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Page 44 of 46

  1. Content type: Research

    In cancer cells, telomerase induction helps maintain telomere length and thereby bypasses senescence and provides enhanced replicative potential. Chemical inhibitors of telomerase have been shown to reactivate...

    Authors: Masood A Shammas, Hemanta Koley, Ramesh B Batchu, Robert C Bertheau, Alexei Protopopov, Nikhil C Munshi and Raj K Goyal

    Citation: Molecular Cancer 2005 4:24

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  2. Content type: Research

    Cell proliferation control depends in part on the carefully ordered regulation of transcription factors. The p53 homolog p73, contributes to this control by directly upregulating the cyclin dependent kinase in...

    Authors: Michael W Harr, Timothy G Graves, Erin L Crawford, Kristy A Warner, Cheryl AM Reed and James C Willey

    Citation: Molecular Cancer 2005 4:23

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  3. Content type: Research

    The development of cancer has been associated with epigenetic alterations such as aberrant histone deacetylase (HDAC) activity. It was recently reported that valproic acid is an effective inhibitor of histone ...

    Authors: Alma Chavez-Blanco, Blanca Segura-Pacheco, Enrique Perez-Cardenas, Lucia Taja-Chayeb, Lucely Cetina, Myrna Candelaria, David Cantu, Aurora Gonzalez-Fierro, Patricia Garcia-Lopez, Pilar Zambrano, Carlos Perez-Plasencia, Gustavo Cabrera, Catalina Trejo-Becerril, Enrique Angeles and Alfonso Duenas-Gonzalez

    Citation: Molecular Cancer 2005 4:22

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  4. Content type: Research

    In the current study we investigated the role of caveolin-1 (cav-1) in pancreatic adenocarcinoma (PC) cell migration and invasion; initial steps in metastasis. Cav-1 is the major structural protein in caveolae...

    Authors: Min Lin, Melinda M DiVito, Sofia D Merajver, Madanamohan Boyanapalli and Kenneth L van Golen

    Citation: Molecular Cancer 2005 4:21

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  5. Content type: Research

    The c-fos gene was originally identified as the cellular homolog of the oncogene v-fos carried by the Finkel-Biskis-Jenkins and Finkel-Biskis-Reilly murine osteogenic sarcoma retroviruses. Sustained expression of...

    Authors: Jared M Ordway, Steven D Fenster, Hong Ruan and Thomas Curran

    Citation: Molecular Cancer 2005 4:19

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  6. Content type: Research

    Although 40–50% of non-small cell lung cancer (NSCLC) tumors respond to cisplatin chemotherapy, there currently is no way to prospectively identify potential responders. The purpose of this study was to determ...

    Authors: David A Weaver, Erin L Crawford, Kristy A Warner, Fadel Elkhairi, Sadik A Khuder and James C Willey

    Citation: Molecular Cancer 2005 4:18

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  7. Content type: Retraction Note

    The corresponding author submitted this article [1] to Molecular Cancer on the assumption that the co-author had agreed to the submission. Since this is not the case, the authors are retracting the article. The c...

    Authors: Osama Al-Assar and Dorothy H Crouch

    Citation: Molecular Cancer 2005 4:17

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    The original article was published in Molecular Cancer 2005 4:13

  8. Content type: Research

    We have previously reported activating mutations of the gene coding for the fibroblast growth factor receptor 3 (FGFR3) in invasive cervical carcinoma. To further analyze the role of FGFR3 in cervical tumor pr...

    Authors: Christophe Rosty, Marie-Hélène Aubriot, David Cappellen, Jérôme Bourdin, Isabelle Cartier, Jean Paul Thiery, Xavier Sastre-Garau and François Radvanyi

    Citation: Molecular Cancer 2005 4:15

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  9. Content type: Research

    Hsulf-1 is a newly identified enzyme, which has the ability to decrease the growth of hepatocellular, ovarian, and head and neck squamous cell carcinoma cells by interfering with heparin-binding growth factor ...

    Authors: Junsheng Li, Jörg Kleeff, Ivane Abiatari, Hany Kayed, Nathalia A Giese, Klaus Felix, Thomas Giese, Markus W Büchler and Helmut Friess

    Citation: Molecular Cancer 2005 4:14

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  10. Content type: Short communication

    c-Myc oncogene is an important regulator of cell cycle and apoptosis, and its dysregulated expression is associated with many malignancies. Myc is instrumental in directly or indirectly regulating the progress...

    Authors: Osama Al-Assar and Dorothy H Crouch

    Citation: Molecular Cancer 2005 4:13

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    The Retraction Note to this article has been published in Molecular Cancer 2005 4:17

  11. Content type: Research

    In this study we have made novel observations with regards to potentiation of the tumoricidal activity of the oncolytic adenovirus, dl1520 (ONYX-015) in rat glioblastoma cell lines expressing heat shock protei...

    Authors: Jonathan Madara, James A Krewet and Maulik Shah

    Citation: Molecular Cancer 2005 4:12

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  12. Content type: Research

    A common feature of neuroblastoma tumours are partial deletions of the short arm of chromosome 1 (1p-deletions). This is indicative of a neuroblastoma tumour suppressor gene being located in the region. Severa...

    Authors: Helena Carén, Katarina Ejeskär, Susanne Fransson, Luke Hesson, Farida Latif, Rose-Marie Sjöberg, Cecilia Krona and Tommy Martinsson

    Citation: Molecular Cancer 2005 4:10

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  13. Content type: Research

    Multiple Endocrine Neoplasia type 1 (MEN1, OMIM 131100) is an autosomal dominant disorder characterized by endocrine tumors of the parathyroids, pancreatic islets and pituitary. The disease is caused by the fu...

    Authors: William G Dilley, Somasundaram Kalyanaraman, Sulekha Verma, J Perren Cobb, Jason M Laramie and Terry C Lairmore

    Citation: Molecular Cancer 2005 4:9

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  14. Content type: Research

    Recent studies have demonstrated that the NKX3.1 protein is commonly down-regulated in testicular germ cell tumors (TGCTs) and prostate carcinomas. The homeobox gene NKX3.1 maps to chromosome band 8p21, which is ...

    Authors: Guro E Lind, Rolf I Skotheim, Mario F Fraga, Vera M Abeler, Rui Henrique, Fahri Saatcioglu, Manel Esteller, Manuel R Teixeira and Ragnhild A Lothe

    Citation: Molecular Cancer 2005 4:8

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  15. Content type: Research

    Insulin-like growth factor binding protein 2 (IGFBP2) is overexpressed in ovarian malignant tissues and in the serum and cystic fluid of ovarian cancer patients, suggesting an important role of IGFBP2 in the b...

    Authors: Eun-Ju Lee, Cristian Mircean, Ilya Shmulevich, Huamin Wang, Jinsong Liu, Antti Niemistö, John J Kavanagh, Je-Ho Lee and Wei Zhang

    Citation: Molecular Cancer 2005 4:7

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  16. Content type: Short communication

    Conventional Comparative Genomic Hybridization (CGH) has been widely used for detecting copy number alterations in cancer and for identifying regions containing candidate tumor responsible genes. Recently, sev...

    Authors: Bárbara Meléndez, Beatriz Martínez-Delgado, Marta Cuadros, Victoria Fernández, Ramón Díaz-Uriarte and Javier Benítez

    Citation: Molecular Cancer 2005 4:5

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  17. Content type: Research

    In cancer, cellular transformation is followed by tumour development. Knowledge on the mechanisms of transformation, involving activation of proto-oncogenes and inactivation of tumour-suppressor genes has cons...

    Authors: Sophie Vasseur, Cédric Malicet, Ezequiel L Calvo, Jean Charles Dagorn and Juan L Iovanna

    Citation: Molecular Cancer 2005 4:4

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  18. Content type: Research

    Signal transducers and activators of transcription (STATs) are involved in growth regulation of cells. They are usually activated by phosphorylation at specific tyrosine residues. In neoplastic cells, constitu...

    Authors: Hosea F Huang, Thomas F Murphy, Ping Shu, Arnold B Barton and Beverly E Barton

    Citation: Molecular Cancer 2005 4:2

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  19. Content type: Research

    We previously reported that lifetime consumption of soy proteins or whey proteins reduced the incidence of azoxymethane (AOM)-induced colon tumors in rats. To obtain insights into these effects, global gene ex...

    Authors: Rijin Xiao, Thomas M Badger and Frank A Simmen

    Citation: Molecular Cancer 2005 4:1

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  20. Content type: Research

    Glioblastoma is the deadliest and most prevalent brain tumor. Dexamethasone (DXM) is a commonly used steroid for treating glioblastoma patients for alleviation of vasogenic edema and pain prior to treatment wi...

    Authors: Arabinda Das, Naren L Banik, Sunil J Patel and Swapan K Ray

    Citation: Molecular Cancer 2004 3:36

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  21. Content type: Research

    Lung cancer remains to be the leading cause of cancer death worldwide. Patients with similar lung cancer may experience quite different clinical outcomes. Reliable molecular prognostic markers are needed to ch...

    Authors: Zhifu Sun, Ping Yang, Marie-Christine Aubry, Farhad Kosari, Chiaki Endo, Julian Molina and George Vasmatzis

    Citation: Molecular Cancer 2004 3:35

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  22. Content type: Research

    Tpl2/Cot oncogene has been identified in murine T-cell lymphomas as a target of MoMuLV insertion. Animal and tissue culture studies have shown that Tpl2/Cot is involved in interleukin-2 (IL-2) and tumor necros...

    Authors: Anna V Christoforidou, Helen A Papadaki, Andrew N Margioris, George D Eliopoulos and Christos Tsatsanis

    Citation: Molecular Cancer 2004 3:34

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  23. Content type: Research

    Granulosa cell tumors (GCTs) are relatively rare and are subtypes of the sex-cord stromal neoplasms. Methylation induced silencing in the promoters of genes such as tumor suppressor genes, DNA repair genes and...

    Authors: Varinderpal S Dhillon, Mohd Shahid and Syed Akhtar Husain

    Citation: Molecular Cancer 2004 3:33

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  24. Content type: Research

    In addition to androgens, growth factors are also implicated in the development and neoplastic growth of the prostate gland. Prosaposin is a potent neurotrophic molecule. Homozygous inactivation of prosaposin in ...

    Authors: Tae-Jin Lee, Oliver Sartor, Ronald B Luftig and Shahriar Koochekpour

    Citation: Molecular Cancer 2004 3:31

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  25. Content type: Short communication

    To examine the relationship between mitochondrial DNA (mtDNA) alterations and colorectal tumorigenesis, we used high-resolution restriction endonucleases and sequencing to assess the mitochondrial genome from ...

    Authors: Felix O Aikhionbare, Masood Khan, Delicia Carey, Joel Okoli and Rodney Go

    Citation: Molecular Cancer 2004 3:30

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  26. Content type: Research

    The hedgehog pathway plays a critical role in the development of prostate. However, the role of the hedgehog pathway in prostate cancer is not clear. Prostate cancer is the second most prevalent cause of cance...

    Authors: Tao Sheng, Chengxin Li, Xiaoli Zhang, Sumin Chi, Nonggao He, Kai Chen, Frank McCormick, Zoran Gatalica and Jingwu Xie

    Citation: Molecular Cancer 2004 3:29

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  27. Content type: Research

    Tumor cell lines are commonly used as experimental tools in cancer research, but their relevance for the in vivo situation is debated. In a series of 11 microsatellite stable (MSS) and 9 microsatellite unstable (...

    Authors: Guro E Lind, Lin Thorstensen, Tone Løvig, Gunn I Meling, Richard Hamelin, Torleiv O Rognum, Manel Esteller and Ragnhild A Lothe

    Citation: Molecular Cancer 2004 3:28

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  28. Content type: Research

    Epithelial ovarian tumours exhibit a range of malignant potential, presenting distinct clinical phenotypes. Improved knowledge of gene expression changes and functional pathways associated with these clinical ...

    Authors: Susanne Warrenfeltz, Stephen Pavlik, Susmita Datta, Eileen T Kraemer, Benedict Benigno and John F McDonald

    Citation: Molecular Cancer 2004 3:27

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  29. Content type: Short communication

    Pediatric brain tumors may originate from cells endowed with neural stem/precursor cell properties, growing in vitro as neurospheres. We have found that these cells can also be present in adult brain tumors an...

    Authors: Patrizia Tunici, Lorena Bissola, Elena Lualdi, Bianca Pollo, Laura Cajola, Giovanni Broggi, Gabriella Sozzi and Gaetano Finocchiaro

    Citation: Molecular Cancer 2004 3:25

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  30. Content type: Research

    Tumors and complex tissues consist of mixtures of communicating cells that differ significantly in their gene expression status. In order to understand how different cell types influence one another's gene exp...

    Authors: Luiz OF Penalva, Michael D Burdick, Simon M Lin, Hedwig Sutterluety and Jack D Keene

    Citation: Molecular Cancer 2004 3:24

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  31. Content type: Research

    The CBFA2T3 locus located on the human chromosome region 16q24.3 is frequently deleted in breast tumors. CBFA2T3 gene expression levels are aberrant in breast tumor cell lines and the CBFA2T3B isoform is a pot...

    Authors: Anthony J Bais, Alison E Gardner, Olivia LD McKenzie, David F Callen, Grant R Sutherland and Gabriel Kremmidiotis

    Citation: Molecular Cancer 2004 3:22

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  32. Content type: Research

    Colorectal cancers displaying high-degree microsatellite instability (MSI-H) have an improved prognosis compared to microsatellite stable (MSS) cancers. The observation of pronounced lymphocytic infiltrates su...

    Authors: Ayan Banerjea, Shafi Ahmed, Rebecca E Hands, Fei Huang, Xia Han, Peter M Shaw, Roger Feakins, Stephen A Bustin and Sina Dorudi

    Citation: Molecular Cancer 2004 3:21

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  33. Content type: Research

    Neurofibromatosis type 1 (NF1) is an autosomal dominant disorder with a complex range of clinical symptoms. The hallmark of NF1 is the onset of heterogeneous (dermal or plexiform) benign neurofibromas. Plexiform ...

    Authors: Pascale Lévy, Dominique Vidaud, Karen Leroy, Ingrid Laurendeau, Janine Wechsler, Giulia Bolasco, Béatrice Parfait, Pierre Wolkenstein, Michel Vidaud and Ivan Bièche

    Citation: Molecular Cancer 2004 3:20

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  34. Content type: Research

    Hypoxia-tolerant human glioma cells reduce oxygen consumption rate in response to oxygen deficit, a defense mechanism that contributes to survival under moderately hypoxic conditions. In contrast, hypoxia-sens...

    Authors: Carrie DeHaan, Bahram Habibi-Nazhad, Elizabeth Yan, Nicole Salloum, Matthew Parliament and Joan Allalunis-Turner

    Citation: Molecular Cancer 2004 3:19

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  35. Content type: Research

    The agouti protein is a paracrine factor that is normally present in the skin of many species of mammals. Agouti regulates the switch between black and yellow hair pigmentation by signalling through the melano...

    Authors: Alexander I Kuklin, Randall L Mynatt, Mitchell L Klebig, Laura L Kiefer, William O Wilkison, Richard P Woychik and Edward J Michaud

    Citation: Molecular Cancer 2004 3:17

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  36. Content type: Research

    Male germ cell tumor (GCT) is a highly curable malignancy, which exhibits exquisite sensitivity to cisplatin treatment. The genetic pathway(s) that determine the chemotherapy sensitivity in GCT remain largely ...

    Authors: Sanjay Koul, James M McKiernan, Gopeshwar Narayan, Jane Houldsworth, Jennifer Bacik, Deborah L Dobrzynski, Adel M Assaad, Mahesh Mansukhani, Victor E Reuter, George J Bosl, Raju SK Chaganti and Vundavalli VVS Murty

    Citation: Molecular Cancer 2004 3:16

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  37. Content type: Research

    The expression of the rodent phosphoinositide-specific phospholipase C δ-4 (PLCδ4) has been found to be elevated upon mitogenic stimulation and expression analysis have linked the upregulation of PLCδ4 express...

    Authors: David W Leung, Chris Tompkins, Jim Brewer, Alexey Ball, Mike Coon, Valerie Morris, David Waggoner and Jack W Singer

    Citation: Molecular Cancer 2004 3:15

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  38. Content type: Research

    CHK2 kinase is a tumor suppressor that plays important role in DNA damage signaling, cell cycle regulation and DNA damage induced apoptosis. CHK2 kinase expression was known to be ubiquitous in mammalian cells...

    Authors: Peilin Zhang, Jie Wang, Weiyi Gao, Bao-Zhu Yuan, John Rogers and Eddie Reed

    Citation: Molecular Cancer 2004 3:14

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  39. Content type: Research

    The cellular retinol binding protein I gene (CRBP) is downregulated in a subset of human breast cancers and in MMTV-Myc induced mouse mammary tumors. Functional studies suggest that CRBP downregulation contribute...

    Authors: Alice Arapshian, Silvina Bertran, Yuvarani S Kuppumbatti, Shigeo Nakajo and Rafael Mira-y-Lopez

    Citation: Molecular Cancer 2004 3:13

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