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  1. The PTEN (Phosphatase and Tensin homolog deleted on chromosome Ten) tumor suppressor gene is frequently mutated or deleted in a wide variety of solid tumors, and these cancers are generally more aggressive and di...

    Authors: Pei-Yin Lin, Susan P Fosmire, See-Hyoung Park, Jin-Young Park, Shairaz Baksh, Jaime F Modiano and Robert H Weiss

    Citation: Molecular Cancer 2007 6:16

    Content type: Research

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  2. The Cox proportional hazards model is the most widely used model for survival analysis because of its simplicity. The fundamental assumption in this model is the proportionality of the hazard function. When th...

    Authors: Farid E Ahmed, Paul W Vos and Don Holbert

    Citation: Molecular Cancer 2007 6:15

    Content type: Hypothesis

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  3. Alterations of chromosome 8 and hypomethylation of LINE-1 retrotransposons are common alterations in advanced prostate carcinoma. In a former study including many metastatic cases, they strongly correlated wit...

    Authors: Wolfgang A Schulz, Adrian Alexa, Volker Jung, Christiane Hader, Michèle J Hoffmann, Masanori Yamanaka, Sandy Fritzsche, Agnes Wlazlinski, Mirko Müller, Thomas Lengauer, Rainer Engers, Andrea R Florl, Bernd Wullich and Jörg Rahnenführer

    Citation: Molecular Cancer 2007 6:14

    Content type: Research

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  4. The consecutive acquisition of genetic alterations characterizes neoplastic processes. As a consequence of these alterations, molecular interactions are reprogrammed in the context of highly connected and regu...

    Authors: Pilar Hernández, Xavier Solé, Joan Valls, Víctor Moreno, Gabriel Capellá, Ander Urruticoechea and Miguel Angel Pujana

    Citation: Molecular Cancer 2007 6:13

    Content type: Research

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  5. Ovarian germ cell tumours (OGCTs) typically arise in young females and their pathogenesis remains poorly understood. We investigated the origin of malignant OGCTs and underlying molecular events in the develop...

    Authors: Christina E Hoei-Hansen, Sigrid M Kraggerud, Vera M Abeler, Janne Kærn, Ewa Rajpert-De Meyts and Ragnhild A Lothe

    Citation: Molecular Cancer 2007 6:12

    Content type: Research

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  6. Aberrant methylation of gene promoter regions has been linked to changes in gene expression in cancer development and progression. Genes associated with CpG islands (CGIs) are especially prone to methylation, ...

    Authors: Laura Menendez, DeEtte Walker, Lilya V Matyunina, Erin B Dickerson, Nathan J Bowen, Nalini Polavarapu, Benedict B Benigno and John F McDonald

    Citation: Molecular Cancer 2007 6:10

    Content type: Research

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  7. Sapphyrin analogues and related porphyrin-like species have attracted attention as anticancer agents due to their selective localization in various cancers, including hematologic malignancies, relative to surr...

    Authors: Zhong Wang, Philip S Lecane, Patricia Thiemann, Qing Fan, Cecilia Cortez, Xuan Ma, Danielle Tonev, Dale Miles, Louie Naumovski, Richard A Miller, Darren Magda, Dong-Gyu Cho, Jonathan L Sessler, Brian L Pike, Samantha M Yeligar, Mazen W Karaman…

    Citation: Molecular Cancer 2007 6:9

    Content type: Research

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  8. Malignant melanoma is one of the most aggressive skin cancer and chemotherapeutic agents currently in use are still unsatisfactory. Prevention and early diagnosis are the only effective tools against this tumo...

    Authors: Marina Pisano, Gabriella Pagnan, Monica Loi, Maria Elena Mura, Maria Giovanna Tilocca, Giuseppe Palmieri, Davide Fabbri, Maria Antonietta Dettori, Giovanna Delogu, Mirco Ponzoni and Carla Rozzo

    Citation: Molecular Cancer 2007 6:8

    Content type: Research

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  9. Human mammary epithelial cells (HMEC) overcome two well-characterized genetic and epigenetic barriers as they progress from primary cells to fully immortalized cell lines in vitro. Finite lifespan HMEC overcome a...

    Authors: Yizheng Li, Jing Pan, Jian-Liang Li, Jee Hyung Lee, Chris Tunkey, Katie Saraf, James C Garbe, Maryann Z Whitley, Scott A Jelinsky, Martha R Stampfer and Steven A Haney

    Citation: Molecular Cancer 2007 6:7

    Content type: Research

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  10. Osteopontin (OPN), a secreted phosphoglycoprotein, has been strongly associated with tumor progression and aggressive cancers. MDA-MB-435 cells secrete very high levels of OPN. However metastasis-suppressed MD...

    Authors: Rajeev S Samant, David W Clark, Rebecca A Fillmore, Muzaffer Cicek, Brandon J Metge, Kondethimmana H Chandramouli, Ann F Chambers, Graham Casey, Danny R Welch and Lalita A Shevde

    Citation: Molecular Cancer 2007 6:6

    Content type: Research

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  11. HMGA2 expression has been shown to be associated with enhanced selective chemosensitivity towards the topoisomerase (topo) II inhibitor, doxorubicin, in cancer cells. Although the roles of signaling cascades a...

    Authors: Carla Hebert, Kathleen Norris, Mark A Scheper, Nikolaos Nikitakis and John J Sauk

    Citation: Molecular Cancer 2007 6:5

    Content type: Research

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  12. Pituitary tumor transforming gene (pttg) is a novel oncogene that is expressed at higher level in most of the tumors analyzed to date compared to normal tissues. Nevertheless, its expression in prolactinomas a...

    Authors: Carolina Cristina, Graciela S Díaz-Torga, Rodolfo G Goya, Sham S Kakar, María I Perez-Millán, Vanessa Q Passos, Daniel Giannella-Neto, Marcello D Bronstein and Damasia Becu-Villalobos

    Citation: Molecular Cancer 2007 6:4

    Content type: Research

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  13. Epigenetic silencing of regulatory genes by aberrant methylation contributes to tumorigenesis. DNA methyltransferase inhibitors (DNMTI) represent promising new drugs for anti-cancer therapies. The DNMTI 5-Azac...

    Authors: Sieta P Rao, Markus P Rechsteiner, Christoph Berger, Jürg A Sigrist, David Nadal and Michele Bernasconi

    Citation: Molecular Cancer 2007 6:3

    Content type: Short communication

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  14. Despite the fact that metastases are the leading cause of colorectal cancer deaths, little is known about the underlying molecular changes in these advanced disease stages. Few have studied the overall gene ex...

    Authors: Kristine Kleivi, Guro E Lind, Chieu B Diep, Gunn I Meling, Lin T Brandal, Jahn M Nesland, Ola Myklebost, Torleiv O Rognum, Karl-Erik Giercksky, Rolf I Skotheim and Ragnhild A Lothe

    Citation: Molecular Cancer 2007 6:2

    Content type: Research

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  15. Many chemotherapeutic agents have been used to treat pancreatic cancer without success. Apigenin, a naturally occurring flavonoid, has been shown to inhibit growth in some cancer cell lines but has not been st...

    Authors: Michael B Ujiki, Xian-Zhong Ding, M Reza Salabat, David J Bentrem, Laleh Golkar, Ben Milam, Mark S Talamonti, Richard H Bell Jr, Takeshi Iwamura and Thomas E Adrian

    Citation: Molecular Cancer 2006 5:76

    Content type: Research

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  16. Gastric adenocarcinomas comprise one of the common types of cancers in Asian countries including Japan. Comprehensive protein profiling of paired surgical specimens of primary gastric adenocarcinomas and nontu...

    Authors: Takahiro Yoshihara, Yoshito Kadota, Yoshiyuki Yoshimura, Yutaka Tatano, Naohiro Takeuchi, Hiroshi Okitsu, Atsushi Umemoto, Takashi Yamauchi and Kohji Itoh

    Citation: Molecular Cancer 2006 5:75

    Content type: Research

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  17. Skin cancer accounts for 1/3 of all newly diagnosed cancer. Although seldom fatal, basal cell carcinoma (BCC) is associated with severe disfigurement and morbidity. BCC has a unique interest for researchers, a...

    Authors: Lorraine O'Driscoll, Jason McMorrow, Padraig Doolan, Eadaoin McKiernan, Jai Prakash Mehta, Eoin Ryan, Patrick Gammell, Helena Joyce, Norma O'Donovan, Nicholas Walsh and Martin Clynes

    Citation: Molecular Cancer 2006 5:74

    Content type: Research

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  18. Somatic mutations of mitochondrial DNA (mtDNA) are common in many human cancers. We have described an oligonucleotide microarray ("MitoChip") for rapid sequencing of the entire mitochondrial genome (Zhou et al, J...

    Authors: Guoping Sui, Shaoyu Zhou, Jean Wang, Marcia Canto, Edward E Lee, James R Eshleman, Elizabeth A Montgomery, David Sidransky, Joseph A Califano and Anirban Maitra

    Citation: Molecular Cancer 2006 5:73

    Content type: Research

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  19. In eukaryotic cells, the genomic DNA is packed with histones to form the nucleosome and chromatin structure. Reversible acetylation of the histone tails plays an important role in the control of specific gene ...

    Authors: Jihong Chen, Feras M Ghazawi, Wafae Bakkar and Qiao Li

    Citation: Molecular Cancer 2006 5:71

    Content type: Research

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  20. microRNAs (miRNAs) are a group of non-coding single stranded RNAs measuring approximately 22 nt in length that have been found to control cell growth, differentiation and apoptosis. miRNAs negatively regulate ...

    Authors: Susanne Cahill, Paul Smyth, Stephen P Finn, Karen Denning, Richard Flavin, Esther M O'Regan, Jinghuan Li, Astrid Potratz, Simone M Guenther, Richard Henfrey, John J O'Leary and Orla Sheils

    Citation: Molecular Cancer 2006 5:70

    Content type: Research

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  21. Lysophosphatidic acid (LPA) and sphingosine 1-phosphate (S1P) are bioactive lipid signaling molecules implicated in tumor dissemination. Membrane-type matrix metalloproteinase 1 (MT1-MMP) is a membrane-tethere...

    Authors: Kevin E Fisher, Andreia Pop, Wonshill Koh, Nicholas J Anthis, W Brian Saunders and George E Davis

    Citation: Molecular Cancer 2006 5:69

    Content type: Research

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  22. Recently, a small population of cancer stem cells in adult and pediatric brain tumors has been identified. Some evidence has suggested that CD133 is a marker for a subset of leukemia and glioblastoma cancer st...

    Authors: Gentao Liu, Xiangpeng Yuan, Zhaohui Zeng, Patrizia Tunici, Hiushan Ng, Iman R Abdulkadir, Lizhi Lu, Dwain Irvin, Keith L Black and John S Yu

    Citation: Molecular Cancer 2006 5:67

    Content type: Research

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  23. Metastatic renal cell carcinoma (RCC) remains the leading cause of mortality in patients with clear cell RCC arising from mutations in the von Hippel Lindau (VHL) tumor suppressor. Successful RCC tumor suppres...

    Authors: Brenda L Petrella and Constance E Brinckerhoff

    Citation: Molecular Cancer 2006 5:66

    Content type: Research

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  24. Renal cell carcinoma (RCC) is the sixth leading cause of cancer death and is responsible for 11,000 deaths per year in the US. Approximately one-third of patients present with disease which is already metastat...

    Authors: Bertrand Perroud, Jinoo Lee, Nelly Valkova, Amy Dhirapong, Pei-Yin Lin, Oliver Fiehn, Dietmar Kültz and Robert H Weiss

    Citation: Molecular Cancer 2006 5:64

    Content type: Research

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  25. Constitutive activation of MEK1 (caMEK) can induce the oncogenic transformation of normal intestinal epithelial cells. To define the genetic changes that occur during this process, we used oligonucleotide micr...

    Authors: Koga Komatsu, F Gregory Buchanan, Michiro Otaka, Mario Jin, Masaru Odashima, Yohei Horikawa, Sumio Watanabe and Raymond N DuBois

    Citation: Molecular Cancer 2006 5:63

    Content type: Research

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  26. The involvement of the cyclooxygenases (COX), in particular COX-2, is well documented for many tumours, e.g. colon, breast and prostate cancer, by both experimental and clinical studies. There are epidemiologi...

    Authors: Katarina Rask, Yihong Zhu, Wanzhong Wang, Lars Hedin and Karin Sundfeldt

    Citation: Molecular Cancer 2006 5:62

    Content type: Research

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  27. Pituitary tumor transforming gene (PTTG) is a novel oncogene that is expressed at higher level in most of the tumors analyzed to date compared to normal tissues. Existence of a relationship between PTTG levels...

    Authors: Mohammad T Malik and Sham S Kakar

    Citation: Molecular Cancer 2006 5:61

    Content type: Research

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  28. The correlation between epigenetic aberrations and disease underscores the importance of epigenetic mechanisms. Here, we review recent findings regarding chromatin modifications and their relevance to cancer.

    Authors: Miryam Ducasse and Mark A Brown

    Citation: Molecular Cancer 2006 5:60

    Content type: Review

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  29. Metabolic transformations of malignant cells are essential to the development and progression of all cancers. The understanding of the pathogenesis and progression of cancer requires the establishment of the a...

    Authors: Leslie C Costello and Renty B Franklin

    Citation: Molecular Cancer 2006 5:59

    Content type: Commentary

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  30. Changes in the structure of commercial scholarly publishing have led to spiraling subscription prices. This has resulted in a "serials crisis" that has eroded library budgets and threatened the system of scien...

    Authors: Edwin V Sperr Jr

    Citation: Molecular Cancer 2006 5:58

    Content type: Commentary

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  31. The MUC1 gene encodes a mucin glycoprotein(s) which is basally expressed in most epithelial cells. In breast adenocarcinoma and a variety of epithelial tumors its transcription is dramatically upregulated. Of ...

    Authors: Joseph Z Zaretsky, Itay Barnea, Yael Aylon, Marat Gorivodsky, Daniel H Wreschner and Iafa Keydar

    Citation: Molecular Cancer 2006 5:57

    Content type: Research

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  32. Renal cell carcinoma (RCC) is characterized by organ-specific metastases. The chemokine stromal derived factor-1 (SDF-1/CXCL12) and its receptor CXCR4 have been suggested to regulate organ-specific metastasis ...

    Authors: Judong Pan, Javier Mestas, Marie D Burdick, Roderick J Phillips, George V Thomas, Karen Reckamp, John A Belperio and Robert M Strieter

    Citation: Molecular Cancer 2006 5:56

    Content type: Research

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  33. Genes that cause cancer have been divided into two general classes – oncogenes that act in a dominant fashion to transform normal cells into a malignant state, and tumor suppressor genes that act in a dominant...

    Authors: Shu-ling Fu, Brigitte Ganter and Joseph S Lipsick

    Citation: Molecular Cancer 2006 5:54

    Content type: Research

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  34. Deregulated expression of oncogenes such as MYC and PAX3-FKHR often occurs in rhabdomyosarcomas. MYC can enhance cell proliferation and apoptosis under specific conditions, whereas PAX3-FKHR has only been describ...

    Authors: Alan C Taylor, Katja Schuster, Pamela P McKenzie and Linda C Harris

    Citation: Molecular Cancer 2006 5:53

    Content type: Research

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  35. The Calcium-Sensing Receptor is a key component of Calcium/Parathyroid hormone homeostatic system that helps maintain appropriate plasma Ca2+ concentrations. It also has a number of non-homeostatic functions, inc...

    Authors: Richard Morgan, Benjamin Fairfax and Hardev S Pandha

    Citation: Molecular Cancer 2006 5:51

    Content type: Research

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  36. The mucin MUC16 and the glycosylphosphatidylinositol anchored glycoprotein mesothelin likely facilitate the peritoneal metastasis of ovarian tumors. The biochemical basis and the kinetics of the binding betwee...

    Authors: Jennifer AA Gubbels, Jennifer Belisle, Masanori Onda, Claudine Rancourt, Martine Migneault, Mitchell Ho, Tapan K Bera, Joseph Connor, Bangalore K Sathyanarayana, Byungkook Lee, Ira Pastan and Manish S Patankar

    Citation: Molecular Cancer 2006 5:50

    Content type: Research

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  37. Cervical cancer is the second most common gynecological cancer amongst women world-wide. Despite optimized protocols, standard treatments still face several disadvantages. Therefore, research aims at the devel...

    Authors: Nathalie Cools, Peter Ponsaerts, Marc Lenjou, Griet Nijs, Dirk R Van Bockstaele, Viggo FI Van Tendeloo and Zwi N Berneman

    Citation: Molecular Cancer 2006 5:49

    Content type: Research

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  38. Barrett's esophagus, a risk factor for esophageal adenocarcinoma, is associated with reflux disease. The aim of this study was to assess the expression of bile acid receptors in the esophagus (normal, esophagi...

    Authors: Andrea De Gottardi, Jean-Marc Dumonceau, Fabien Bruttin, Alain Vonlaufen, Isabelle Morard, Laurent Spahr, Laura Rubbia-Brandt, Jean-Louis Frossard, Winand NM Dinjens, Peter S Rabinovitch and Antoine Hadengue

    Citation: Molecular Cancer 2006 5:48

    Content type: Research

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  39. The tumor suppressor gene p53 (TP53) controls numerous signaling pathways and is frequently mutated in human cancers. Novel p53 isoforms suggest alternative splicing as a regulatory feature of p53 activity.

    Authors: Lars O Baumbusch, Simen Myhre, Anita Langerød, Anna Bergamaschi, Stephanie B Geisler, Per E Lønning, Wolfgang Deppert, Irene Dornreiter and Anne-Lise Børresen-Dale

    Citation: Molecular Cancer 2006 5:47

    Content type: Research

    Published on:

  40. The transmembrane protein c-kit is a receptor tyrosine kinase (KIT) and KIT is expressed in solid tumors and hematological malignancies such as gastrointestinal stromal tumor (GIST), small-cell lung cancer and ch...

    Authors: Akira Yasuda, Hirozumi Sawai, Hiroki Takahashi, Nobuo Ochi, Yoichi Matsuo, Hitoshi Funahashi, Mikinori Sato, Yuji Okada, Hiromitsu Takeyama and Tadao Manabe

    Citation: Molecular Cancer 2006 5:46

    Content type: Research

    Published on:

  41. Endometrial cancer is the fourth most prominent cancer among all feminine cancers in the Western world. Resveratrol, a natural anti-oxidant found in red wine emerging as a novel anticancer agent, exerts antipr...

    Authors: Émilie Sexton, Céline Van Themsche, Kim Leblanc, Sophie Parent, Pascal Lemoine and Eric Asselin

    Citation: Molecular Cancer 2006 5:45

    Content type: Research

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  42. Cancer research has mainly focused on alterations of genes and proteins in cancer cells themselves that result in either gain-of-function in oncogenes or loss-of-function in tumour-suppressor genes. However, s...

    Authors: Xiao-Feng Sun and Hong Zhang

    Citation: Molecular Cancer 2006 5:43

    Content type: Review

    Published on:

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