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  1. In this study we have made novel observations with regards to potentiation of the tumoricidal activity of the oncolytic adenovirus, dl1520 (ONYX-015) in rat glioblastoma cell lines expressing heat shock protei...

    Authors: Jonathan Madara, James A Krewet and Maulik Shah

    Citation: Molecular Cancer 2005 4:12

    Content type: Research

    Published on:

  2. A common feature of neuroblastoma tumours are partial deletions of the short arm of chromosome 1 (1p-deletions). This is indicative of a neuroblastoma tumour suppressor gene being located in the region. Severa...

    Authors: Helena Carén, Katarina Ejeskär, Susanne Fransson, Luke Hesson, Farida Latif, Rose-Marie Sjöberg, Cecilia Krona and Tommy Martinsson

    Citation: Molecular Cancer 2005 4:10

    Content type: Research

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  3. Multiple Endocrine Neoplasia type 1 (MEN1, OMIM 131100) is an autosomal dominant disorder characterized by endocrine tumors of the parathyroids, pancreatic islets and pituitary. The disease is caused by the fu...

    Authors: William G Dilley, Somasundaram Kalyanaraman, Sulekha Verma, J Perren Cobb, Jason M Laramie and Terry C Lairmore

    Citation: Molecular Cancer 2005 4:9

    Content type: Research

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  4. Recent studies have demonstrated that the NKX3.1 protein is commonly down-regulated in testicular germ cell tumors (TGCTs) and prostate carcinomas. The homeobox gene NKX3.1 maps to chromosome band 8p21, which is ...

    Authors: Guro E Lind, Rolf I Skotheim, Mario F Fraga, Vera M Abeler, Rui Henrique, Fahri Saatcioglu, Manel Esteller, Manuel R Teixeira and Ragnhild A Lothe

    Citation: Molecular Cancer 2005 4:8

    Content type: Research

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  5. Insulin-like growth factor binding protein 2 (IGFBP2) is overexpressed in ovarian malignant tissues and in the serum and cystic fluid of ovarian cancer patients, suggesting an important role of IGFBP2 in the b...

    Authors: Eun-Ju Lee, Cristian Mircean, Ilya Shmulevich, Huamin Wang, Jinsong Liu, Antti Niemistö, John J Kavanagh, Je-Ho Lee and Wei Zhang

    Citation: Molecular Cancer 2005 4:7

    Content type: Research

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  6. Conventional Comparative Genomic Hybridization (CGH) has been widely used for detecting copy number alterations in cancer and for identifying regions containing candidate tumor responsible genes. Recently, sev...

    Authors: Bárbara Meléndez, Beatriz Martínez-Delgado, Marta Cuadros, Victoria Fernández, Ramón Díaz-Uriarte and Javier Benítez

    Citation: Molecular Cancer 2005 4:5

    Content type: Short communication

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  7. In cancer, cellular transformation is followed by tumour development. Knowledge on the mechanisms of transformation, involving activation of proto-oncogenes and inactivation of tumour-suppressor genes has cons...

    Authors: Sophie Vasseur, Cédric Malicet, Ezequiel L Calvo, Jean Charles Dagorn and Juan L Iovanna

    Citation: Molecular Cancer 2005 4:4

    Content type: Research

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  8. Signal transducers and activators of transcription (STATs) are involved in growth regulation of cells. They are usually activated by phosphorylation at specific tyrosine residues. In neoplastic cells, constitu...

    Authors: Hosea F Huang, Thomas F Murphy, Ping Shu, Arnold B Barton and Beverly E Barton

    Citation: Molecular Cancer 2005 4:2

    Content type: Research

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  9. We previously reported that lifetime consumption of soy proteins or whey proteins reduced the incidence of azoxymethane (AOM)-induced colon tumors in rats. To obtain insights into these effects, global gene ex...

    Authors: Rijin Xiao, Thomas M Badger and Frank A Simmen

    Citation: Molecular Cancer 2005 4:1

    Content type: Research

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  10. Glioblastoma is the deadliest and most prevalent brain tumor. Dexamethasone (DXM) is a commonly used steroid for treating glioblastoma patients for alleviation of vasogenic edema and pain prior to treatment wi...

    Authors: Arabinda Das, Naren L Banik, Sunil J Patel and Swapan K Ray

    Citation: Molecular Cancer 2004 3:36

    Content type: Research

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  11. Lung cancer remains to be the leading cause of cancer death worldwide. Patients with similar lung cancer may experience quite different clinical outcomes. Reliable molecular prognostic markers are needed to ch...

    Authors: Zhifu Sun, Ping Yang, Marie-Christine Aubry, Farhad Kosari, Chiaki Endo, Julian Molina and George Vasmatzis

    Citation: Molecular Cancer 2004 3:35

    Content type: Research

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  12. Tpl2/Cot oncogene has been identified in murine T-cell lymphomas as a target of MoMuLV insertion. Animal and tissue culture studies have shown that Tpl2/Cot is involved in interleukin-2 (IL-2) and tumor necros...

    Authors: Anna V Christoforidou, Helen A Papadaki, Andrew N Margioris, George D Eliopoulos and Christos Tsatsanis

    Citation: Molecular Cancer 2004 3:34

    Content type: Research

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  13. Granulosa cell tumors (GCTs) are relatively rare and are subtypes of the sex-cord stromal neoplasms. Methylation induced silencing in the promoters of genes such as tumor suppressor genes, DNA repair genes and...

    Authors: Varinderpal S Dhillon, Mohd Shahid and Syed Akhtar Husain

    Citation: Molecular Cancer 2004 3:33

    Content type: Research

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  14. In addition to androgens, growth factors are also implicated in the development and neoplastic growth of the prostate gland. Prosaposin is a potent neurotrophic molecule. Homozygous inactivation of prosaposin in ...

    Authors: Tae-Jin Lee, Oliver Sartor, Ronald B Luftig and Shahriar Koochekpour

    Citation: Molecular Cancer 2004 3:31

    Content type: Research

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  15. To examine the relationship between mitochondrial DNA (mtDNA) alterations and colorectal tumorigenesis, we used high-resolution restriction endonucleases and sequencing to assess the mitochondrial genome from ...

    Authors: Felix O Aikhionbare, Masood Khan, Delicia Carey, Joel Okoli and Rodney Go

    Citation: Molecular Cancer 2004 3:30

    Content type: Short communication

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  16. The hedgehog pathway plays a critical role in the development of prostate. However, the role of the hedgehog pathway in prostate cancer is not clear. Prostate cancer is the second most prevalent cause of cance...

    Authors: Tao Sheng, Chengxin Li, Xiaoli Zhang, Sumin Chi, Nonggao He, Kai Chen, Frank McCormick, Zoran Gatalica and Jingwu Xie

    Citation: Molecular Cancer 2004 3:29

    Content type: Research

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  17. Tumor cell lines are commonly used as experimental tools in cancer research, but their relevance for the in vivo situation is debated. In a series of 11 microsatellite stable (MSS) and 9 microsatellite unstable (...

    Authors: Guro E Lind, Lin Thorstensen, Tone Løvig, Gunn I Meling, Richard Hamelin, Torleiv O Rognum, Manel Esteller and Ragnhild A Lothe

    Citation: Molecular Cancer 2004 3:28

    Content type: Research

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  18. Epithelial ovarian tumours exhibit a range of malignant potential, presenting distinct clinical phenotypes. Improved knowledge of gene expression changes and functional pathways associated with these clinical ...

    Authors: Susanne Warrenfeltz, Stephen Pavlik, Susmita Datta, Eileen T Kraemer, Benedict Benigno and John F McDonald

    Citation: Molecular Cancer 2004 3:27

    Content type: Research

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  19. Pediatric brain tumors may originate from cells endowed with neural stem/precursor cell properties, growing in vitro as neurospheres. We have found that these cells can also be present in adult brain tumors an...

    Authors: Patrizia Tunici, Lorena Bissola, Elena Lualdi, Bianca Pollo, Laura Cajola, Giovanni Broggi, Gabriella Sozzi and Gaetano Finocchiaro

    Citation: Molecular Cancer 2004 3:25

    Content type: Short communication

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  20. Tumors and complex tissues consist of mixtures of communicating cells that differ significantly in their gene expression status. In order to understand how different cell types influence one another's gene exp...

    Authors: Luiz OF Penalva, Michael D Burdick, Simon M Lin, Hedwig Sutterluety and Jack D Keene

    Citation: Molecular Cancer 2004 3:24

    Content type: Research

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  21. The CBFA2T3 locus located on the human chromosome region 16q24.3 is frequently deleted in breast tumors. CBFA2T3 gene expression levels are aberrant in breast tumor cell lines and the CBFA2T3B isoform is a pot...

    Authors: Anthony J Bais, Alison E Gardner, Olivia LD McKenzie, David F Callen, Grant R Sutherland and Gabriel Kremmidiotis

    Citation: Molecular Cancer 2004 3:22

    Content type: Research

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  22. Colorectal cancers displaying high-degree microsatellite instability (MSI-H) have an improved prognosis compared to microsatellite stable (MSS) cancers. The observation of pronounced lymphocytic infiltrates su...

    Authors: Ayan Banerjea, Shafi Ahmed, Rebecca E Hands, Fei Huang, Xia Han, Peter M Shaw, Roger Feakins, Stephen A Bustin and Sina Dorudi

    Citation: Molecular Cancer 2004 3:21

    Content type: Research

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  23. Neurofibromatosis type 1 (NF1) is an autosomal dominant disorder with a complex range of clinical symptoms. The hallmark of NF1 is the onset of heterogeneous (dermal or plexiform) benign neurofibromas. Plexiform ...

    Authors: Pascale Lévy, Dominique Vidaud, Karen Leroy, Ingrid Laurendeau, Janine Wechsler, Giulia Bolasco, Béatrice Parfait, Pierre Wolkenstein, Michel Vidaud and Ivan Bièche

    Citation: Molecular Cancer 2004 3:20

    Content type: Research

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  24. Hypoxia-tolerant human glioma cells reduce oxygen consumption rate in response to oxygen deficit, a defense mechanism that contributes to survival under moderately hypoxic conditions. In contrast, hypoxia-sens...

    Authors: Carrie DeHaan, Bahram Habibi-Nazhad, Elizabeth Yan, Nicole Salloum, Matthew Parliament and Joan Allalunis-Turner

    Citation: Molecular Cancer 2004 3:19

    Content type: Research

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  25. The agouti protein is a paracrine factor that is normally present in the skin of many species of mammals. Agouti regulates the switch between black and yellow hair pigmentation by signalling through the melano...

    Authors: Alexander I Kuklin, Randall L Mynatt, Mitchell L Klebig, Laura L Kiefer, William O Wilkison, Richard P Woychik and Edward J Michaud

    Citation: Molecular Cancer 2004 3:17

    Content type: Research

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  26. Male germ cell tumor (GCT) is a highly curable malignancy, which exhibits exquisite sensitivity to cisplatin treatment. The genetic pathway(s) that determine the chemotherapy sensitivity in GCT remain largely ...

    Authors: Sanjay Koul, James M McKiernan, Gopeshwar Narayan, Jane Houldsworth, Jennifer Bacik, Deborah L Dobrzynski, Adel M Assaad, Mahesh Mansukhani, Victor E Reuter, George J Bosl, Raju SK Chaganti and Vundavalli VVS Murty

    Citation: Molecular Cancer 2004 3:16

    Content type: Research

    Published on:

  27. The expression of the rodent phosphoinositide-specific phospholipase C δ-4 (PLCδ4) has been found to be elevated upon mitogenic stimulation and expression analysis have linked the upregulation of PLCδ4 express...

    Authors: David W Leung, Chris Tompkins, Jim Brewer, Alexey Ball, Mike Coon, Valerie Morris, David Waggoner and Jack W Singer

    Citation: Molecular Cancer 2004 3:15

    Content type: Research

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  28. CHK2 kinase is a tumor suppressor that plays important role in DNA damage signaling, cell cycle regulation and DNA damage induced apoptosis. CHK2 kinase expression was known to be ubiquitous in mammalian cells...

    Authors: Peilin Zhang, Jie Wang, Weiyi Gao, Bao-Zhu Yuan, John Rogers and Eddie Reed

    Citation: Molecular Cancer 2004 3:14

    Content type: Research

    Published on:

  29. The cellular retinol binding protein I gene (CRBP) is downregulated in a subset of human breast cancers and in MMTV-Myc induced mouse mammary tumors. Functional studies suggest that CRBP downregulation contribute...

    Authors: Alice Arapshian, Silvina Bertran, Yuvarani S Kuppumbatti, Shigeo Nakajo and Rafael Mira-y-Lopez

    Citation: Molecular Cancer 2004 3:13

    Content type: Research

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  30. Established colorectal cancer cell lines subjected to different 5-fluorouracil (5-FU) treatment protocols are often used as in vitro model systems for investigations of downstream cellular responses to 5-FU and t...

    Authors: Paula M De Angelis, Katherine L Kravik, Siv H Tunheim, Terje Haug and Wenche H Reichelt

    Citation: Molecular Cancer 2004 3:11

    Content type: Research

    Published on:

  31. Small GTPases of the Rho family are critical regulators of various cellular functions including actin cytoskeleton organization, activation of kinase cascades and mitogenesis. For this reason, a major objectiv...

    Authors: Christina Curtis, Bianca Hemmeryckx, Leena Haataja, Dinithi Senadheera, John Groffen and Nora Heisterkamp

    Citation: Molecular Cancer 2004 3:10

    Content type: Research

    Published on:

  32. Nuclear factor kappa B (NFκB) is a pro-malignant transcription factor with reciprocal effects on pro-metastatic and anti-metastatic gene expression. Interestingly, NFκB blockade results in the reciprocal induc...

    Authors: Valentine B Andela and Randy N Rosier

    Citation: Molecular Cancer 2004 3:8

    Content type: Research

    Published on:

  33. Cyclooxygenase-2 (COX-2) has been shown to be highly expressed in a broad series of primary endometrial tumors and its expression may be closely associated with parameters of tumor aggressiveness. In human end...

    Authors: Marie-Eve St-Germain, Veronique Gagnon, Sophie Parent and Eric Asselin

    Citation: Molecular Cancer 2004 3:7

    Content type: Research

    Published on:

  34. Colorectal cancer (CRC) is one of the most common causes of cancer-related deaths in the Western world, and despite the fact that metastases are usually the ultimate cause of deaths, the knowledge of the genet...

    Authors: Chieu B Diep, Manuel R Teixeira, Lin Thorstensen, Johan N Wiig, Mette Eknæs, Jahn M Nesland, Karl-Erik Giercksky, Bertil Johansson and Ragnhild A Lothe

    Citation: Molecular Cancer 2004 3:6

    Content type: Research

    Published on:

  35. Probe based detection assays form the mainstay of transcript quantification. Problems with these assays include varying hybridization efficiencies of the probes used for transcript quantification and the expen...

    Authors: Vincenzo Pagliarulo, Ben George, Stephen J Beil, Susan Groshen, Peter W Laird, Jie Cai, James Willey, Richard J Cote and Ram H Datar

    Citation: Molecular Cancer 2004 3:5

    Content type: Research

    Published on:

  36. The expression of pro-angiogenic cytokines, such as vascular endothelial growth factor (VEGF) and interleukin-8/CXCL8 (IL-8), plays an important role in tumor growth and metastasis. Low oxygen tension within p...

    Authors: Philip L Marjon, Ekaterina V Bobrovnikova-Marjon and Steve F Abcouwer

    Citation: Molecular Cancer 2004 3:4

    Content type: Research

    Published on:

  37. Cellular senescence is a state in which mammalian cells enter into an irreversible growth arrest and altered biological functions. The senescence response in mammalian cells can be elicited by DNA-damaging age...

    Authors: Aruna S Jaiswal, Asha S Multani, Sen Pathak and Satya Narayan

    Citation: Molecular Cancer 2004 3:3

    Content type: Research

    Published on:

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