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  1. The evolutionary conserved cyclin-dependent kinase phosphatase hCdc14A has been shown to play potential roles in the regulation of mitotic exit and in the centrosome duplication cycle. We have recently shown t...

    Authors: Michelle T Paulsen, Adrienne M Starks, Frederick A Derheimer, Sheela Hanasoge, Liwu Li, Jack E Dixon and Mats Ljungman

    Citation: Molecular Cancer 2006 5:25

    Content type: Research

    Published on:

  2. Recent studies indicate that microRNAs (miRNAs) are mechanistically involved in the development of various human malignancies, suggesting that they represent a promising new class of cancer biomarkers. However...

    Authors: Michael D Mattie, Christopher C Benz, Jessica Bowers, Kelly Sensinger, Linda Wong, Gary K Scott, Vita Fedele, David Ginzinger, Robert Getts and Chris Haqq

    Citation: Molecular Cancer 2006 5:24

    Content type: Research

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  3. The Helicase-Like Transcription Factor (HLTF/SMARCA3) belongs to the family of SWI/SNF proteins that use the energy of ATP hydrolysis to remodel chromatin in a variety of cellular processes. Several SWI/SNF ge...

    Authors: Gaël Debauve, Denis Nonclercq, Fabrice Ribaucour, Murielle Wiedig, Cécile Gerbaux, Oberdan Leo, Guy Laurent, Fabrice Journé, Alexandra Belayew and Gérard Toubeau

    Citation: Molecular Cancer 2006 5:23

    Content type: Research

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  4. Gene-targeted iMyc mice that carry a His6-tagged mouse Myc(c-myc)cDNA, MycHis, just 5' of the immunoglobulin heavy-chain enhancer, Eμ, are prone to B cell and plasma cell neoplasms, such as lymphoblastic B-cell...

    Authors: Seong-Su Han, Liangping Peng, Seung-Tae Chung, Wendy DuBois, Sung-Ho Maeng, Arthur L Shaffer, Michael B Sporn and Siegfried Janz

    Citation: Molecular Cancer 2006 5:22

    Content type: Research

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  5. There is little understanding of the effect that reactive oxygen metabolites have on cellular behavior during the processes of invasion and metastasis. These oxygen metabolites could interact with a number of ...

    Authors: Danielle Lejeune, Mohammad Hasanuzzaman, Amanda Pitcock, Joseph Francis and Inder Sehgal

    Citation: Molecular Cancer 2006 5:21

    Content type: Short communication

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  6. Treatment of cells with the anti-cancer drug 5-fluorouracil (5-FU) causes DNA damage, which in turn affects cell proliferation and survival. Two stable wild-type TP53 5-FU-resistant cell lines, ContinB and Contin...

    Authors: Paula M De Angelis, Debbie H Svendsrud, Katherine L Kravik and Trond Stokke

    Citation: Molecular Cancer 2006 5:20

    Content type: Research

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  7. 2,5-Dimethyl-celecoxib (DMC) is a close structural analog of the selective cyclooxygenase-2 (COX-2) inhibitor celecoxib (Celebrex®) that lacks COX-2-inhibitory function. However, despite its inability to block CO...

    Authors: Peter Pyrko, Nathaniel Soriano, Adel Kardosh, Yen-Ting Liu, Jasim Uddin, Nicos A Petasis, Florence M Hofman, Ching-Shih Chen, Thomas C Chen and Axel H Schönthal

    Citation: Molecular Cancer 2006 5:19

    Content type: Research

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  8. Chromosomal aberrations of BCL11A at 2p16.1 have been reported in a variety of B-cell malignancies and its deficiency in mice leads to a profound block in B-cell development.

    Authors: Hui Liu, Gregory C Ippolito, Jason K Wall, Teresa Niu, Loren Probst, Baeck-Seung Lee, Karen Pulford, Alison H Banham, Luke Stockwin, Arthur L Shaffer, Louis M Staudt, Chhaya Das, Martin JS Dyer and Philip W Tucker

    Citation: Molecular Cancer 2006 5:18

    Content type: Research

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  9. Cervical Cancer (CC) exhibits highly complex genomic alterations. These include hemizygous deletions at 4p15.3, 10q24, 5q35, 3p12.3, and 11q24, the chromosomal sites of Slit-Robo pathway genes. However, no can...

    Authors: Gopeshwar Narayan, Chandra Goparaju, Hugo Arias-Pulido, Andreas M Kaufmann, Achim Schneider, Matthias Dürst, Mahesh Mansukhani, Bhavana Pothuri and Vundavalli V Murty

    Citation: Molecular Cancer 2006 5:16

    Content type: Research

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  10. Squamous cell carcinoma (SCC) of the skin is the most aggressive form of non-melanoma skin cancer (NMSC), and is the single most commonly diagnosed cancer in the U.S., with over one million new cases reported ...

    Authors: Weihong Yin, Satish Cheepala, Jennifer N Roberts, Keith Syson-Chan, John DiGiovanni and John L Clifford

    Citation: Molecular Cancer 2006 5:15

    Content type: Research

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  11. In prostate cancer, normal citrate-producing glandular secretory epithelial cells undergo a metabolic transformation to malignant citrate-oxidizing cells. m-Aconitase is the critical step involved in this alte...

    Authors: Keshav K Singh, Mohamed M Desouki, Renty B Franklin and Leslie C Costello

    Citation: Molecular Cancer 2006 5:14

    Content type: Research

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  12. Fenofibrate, an agonist of PPAR-alpha, in doses above 25 μM, inhibits proliferation and induces apoptosis in Ishikawa endometrial cancer cells. We show that these effects are potentiated by retinoic acid, an a...

    Authors: Samir A Saidi, Cathrine M Holland, D Stephen Charnock-Jones and Stephen K Smith

    Citation: Molecular Cancer 2006 5:13

    Content type: Research

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  13. Retinoic acid suppresses cell growth and promotes cell differentiation, and pharmacological retinoic acid receptor (RAR) activation is anti-tumorigenic. This begs the question of whether chronic physiological ...

    Authors: Tara S Kupumbati, Giorgio Cattoretti, Christine Marzan, Eduardo F Farias, Reshma Taneja and Rafael Mira-y-Lopez

    Citation: Molecular Cancer 2006 5:12

    Content type: Research

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  14. Early detection of a premalignant or cancerous oral lesion promises to improve the survival and the morbidity of patients suffering from these conditions. Cytological study of oral cells is a non-aggressive te...

    Authors: Ravi Mehrotra, Anurag Gupta, Mamta Singh and Rahela Ibrahim

    Citation: Molecular Cancer 2006 5:11

    Content type: Review

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    The Retraction Note to this article has been published in Molecular Cancer 2012 11:57

  15. Helicobacter pylori (H. pylori) causes gastritis and intestinal metaplasia (IM) that may evolve to gastric carcinoma. The objective of this study was to compare the profile of mucins in the progressive stages of

    Authors: Subramani Durai Babu, Venkataraman Jayanthi, Niranjali Devaraj, Celso A Reis and Halagowder Devaraj

    Citation: Molecular Cancer 2006 5:10

    Content type: Research

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  16. Genetic studies associated the CAPB locus with familial risk of brain and prostate cancers. We have identified HSPG2 (Perlecan) as a candidate gene for CAPB. Previously we have linked Perlecan to Hedgehog signali...

    Authors: Milton W Datta, Ana Maria Hernandez, Michael J Schlicht, Andrea J Kahler, Amy M DeGueme, Rajiv Dhir, Rajal B Shah, Cindy Farach-Carson, Andrea Barrett and Sumana Datta

    Citation: Molecular Cancer 2006 5:9

    Content type: Research

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  17. Cyclin D1 is an important regulator of G1-S phase cell cycle transition and has been shown to be important for breast cancer development. GSK3β phosphorylates cyclin D1 on Thr-286, resulting in enhanced ubiqui...

    Authors: John P Alao, Alexandra V Stavropoulou, Eric W-F Lam, R Charles Coombes and David M Vigushin

    Citation: Molecular Cancer 2006 5:8

    Content type: Research

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  18. The cyclin D1 proto-oncogene is an important regulator of G1 to S-phase transition and an important cofactor for several transcription factors in numerous cell types. Studies on neonatal cardiomyocytes and pos...

    Authors: John P Alao, Simon C Gamble, Alexandra V Stavropoulou, Karen M Pomeranz, Eric W-F Lam, R Charles Coombes and David M Vigushin

    Citation: Molecular Cancer 2006 5:7

    Content type: Research

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  19. Cancer growth, invasion and metastasis are highly related to tumor-associated neovasculature. The presence and progression of endothelial cells in cancer is chaotic, unorganized, and angiogenic vessels are les...

    Authors: Finie Hunter, Jianwu Xie, Cameron Trimble, Monica Bur and King CP Li

    Citation: Molecular Cancer 2006 5:5

    Content type: Research

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  20. Polymorphisms or mutations in hypoxia inducible factor-1 alpha (HIF-1alpha) that increases its activity and stability under normoxia have recently been identified. Likewise, disruption of the TSC1/TSC2 complex...

    Authors: Carla Hebert, Kathleen Norris, Pallavi Parashar, Robert A Ord, Nikolaos G Nikitakis and John J Sauk

    Citation: Molecular Cancer 2006 5:3

    Content type: Research

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  21. BRAF is a member of RAF family of serine/threonine kinases and mediates cellular responses to growth signals through the RAS-RAF-MAP kinase pathway. Activating mutations in BRAF have recently been found in about ...

    Authors: Wei Qi Li, Kazuyuki Kawakami, Andrew Ruszkiewicz, Graeme Bennett, James Moore and Barry Iacopetta

    Citation: Molecular Cancer 2006 5:2

    Content type: Research

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  22. Deregulated cell cycle progression and loss of proliferation control are key properties of malignant cells. In previous studies, an interactive transcript abundance index (ITAI) comprising three cell cycle con...

    Authors: Timothy G Graves, Michael W Harr, Erin L Crawford and James C Willey

    Citation: Molecular Cancer 2006 5:1

    Content type: Research

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  23. Metallothionein 3 (MT3) inhibits growth in a variety of cell types. We measured MT3 gene expression by RT-PCR, and DNA methylation in the MT3 promoter by combined bisulphite restriction analysis, in four oesophag...

    Authors: Eric Smith, Paul A Drew, Zi-Qing Tian, Neville J De Young, Jun-Feng Liu, George C Mayne, Andrew R Ruszkiewicz, David I Watson and Glyn G Jamieson

    Citation: Molecular Cancer 2005 4:42

    Content type: Research

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  24. p21WAF1, implicated in the cell cycle control of both normal and malignant cells, can be induced by p53-dependent and independent mechanisms. In some cells, MEKs/ERKs regulate p21WAF1 transcriptionally, while in ...

    Authors: Carmela Ciccarelli, Francesco Marampon, Arianna Scoglio, Annunziata Mauro, Cristina Giacinti, Paola De Cesaris and Bianca M Zani

    Citation: Molecular Cancer 2005 4:41

    Content type: Research

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  25. Myc-induced lymphoblastic B-cell lymphoma (LBL) in iMyc mice may provide a model system for the study of the mechanism by which human MYC facilitates the initiation and progression of B cell and plasma cell neo...

    Authors: Seong Su Han, Arthur L Shaffer, Liangping Peng, Seung Tae Chung, Jae Hwan Lim, Sungho Maeng, Joong Su Kim, Nicole McNeil, Thomas Ried, Louis M Staudt and Siegfried Janz

    Citation: Molecular Cancer 2005 4:40

    Content type: Research

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  26. Amplification of the q21-q23 region on chromosome 1 is frequently found in sarcomas and a variety of other solid tumours. Previous analyses of sarcomas have indicated the presence of at least two separate ampl...

    Authors: Stine H Kresse, Jeanne-Marie Berner, Leonardo A Meza-Zepeda, Simon G Gregory, Wen-Lin Kuo, Joe W Gray, Anne Forus and Ola Myklebost

    Citation: Molecular Cancer 2005 4:39

    Content type: Research

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  27. Cervical cancer remains one of the greatest killers of women worldwide. It is difficult to foresee a dramatic increase in cure rate even with the most optimal combination of cytotoxic drugs, surgery, and radia...

    Authors: Alfonso Dueñas-González, Marcela Lizano, Myrna Candelaria, Lucely Cetina, Claudia Arce and Eduardo Cervera

    Citation: Molecular Cancer 2005 4:38

    Content type: Review

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  28. Interaction with integrin and focal adhesion kinase (FAK) regulates the cancer cell adhesion and invasion into extracellular matrix (ECM). In addition, phosphorylation of FAK correlates with the increase of ce...

    Authors: Hirozumi Sawai, Yuji Okada, Hitoshi Funahashi, Yoichi Matsuo, Hiroki Takahashi, Hiromitsu Takeyama and Tadao Manabe

    Citation: Molecular Cancer 2005 4:37

    Content type: Research

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  29. Several studies of tumors have revealed substantial numbers of clonally expanded somatic mutations in mitochondrial DNA (mtDNA), not observed in adjacent intact tissues. These findings were interpreted as indi...

    Authors: M Khaidakov and RJ Shmookler Reis

    Citation: Molecular Cancer 2005 4:36

    Content type: Review

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  30. Allelic loss of chromosome 1p is frequently observed in oligodendroglioma. We screened 177 oligodendroglial tumors for 1p deletions and found 6 tumors with localized 1p36 deletions. Several apoptosis regulatio...

    Authors: J Matthew McDonald, Valerie Dunmire, Ellen Taylor, Raymond Sawaya, Janet Bruner, Gregory N Fuller, Kenneth Aldape and Wei Zhang

    Citation: Molecular Cancer 2005 4:35

    Content type: Research

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  31. The Structural Maintenance of Chromosome 3 protein (SMC3) plays an essential role during the sister chromatid separation, is involved in DNA repair and recombination and participates in microtubule-mediated in...

    Authors: Giancarlo Ghiselli and Chang-Gong Liu

    Citation: Molecular Cancer 2005 4:34

    Content type: Research

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  32. The genetic and molecular mechanisms responsible for and associated with the development and progression of prostate malignancy are largely unidentified. The peripheral zone is the major region of the human pr...

    Authors: Renty B Franklin, Pei Feng, B Milon, Mohamed M Desouki, Keshav K Singh, André Kajdacsy-Balla, Omar Bagasra and Leslie C Costello

    Citation: Molecular Cancer 2005 4:32

    Content type: Research

    Published on:

  33. Tumor metastasis and changes in host immunosurveillance are important components in cancer development. Tumor cell invasion into the bloodstream is an essential step for systemic metastasis. Currently, the det...

    Authors: Xin Li, Carson Wong, Ralph Mysel, Gennady Slobodov, Adam Metwalli, Jarrett Kruska, C Scott Manatt, Daniel J Culkin, Bradley P Kropp and Hsueh-Kung Lin

    Citation: Molecular Cancer 2005 4:30

    Content type: Research

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  34. Introduction of cDNA or genomic clones of the tumor suppressor in lung cancer 1 (TSLC1) gene into the non-small cell lung cancer line, A549, reverses tumorigenic growth properties of these cells. These results an...

    Authors: Thomas E Sussan, Mathew T Pletcher, Yoshinori Murakami and Roger H Reeves

    Citation: Molecular Cancer 2005 4:28

    Content type: Research

    Published on:

  35. Cyclooxygenase 2 (COX-2), the inducible form of prostaglandin G/H synthase, is associated with several human cancers including pancreatic adenocarcinoma. Pancreatic stellate cells (PSCs) play a central role in...

    Authors: Seiya Yoshida, Michael Ujiki, Xian-Zhong Ding, Carolyn Pelham, Mark S Talamonti, Richard H Bell Jr, Woody Denham and Thomas E Adrian

    Citation: Molecular Cancer 2005 4:27

    Content type: Research

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  36. While numerous studies have characterized primary ovarian tumors, little information is available regarding expression patterns of metastatic sites of this cancer. To define sets of genes that distinguish prim...

    Authors: Marci E Schaner, Ben Davidson, Martina Skrede, Reuven Reich, Vivi Ann Flørenes, Björn Risberg, Aasmund Berner, Iris Goldberg, Vered Givant-Horwitz, Claes G Tropè, Gunnar B Kristensen, Jahn M Nesland and Anne-Lise Børresen-Dale

    Citation: Molecular Cancer 2005 4:26

    Content type: Research

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  37. Cisplatin resistance is complex and involves several different mechanisms. Employing cDNA microarray analysis, we have found that cisplatin resistant cells share the common characteristic of increase in riboso...

    Authors: Chunjing Wu, Medhi Wangpaichitr, Lynn Feun, Marcus Tien Kuo, Carlos Robles, Theodore Lampidis and Niramol Savaraj

    Citation: Molecular Cancer 2005 4:25

    Content type: Research

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  38. In cancer cells, telomerase induction helps maintain telomere length and thereby bypasses senescence and provides enhanced replicative potential. Chemical inhibitors of telomerase have been shown to reactivate...

    Authors: Masood A Shammas, Hemanta Koley, Ramesh B Batchu, Robert C Bertheau, Alexei Protopopov, Nikhil C Munshi and Raj K Goyal

    Citation: Molecular Cancer 2005 4:24

    Content type: Research

    Published on:

  39. Cell proliferation control depends in part on the carefully ordered regulation of transcription factors. The p53 homolog p73, contributes to this control by directly upregulating the cyclin dependent kinase in...

    Authors: Michael W Harr, Timothy G Graves, Erin L Crawford, Kristy A Warner, Cheryl AM Reed and James C Willey

    Citation: Molecular Cancer 2005 4:23

    Content type: Research

    Published on:

  40. The development of cancer has been associated with epigenetic alterations such as aberrant histone deacetylase (HDAC) activity. It was recently reported that valproic acid is an effective inhibitor of histone ...

    Authors: Alma Chavez-Blanco, Blanca Segura-Pacheco, Enrique Perez-Cardenas, Lucia Taja-Chayeb, Lucely Cetina, Myrna Candelaria, David Cantu, Aurora Gonzalez-Fierro, Patricia Garcia-Lopez, Pilar Zambrano, Carlos Perez-Plasencia, Gustavo Cabrera, Catalina Trejo-Becerril, Enrique Angeles and Alfonso Duenas-Gonzalez

    Citation: Molecular Cancer 2005 4:22

    Content type: Research

    Published on:

  41. In the current study we investigated the role of caveolin-1 (cav-1) in pancreatic adenocarcinoma (PC) cell migration and invasion; initial steps in metastasis. Cav-1 is the major structural protein in caveolae...

    Authors: Min Lin, Melinda M DiVito, Sofia D Merajver, Madanamohan Boyanapalli and Kenneth L van Golen

    Citation: Molecular Cancer 2005 4:21

    Content type: Research

    Published on:

  42. The c-fos gene was originally identified as the cellular homolog of the oncogene v-fos carried by the Finkel-Biskis-Jenkins and Finkel-Biskis-Reilly murine osteogenic sarcoma retroviruses. Sustained expression of...

    Authors: Jared M Ordway, Steven D Fenster, Hong Ruan and Thomas Curran

    Citation: Molecular Cancer 2005 4:19

    Content type: Research

    Published on:

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