:34

    Content type: Research

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  30. In order to gain new insights into the molecular mechanisms involved in prostate cancer, we performed array-based comparative genomic hybridization (aCGH) on a series of 46 primary prostate carcinomas using a ...

    Authors: Franclim R Ribeiro, Rui Henrique, Merete Hektoen, Marianne Berg, Carmen Jerónimo, Manuel R Teixeira and Ragnhild A Lothe

    Citation: Molecular Cancer 2006 5:33

    Content type: Research

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  31. The aim of the present study was to develop and characterize a novel in vivo cancer gene therapy model in which intra-arterial adenoviral gene delivery can be characterized. In this model, the rat cremaster muscl...

    Authors: Gustavo Cabrera, Stacy L Porvasnik, Paul E DiCorleto, Maria Siemionow and Corey K Goldman

    Citation: Molecular Cancer 2006 5:32

    Content type: Research

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  32. Expression of c-myc proto-oncogene is inappropriate in a wide range of human tumors, and is a downstream target of Ras/Raf/ERK pathway, which promotes c-Myc stability by enhancing c-Myc expression and activity.

    Authors: Francesco Marampon, Carmela Ciccarelli and Bianca M Zani

    Citation: Molecular Cancer 2006 5:31

    Content type: Research

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  33. Carcinogenesis is a multi-step process indicated by several genes up- or down-regulated during tumor progression. This study examined and identified differentially expressed genes in cutaneous squamous cell ca...

    Authors: Ingo Nindl, Chantip Dang, Tobias Forschner, Ralf J Kuban, Thomas Meyer, Wolfram Sterry and Eggert Stockfleth

    Citation: Molecular Cancer 2006 5:30

    Content type: Research

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  34. MicroRNAs (miRNAs) are short non-coding RNA molecules playing regulatory roles by repressing translation or cleaving RNA transcripts. Although the number of verified human miRNA is still expanding, only few ha...

    Authors: E Bandrés, E Cubedo, X Agirre, R Malumbres, R Zárate, N Ramirez, A Abajo, A Navarro, I Moreno, M Monzó and J García-Foncillas

    Citation: Molecular Cancer 2006 5:29

    Content type: Research

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  35. Transcriptional silencing associated with aberrant promoter methylation has been established as an alternate pathway for the development of cancer by inactivating tumor suppressor genes. TMS1 (Target of Methylati...

    Authors: Partha M Das, Kavitha Ramachandran, Jane VanWert, Larry Ferdinand, Gopal Gopisetty, Isildinha M Reis and Rakesh Singal

    Citation: Molecular Cancer 2006 5:28

    Content type: Research

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  36. Disrupting the balance of histone lysine methylation alters the expression of genes involved in tumorigenesis including proto-oncogenes and cell cycle regulators. Methylation of lysine residues is commonly cat...

    Authors: Mark A Brown, Robert J Sims III, Paul D Gottlieb and Philip W Tucker

    Citation: Molecular Cancer 2006 5:26

    Content type: Research

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  37. The evolutionary conserved cyclin-dependent kinase phosphatase hCdc14A has been shown to play potential roles in the regulation of mitotic exit and in the centrosome duplication cycle. We have recently shown t...

    Authors: Michelle T Paulsen, Adrienne M Starks, Frederick A Derheimer, Sheela Hanasoge, Liwu Li, Jack E Dixon and Mats Ljungman

    Citation: Molecular Cancer 2006 5:25

    Content type: Research

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  38. Recent studies indicate that microRNAs (miRNAs) are mechanistically involved in the development of various human malignancies, suggesting that they represent a promising new class of cancer biomarkers. However...

    Authors: Michael D Mattie, Christopher C Benz, Jessica Bowers, Kelly Sensinger, Linda Wong, Gary K Scott, Vita Fedele, David Ginzinger, Robert Getts and Chris Haqq

    Citation: Molecular Cancer 2006 5:24

    Content type: Research

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  39. The Helicase-Like Transcription Factor (HLTF/SMARCA3) belongs to the family of SWI/SNF proteins that use the energy of ATP hydrolysis to remodel chromatin in a variety of cellular processes. Several SWI/SNF ge...

    Authors: Gaël Debauve, Denis Nonclercq, Fabrice Ribaucour, Murielle Wiedig, Cécile Gerbaux, Oberdan Leo, Guy Laurent, Fabrice Journé, Alexandra Belayew and Gérard Toubeau

    Citation: Molecular Cancer 2006 5:23

    Content type: Research

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  40. Gene-targeted iMyc mice that carry a His6-tagged mouse Myc(c-myc)cDNA, MycHis, just 5' of the immunoglobulin heavy-chain enhancer, Eμ, are prone to B cell and plasma cell neoplasms, such as lymphoblastic B-cell...

    Authors: Seong-Su Han, Liangping Peng, Seung-Tae Chung, Wendy DuBois, Sung-Ho Maeng, Arthur L Shaffer, Michael B Sporn and Siegfried Janz

    Citation: Molecular Cancer 2006 5:22

    Content type: Research

    Published on:

  41. There is little understanding of the effect that reactive oxygen metabolites have on cellular behavior during the processes of invasion and metastasis. These oxygen metabolites could interact with a number of ...

    Authors: Danielle Lejeune, Mohammad Hasanuzzaman, Amanda Pitcock, Joseph Francis and Inder Sehgal

    Citation: Molecular Cancer 2006 5:21

    Content type: Short communication

    Published on:

  42. Treatment of cells with the anti-cancer drug 5-fluorouracil (5-FU) causes DNA damage, which in turn affects cell proliferation and survival. Two stable wild-type TP53 5-FU-resistant cell lines, ContinB and Contin...

    Authors: Paula M De Angelis, Debbie H Svendsrud, Katherine L Kravik and Trond Stokke

    Citation: Molecular Cancer 2006 5:20

    Content type: Research

    Published on:

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