Skip to main content

Articles

Page 51 of 65

  1. The epidermal specific ablation of Trp53 gene leads to the spontaneous development of aggressive tumors in mice through a process that is accelerated by the simultaneous ablation of Rb gene. Since alterations of ...

    Authors: Ramón García-Escudero, Ana B Martínez-Cruz, Mirentxu Santos, Corina Lorz, Carmen Segrelles, Guillermo Garaulet, Cristina Saiz-Ladera, Clotilde Costa, Águeda Buitrago-Pérez, Marta Dueñas and Jesús M Paramio
    Citation: Molecular Cancer 2010 9:193
  2. Growing evidence suggests that the majority of tumors are organized hierarchically, comprising a population of tumor-initiating, or cancer stem cells (CSCs) responsible for tumor development, maintenance and r...

    Authors: Galina I Botchkina, Edison S Zuniga, Manisha Das, Yuan Wang, Haichao Wang, Shu Zhu, Anne G Savitt, Rebecca A Rowehl, Yan Leyfman, Jingfang Ju, Kenneth Shroyer and Iwao Ojima
    Citation: Molecular Cancer 2010 9:192
  3. High frequency of loss of heterozygosity (LOH) was found at D7S486 in primary gastric cancer (GC). And we found a high frequency of LOH region on 7q31 in primary GC from China, and identified D7S486 to be the ...

    Authors: Haiqing Ma, Desheng Weng, Yibing Chen, Wei Huang, Ke Pan, Hui Wang, Jiancong Sun, Qijing Wang, Zhiwei Zhou, Huiyun Wang and Jianchuan Xia
    Citation: Molecular Cancer 2010 9:190
  4. Dietary or therapeutic interventions to counteract the loss of PTEN expression could contribute to the prevention of prostate carcinogenesis or reduce the rate of cancer progression. In this study, we investig...

    Authors: Maria H Traka, Caroline A Spinks, Joanne F Doleman, Antonietta Melchini, Richard Y Ball, Robert D Mills and Richard F Mithen
    Citation: Molecular Cancer 2010 9:189
  5. The anaplastic lymphoma kinase (ALK) gene is frequently involved in translocations that lead to gene fusions in a variety of human malignancies, including lymphoma and lung cancer. Fusion partners of ALK include

    Authors: Xuchao Zhang, Shirley Zhang, Xuening Yang, Jinji Yang, Qing Zhou, Lucy Yin, Shejuan An, Jiaying Lin, Shiliang Chen, Zhi Xie, Mike Zhu, Xiaolin Zhang and Yi-long Wu
    Citation: Molecular Cancer 2010 9:188
  6. The transcription factor SOX11 plays an important role in embryonic development of the central nervous system (CNS) and is expressed in the adult immature neuron but is normally not expressed in any other adul...

    Authors: Elin Gustavsson, Sandra Sernbo, Elin Andersson, Donal J. Brennan, Michael Dictor, Mats Jerkeman, Carl A. K. Borrebaeck and Sara Ek
    Citation: Molecular Cancer 2010 9:187
  7. Sulfatides (ST) are a category of sulfated galactosylceramides (GalCer) that are elevated in many types of cancer including, possibly, ovarian cancer. Previous evidence for elevation of ST in ovarian cancer wa...

    Authors: Ying Liu, Yanfeng Chen, Amin Momin, Rebecca Shaner, Elaine Wang, Nathan J Bowen, Lilya V Matyunina, L DeEtte Walker, John F McDonald, M Cameron Sullards and Alfred H Merrill Jr
    Citation: Molecular Cancer 2010 9:186
  8. Hypoxia is a condition of low oxygen tension occurring in the tumor microenvironment and it is related to poor prognosis in human cancer. To examine the relationship between hypoxia and neuroblastoma, we gener...

    Authors: Paolo Fardin, Annalisa Barla, Sofia Mosci, Lorenzo Rosasco, Alessandro Verri, Rogier Versteeg, Huib N Caron, Jan J Molenaar, Ingrid Øra, Alessandra Eva, Maura Puppo and Luigi Varesio
    Citation: Molecular Cancer 2010 9:185
  9. Cadmium has been classified as a human carcinogen, affecting health through occupational and environmental exposure. Cadmium has a long biological half-life (>25 years), due to the flat kinetics of its excreti...

    Authors: Konstantin Golovine, Peter Makhov, Robert G Uzzo, Alexander Kutikov, David J Kaplan, Eric Fox and Vladimir M Kolenko
    Citation: Molecular Cancer 2010 9:183
  10. NF-κB is a transcription factor that promotes inhibition of apoptosis and resistance to chemotherapy. It is commonly believed that inhibition of NF-κB activity can increase sensitivity of cancer cells to chemo...

    Authors: Ricardo Parrondo, Alicia de las Pozas, Teresita Reiner, Priyamvada Rai and Carlos Perez-Stable
    Citation: Molecular Cancer 2010 9:182
  11. Since the first suggestion of prospectively identifiable cancer stem cells in solid tumors, efforts have been made to characterize reported cancer stem cell surrogates in existing cancer cell lines, and cell l...

    Authors: Bisrat G Debeb, Xiaomei Zhang, Savitri Krishnamurthy, Hui Gao, Evan Cohen, Li Li, Angel A Rodriguez, Melissa D Landis, Anthony Lucci, Naoto T Ueno, Fredika Robertson, Wei Xu, Lara Lacerda, Thomas A Buchholz, Massimo Cristofanilli, James M Reuben…
    Citation: Molecular Cancer 2010 9:180
  12. Trichostatin A (TSA), a potent inhibitor of histone deacetylases exhibits strong anti-tumor and growth inhibitory activities, but its mechanism(s) of action is not completely understood. Osteopontin (OPN) is a...

    Authors: Priyanka Sharma, Santosh Kumar and Gopal C Kundu
    Citation: Molecular Cancer 2010 9:178
  13. Barrett's esophagus (BE) is caused by gastroesophageal reflux with consecutive mucosal inflammation, predisposing patients to the development of esophageal adenocarcinoma (EAC). We investigated changes in T ce...

    Authors: Uta Berndt, Lars Philipsen, Sebastian Bartsch, Yuqin Hu, Christoph Röcken, Wiedenmann Bertram, Marcus Hämmerle, Thomas Rösch and Andreas Sturm
    Citation: Molecular Cancer 2010 9:177
  14. Components of the microenvironment such as bone marrow stromal cells (BMSCs) are well known to support multiple myeloma (MM) disease progression and resistance to chemotherapy including the proteasome inhibito...

    Authors: Stephanie Markovina, Natalie S Callander, Shelby L O'Connor, Guangwu Xu, Yufang Shi, Catherine P Leith, KyungMann Kim, Parul Trivedi, Jaehyup Kim, Peiman Hematti and Shigeki Miyamoto
    Citation: Molecular Cancer 2010 9:176
  15. The oncolytic adenovirus dl 922-947 replicates selectively within and lyses cells with a dysregulated Rb pathway, a finding seen in > 90% human cancers. dl 922-947 is more potent than wild type adenovirus and the...

    Authors: Magdalena B Flak, Claire M Connell, Claude Chelala, Kyra Archibald, Michael A Salako, Katrina J Pirlo, Michelle Lockley, Sally P Wheatley, Frances R Balkwill and Iain A McNeish
    Citation: Molecular Cancer 2010 9:175
  16. Prostate cancer is the second leading cause of cancer mortality in American men. Although serum PSA testing is widely used for early detection, more specific prognostic tests are needed to guide treatment deci...

    Authors: Matthias Jost, John R Day, Ryan Slaughter, Theodore D Koreckij, Deanna Gonzales, Martin Kinnunen, Jack Groskopf, Harry G Rittenhouse, Robert L Vessella and Mark A Reynolds
    Citation: Molecular Cancer 2010 9:174
  17. The tumor suppressor pRb plays a key role regulating cell cycle arrest, and disturbances in the RB1 gene have been reported in different cancer forms. However, the literature reports contradictory findings with r...

    Authors: Elisabet Ognedal Berge, Stian Knappskog, Stephanie Geisler, Vidar Staalesen, Marec Pacal, Anne-Lise Børresen-Dale, Pål Puntervoll, Johan Richard Lillehaug and Per Eystein Lønning
    Citation: Molecular Cancer 2010 9:173
  18. A hallmark of several human cancers is loss of heterozygosity (LOH) of chromosome 17p13. The same chromosomal region is also frequently hypermethylated in cancer. Although loss of 17p13 has been often associat...

    Authors: M Michela Mancarelli, Francesca Zazzeroni, Lucia Ciccocioppo, Daria Capece, Agnese Po, Simona Murgo, Raffaello Di Camillo, Christian Rinaldi, Elisabetta Ferretti, Alberto Gulino and Edoardo Alesse
    Citation: Molecular Cancer 2010 9:172
  19. The transcription factor Runx2 has an established role in cancers that metastasize to bone. In metastatic breast cancer cells Runx2 is overexpressed and contributes to the invasive capacity of the cells by reg...

    Authors: Daniel Mendoza-Villanueva, Wensheng Deng, Cesar Lopez-Camacho and Paul Shore
    Citation: Molecular Cancer 2010 9:171
  20. Wnt factors control cell differentiation through semi-independent molecular cascades known as the β-catenin-dependent (canonical) and -independent (non-canonical) Wnt signalling pathways. Genetic and epigeneti...

    Authors: Ester Lara, Vincenzo Calvanese, Covadonga Huidobro, Agustin F Fernández, Ángela Moncada-Pazos, Álvaro J Obaya, Oscar Aguilera, José Manuel González-Sancho, Laura Sánchez, Aurora Astudillo, Alberto Muñoz, Carlos López-Otín, Manel Esteller and Mario F Fraga
    Citation: Molecular Cancer 2010 9:170
  21. Recently, the microRNA-200 family was reported to affect cancer biology by regulating epithelial to mesenchymal transition (EMT). Especially, the expression of miR-200c has been shown to be associated with upregu...

    Authors: Jun Yu, Kenoki Ohuchida, Kazuhiro Mizumoto, Norihiro Sato, Tadashi Kayashima, Hayato Fujita, Kouhei Nakata and Masao Tanaka
    Citation: Molecular Cancer 2010 9:169
  22. Cancer associated fibroblasts (CAFs) play a critical role for growth, invasion, and metastasis of cancer. Therefore, targeting CAFs with small molecule inhibitors may be an attractive anti-tumor strategy. The ...

    Authors: Silke Haubeiss, Jens O Schmid, Thomas E Mürdter, Maike Sonnenberg, Godehard Friedel, Heiko van der Kuip and Walter E Aulitzky
    Citation: Molecular Cancer 2010 9:168
  23. A substantial number of microRNAs (miRNAs) is subject to epigenetic silencing in cancer. Although epigenetic silencing of tumour suppressor genes is an important feature of cervical cancer, little is known abo...

    Authors: Saskia M Wilting, Robert AA van Boerdonk, Florianne E Henken, Chris JLM Meijer, Begoňa Diosdado, Gerrit A Meijer, Carlos le Sage, Reuven Agami, Peter JF Snijders and Renske DM Steenbergen
    Citation: Molecular Cancer 2010 9:167
  24. Epidermal growth factor (EGF) and its receptor (EGFR) constitute a principal growth-promoting pathway in endometrial cancer cells. Pre-clinical studies were undertaken to compare the expression of EGFR isoform...

    Authors: Lina Albitar, Gavin Pickett, Marilee Morgan, Jason A Wilken, Nita J Maihle and Kimberly K Leslie
    Citation: Molecular Cancer 2010 9:166
  25. We characterized the biologic effects of a novel small molecule STAT3 pathway inhibitor that is derived from the natural product curcumin. We hypothesized this lead compound would specifically inhibit the STAT...

    Authors: Matthew A Bill, James R Fuchs, Chenglong Li, Jennifer Yui, Courtney Bakan, Don M Benson Jr, Eric B Schwartz, Dalia Abdelhamid, Jiayuh Lin, Dale G Hoyt, Stacey L Fossey, Gregory S Young, William E Carson III, Pui-Kai Li and Gregory B Lesinski
    Citation: Molecular Cancer 2010 9:165
  26. Human renal cell carcinoma (RCC) is very resistant to chemotherapy. ABT-737 is a novel inhibitor of anti-apoptotic proteins of the Bcl-2 family that has shown promise in various preclinical tumour models.

    Authors: Henry Zall, Arnim Weber, Robert Besch, Niko Zantl and Georg Häcker
    Citation: Molecular Cancer 2010 9:164
  27. Aberrant promoter DNA methylation has been reported in childhood acute lymphoblastic leukaemia (ALL) and has the potential to contribute to its onset and outcome. However, few reports demonstrate consistent, p...

    Authors: Robert J. Weeks, Ursula R. Kees, Sarah Song and Ian M. Morison
    Citation: Molecular Cancer 2010 9:163
  28. Aberrations in the Wnt pathway have been reported to be involved in the metastasis of prostate cancer (PCa) to bone. We investigated the effect and underlying mechanism of a naturally-occurring Wnt inhibitor, ...

    Authors: David S. Yee, Yaxiong Tang, Xuesen Li, Zhongbo Liu, Yi Guo, Samia Ghaffar, Peter McQueen, Dash Atreya, Jun Xie, Anne R. Simoneau, Bang H. Hoang and Xiaolin Zi
    Citation: Molecular Cancer 2010 9:162
  29. CD95 is a death receptor controlling not only apoptotic pathways but also activating mechanisms promoting tumor growth. During the acquisition of chemoresistance to oxaliplatin there is a progressive loss of C...

    Authors: Elisabet Ametller, Susana García-Recio, Domizziana Costamagna, Cristina Mayordomo, Patricia Fernández-Nogueira, Neus Carbó, Eva María Pastor-Arroyo, Pedro Gascón and Vanessa Almendro
    Citation: Molecular Cancer 2010 9:161
  30. Germline mutations in the FLCN gene are responsible for the development of fibrofolliculomas, lung cysts and renal neoplasia in Birt-Hogg-Dube' (BHD) syndrome. The encoded protein folliculin (FLCN) is conserved a...

    Authors: Seung-Beom Hong, HyoungBin Oh, Vladimir A Valera, Jaime Stull, Duy-Tan Ngo, Masaya Baba, Maria J Merino, W Marston Linehan and Laura S Schmidt
    Citation: Molecular Cancer 2010 9:160
  31. Glioblastomas are characterized by rapid cell growth, aggressive CNS infiltration, and are resistant to all known anticancer regimens. Recent studies indicate that fibrates and statins possess anticancer poten...

    Authors: Justyna Drukala, Katarzyna Urbanska, Anna Wilk, Maja Grabacka, Ewa Wybieralska, Luis Del Valle, Zbigniew Madeja and Krzysztof Reiss
    Citation: Molecular Cancer 2010 9:159
  32. The polycomb group (PcG) protein BMI1 is an important regulator of development. Additionally, aberrant expression of BMI1 has been linked to cancer stem cell phenotype and oncogenesis. In particular, its overe...

    Authors: Ajay K Yadav, Anagh A Sahasrabuddhe, Manjari Dimri, Prashant V Bommi, Rachana Sainger and Goberdhan P Dimri
    Citation: Molecular Cancer 2010 9:158
  33. Although several anti-angiogenic therapies have been approved in the treatment of cancer, the survival benefits of such therapies are relatively modest. Discovering new molecules and/or better understating sig...

    Authors: Rodrigue Romon, Eric Adriaenssens, Chann Lagadec, Emmanuelle Germain, Hubert Hondermarck and Xuefen Le Bourhis
    Citation: Molecular Cancer 2010 9:157
  34. Ca2+ is a ubiquitous messenger that has been shown to be responsible for controlling numerous cellular processes including cell growth and cell death. Whereas the involvement of IP3-induced Ca2+ signalling (IICS)...

    Authors: Cécilia Szatkowski, Jan B Parys, Halima Ouadid-Ahidouch and Fabrice Matifat
    Citation: Molecular Cancer 2010 9:156
  35. Epstein-Barr virus (EBV)-encoded LMP1 protein is commonly expressed in nasopharyngeal carcinoma (NPC). LMP1 is a prime candidate for driving tumourigenesis given its ability to activate multiple signalling pat...

    Authors: Angela KF Lo, Christopher W Dawson, Kwok W Lo, Yanxing Yu and Lawrence S Young
    Citation: Molecular Cancer 2010 9:155
  36. Formation of tumour cell aggregation/emboli prolongs the survival of circulating tumour cells in the circulation, enhances their physical trapping in the micro-vasculature and thus increases metastatic spread ...

    Authors: Qicheng Zhao, Monica Barclay, John Hilkens, Xiuli Guo, Hannah Barrow, Jonathan M Rhodes and Lu-Gang Yu
    Citation: Molecular Cancer 2010 9:154
  37. Centrosome aberrations can cause genomic instability and correlate with malignant progression in common human malignancies such as breast and prostate cancer. Deregulation of cyclin/cyclin-dependent kinase 2 (...

    Authors: Nina Korzeniewski, Sarah Wheeler, Payel Chatterjee, Anette Duensing and Stefan Duensing
    Citation: Molecular Cancer 2010 9:153
  38. Selection of early stage non-small cell lung cancer patients with a high risk of recurrence is warranted in order to select patients who will benefit from adjuvant treatment strategies. We evaluated the progno...

    Authors: Anne-Marie C Dingemans, Vivian van den Boogaart, Bettine A Vosse, Robert-Jan van Suylen, Arjan W Griffioen and Victor L Thijssen
    Citation: Molecular Cancer 2010 9:152
  39. NK- and T-cells are closely related lymphocytes, originating from the same early progenitor cells during hematopoiesis. In these differentiation processes deregulation of developmental genes may contribute to ...

    Authors: Stefan Nagel, Letizia Venturini, Victor E Marquez, Corinna Meyer, Maren Kaufmann, Michaela Scherr, Roderick AF MacLeod and Hans G Drexler
    Citation: Molecular Cancer 2010 9:151
  40. The HER4 intracellular domain (4ICD) is a potent estrogen receptor (ERα) coactivator with activities in breast cancer and the developing mammary gland that appear to overlap with progesterone receptor (PgR). I...

    Authors: Jerzy Rokicki, Partha M Das, Jennifer M Giltnane, Olivia Wansbury, David L Rimm, Beatrice A Howard and Frank E Jones
    Citation: Molecular Cancer 2010 9:150
  41. Pancreatic intraepithelial neoplasias (PanINs) are precursors of malignant pancreatic cancer, an ideal stage for early cancer detection. We applied quantitative proteomics to identify aberrantly elevated prote...

    Authors: Ru Chen, Sheng Pan, Xiaobo Duan, Brad H Nelson, Rob A Sahota, Sarah de Rham, Richard A Kozarek, Martin McIntosh and Teresa A Brentnall
    Citation: Molecular Cancer 2010 9:149
  42. Prostate-derived Ets factor (PDEF) is expressed in tissues of high epithelial content including prostate, although its precise function has not been fully established. Conventional therapies produce a high rat...

    Authors: Thomas R Johnson, Sweaty Koul, Binod Kumar, Lakshmipathi Khandrika, Sarah Venezia, Paul D Maroni, Randall B Meacham and Hari K Koul
    Citation: Molecular Cancer 2010 9:148

    The Retraction Note to this article has been published in Molecular Cancer 2021 20:109

  43. Cisplatin and its derivatives are commonly used anti-cancer drugs. However, cisplatin has clinical limitations including serious side effects and frequent emergence of intrinsic or acquired resistance. Thus, t...

    Authors: Veronika Kvardova, Roman Hrstka, Dawid Walerych, Petr Muller, Eva Matoulkova, Veronika Hruskova, Dagmar Stelclova, Petr Sova and Borivoj Vojtesek
    Citation: Molecular Cancer 2010 9:147
  44. Hepatocellular carcinoma (HCC) is the third-leading cause of cancer-related deaths worldwide. It is often diagnosed at an advanced stage, and hence typically has a poor prognosis. To identify distinct molecula...

    Authors: Dilek Colak, Muhammad A Chishti, Al-Bandary Al-Bakheet, Ahmed Al-Qahtani, Mohamed M Shoukri, Malcolm H Goyns, Pinar T Ozand, John Quackenbush, Ben H Park and Namik Kaya
    Citation: Molecular Cancer 2010 9:146
  45. Lymphotropism in oral squamous cell carcinoma (OSCC) is one of the most important prognostic factors of 5-year survival. In an effort to identify genes that may be responsible for the initiation of OSCC lympho...

    Authors: Chang Xu, Yan Liu, Pei Wang, Wenhong Fan, Tessa C Rue, Melissa P Upton, John R Houck, Pawadee Lohavanichbutr, David R Doody, Neal D Futran, Lue Ping Zhao, Stephen M Schwartz, Chu Chen and Eduardo Méndez
    Citation: Molecular Cancer 2010 9:143

Annual Journal Metrics

  • 2022 Citation Impact
    37.3 - 2-year Impact Factor
    33.1 - 5-year Impact Factor
    5.740 - SNIP (Source Normalized Impact per Paper)
    8.703 - SJR (SCImago Journal Rank)

    2023 Speed
    5 days submission to first editorial decision for all manuscripts (Median)
    91 days submission to accept (Median)

    2023 Usage 
    3,569,666 downloads
    2,070 Altmetric mentions