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  1. Histone acetylation is an epigenetic modification involved in the regulation of gene expression, balanced by histone acetyl transferases and histone deacetylase (HDAC) enzymes. HDAC inhibitors (HDACi) induce g...

    Authors: Marielle Dejligbjerg, Morten Grauslund, Thomas Litman, Laura Collins, Xiaozhong Qian, Michael Jeffers, Henri Lichenstein, Peter Buhl Jensen and Maxwell Sehested
    Citation: Molecular Cancer 2008 7:70
  2. We have identified an alternative pathway of tumorigenesis in sporadic colon cancer, involving microsatellite instability due to mismatched repair methylation, which may be driven by mutations in the BRAF gene...

    Authors: Hassan Brim, Pooneh Mokarram, Fakhraddin Naghibalhossaini, Mehdi Saberi-Firoozi, Mansour Al-Mandhari, Kamla Al-Mawaly, Rayhaneh Al-Mjeni, Abeer Al-Sayegh, Sandy Raeburn, Edward Lee, Francis Giardiello, Duane T Smoot, Alexander Vilkin, C Richard Boland, Ajay Goel, Mitra Hafezi…
    Citation: Molecular Cancer 2008 7:68
  3. Childhood pre-B acute lymphoblastic leukemia (ALL) is a bone marrow (BM) derived disease, which often disseminates out of the BM cavity, where malignant cells to a variable degree can be found circulating in t...

    Authors: Frida Hansson, Jacek Toporski, Robert Månsson, Bertil Johansson, Ulrika Norén-Nyström, Sten Eirik W Jacobsen, Thomas Wiebe, Marcus Larsson, Mikael Sigvardsson and Anders Castor
    Citation: Molecular Cancer 2008 7:67
  4. The clinical efficacy of camptothecin (CPT), a drug specifically targeting topoisomerase I (TopoI), is under evaluation for the treatment of malignant gliomas. Due to the high unresponsiveness of these tumours...

    Authors: Elena Morandi, Cinzia Severini, Daniele Quercioli, Giovanni D'Ario, Stefania Perdichizzi, Miriam Capri, Giovanna Farruggia, Maria Grazia Mascolo, Wolfango Horn, Monica Vaccari, Roberto Serra, Annamaria Colacci and Paola Silingardi
    Citation: Molecular Cancer 2008 7:66
  5. Pancreatic ductal adenocarcinoma (PDAC) is one of the most common causes of cancer related death. Despite the advances in understanding of the molecular pathogenesis, pancreatic cancer remains a major unsolved...

    Authors: Rainer Hamacher, Roland M Schmid, Dieter Saur and Günter Schneider
    Citation: Molecular Cancer 2008 7:64
  6. By nature, scientists contribute to our understanding of nature and ourselves. As communities undergo significant changes, new challenges are presented. Here, we offer alternative views on recent changes in so...

    Authors: Laura M Christian, Hassan R Naqvi, Christian Schmidt, David Covarrubias and Shawn Mathur
    Citation: Molecular Cancer 2008 7:63
  7. Lung cancer is the leading cause of cancer death in men and women in the United States and Western Europe. Over 160,000 Americans die of this disease every year. The five-year survival rate is 15% – significan...

    Authors: Paul P Anglim, Janice S Galler, Michael N Koss, Jeffrey A Hagen, Sally Turla, Mihaela Campan, Daniel J Weisenberger, Peter W Laird, Kimberly D Siegmund and Ite A Laird-Offringa
    Citation: Molecular Cancer 2008 7:62
  8. Chromatin-associated histone H2AX is a key regulator of the cellular responses to DNA damage. However, non-nucleosomal functions of histone H2AX are poorly characterized. We have recently shown that soluble H2...

    Authors: Ying Liu, Joshua A Parry, Anna Chin, Stefan Duensing and Anette Duensing
    Citation: Molecular Cancer 2008 7:61
  9. Drug resistance is a major concern in cancer therapy. Here, we investigate the clinical potential of the second mitochondria-derived activator of caspase (Smac/DIABLO) in enhancing the apoptosis-inducing poten...

    Authors: Tamer E Fandy, Sharmila Shankar and Rakesh K Srivastava
    Citation: Molecular Cancer 2008 7:60
  10. Authors: Cinzia Di Pietro, Marco Ragusa, Davide Barbagallo, Laura R Duro, Maria R Guglielmino, Alessandra Majorana, Veronica Giunta, Antonella Rapisarda, Elisa Tricarichi, Marco Miceli, Rosario Angelica, Agata Grillo, Barbara Banelli, Isabella Defferari, Stefano Forte, Alessandro Laganà…
    Citation: Molecular Cancer 2008 7:59

    The original article was published in Molecular Cancer 2008 7:52

  11. Copy number gains and amplifications are characteristic feature of cervical cancer (CC) genomes for which the underlying mechanisms are unclear. These changes may possess oncogenic properties by deregulating t...

    Authors: Luigi Scotto, Gopeshwar Narayan, Subhadra V Nandula, Shivakumar Subramaniyam, Andreas M Kaufmann, Jason D Wright, Bhavana Pothuri, Mahesh Mansukhani, Achim Schneider, Hugo Arias-Pulido and Vundavalli V Murty
    Citation: Molecular Cancer 2008 7:58
  12. Certain endogenous metabolites can influence the rate of cancer cell growth. For example, diacylglycerol, ceramides and sphingosine, NAD+ and arginine exert this effect by acting as signaling molecules, while car...

    Authors: Adrian K Arakaki, Roman Mezencev, Nathan J Bowen, Ying Huang, John F McDonald and Jeffrey Skolnick
    Citation: Molecular Cancer 2008 7:57
  13. Photodynamic therapy (PDT) involves the administration of a tumor-localizing photosensitizing drug, which is activated by light of specific wavelength in the presence of molecular oxygen thus generating reacti...

    Authors: Ramaswamy Bhuvaneswari, Yik Y Gan, Sasidharan S Lucky, William WL Chin, Seyed M Ali, Khee C Soo and Malini Olivo
    Citation: Molecular Cancer 2008 7:56
  14. Histone deacetylase inhibitors (HDACi) are a new class of promising anti-tumour agent inhibiting cell proliferation and survival in tumour cells with very low toxicity toward normal cells. Neuroblastoma (NB) i...

    Authors: Annick Mühlethaler-Mottet, Roland Meier, Marjorie Flahaut, Katia Balmas Bourloud, Katya Nardou, Jean-Marc Joseph and Nicole Gross
    Citation: Molecular Cancer 2008 7:55
  15. Mutation of a tumor suppressor allele leaves the second as backup. Not necessarily so with p53. This homo-tetrameric transcription factor can become contaminated with mutant p53 through hetero-tetramerization....

    Authors: Kristina Heyne, Katrin Schmitt, Daniel Mueller, Vivienne Armbruester, Pedro Mestres and Klaus Roemer
    Citation: Molecular Cancer 2008 7:54
  16. Aberrant accumulation of β-catenin plays an important role in a variety of human neoplasms. We recently reported accumulation of β-catenin in parathyroid adenomas from patients with primary hyperparathyroidism...

    Authors: Peyman Björklund, Daniel Lindberg, Göran Åkerström and Gunnar Westin
    Citation: Molecular Cancer 2008 7:53
  17. The General Transcription Apparatus (GTA) comprises more than one hundred proteins, including RNA Polymerases, GTFs, TAFs, Mediator, and cofactors such as heterodimeric NC2. This complexity contrasts with the ...

    Authors: Cinzia Di Pietro, Marco Ragusa, Davide Barbagallo, Laura R Duro, Maria R Guglielmino, Alessandra Majorana, Veronica Giunta, Antonella Rapisarda, Elisa Tricarichi, Marco Miceli, Rosario Angelica, Agata Grillo, Barbara Banelli, Isabella Defferari, Stefano Forte, Alessandro Laganà…
    Citation: Molecular Cancer 2008 7:52
  18. Widely accepted somatic mutation theory of carcinogenesis states that mutations in oncogenes and tumor suppressor genes in genomes of somatic cells is the cause of neoplastic transformation. Identifying freque...

    Authors: Helena Zientek-Targosz, Dimiter Kunnev, Lesleyann Hawthorn, Mikhail Venkov, Sei-Ichi Matsui, Richard T Cheney and Yuri Ionov
    Citation: Molecular Cancer 2008 7:51
  19. Bortezomib, a specific and selective inhibitor of the 26S proteasome with antitumor activity against a wide range of malignancies, has been approved for the treatment of relapsed or refractory multiple myeloma...

    Authors: Valérie Combaret, Sandrine Boyault, Isabelle Iacono, Stéphanie Brejon, Raphaël Rousseau and Alain Puisieux
    Citation: Molecular Cancer 2008 7:50
  20. Malignant peripheral nerve sheath tumors (MPNSTs) are rare and highly aggressive soft tissue tumors showing complex chromosomal aberrations. In order to identify recurrent chromosomal regions of gain and loss,...

    Authors: Stine H Kresse, Magne Skårn, Hege O Ohnstad, Heidi M Namløs, Bodil Bjerkehagen, Ola Myklebost and Leonardo A Meza-Zepeda
    Citation: Molecular Cancer 2008 7:48
  21. Antisense (AS) induced down-regulation of uPAR in ACCS adenoid-cyctic carcinoma cells decreased the cellular adhesion and invasion on various extracellular matrices. Additionally, ACCS-AS cells showed an incre...

    Authors: Samah Abu-Ali, Abbas Fotovati and Kanemitsu Shirasuna
    Citation: Molecular Cancer 2008 7:47
  22. Carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1), a cell adhesion molecule expressed in a variety of cell types is a putative tumor suppressor gene. Alternative splicing of CEACAM1 generates...

    Authors: Shikha Gaur, John E Shively, Yun Yen and Rajesh K Gaur
    Citation: Molecular Cancer 2008 7:46
  23. Hashimoto Thyroiditis (H.T.) is a destructive autoimmune thyroid condition whose precise molecular pathogenesis remains unclear. ret/PTC-1 is a chimeric transcript which has been described in autoimmune thyroid d...

    Authors: Karen Denning, Paul Smyth, Susanne Cahill, Jinghuan Li, Richard Flavin, Sinead Aherne, John J O' Leary and Orla Sheils
    Citation: Molecular Cancer 2008 7:44
  24. Previous findings have suggested that epigenetic-mediated HLA-G expression in tumor cells may be associated with resistance to host immunosurveillance. To explore the potential role of DNA methylation on HLA-G ex...

    Authors: Laura Menendez, L DeEtte Walker, Lilya V Matyunina, Kimberly A Totten, Benedict B Benigno and John F McDonald
    Citation: Molecular Cancer 2008 7:43
  25. Gefitinib (Iressa)–a specific inhibitor of epidermal growth factor receptor (EGFR) tyrosine kinase–has been shown to suppress the activation of EGFR signaling required for cell survival and proliferation in no...

    Authors: Yukio Nishimura, Kiyoko Yoshioka, Biborka Bereczky and Kazuyuki Itoh
    Citation: Molecular Cancer 2008 7:42
  26. In high grade gliomas, 1p19q codeletion and EGFR amplification are mutually exclusive and predictive of dramatically different outcomes. We performed a microarray gene expression study of four high grade gliomas ...

    Authors: François Ducray, Ahmed Idbaih, Aurélien de Reyniès, Ivan Bièche, Joëlle Thillet, Karima Mokhtari, Séverine Lair, Yannick Marie, Sophie Paris, Michel Vidaud, Khê Hoang-Xuan, Olivier Delattre, Jean-Yves Delattre and Marc Sanson
    Citation: Molecular Cancer 2008 7:41
  27. The proteasome inhibitor bortezomib can inhibit activation of the transcription factor NF-κB, a mechanism implicated in its anti-neoplastic effects observed in mantle cell lymphoma (MCL). However, NF-κB can be...

    Authors: David T Yang, Ken H Young, Brad S Kahl, Stephanie Markovina and Shigeki Miyamoto
    Citation: Molecular Cancer 2008 7:40
  28. We have used a mouse model based on overexpression of c-Myc in B cells genetically engineered to be self-reactive to test the hypothesis that farnesyl transferase inhibitors (FTIs) can effectively treat mature B ...

    Authors: Kenneth A Field, Soratree Charoenthongtrakul, J Michael Bishop and Yosef Refaeli
    Citation: Molecular Cancer 2008 7:39
  29. An increasing number of reports is challenging the notion that the antitumor potential of the selective COX-2 inhibitor celecoxib (Celebrex®) is mediated primarily via the inhibition of COX-2. We have investigate...

    Authors: Huan-Ching Chuang, Adel Kardosh, Kevin J Gaffney, Nicos A Petasis and Axel H Schönthal
    Citation: Molecular Cancer 2008 7:38
  30. AMP-activated protein kinase (AMPK) is a known physiological cellular energy sensor and becomes phosphorylated at Thr-172 in response to changes in cellular ATP levels. Activated AMPK acts as either an inducer...

    Authors: Purna Mukherjee, Tiernan J Mulrooney, Jeremy Marsh, Derek Blair, Thomas C Chiles and Thomas N Seyfried
    Citation: Molecular Cancer 2008 7:37
  31. Breast and ovarian cancers increased in the last decades. Except rare cases with a genetic predisposition and high penetrance, these pathologies are viewed as a polygenic disease. In this concept, association ...

    Authors: Dominique Bernard-Gallon, Rémy Bosviel, Laetitia Delort, Luc Fontana, Alain Chamoux, Nadège Rabiau, Fabrice Kwiatkowski, Nasséra Chalabi, Samir Satih and Yves-Jean Bignon
    Citation: Molecular Cancer 2008 7:36
  32. MicroRNAs (miRNAs) are small, noncoding RNAs that negatively regulate gene expression by binding to target mRNAs. miRNAs have not been comprehensively studied in recurrent ovarian cancer, yet an incurable dise...

    Authors: Alexandros Laios, Sharon O'Toole, Richard Flavin, Cara Martin, Lynne Kelly, Martina Ring, Stephen P Finn, Ciara Barrett, Massimo Loda, Noreen Gleeson, Tom D'Arcy, Eamonn McGuinness, Orla Sheils, Brian Sheppard and John O' Leary
    Citation: Molecular Cancer 2008 7:35
  33. Metastatic melanoma is a severe disease. Few experimental animal models of metastatic melanoma exist. MeLiM minipigs exhibit spontaneous melanoma. Cutaneous and metastatic lesions are histologically similar to...

    Authors: Giorgia Egidy, Sophia Julé, Philippe Bossé, Florence Bernex, Claudine Geffrotin, Silvia Vincent-Naulleau, Vratislav Horak, Xavier Sastre-Garau and Jean-Jacques Panthier
    Citation: Molecular Cancer 2008 7:34
  34. This study was conducted in order to elucidate metabolic differences between human rectal cancer biopsies and colorectal HT29, HCT116 and SW620 xenografts by using high-resolution magnetic angle spinning (MAS)...

    Authors: Therese Seierstad, Kathrine Røe, Beathe Sitter, Jostein Halgunset, Kjersti Flatmark, Anne H Ree, Dag Rune Olsen, Ingrid S Gribbestad and Tone F Bathen
    Citation: Molecular Cancer 2008 7:33
  35. C-Myc is a short-lived oncoprotein that is destroyed by ubiquitin-mediated proteolysis. Dysregulated accumulation of c-Myc commonly occurs in human cancers. Some of those cases with the dysregulated c-Myc prot...

    Authors: Jing An, Dong-Yan Yang, Qin-Zhi Xu, Shi-Meng Zhang, Yan-Ying Huo, Zeng-Fu Shang, Yu Wang, De-Chang Wu and Ping-Kun Zhou
    Citation: Molecular Cancer 2008 7:32
  36. The t(6;8) translocation found in rare and agressive myeloproliferative disorders results in a chimeric gene encoding the FOP-FGFR1 fusion protein. This protein comprises the N-terminal region of the centrosom...

    Authors: Hélène Lelièvre, Véronique Chevrier, Anne-Marie Tassin and Daniel Birnbaum
    Citation: Molecular Cancer 2008 7:30
  37. Development of therapies for patients with BRCA1 mutations has been hampered by lack of readily available in vitro and in vivo models. We recently showed that transplantation of transgenic mammary tumors as cell ...

    Authors: Mollie H Wright, Ana I Robles, Jason I Herschkowitz, Melinda G Hollingshead, Miriam R Anver, Charles M Perou and Lyuba Varticovski
    Citation: Molecular Cancer 2008 7:29
  38. Telomerase expression is detectable in 81–95% of breast carcinomas and may serve as a therapeutic target. The objective of this study was to investigate repression of telomerase activity in primary ductal brea...

    Authors: Kimberly A Elliott, Lee F Rickords and J Marcelete Labrum
    Citation: Molecular Cancer 2008 7:28
  39. it is now well established that hypoxia renders tumor cells resistant to radio- but also chemotherapy. However, few elements are currently available as for the mechanisms underlying this protection.

    Authors: Audrey Sermeus, Jean-Philippe Cosse, Marianne Crespin, Veronique Mainfroid, Francoise de Longueville, Noelle Ninane, Martine Raes, Jose Remacle and Carine Michiels
    Citation: Molecular Cancer 2008 7:27
  40. Secretion of human chorionic gonadotropin, especially its beta subunit by malignant trophoblastic tumors and varieties of tumors of different origin is now well documented; however the role of hCG in tumorogen...

    Authors: Anna Jankowska, Samuel I Gunderson, Miroslaw Andrusiewicz, Beata Burczynska, Anna Szczerba, Artur Jarmolowski, Ewa Nowak-Markwitz and Jerzy B Warchol
    Citation: Molecular Cancer 2008 7:26
  41. The development and progression of prostate cancer requires the transformation of normal zinc-accumulating epithelial cells to malignant cells that have lost the ability to accumulate zinc. This metabolic tran...

    Authors: Pei Feng, Tieluo Li, Zhixin Guan, Renty B Franklin and Leslie C Costello
    Citation: Molecular Cancer 2008 7:25
  42. There have been few studies on lymphangiogenesis in the past due to the lack of specific lymphatic endothelial markers, and lymphatic-specific growth factors. Recently, these limitations have been relieved by ...

    Authors: Giles H Cunnick, Wen G Jiang, Tony Douglas-Jones, Gareth Watkins, Kelvin F Gomez, Mike J Morgan, Ashok Subramanian, Kefah Mokbel and Robert E Mansel
    Citation: Molecular Cancer 2008 7:23
  43. Worldwide gastric carcinoma has marked geographical variations and worse outcome in patients from the West compared to the East. Although these differences has been explained by better diagnostic criteria, imp...

    Authors: Francisco J Ossandon, Cynthia Villarroel, Francisco Aguayo, Eudocia Santibanez, Naohide Oue, Wataru Yasui and Alejandro H Corvalan
    Citation: Molecular Cancer 2008 7:22
  44. Aberrant Wnt-signaling caused by mutants of β-catenin, a key regulator of the canonical Wnt-signaling pathway, is frequently detected in cancer. Only recently, it was suggested that in hepatocellular carcinoma...

    Authors: Madeleine Austinat, Ruediger Dunsch, Christian Wittekind, Andrea Tannapfel, Rolf Gebhardt and Frank Gaunitz
    Citation: Molecular Cancer 2008 7:21

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