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  1. There are conflicting reports regarding the function of EFEMP1 in different cancer types. In this study, we sought to evaluate the role of EFEMP1 in malignant glioma biology.

    Authors: Yuanjie Hu, Peter Dion Pioli, Eric Siegel, Qinghua Zhang, Jodi Nelson, Abhishek Chaturbedi, Marlon S Mathews, Daniel I Ro, Selma Alkafeef, Nelson Hsu, Mark Hamamura, Liping Yu, Kenneth R Hess, Bruce J Tromberg, Mark E Linskey and Yi-Hong Zhou
    Citation: Molecular Cancer 2011 10:123
  2. Connective tissue growth factor (CTGF) has been shown to be implicated in tumor development and progression. However, the role of CTGF in gastric cancer remains largely unknown.

    Authors: Cheng-Gang Jiang, Ling Lv, Fu-Rong Liu, Zhen-Ning Wang, Fu-Nan Liu, Yan-Shu Li, Chun-Yu Wang, Hong-Yan Zhang, Zhe Sun and Hui-Mian Xu
    Citation: Molecular Cancer 2011 10:122
  3. The CCL2 chemokine is involved in promoting cancer angiogenesis, proliferation and metastasis by malignancies that express CCR2 receptor. Thus the CCL2/CCR2 axis is an attractive molecular target for anticance...

    Authors: Moutih Rafei, Jiusheng Deng, Marie-Noëlle Boivin, Patrick Williams, Shannon M Matulis, Shala Yuan, Elena Birman, Kathy Forner, Liangping Yuan, Craig Castellino, Lawrence H Boise, Tobey J MacDonald and Jacques Galipeau
    Citation: Molecular Cancer 2011 10:121
  4. There is growing evidence that interconnections among molecular pathways governing tissue differentiation are nodal points for malignant transformation. In this scenario, microRNAs appear as crucial players. T...

    Authors: Rossella Rota, Roberta Ciarapica, Antonio Giordano, Lucio Miele and Franco Locatelli
    Citation: Molecular Cancer 2011 10:120
  5. Expression of transglutaminase 2 (TGase 2) is related to invasion and resistance to chemotherapeutic agents in several cancer cells. However, there has been only limited clinical validation of TGase 2 as an in...

    Authors: Chang-Min Choi, Se-Jin Jang, Seong-Yeol Park, Yong-Bock Choi, Jae-Heon Jeong, Dae-Seok Kim, Hyun-Kyoung Kim, Kang-Seo Park, Byung-Ho Nam, Hyeong-Ryul Kim, Soo-Youl Kim and Kyeong-Man Hong
    Citation: Molecular Cancer 2011 10:119
  6. Colorectal cancer is a common disease that involves genetic alterations, such as inactivation of tumour suppressor genes and activation of oncogenes. Among them are RAS and BRAF mutations, which rarely coexist...

    Authors: Eleni Makrodouli, Eftychia Oikonomou, Michal Koc, Ladislav Andera, Takehiko Sasazuki, Senji Shirasawa and Alexander Pintzas
    Citation: Molecular Cancer 2011 10:118
  7. Tumor-associated macrophages (TAMs) are alternatively activated cells induced by interleukin-4 (IL-4)-releasing CD4+ T cells. TAMs promote breast cancer invasion and metastasis; however, the mechanisms underlying...

    Authors: Mei Yang, Jingqi Chen, Fang Su, Bin Yu, Fengxi Su, Ling Lin, Yujie Liu, Jian-Dong Huang and Erwei Song
    Citation: Molecular Cancer 2011 10:117
  8. Epidermal growth factor receptor (EGFR) has been reported to downregulate E-cadherin (E-cad); however, whether the downregulation of E-cad has any effect on EGFR expression has not been elucidated. Our previou...

    Authors: Dongsheng Wang, Ling Su, Donghai Huang, Hongzheng Zhang, Dong M Shin and Zhuo G Chen
    Citation: Molecular Cancer 2011 10:116
  9. GSK-3β phosphorylates numerous substrates that govern cell survival. It phosphorylates p53, for example, and induces its nuclear export, HDM2-dependent ubiquitination, and p...

    Authors: Qingjun Liu, James W Mier and David J Panka
    Citation: Molecular Cancer 2011 10:115

    The Retraction Note to this article has been published in Molecular Cancer 2021 20:92

  10. In contrast to tumor-suppressive apoptosis and autophagic cell death, necrosis promotes tumor progression by releasing the pro-inflammatory and tumor-promoting cytokine high mobility group box 1 (HMGB1), and i...

    Authors: Su Yeon Lee, Hyun Min Jeon, Cho Hee Kim, Min Kyung Ju, Hye Sun Bae, Hye Gyeong Park, Sung-Chul Lim, Song Iy Han and Ho Sung Kang
    Citation: Molecular Cancer 2011 10:113
  11. Subpopulations of cancer cells with the capacity of generating solid tumors have been characterized. In various cancer types, including prostate cancer cells, a side population (SP) and CD133-expressing cells ...

    Authors: Jianjun Zhou, Honghe Wang, Virginetta Cannon, Karen Marie Wolcott, Hongbin Song and Clayton Yates
    Citation: Molecular Cancer 2011 10:112
  12. In around 50% of all human cancers the tumor suppressor p53 is mutated. It is generally assumed that in the remaining tumors the wild-type p53 protein is functionally impaired. The two main inhibitors of p53, ...

    Authors: Kristiaan Lenos, Job de Lange, Amina FAS Teunisse, Kirsten Lodder, Matty Verlaan-de Vries, Eliza Wiercinska, Marja JM van der Burg, Karoly Szuhai and Aart G Jochemsen
    Citation: Molecular Cancer 2011 10:111
  13. Anti-apoptotic signals induced downstream of HER2 are known to contribute to the resistance to current treatments of breast cancer cells that overexpress this member of the EGFR family. Whether or not some of ...

    Authors: Mario Campone, Bélinda Noël, Cécile Couriaud, Morgan Grau, Yannis Guillemin, Fabien Gautier, Wilfried Gouraud, Catherine Charbonnel, Loïc Campion, Pascal Jézéquel, Frédérique Braun, Benjamin Barré, Olivier Coqueret, Sophie Barillé-Nion and Philippe Juin
    Citation: Molecular Cancer 2011 10:110
  14. The search for strategies to target ion channels for therapeutic applications has become of increasing interest. Especially, the potassium channel KV10.1 (Ether-á-go-go) is attractive as target since this surface...

    Authors: Franziska Hartung, Walter Stühmer and Luis A Pardo
    Citation: Molecular Cancer 2011 10:109
  15. Although current chemotherapy regimens have remarkably improved the cure rate of pediatric acute promyelocytic leukemia (APL) over the past decade, more than 20% of patients still die of the disease, and the 5...

    Authors: Hua Zhang, Xue-Qun Luo, Dan-Dan Feng, Xing-Ju Zhang, Jun Wu, Yu-Sheng Zheng, Xiao Chen, Ling Xu and Yue-Qin Chen
    Citation: Molecular Cancer 2011 10:108
  16. Increasing evidence indicates that the interaction between the CXC chemokine receptor-4 (CXCR4) and its ligand CXCL12 is critical in the process of metastasis that accounts for more than 90% of cancer-related ...

    Authors: Kanjoormana Aryan Manu, Muthu K Shanmugam, Peramaiyan Rajendran, Feng Li, Lalitha Ramachandran, Hui Sin Hay, Radhamani Kannaiyan, Shivananju Nanjunda Swamy, Shireen Vali, Shweta Kapoor, Bhargavi Ramesh, Pradeep Bist, Evelyn S Koay, Lina HK Lim, Kwang Seok Ahn, Alan Prem Kumar…
    Citation: Molecular Cancer 2011 10:107
  17. Previous studies showed that mesothelin (MSLN) plays important roles in survival of pancreatic cancer (PC) cells under anchorage dependent/independent conditions as well as resistance to chemotherapy. The rece...

    Authors: Uddalak Bharadwaj, Christian Marin-Muller, Min Li, Changyi Chen and Qizhi Yao
    Citation: Molecular Cancer 2011 10:106
  18. Tumor cells can escape the immune system by overexpressing molecules of the B7 family, e.g. B7-H1 (PD-L1 or CD86), which suppresses the anti-tumor T-cell responses through binding to the PD-1 receptor, and sim...

    Authors: Elodie Grellier, Katia Lécolle, Sophie Rogée, Cyril Couturier, Jean-Claude D'Halluin, Saw-See Hong, Pascal Fender, Pierre Boulanger, Bruno Quesnel and Morvane Colin
    Citation: Molecular Cancer 2011 10:105
  19. Multiple myeloma (MM) is a B-cell malignancy that is largely incurable and is characterized by the accumulation of malignant plasma cells in the bone marrow. Apigenin, a common flavonoid, has been reported to ...

    Authors: Ming Zhao, Jian Ma, Hai-Yan Zhu, Xu-Hui Zhang, Zhi-Yan Du, Yuan-Ji Xu and Xiao-Dan Yu
    Citation: Molecular Cancer 2011 10:104
  20. The ETS family transcription factor ESE-1 is often overexpressed in human breast cancer. ESE-1 initiates transformation of MCF-12A cells via a non-transcriptional, cytoplasmic process that is mediated by a uni...

    Authors: Jason D Prescott, Joanna M Poczobutt, John J Tentler, Darius M Walker and Arthur Gutierrez-Hartmann
    Citation: Molecular Cancer 2011 10:103
  21. Cyclophilin A (CypA) expression is associated with malignant phenotypes in many cancers. However, the role and mechanisms of CypA in liver fluke-associated cholangiocarcinoma (CCA) are not presently known. In ...

    Authors: Sumalee Obchoei, Sarah M Weakley, Sopit Wongkham, Chaisiri Wongkham, Kanlayanee Sawanyawisuth, Qizhi Yao and Changyi Chen
    Citation: Molecular Cancer 2011 10:102
  22. Mutations in the adenomatous polyposis coli (APC) tumor suppressor gene strongly predispose to development of gastro-intestinal tumors. Central to the tumorigenic events in APC mutant cells is the uncontrolled st...

    Authors: David P Minde, Zeinab Anvarian, Stefan GD Rüdiger and Madelon M Maurice
    Citation: Molecular Cancer 2011 10:101
  23. Epithelial-mesenchymal transition (EMT) is the key process driving cancer metastasis. Oncogene/self renewal factor BMI-1 has been shown to induce EMT in cancer cells. Recent studies have implied that noncoding...

    Authors: Peixin Dong, Masanori Kaneuchi, Hidemichi Watari, Junichi Hamada, Satoko Sudo, Jingfang Ju and Noriaki Sakuragi
    Citation: Molecular Cancer 2011 10:99
  24. Gemcitabine is used to treat several cancers including lung cancer. However, tumor cells often escape gemcitabine-induced cell death via various mechanisms, which include modulating bcl-2 family members and NF...

    Authors: Min-Kyoung Kim, Yoon-Kyung Jeon, Jong-Kyu Woo, Yun Choi, Dae-Han Choi, Yeul-Hong Kim and Chul-Woo Kim
    Citation: Molecular Cancer 2011 10:98
  25. In normal cells proliferation and apoptosis are tightly regulated, whereas in tumor cells the balance is shifted in favor of increased proliferation and reduced apoptosis. Anticancer agents mediate tumor cell ...

    Authors: Samina Alam, Brian S Bowser, Michael J Conway, Mohd Israr, Apurva Tandon and Craig Meyers
    Citation: Molecular Cancer 2011 10:97
  26. Mortality rates for advanced lung cancer have not declined for decades, even with the implementation of novel chemotherapeutic regimens or the use of tyrosine kinase inhibitors. Cancer Stem Cells (CSCs) are th...

    Authors: Diego Serrano, Anne-Marie Bleau, Ignacio Fernandez-Garcia, Tamara Fernandez-Marcelo, Pilar Iniesta, Carlos Ortiz-de-Solorzano and Alfonso Calvo
    Citation: Molecular Cancer 2011 10:96
  27. Caspase-8 is a key upstream mediator in death receptor-mediated apoptosis and also participates in mitochondria-mediated apoptosis via cleavage of proapoptotic Bid. However, the role of caspase-8 in p53- and p...

    Authors: Juan Liu, Hiroshi Uematsu, Nobuo Tsuchida and Masa-Aki Ikeda
    Citation: Molecular Cancer 2011 10:95
  28. Epigenetic control is essential for maintenance of tissue hierarchy and correct differentiation. In cancer, this hierarchical structure is altered and epigenetic control deregulated, but the relationship betwe...

    Authors: Davide Pellacani, Richard J Packer, Fiona M Frame, Emma E Oldridge, Paul A Berry, Marie-Christine Labarthe, Michael J Stower, Matthew S Simms, Anne T Collins and Norman J Maitland
    Citation: Molecular Cancer 2011 10:94
  29. The mucin MUC1, a type I transmembrane glycoprotein, is overexpressed in breast cancer and has been correlated with increased metastasis. We were the first to report binding between MUC1 and Intercellular adhe...

    Authors: Ashlyn J Bernier, Jing Zhang, Erik Lillehoj, Andrew RE Shaw, Nirosha Gunasekara and Judith C Hugh
    Citation: Molecular Cancer 2011 10:93
  30. A novel anticancer drug 1-(3-C-ethynyl-β-D-ribo-pentofuranosyl)cytosine (ECyd, TAS106) has been shown to radiosensitize tumor cells and to improve the therapeutic efficiency of X-irradiation. However, the effe...

    Authors: Shunsuke Meike, Tohru Yamamori, Hironobu Yasui, Masato Eitaki, Akira Matsuda, Masami Morimatsu, Masakazu Fukushima, Yasundo Yamasaki and Osamu Inanami
    Citation: Molecular Cancer 2011 10:92
  31. We have previously reported that RAS-MEK (Cancer Res. 2003 May 1;63(9):2088-95) and TGF-β (Cancer Res. 2006 Feb 1;66(3):1648-57) signaling negatively regulate coxsackie virus and adenovirus receptor (CAR) cell...

    Authors: Markus D Lacher, Marisa Shiina, Peter Chang, Debora Keller, Maarit I Tiirikainen and W Michael Korn
    Citation: Molecular Cancer 2011 10:91
  32. Targeted therapies for metastatic renal cell carcinoma (RCC), including mammalian target of rapamycin (mTOR) inhibitors and small-molecule multikinase inhibitors, have produced clinical effects. However, most ...

    Authors: Didier Roulin, Laurent Waselle, Anne Dormond-Meuwly, Marc Dufour, Nicolas Demartines and Olivier Dormond
    Citation: Molecular Cancer 2011 10:90
  33. 209 000 new cases of renal carcinoma are diagnosed each year worldwide and new therapeutic targets are urgently required. The great majority of clear cell renal cancer involves inactivation of VHL, which acts as ...

    Authors: Sarah K Harten, Miguel A Esteban, Deepa Shukla, Margaret Ashcroft and Patrick H Maxwell
    Citation: Molecular Cancer 2011 10:89
  34. The proto-oncogene, c-Abl encodes a ubiquitously expressed tyrosine kinase that critically governs the cell death response induced by genotoxic agents such as ionizing radiation and cisplatin. The catalytic fu...

    Authors: Zhihua Jiang, Ravindra Kamath, Shunquian Jin, Manimalha Balasubramani, Tej K Pandita and Baskaran Rajasekaran
    Citation: Molecular Cancer 2011 10:88
  35. Cancer progression is closely linked to the epithelial-mesenchymal transition (EMT) process. Studies have shown that there is increased expression of tissue tranglutaminase (TG2) in advanced invasive cancer ce...

    Authors: Chun-Yu Lin, Pei-Hsun Tsai, Chithan C Kandaswami, Geen-Dong Chang, Chia-Hsiung Cheng, Chang-Jen Huang, Ping-Ping Lee, Jiuan-Jiuan Hwang and Ming-Ting Lee
    Citation: Molecular Cancer 2011 10:87
  36. Basal breast cancers (BCs) represent ~15% of BCs. Although overall poor, prognosis is heterogeneous. Identification of good- versus poor-prognosis patients is difficult or impossible using the standard histoclini...

    Authors: Renaud Sabatier, Pascal Finetti, Emilie Mamessier, Stéphane Raynaud, Nathalie Cervera, Eric Lambaudie, Jocelyne Jacquemier, Patrice Viens, Daniel Birnbaum and François Bertucci
    Citation: Molecular Cancer 2011 10:86
  37. The presence of cancer-specific DNA methylation patterns in epithelial colorectal cells in human feces provides the prospect of a simple, non-invasive screening test for colorectal cancer and its precursor, th...

    Authors: Guro E Lind, Stine A Danielsen, Terje Ahlquist, Marianne A Merok, Kim Andresen, Rolf I Skotheim, Merete Hektoen, Torleiv O Rognum, Gunn I Meling, Geir Hoff, Michael Bretthauer, Espen Thiis-Evensen, Arild Nesbakken and Ragnhild A Lothe
    Citation: Molecular Cancer 2011 10:85
  38. Although integrins have been implicated in the progression of breast cancer, the exact mechanism whereby they exert this regulation is clearly not understood. To understand the role of integrins in breast canc...

    Authors: Yanfang Wang, Sylvia Shenouda, Somesh Baranwal, Rajamani Rathinam, Prachi Jain, Lili Bao, Siddhartha Hazari, Srikanta Dash and Suresh K Alahari
    Citation: Molecular Cancer 2011 10:84
  39. RecQ helicases play an essential role in the maintenance of genome stability. In humans, loss of RecQ helicase function is linked with predisposition to cancer and/or premature ageing. Current data show that t...

    Authors: Ramiro Mendoza-Maldonado, Valentina Faoro, Sailesh Bajpai, Matteo Berti, Federico Odreman, Marco Vindigni, Tamara Ius, Abdollah Ghasemian, Serena Bonin, Miran Skrap, Giorgio Stanta and Alessandro Vindigni
    Citation: Molecular Cancer 2011 10:83
  40. Overexpression of the RON receptor tyrosine kinase contributes to epithelial cell transformation, malignant progression, and acquired drug resistance. RON also has been considered as a potential target for the...

    Authors: Hang-Ping Yao, Yong-Qing Zhou, Qi Ma, Sunny Guin, Snehal S Padhye, Rui-Wen Zhang and Ming-Hai Wang
    Citation: Molecular Cancer 2011 10:82
  41. The MFSD2A gene maps within a linkage disequilibrium block containing the MYCL1-EcoRI polymorphism associated with prognosis and survival in lung cancer patients. Survival discrepancies between Asians and Caucasi...

    Authors: Francesca Colombo, Felicia S Falvella, Antonella Galvan, Elisa Frullanti, Hideo Kunitoh, Toshikazu Ushijima and Tommaso A Dragani
    Citation: Molecular Cancer 2011 10:81
  42. Resistance to chemotherapy remains one of the principle obstacles to the treatment of colon cancer. In order to identify the molecular mechanism of this resistance, we investigated the role of the steroid and ...

    Authors: Agnes Basseville, Laurence Preisser, Sophie de Carné Trécesson, Michèle Boisdron-Celle, Erick Gamelin, Olivier Coqueret and Alain Morel
    Citation: Molecular Cancer 2011 10:80
  43. Rho-associated coiled-coil containing protein kinase (Rho-kinase/ROCK) is involved in various cellular functions including cell proliferation, and is generally considered to be oncogenic, while some studies sh...

    Authors: Masanori Nakashima, Seiji Adachi, Ichiro Yasuda, Takahiro Yamauchi, Junji Kawaguchi, Toshimasa Hanamatsu, Takashi Yoshioka, Yukio Okano, Yoshinobu Hirose, Osamu Kozawa and Hisataka Moriwaki
    Citation: Molecular Cancer 2011 10:79
  44. The aim of both classical (e.g. taxol) and targeted anti-mitotic agents (e.g. Aurora kinase inhibitors) is to disrupt the mitotic spindle. Such compounds are currently used in the clinic and/or are being teste...

    Authors: Sanket Joshi, Antony W Braithwaite, Phillip J Robinson and Megan Chircop
    Citation: Molecular Cancer 2011 10:78
  45. The aim of this study was to determine whether low prevalence human papillomavirus (HPV) 16 E6 variants differ from high prevalence types in their functional abilities. We evaluated functions relevant to carci...

    Authors: Ingeborg Zehbe, Hava Lichtig, Ashley Westerback, Paul F Lambert, Massimo Tommasino and Levana Sherman
    Citation: Molecular Cancer 2011 10:77
  46. Worldwide, lung cancer kills more people than breast, colon and prostate cancer combined. Alterations in macrophage number and function during lung tumorigenesis suggest that these immune effector cells stimul...

    Authors: Jason M Fritz, Lori D Dwyer-Nield and Alvin M Malkinson
    Citation: Molecular Cancer 2011 10:76
  47. Platinum-containing chemotherapy produces specific DNA damage and is used to treat several human solid tumors. Tumors initially sensitive to platinum-based drugs frequently become resistant. Inhibition of DNA ...

    Authors: Janna Sand-Dejmek, Guillaume Adelmant, Bijan Sobhian, Anne S Calkins, Jarrod Marto, Dirk J Iglehart and Jean-Bernard Lazaro
    Citation: Molecular Cancer 2011 10:74

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