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  1. Content type: Review

    Pancreatic adenocarcinoma is characterized by poor prognosis, because of late diagnosis and lack of response to chemo- and/or radiation therapies. Resistance to apoptosis mainly causes this insensitivity to co...

    Authors: Sabine Westphal and Holger Kalthoff

    Citation: Molecular Cancer 2003 2:6

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  2. Content type: Review

    About 80% of pancreatic cancer patients have glucose intolerance or frank diabetes. This observation has led to the following two hypotheses: i. pancreatic cancer causes the associated diabetes and ii. the condit...

    Authors: Feng Wang, Margery Herrington, Jörgen Larsson and Johan Permert

    Citation: Molecular Cancer 2003 2:4

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  3. Content type: Research

    Glucocorticoids inhibit hepatocellular proliferation and modulate the expression of oncogenes and tumor suppressor genes via mechanisms involving the glucocorticoid receptor. Glucocorticoids also produce a recept...

    Authors: Jihan A Youssef and Mostafa Z Badr

    Citation: Molecular Cancer 2003 2:3

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  4. Content type: Research

    Gleevec (aka STI571, Imatinib) is a recently FDA approved anti-tumor drug for chronic myelogenous leukemia. Gleevec binds specifically to BCR-ABL tyrosine kinase and inhibit the tyrosine kinase activity. It cr...

    Authors: Peilin Zhang, Wei Yi Gao, Steven Turner and Barbara S Ducatman

    Citation: Molecular Cancer 2003 2:1

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  5. Content type: Research

    Rhabdomyosarcoma is a common malignancy in children. There are two major types of rhabdomyosarcomas, the embryonal and the alveolar, differing in cytogenetic and morphologic features. The alveolar type of rhab...

    Authors: Peilin Zhang, Kunjan S Bhakta, Pier Lorenzo Puri, Robert O Newbury, James R Feramisco and Jean Y Wang

    Citation: Molecular Cancer 2003 2:2

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    The Retraction Note to this article has been published in Molecular Cancer 2003 2:17

  6. Content type: Review

    Mitochondria play important roles in cellular energy metabolism, free radical generation, and apoptosis. Defects in mitochondrial function have long been suspected to contribute to the development and progress...

    Authors: Jennifer S Carew and Peng Huang

    Citation: Molecular Cancer 2002 1:9

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  7. Content type: Research

    Human male germ cell tumors (GCTs) arise from undifferentiated primordial germ cells (PGCs), a stage in which extensive methylation reprogramming occurs. GCTs exhibit pluripotentality and are highly sensitive ...

    Authors: Sanjay Koul, Jane Houldsworth, Mahesh M Mansukhani, Alessia Donadio, James M McKiernan, Victor E Reuter, George J Bosl, Raju S Chaganti and Vundavalli V Murty

    Citation: Molecular Cancer 2002 1:8

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  8. Content type: Review

    Sex steroid hormones, estrogen, progesterone and androgen, play pivotal roles in sex differentiation and development, and in reproductive functions and sexual behavior. Studies have shown that sex steroid horm...

    Authors: Xiuhua Gao, Brian W Loggie and Zafar Nawaz

    Citation: Molecular Cancer 2002 1:7

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  9. Content type: Research

    The interaction of nuclear and mitochondrial genes is an essential feature in maintenance of normal cellular function. Of 82 structural subunits that make up the oxidative phosphorylation system in the mitocho...

    Authors: Robert Delsite, Sushant Kachhap, Ramaswamy Anbazhagan, Edward Gabrielson and Keshav K Singh

    Citation: Molecular Cancer 2002 1:6

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  10. Content type: Research

    PGE-2 is constitutively produced by many non-small cell lung cancers (NSCLC) and its immunosuppressive effects have been linked to altered immune responses in lung cancer. We asked whether elevated levels of p...

    Authors: Giovanna E Hidalgo, Li Zhong, Dennis E Doherty and Edward A Hirschowitz

    Citation: Molecular Cancer 2002 1:5

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  11. Content type: Research

    Anaplastic thyroid carcinoma, which is one of the most aggressive, malignant tumors in humans, results in an extremely poor prognosis despite chemotherapy and radiotherapy. The present study was designed to ev...

    Authors: Ken Ohnishi, Ichiro Ota, Katsunari Yane, Akihisa Takahashi, Kazue Yuki, Mie Emoto, Hiroshi Hosoi and Takeo Ohnishi

    Citation: Molecular Cancer 2002 1:4

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  12. Content type: Research

    Previous studies have shown that the short arm of chromosome 5 (5p) exhibit frequent genetic changes in invasive cervical carcinoma (CC), and that these changes arise early during the carcinogenesis, in precan...

    Authors: Hugo Arias-Pulido, Gopeshwar Narayan, Hernan Vargas, Mahesh Mansukhani and Vundavalli VVS Murty

    Citation: Molecular Cancer 2002 1:3

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  13. Content type: Research

    The active copy of the imprinted gene H19 is turned off by inappropriate methylation in several pediatric tumors including Wilms' Tumour and embryonal rhabdomyosarcoma. H19 controls in cis the linked Insulin-like...

    Authors: Catherine A Lynch, Benjamin Tycko, Timothy H Bestor and Colum P Walsh

    Citation: Molecular Cancer 2002 1:2

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