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Molecular Cancer

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  1. Content type: Review

    Tumour progression is dependent on the interaction between tumour cells and cells of the surrounding microenvironment. The tumour is a dynamic milieu consisting of various cell types such as endothelial cells,...

    Authors: Sarah M. Ridge, Francis J. Sullivan and Sharon A. Glynn

    Citation: Molecular Cancer 2017 16:31

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  2. Content type: Research

    Contemporary challenges of prostate cancer (PCa) include overdiagnosis and overtreatment, entailing the need for novel clinical tools to improve risk stratification and therapy selection. PCa diagnosis and pro...

    Authors: Jorge Torres-Ferreira, João Ramalho-Carvalho, Antonio Gomez, Francisco Duarte Menezes, Rui Freitas, Jorge Oliveira, Luís Antunes, Maria José Bento, Manel Esteller, Rui Henrique and Carmen Jerónimo

    Citation: Molecular Cancer 2017 16:26

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  3. Content type: Research

    Pilocytic astrocytomas (PAs) are the most common pediatric central nervous system neoplasms. In the majority of cases these tumors are benign and receive favorable prognosis following gross total surgical rese...

    Authors: Guifa Xi, Yuping Derek Li, Gordan Grahovac, Veena Rajaram, Nitin Wadhwani, Tatiana Pundy, Barbara Mania-Farnell, Charles David James and Tadanori Tomita

    Citation: Molecular Cancer 2017 16:21

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  4. Content type: Research

    Colorectal cancer remains one of the most common malignant tumors worldwide. Colorectal cancer initiating cells (CCICs) are a small subpopulation responsible for malignant behaviors of colorectal cancer. Aberr...

    Authors: Zhenzhen Wen, Tianhui Pan, Saisai Yang, Jingwen Liu, Haiying Tao, Yiming Zhao, Dingting Xu, Wei Shao, Jia Wu, Xiyong Liu, Yongjiang Wang, Jianshan Mao and Yongliang Zhu

    Citation: Molecular Cancer 2017 16:20

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  5. Content type: Review

    CircRNAs are a novel type of RNAs. With the newly developed technology of next-generation sequencing (NGS), especially RNA-seq technology, over 30,000 circRNAs have already been found. Owing to their unique st...

    Authors: Yumin Wang, Yongzhen Mo, Zhaojian Gong, Xiang Yang, Mo Yang, Shanshan Zhang, Fang Xiong, Bo Xiang, Ming Zhou, Qianjin Liao, Wenling Zhang, Xiayu Li, Xiaoling Li, Yong Li, Guiyuan Li, Zhaoyang Zeng…

    Citation: Molecular Cancer 2017 16:25

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  6. Content type: Short communication

    Breast cancer is the major cause of cancer-related mortality in women. It is thought that quiescent stem-like cells within solid tumors are responsible for cancer maintenance, progression and eventual metastas...

    Authors: Sarah T. Boyle, Krystyna A. Gieniec, Carly E. Gregor, Jessica W. Faulkner, Shaun R. McColl and Marina Kochetkova

    Citation: Molecular Cancer 2017 16:19

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  7. Content type: Review

    Radiation therapy is one of the major tools of cancer treatment, and is widely used for a variety of malignant tumours. Radiotherapy causes DNA damage directly by ionization or indirectly via the generation of...

    Authors: Su Yeon Lee, Eui Kyong Jeong, Min Kyung Ju, Hyun Min Jeon, Min Young Kim, Cho Hee Kim, Hye Gyeong Park, Song Iy Han and Ho Sung Kang

    Citation: Molecular Cancer 2017 16:10

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  8. Content type: Review

    Epithelial-to-mesenchymal transition (EMT) is associated with metastasis formation as well as with generation and maintenance of cancer stem cells. In this way, EMT contributes to tumor invasion, heterogeneity...

    Authors: Davide Pradella, Chiara Naro, Claudio Sette and Claudia Ghigna

    Citation: Molecular Cancer 2017 16:8

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  9. Content type: Review

    The insulin-like growth factor-I (IGF-I) signaling induces epithelial to mesenchymal transition (EMT) program and contributes to metastasis and drug resistance in several subtypes of tumors. In preclinical stu...

    Authors: Heming Li, Izhar Singh Batth, Xiujuan Qu, Ling Xu, Na Song, Ruoyu Wang and Yunpeng Liu

    Citation: Molecular Cancer 2017 16:6

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  10. Content type: Review

    Epithelial-mesenchymal transition (EMT) and cancer stem-like cells (CSC) are becoming highly relevant targets in anticancer drug discovery. A large body of evidence suggests that epithelial-mesenchymal transit...

    Authors: Fabrizio Marcucci, Pietro Ghezzi and Cristiano Rumio

    Citation: Molecular Cancer 2017 16:3

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  11. Content type: Review

    Liver cancer is an often fatal malignant tumor with a high recurrence rate and chemoresistance. The major malignant phenotypes of cancer, including recurrence, metastasis, and chemoresistance, are related to t...

    Authors: Kouki Nio, Taro Yamashita and Shuichi Kaneko

    Citation: Molecular Cancer 2017 16:4

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  12. Content type: Research

    Dominant-activating mutations in the RET proto-oncogene, a receptor tyrosine kinase, are responsible for the development of medullary thyroid carcinoma (MTC) and causative for multiple endocrine neoplasia (MEN...

    Authors: Alf Spitschak, Claudia Meier, Bhavani Kowtharapu, David Engelmann and Brigitte M. Pützer

    Citation: Molecular Cancer 2017 16:24

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  13. Content type: Research

    Genetic alterations in chromatin modulators such as BRCA-1 associated protein-1 (BAP1) are the most frequent genetic alteration in intrahepatic cholangiocarcinomas (CCA). We evaluated the contribution of BAP1 ...

    Authors: Mansi Parasramka, Irene K. Yan, Xue Wang, Phuong Nguyen, Akiko Matsuda, Sayantan Maji, Catherine Foye, Yan Asmann and Tushar Patel

    Citation: Molecular Cancer 2017 16:22

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  14. Content type: Research

    The development of chemoresistance and metastasis are the leading causes of death for gastric cancer (GC) patients, however, the molecular mechanisms involved remain unclear. Dysregulation of miRNAs is associa...

    Authors: Jia-Xing Zhang, Yi Xu, Ying Gao, Cui Chen, Zhou-San Zheng, Miao Yun, Hui-Wen Weng, Dan Xie and Sheng Ye

    Citation: Molecular Cancer 2017 16:18

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  15. Content type: Research

    Numerous studies have shown that long non-coding RNAs (lncRNAs) behave as a novel class of transcript during multiple cancer processes, such as cell proliferation, apoptosis, migration, and invasion. LINC00152...

    Authors: Qin-nan Chen, Xin Chen, Zhen-yao Chen, Feng-qi Nie, Chen-chen Wei, Hong-wei Ma, Li Wan, Shuai Yan, Sheng-nan Ren and Zhao-xia Wang

    Citation: Molecular Cancer 2017 16:17

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  16. Content type: Review

    The development of childhood solid tumours is tied to early developmental processes. These tumours may be complex and heterogeneous, and elucidating the aberrant mechanisms that alter the early embryonic envir...

    Authors: Anna L. Leichter, Michael J. Sullivan, Michael R. Eccles and Aniruddha Chatterjee

    Citation: Molecular Cancer 2017 16:15

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  17. Content type: Research

    Breast cancer stem cells (CSCs) are small sub-type of the whole cancer cells that drive tumor initiation, progression and metastasis. Recent studies have demonstrated a role for the aryl hydrocarbon receptor (...

    Authors: Abdullah Al-Dhfyan, Ali Alhoshani and Hesham M. Korashy

    Citation: Molecular Cancer 2017 16:14

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    The Erratum to this article has been published in Molecular Cancer 2017 16:69

  18. Content type: Research

    Diffuse large B-cell lymphoma (DLBCL) is an aggressive and complex disease characterized by wide clinical, phenotypic and molecular heterogeneities. The expression pattern and clinical implication of long non-...

    Authors: Meng Zhou, Hengqiang Zhao, Wanying Xu, Siqi Bao, Liang Cheng and Jie Sun

    Citation: Molecular Cancer 2017 16:16

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  19. Content type: Research

    Cancer metastasis is determined by the formation of the metastatic niche and the ability of cancer cells to adapt to microenvironmental stresses. Anoikis resistance is a fundamental feature of metastatic cance...

    Authors: Celia S. L. Mak, Mingo M. H. Yung, Lynn M. N. Hui, Leanne L. Leung, Rui Liang, Kangmei Chen, Stephanie S. Liu, Yiming Qin, Thomas H. Y. Leung, Kai-Fai Lee, Karen K. L. Chan, Hextan Y. S. Ngan and David W. Chan

    Citation: Molecular Cancer 2017 16:11

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  20. Content type: Research

    Despite advancements in the diagnosis and treatment of colorectal cancer (CRC), many patients die because of tumor metastasis or recurrence. Therefore, identifying new prognostic markers and elucidating the me...

    Authors: Senlin Zhao, Hongcheng Sun, Weiliang Jiang, Yushuai Mi, Dongyuan Zhang, Yugang Wen, Dantong Cheng, Huamei Tang, Shaohan Wu, Yang Yu, Xisheng Liu, Weiyingqi Cui, Meng Zhang, Xiaofeng Sun, Zongguang Zhou, Zhihai Peng…

    Citation: Molecular Cancer 2017 16:12

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  21. Content type: Research

    With more than 600,000 mortalities each year, colorectal cancer (CRC) is the third most commonly diagnosed type of cancer worldwide. Recently, mechanisms involving noncoding RNAs have been implicated in the de...

    Authors: Peng Han, Jing-wen Li, Bo-miao Zhang, Jia-chen Lv, Yong-min Li, Xin-yue Gu, Zhi-wei Yu, Yun-he Jia, Xue-feng Bai, Li Li, Yan-long Liu and Bin-bin Cui

    Citation: Molecular Cancer 2017 16:9

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