Articles

Nuclear genes involved in mitochondria-to-nucleus communication in breast cancer cells

The interaction of nuclear and mitochondrial genes is an essential feature in maintenance of normal cellular function. Of 82 structural subunits that make up the oxidative phosphorylation system in the mitocho...

Authors: Robert Delsite, Sushant Kachhap, Ramaswamy Anbazhagan, Edward Gabrielson and Keshav K Singh

Plasma PGE-2 levels and altered cytokine profiles in adherent peripheral blood mononuclear cells in non-small cell lung cancer (NSCLC)

PGE-2 is constitutively produced by many non-small cell lung cancers (NSCLC) and its immunosuppressive effects have been linked to altered immune responses in lung cancer. We asked whether elevated levels of p...

Authors: Giovanna E Hidalgo, Li Zhong, Dennis E Doherty and Edward A Hirschowitz

Glycerol as a chemical chaperone enhances radiation-induced apoptosis in anaplastic thyroid carcinoma cells

Anaplastic thyroid carcinoma, which is one of the most aggressive, malignant tumors in humans, results in an extremely poor prognosis despite chemotherapy and radiotherapy. The present study was designed to ev...

Authors: Ken Ohnishi, Ichiro Ota, Katsunari Yane, Akihisa Takahashi, Kazue Yuki, Mie Emoto, Hiroshi Hosoi and Takeo Ohnishi

Mapping common deleted regions on 5p15 in cervical carcinoma and their occurrence in precancerous lesions

Previous studies have shown that the short arm of chromosome 5 (5p) exhibit frequent genetic changes in invasive cervical carcinoma (CC), and that these changes arise early during the carcinogenesis, in precan...

Authors: Hugo Arias-Pulido, Gopeshwar Narayan, Hernan Vargas, Mahesh Mansukhani and Vundavalli VVS Murty

Reactivation of a silenced H19 gene in human rhabdomyosarcoma by demethylation of DNA but not by histone hyperacetylation

The active copy of the imprinted gene H19 is turned off by inappropriate methylation in several pediatric tumors including Wilms' Tumour and embryonal rhabdomyosarcoma. H19 controls in cis the linked Insulin-like...

Authors: Catherine A Lynch, Benjamin Tycko, Timothy H Bestor and Colum P Walsh

Bench and Bedside

Authors: Christian Schmidt