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  1. Immunity, based on a natural and an educated system, is responsible for recognition and elimination of infectious particles, cellular waste, modified self and transformed cells. This dual system guarantees tha...

    Authors: H Peter Vollmers and Stephanie Brändlein

    Citation: Molecular Cancer 2007 6:78

    Content type: Review

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  2. Neoplastic cells increase glycolysis in order to produce anabolic precursors and energy within the hypoxic environment of a tumor. Ras signaling is activated in several cancers and has been found to regulate m...

    Authors: Sucheta Telang, Andrew N Lane, Kristin K Nelson, Sengodagounder Arumugam and Jason Chesney

    Citation: Molecular Cancer 2007 6:77

    Content type: Research

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  3. Although a high level of functional voltage-gated sodium channel (VGSC) expression has been found in strongly metastatic human and rat prostate cancer (PCa) cells, the mechanism(s) responsible for the upregula...

    Authors: Pinar Uysal-Onganer and Mustafa BA Djamgoz

    Citation: Molecular Cancer 2007 6:76

    Content type: Research

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  4. The studies on cancer-stem-cells (CSCs) have attracted so much attention in recent years as possible therapeutic implications. This study was carried out to investigate the gene expression profile of CSCs in h...

    Authors: Dong-Cheol Seo, Ji-Min Sung, Hee-Jung Cho, Hee Yi, Kun-Ho Seo, In-Soo Choi, Dong-Ku Kim, Jin-Suk Kim, Abd El-Aty AM and Ho-Chul Shin

    Citation: Molecular Cancer 2007 6:75

    Content type: Research

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  5. GPI anchor attachment is catalyzed by the GPI transamidase (GPIT) complex. GAA1, PIG-T and PIG-U are the three of five GPIT subunits. Previous studies demonstrated amplification and overexpression of GPIT subunit...

    Authors: Wei-Wen Jiang, Marianna Zahurak, Zeng-Tong Zhou, Hannah Lui Park, Zhong-Min Guo, Guo-Jun Wu, David Sidransky, Barry Trink and Joseph A Califano

    Citation: Molecular Cancer 2007 6:74

    Content type: Research

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  6. Bortezomib is a novel anti-cancer agent which has shown promising activity in non-small lung cancer (NSCLC) patients. However, only a subset of patients respond to this treatment. We show that NSCLC cell lines...

    Authors: Jens Voortman, Agnieszka Chęcińska and Giuseppe Giaccone

    Citation: Molecular Cancer 2007 6:73

    Content type: Short communication

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  7. Enhanced osteoblast-dependent osteoclastogenesis due to inhibition of Wnt/β-catenin signaling in bone morphogenic protein (BMP)-driven osteoprogenitors has been repeatedly implicated in the natural history of ...

    Authors: Ken-ichi Fujita and Siegfried Janz

    Citation: Molecular Cancer 2007 6:71

    Content type: Research

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  8. Lung cancer is the number one cancer killer of both men and women in the United States. Three quarters of lung cancer patients are diagnosed with regionally or distantly disseminated disease; their 5-year surv...

    Authors: Jeffrey A Tsou, Janice S Galler, Kimberly D Siegmund, Peter W Laird, Sally Turla, Wendy Cozen, Jeffrey A Hagen, Michael N Koss and Ite A Laird-Offringa

    Citation: Molecular Cancer 2007 6:70

    Content type: Research

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  9. Histone deacetylase inhibitors (HDACIs) have many effects on cancer cells, such as growth inhibition, induction of cell death, differentiation, and anti-angiogenesis, all with a wide therapeutic index. However...

    Authors: Selena Kuljaca, Tao Liu, Andrew EL Tee, Michelle Haber, Murray D Norris, Tanya Dwarte and Glenn M Marshall

    Citation: Molecular Cancer 2007 6:68

    Content type: Research

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  10. Ph-positive leukemias are caused by the aberrant fusion of the BCR and ABL genes. Nilotinib is a selective Bcr/Abl tyrosine kinase inhibitor related to imatinib, which is widely used to treat chronic myelogenous ...

    Authors: Pavinder Kaur, Niklas Feldhahn, Bin Zhang, Daniel Trageser, Markus Müschen, Veerle Pertz, John Groffen and Nora Heisterkamp

    Citation: Molecular Cancer 2007 6:67

    Content type: Research

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  11. The incidence of malignant pleural mesothelioma (MPM) is associated with exposure to asbestos, and projections suggest that the yearly number of deaths in Western Europe due to MPM will increase until 2020. De...

    Authors: Larisa L Belyanskaya, Thomas M Marti, Sally Hopkins-Donaldson, Stefanie Kurtz, Emanuela Felley-Bosco and Rolf A Stahel

    Citation: Molecular Cancer 2007 6:66

    Content type: Research

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  12. PP2Cα is the representative member of the type 2C family of protein phosphatases, and it has recently been implicated in the regulation of p53-, TGFβ-, cyclin-dependent kinase- and apoptosis-signaling. To inve...

    Authors: Twan Lammers, Peter Peschke, Volker Ehemann, Jürgen Debus, Boris Slobodin, Sara Lavi and Peter Huber

    Citation: Molecular Cancer 2007 6:65

    Content type: Research

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  13. Meningiomas are common brain tumors that are classified into three World Health Organization grades (benign, atypical and malignant) and are molecularly ill-defined tumors. The purpose of this study was identi...

    Authors: Lucia Helena Carvalho, Ivan Smirnov, Gilson S Baia, Zora Modrusan, Justin S Smith, Peter Jun, Joseph F Costello, Michael W McDermott, Scott R VandenBerg and Anita Lal

    Citation: Molecular Cancer 2007 6:64

    Content type: Research

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  14. Searching for novel molecular markers that dependably predict or indicate responses of human cancer cells to epidermal growth factor receptor (EGFR)-targeted therapy is strongly warranted. The purpose of the c...

    Authors: Yang Lu, Ke Liang, Xinqun Li and Zhen Fan

    Citation: Molecular Cancer 2007 6:63

    Content type: Research

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  15. Oral leukoplakia is a precancerous change developed in the oral mucosa, and the mechanism that oral leukoplakia becomes malignant through atypical epithelium is not known. Here we compared the β-catenin expres...

    Authors: Kosei Ishida, Satoshi Ito, Naoyuki Wada, Hiroyo Deguchi, Tsuyoshi Hata, Masaru Hosoda and Tsutomu Nohno

    Citation: Molecular Cancer 2007 6:62

    Content type: Research

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  16. It is more and more recognized that hypoxia plays a role in the resistance of cancer cells to chemotherapy. However, the mechanisms underlying this resistance still need deeper understanding. The aim of this s...

    Authors: Jean-Philippe Cosse, Audrey Sermeus, Kayleen Vannuvel, Noelle Ninane, Martine Raes and Carine Michiels

    Citation: Molecular Cancer 2007 6:61

    Content type: Research

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  17. Multiple myeloma (MM) is a common hematological malignancy which remains incurable due to both intrinsic and acquired resistance to conventional or more novel drugs. Estrogenic and antiestrogenic compounds are...

    Authors: Brigitte Sola and Jack-Michel Renoir

    Citation: Molecular Cancer 2007 6:59

    Content type: Review

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  18. Drug resistance is a major problem in cancer chemotherapy. Acquisition of chemo-resistance not only reduces the effectiveness of drugs, but also promotes side effects and markedly reduces the patient's quality...

    Authors: Jun Hamaguchi, Hiroaki Nakagawa, Masato Takahashi, Takeaki Kudo, Naoya Kamiyama, Bailong Sun, Takahiro Oshima, Yuji Sato, Kisaburo Deguchi, Satoru Todo and Shin-Ichiro Nishimura

    Citation: Molecular Cancer 2007 6:58

    Content type: Research

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  19. The use of retinoids as anti-cancer agents has been limited due to resistance and low efficacy. The dynamics of nuclear receptor coregulation are incompletely understood. Cell-and context-specific activities o...

    Authors: Kelly C Heim, Kristina A White, Dexin Deng, Craig R Tomlinson, Jason H Moore, Sarah J Freemantle and Michael J Spinella

    Citation: Molecular Cancer 2007 6:57

    Content type: Research

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  20. The presence of EGFR kinase domain mutations in a subset of NSCLC patients correlates with the response to treatment with the EGFR tyrosine kinase inhibitors gefitinib and erlotinib. Although most EGFR mutatio...

    Authors: Matheus M de Gunst, Marielle I Gallegos-Ruiz, Giuseppe Giaccone and Jose Antonio Rodriguez

    Citation: Molecular Cancer 2007 6:56

    Content type: Research

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  21. Neuroblastoma (NB) is an extra-cranial solid tumour of childhood. In spite of the good clinical response to first-line therapy, complete eradication of NB cells is rarely achieved. Thus, new therapeutic strate...

    Authors: Roberta Carosio, Guendalina Zuccari, Isabella Orienti, Salvatore Mangraviti and Paolo G Montaldo

    Citation: Molecular Cancer 2007 6:55

    Content type: Research

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  22. Colorectal cancer develops through two main genetic instability pathways characterized by distinct pathologic features and clinical outcome.

    Authors: Giovanni Lanza, Manuela Ferracin, Roberta Gafà, Angelo Veronese, Riccardo Spizzo, Flavia Pichiorri, Chang-gong Liu, George A Calin, Carlo M Croce and Massimo Negrini

    Citation: Molecular Cancer 2007 6:54

    Content type: Research

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  23. Testicular germ cell tumors (TGCTs) respond well to cisplatin-based chemotherapy and show a low incidence of acquired resistance compared to most somatic tumors. The reasons for these specific characteristics ...

    Authors: Nur Duale, Birgitte Lindeman, Mitsuko Komada, Ann-Karin Olsen, Ashild Andreassen, Erik J Soderlund and Gunnar Brunborg

    Citation: Molecular Cancer 2007 6:53

    Content type: Research

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  24. Fusion of the MOZ and TIF2 genes by an inv (8) (p11q13) translocation has been identified in patients with acute mixed-lineage leukemia. Characterization of the molecular structure of the MOZ-TIF2 fusion prote...

    Authors: Hong Yin, Jonathan Glass and Kerry L Blanchard

    Citation: Molecular Cancer 2007 6:51

    Content type: Research

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  25. Efforts aimed at deciphering the molecular basis of complex disease are underpinned by the availability of high throughput strategies for the identification of biomolecules that drive the disease process. The ...

    Authors: David Murray, Peter Doran, Padraic MacMathuna and Alan C Moss

    Citation: Molecular Cancer 2007 6:50

    Content type: Review

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  26. Epigenetic silencing of the RAS association domain family 1A (RASSF1A) tumor suppressor gene promoter has been demonstrated in renal cell carcinoma (RCC) as a result of promoter hypermethylation. Contradictory re...

    Authors: Inga Peters, Kristina Rehmet, Nadine Wilke, Markus A Kuczyk, Jörg Hennenlotter, Tyark Eilers, Stefan Machtens, Udo Jonas and Jürgen Serth

    Citation: Molecular Cancer 2007 6:49

    Content type: Research

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  27. Resistance to modern adjuvant treatment is in part due to the failure of programmed cell death. Therefore the molecules that execute the apoptotic program are potential targets for the development of anti-canc...

    Authors: Hiroyuki Kashiwagi, Jonathan E McDunn, Peter O Simon Jr, Peter S Goedegebuure, Jinbin Xu, Lynne Jones, Katherine Chang, Fabian Johnston, Kathryn Trinkaus, Richard S Hotchkiss, Robert H Mach and William G Hawkins

    Citation: Molecular Cancer 2007 6:48

    Content type: Research

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  28. Ependymal tumors constitute a clinicopathologically heterogeneous group of brain tumors. They vary in regard to their age at first symptom, localization, morphology and prognosis. Genetic data also suggests he...

    Authors: Emmanuel Rousseau, Thomas Palm, Francesco Scaravilli, Marie-Magdeleine Ruchoux, Dominique Figarella-Branger, Isabelle Salmon, David Ellison, Catherine Lacroix, Françoise Chapon, Jacqueline Mikol, Miikka Vikkula and Catherine Godfraind

    Citation: Molecular Cancer 2007 6:47

    Content type: Research

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  29. Acute lymphoblastic leukemia (ALL) is the most common hematological malignancy affecting children. Despite significant progress and success in the treatment of ALL, a significant number of children continue to...

    Authors: Tapas K Sengupta, Gilles M Leclerc, Ting Ting Hsieh-Kinser, Guy J Leclerc, Inderjit Singh and Julio C Barredo

    Citation: Molecular Cancer 2007 6:46

    Content type: Research

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  30. The epigenetics of ovarian carcinogenesis remains poorly described. We have in the present study investigated the promoter methylation status of 13 genes in primary ovarian carcinomas (n = 52) and their in vitro ...

    Authors: Qinghua Wu, Ragnhild A Lothe, Terje Ahlquist, Ilvars Silins, Claes G Tropé, Francesca Micci, Jahn M Nesland, Zhenhe Suo and Guro E Lind

    Citation: Molecular Cancer 2007 6:45

    Content type: Research

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  31. Angiogenesis is a fundamental process that allows tumor growth by providing nutrients and oxygen to the tumor cells. Beyond the oxygen diffusion limit from a capillary blood vessel, tumor cells become apoptoti...

    Authors: Thaysa Paschoalin, Adriana K Carmona, Elaine G Rodrigues, Vitor Oliveira, Hugo P Monteiro, Maria A Juliano, Luiz Juliano and Luiz R Travassos

    Citation: Molecular Cancer 2007 6:44

    Content type: Research

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  32. Sovereign power is retained and shared by the citizens of a country. Using electoral tools, governing structures are formed to ensure protection of national interests. As with any institution, proper control o...

    Authors: Shawn Mathur and Christian Schmidt

    Citation: Molecular Cancer 2007 6:43

    Content type: Editorial

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  33. The role of TNF-α in affecting the fate of tumors is controversial, while some studies have reported apoptotic or necrotic effects of TNF-α, others provide evidence that endogenous TNF-α promotes growth and de...

    Authors: Pabbisetty Sudheer Kumar, Anjali Shiras, Gowry Das, Jayashree C Jagtap, Vandna Prasad and Padma Shastry

    Citation: Molecular Cancer 2007 6:42

    Content type: Research

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  34. The cRGD peptide is a promising probe for early non-invasive detection of tumors. This study aimed to demonstrate how RAFT-c(-RGDfK-)4, a molecule allowing a tetrameric presentation of cRGD, improved cRGD-targeti...

    Authors: Zhao-Hui Jin, Véronique Josserand, Stéphanie Foillard, Didier Boturyn, Pascal Dumy, Marie-Christine Favrot and Jean-Luc Coll

    Citation: Molecular Cancer 2007 6:41

    Content type: Research

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  35. LIM kinase 1 (LIMK1), a LIM domain containing serine/threonine kinase, modulates actin dynamics through inactivation of the actin depolymerizing protein cofilin. Recent studies have indicated an important role...

    Authors: Monica Davila, Darshana Jhala, Debashis Ghosh, William E Grizzle and Ratna Chakrabarti

    Citation: Molecular Cancer 2007 6:40

    Content type: Research

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  36. The androgen receptor (AR) plays critical roles in both androgen-dependent and castrate-resistant prostate cancer (PCa). However, little is known about AR target genes that mediate the receptor's roles in dise...

    Authors: Unnati Jariwala, Jennifer Prescott, Li Jia, Artem Barski, Steve Pregizer, Jon P Cogan, Armin Arasheben, Wayne D Tilley, Howard I Scher, William L Gerald, Grant Buchanan, Gerhard A Coetzee and Baruch Frenkel

    Citation: Molecular Cancer 2007 6:39

    Content type: Research

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  37. The androgen receptor is a ligand-induced transcriptional factor, which plays an important role in normal development of the prostate as well as in the progression of prostate cancer to a hormone refractory st...

    Authors: Katia Margiotti, Latif A Wafa, Helen Cheng, Giuseppe Novelli, Colleen C Nelson and Paul S Rennie

    Citation: Molecular Cancer 2007 6:38

    Content type: Research

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  38. The normal human prostate glandular epithelium has the unique function of accumulating high levels of zinc. In prostate cancer this capability is lost as an early event in the development of the malignant cell...

    Authors: Mohamed M Desouki, Joseph Geradts, Beatrice Milon, Renty B Franklin and Leslie C Costello

    Citation: Molecular Cancer 2007 6:37

    Content type: Research

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  39. A novel alkylating agent, temozolomide, has proven efficacious in the treatment of malignant gliomas. However, expression of O 6 -methylguanine-DNA methyltransferase (MGMT) r...

    Authors: Ken Sasai, Tsuyoshi Akagi, Eiko Aoyanagi, Kouichi Tabu, Sadao Kaneko and Shinya Tanaka

    Citation: Molecular Cancer 2007 6:36

    Content type: Research

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  40. Burkitt's lymphoma (BL) is a heterogeneous group of highly aggressive mature B-cell malignancies. It is characterized by a high rate of turnover of malignant cells and deregulation of the c-myc gene. It is typ...

    Authors: Delong Liu, Josif Shimonov, Suneeta Primanneni, Yongrong Lai, Tauseef Ahmed and Karen Seiter

    Citation: Molecular Cancer 2007 6:35

    Content type: Short communication

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  41. The urokinase receptor (uPAR) mediates a diverse array of cellular processes including several events involved in prostate cancer metastasis. Many of these activities are initiated or enhanced by uPAR binding ...

    Authors: Mohammad Hasanuzzaman, Robert Kutner, Siamak Agha-Mohammadi, Jakob Reiser and Inder Sehgal

    Citation: Molecular Cancer 2007 6:34

    Content type: Research

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  42. Acute myeloid leukemia (AML) cells are characterized by non-mutated TP53, high levels of Hdm2, and frequent mutation of the Flt3 receptor tyrosine kinase. The juxtamembrane mutation of FLT3 is the strongest indep...

    Authors: Line Wergeland, Gry Sjøholt, Ingvild Haaland, Randi Hovland, Øystein Bruserud and Bjørn Tore Gjertsen

    Citation: Molecular Cancer 2007 6:33

    Content type: Research

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  43. Correlations of disease phenotypes with glycosylation changes have been analysed intensively in the tumor biology field. Glycoforms potentially associated with carcinogenesis, tumor progression and cancer meta...

    Authors: Takeaki Kudo, Hiroaki Nakagawa, Masato Takahashi, Jun Hamaguchi, Naoya Kamiyama, Hideki Yokoo, Kazuaki Nakanishi, Takahito Nakagawa, Toshiya Kamiyama, Kisaburo Deguchi, Shin-Ichiro Nishimura and Satoru Todo

    Citation: Molecular Cancer 2007 6:32

    Content type: Research

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  44. Relapse due to chemoresistant residual disease is a major cause of death in acute myelogenous leukemia (AML). The present study was undertaken to elucidate the molecular mechanisms of chemoresistance by compar...

    Authors: Tien-sheng Huang, Line M Myklebust, Endre Kjarland, Bjørn Tore Gjertsen, Frederic Pendino, Øystein Bruserud, Stein Ove Døskeland and Johan R Lillehaug

    Citation: Molecular Cancer 2007 6:31

    Content type: Research

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  45. Mutations of the epidermal growth factor receptor (EGFR) are a possible molecular target for cancer therapy. EGFR is frequently amplified in glioblastomas and 30 to 40% of glioblastomas also express the deleti...

    Authors: Dimitri G Trembath, Anita Lal, David J Kroll, Nicholas H Oberlies and Gregory J Riggins

    Citation: Molecular Cancer 2007 6:30

    Content type: Research

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  46. Inflammation is increasingly recognized as an important component of tumorigenesis, although the mechanisms involved are not fully characterized. The invasive capacity of cancers is reflected in the classic me...

    Authors: José-Ignacio Arias, María-Angeles Aller and Jaime Arias

    Citation: Molecular Cancer 2007 6:29

    Content type: Hypothesis

    Published on:

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