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  1. Disappointing clinical efficacy of standard treatment has been proven in refractory metastatic osteosarcoma, and the emerging anti-angiogenic regimens are still in the infantile stage. Thus, there is an urgent...

    Authors: Lingfeng Yu, Hao Zhu, Zhen Wang, Jianhao Huang, Yan Zhu, Gentao Fan, Yicun Wang, Xi Chen and Guangxin Zhou
    Citation: Molecular Cancer 2022 21:167
    Content type: Research Published on:

  2. Developing a strategy to specifically kill cancer cells without inducing obvious damage to normal cells may be of great clinical significance for cancer treatment. In the present study, we developed a new prec...

    Authors: Junfeng Jiang, Yuanyuan Chen, Li Zhang, Qishu Jin, Liujun Wang, Sha Xu, Kexin Chen, Li Li, Tao Zeng, Xingfei Fan, Tingting Liu, Jiaxi Li, Jinjiang Wang, Chaofeng Han, Fu Gao, Yanyong Yang…
    Citation: Molecular Cancer 2022 21:164
    Content type: Letter to the Editor Published on:

  5. This article has been retracted. Please see the Retraction Notice for more detail: https://doi.org/10.1186/s12943-018-0783-3.

    Authors: Xiaomin Fu, Xiaoyan Zhu, Fujun Qin, Yong Zhang, Jizhen Lin, Yuechao Ding, Zihe Yang, Yiman Shang, Li Wang, Qinxian Zhang and Quanli Gao
    Citation: Molecular Cancer 2022 21:161
    Content type: Retraction Note Published on:

  7. Kirsten Rat Sarcoma Viral Oncogene Homolog (KRAS) is the most frequently mutated oncogene, occurring in a variety of tumor types. Targeting KRAS mutations with drugs is challenging because KRAS is considered u...

    Authors: Chunxiao Zhu, Xiaoqing Guan, Xinuo Zhang, Xin Luan, Zhengbo Song, Xiangdong Cheng, Weidong Zhang and Jiang-Jiang Qin
    Citation: Molecular Cancer 2022 21:159
    Content type: Review Published on:

  8. Brother of regulator of imprinted sites (BORIS) is expressed in most cancers and often associated with short survival and poor prognosis in patients. BORIS inhibits apoptosis and promotes proliferation of canc...

    Authors: Yanmei Zhang, Mengdie Fang, Shouye Li, Hao Xu, Juan Ren, Linglan Tu, Bowen Zuo, Wanxin Yao and Guang Liang
    Citation: Molecular Cancer 2022 21:158
    Content type: Research Published on:

  9. This article has been retracted. Please see the Retraction Notice for more detail: https://doi.org/10.1186/s12943-019-0981-7.

    Authors: Tong Liu, Xin Zhang, Lutao Du, Yunshan Wang, Xiaoming Liu, Hui Tian, Lili Wang, Peilong Li, Yinghui Zhao, Weili Duan, Yujiao Xie, Zhaowei Sun and Chuanxin Wang
    Citation: Molecular Cancer 2022 21:157
    Content type: Retraction Note Published on:

  10. Myeloid and lymphoid malignancies associated with chimeric FGFR1 kinases are the hallmark of stem cell leukemia and lymphoma syndrome (SCLL). In all cases, FGFR1 kinase is constitutively phosphoactivated as a ...

    Authors: Baohuan Cai, Yun Liu, Yating Chong, Stephanie Fay Mori, Atsuko Matsunaga, Hualei Zhang, Xuexiu Fang, Chang-Sheng Chang, John K. Cowell and Tianxiang Hu
    Citation: Molecular Cancer 2022 21:156
    Content type: Research Published on:

  12. Epstein-Barr Virus (EBV)-associated nasopharyngeal carcinoma (NPC) exhibits unusual geographic restriction despite ubiquitous lifelong infection. Screening programs can detect most NPC cases at an early stage,...

    Authors: Jacob A. Miller, Malaya K. Sahoo, Fumiko Yamamoto, ChunHong Huang, Hannah Wang, James L. Zehnder, Quynh-Thu Le and Benjamin A. Pinsky
    Citation: Molecular Cancer 2022 21:154
    Content type: Correspondence Published on:

  13. Cell division cycle 6 (CDC6) has been proven to be associated with the initiation and progression of human multiple tumors. However, it’s role in glioma, which is ranked as one of the common primary malignant ...

    Authors: Feng Wang, Fen Zhao, Li Zhang, Lai Xiong, Qing Mao, Yanhui Liu, Xiaoguang Qiu, Xiang Wang, Lin Shui, Xi Chen, Kexing Ren, Pixian Shui, Qiongwen Zhang, Yifei Deng, Weimin Li, Xiaoqi Xie…
    Citation: Molecular Cancer 2022 21:153
    Content type: Correspondence Published on:

  14. Authors: Sara Donzelli, Mario Cioce, Andrea Sacconi, Francesca Zanconato, Theodora Daralioti, Frauke Goeman, Giulia Orlandi, Simona Di Martino, Vito Michele Fazio, Gabriele Alessandrini, Stefano Telera, Mariantonia Carosi, Gennaro Ciliberto, Claudio Botti, Sabrina Strano, Stefano Piccolo…
    Citation: Molecular Cancer 2022 21:152
    Content type: Correspondence Published on:

  15. Recurrence and chemoresistance constitute the leading cause of death in colorectal cancer (CRC). Thus, it is of great significance to clarify the underlying mechanisms and identify predictors for tailoring adj...

    Authors: Haibo Wang, Wenjing Yang, Qiong Qin, Xiaomei Yang, Ying Yang, Hua Liu, Wenxiu Lu, Siyu Gu, Xuedi Cao, Duiping Feng, Zhongtao Zhang and Junqi He
    Citation: Molecular Cancer 2022 21:151
    Content type: Research Published on:

  16. Long non-coding RNAs (lncRNAs) are implicated in the development of multiple cancers. In our previous study, we demonstrated that HDAC1/4-mediated silencing of microRNA-200b (miR-200b) enhances docetaxel (DTX)...

    Authors: Min Jiang, Feng Qi, Kai Zhang, Xiaofei Zhang, Jingjing Ma, Suhua Xia, Longbang Chen, Zhengyuan Yu, Jing Chen and Dongqin Chen
    Citation: Molecular Cancer 2022 21:150
    Content type: Research Published on:

  17. Emerging evidence indicates that circular RNAs (circRNAs) and m6A RNA methylation participate in the pathogenesis and metastasis of multiple malignancies including hepatocellular carcinoma (HCC). However, it rema...

    Authors: Lianyong Liu, Mingjun Gu, Junhua Ma, Ying Wang, Miao Li, Hui Wang, Xin Yin and Xiangqi Li
    Citation: Molecular Cancer 2022 21:149
    Content type: Research Published on:

  18. The resistance of tumor cells to therapy severely impairs the efficacy of treatment, leading to recurrence and metastasis of various cancers. Clarifying the underlying mechanisms of therapeutic resistance may ...

    Authors: Hong Lin, Yuxi Wang, Pinghan Wang, Fangyi Long and Ting Wang
    Citation: Molecular Cancer 2022 21:148
    Content type: Review Published on:

  19. Long Interspersed Nuclear Element-1 (LINE-1, L1) is increasingly regarded as a genetic risk for lung cancer. Transcriptionally active LINE-1 forms a L1-gene chimeric transcript (LCTs), through somatic L1 retro...

    Authors: Zeguo Sun, Rui Zhang, Xiao Zhang, Yifei Sun, Pengpeng Liu, Nancy Francoeur, Lei Han, Wan Yee Lam, Zhengzi Yi, Robert Sebra, Martin Walsh, Jinpu Yu and Weijia Zhang
    Citation: Molecular Cancer 2022 21:147
    Content type: Research Published on:

  20. Increasing evidence has demonstrated that circular RNAs (circRNAs) are implicated in cancer progression. However, the aberrant expression and biological functions of circRNAs in clear cell renal cell carcinoma...

    Authors: Zhipeng Xu, Shuqiu Chen, Ruiji Liu, Hui Chen, Bin Xu, Weizhang Xu and Ming Chen
    Citation: Molecular Cancer 2022 21:146
    Content type: Research Published on:

  21. Circular RNAs (circRNAs) have been demonstrated to contribute to esophageal cancer progression. CircBCAR3 (hsa_circ_0007624) is predicted to be differentially expressed in esophageal cancer by bioinformatics a...

    Authors: Yong Xi, Yaxing Shen, Donglei Wu, Jingtao Zhang, Chengbin Lin, Lijie Wang, Chaoqun Yu, Bentong Yu and Weiyu Shen
    Citation: Molecular Cancer 2022 21:145
    Content type: Research Published on:

  23. This article has been retracted. Please see the Retraction Notice for more detail: https://doi.org/10.1186/s12943-020-1145-5.

    Authors: Mingli Han, Yuanting Gu, Pengwei Lu, Jingyi Li, Hui Cao, Xiangke Li, Xueke Qian, Chao Yu, Yunqing Yang, Xue Yang, Na Han, Dongwei Dou, Jianguo Hu and Huaying Dong
    Citation: Molecular Cancer 2022 21:143
    Content type: Retraction Note Published on:

  25. Increasing studies suggest that circular RNAs (circRNAs) are critical regulators of cancer development and progression. However, the biological roles and mechanisms of circRNAs in gastric cancer (GC) remain la...

    Authors: Xueyan Zang, Jiajia Jiang, Jianmei Gu, Yanke Chen, Maoye Wang, Yu Zhang, Min Fu, Hui Shi, Hui Cai, Hui Qian, Wenrong Xu and Xu Zhang
    Citation: Molecular Cancer 2022 21:141
    Content type: Research Published on:

  26. Aberrant expression of circular RNAs (circRNAs) contributes to the initiation and progression of human malignancies, but the underlying mechanisms remain largely elusive.

    Authors: Bing Yao, Qinglin Zhang, Zhou Yang, Fangmei An, He Nie, Hui Wang, Cheng Yang, Jing Sun, Ke Chen, Jingwan Zhou, Bing Bai, Shouyong Gu, Wei Zhao and Qiang Zhan
    Citation: Molecular Cancer 2022 21:140
    Content type: Research Published on:

  27. This article has been retracted. Please see the Retraction Notice for more detail: https://doi.org/10.1186/s12943-018-0931-9.

    Authors: Huaying Dong, Jianguo Hu, Kejian Zou, Mulin Ye, Yuanwen Chen, Chengyi Wu, Xin Chen and Mingli Han
    Citation: Molecular Cancer 2022 21:139
    Content type: Retraction Note Published on:

  28. Triple-negative breast cancers (TNBCs) are clinically aggressive subtypes of breast cancer. TNBC is difficult to treat with targeted agents due to the lack of commonly targeted therapies within this subtype. A...

    Authors: Shengli Dong, Hassan Yousefi, Isabella Van Savage, Samuel C. Okpechi, Maryl K. Wright, Margarite D. Matossian, Bridgette M. Collins-Burow, Matthew E. Burow and Suresh K. Alahari
    Citation: Molecular Cancer 2022 21:138
    Content type: Research Published on:

  29. CircRNAs are a novel class of evolutionarily conserved noncoding RNA molecules that form covalently closed continuous loop structures without 5′ caps and 3′ poly(A) tails. Accumulating evidence suggests that c...

    Authors: Mengting Wu, Qiongzi Qiu, Qing Zhou, Jia Li, Juze Yang, Chengcai Zheng, Aoran Luo, Xufan Li, Honghe Zhang, Xiaodong Cheng, Weiguo Lu, Pengyuan Liu, Bingjian Lu and Yan Lu
    Citation: Molecular Cancer 2022 21:137
    Content type: Research Published on:

  31. In recent years, an increasing number of studies have indicated that circular RNA plays crucial roles in regulating tumor development and chemoresistance. Using two high-throughput RNA sequence datasets, we pr...

    Authors: Xiaomin Li, Jianjun Wang, Weihao Lin, Qinzi Yuan, Yanxia Lu, Haowei Wang, Yujia Chen, Lixia Chen, Peiling Dai, Huaicheng Long and Xuenong Li
    Citation: Molecular Cancer 2022 21:135
    Content type: Research Published on:

  33. Undifferentiated carcinoma with osteoclast-like giant cells (OGCs) of pancreas (UCOGCP) is a rare subtype of pancreatic ductal adenocarcinoma (PDAC), which had poorly described histopathological and clinical f...

    Authors: Xinbo Wang, Jiaying Miao, Sizhen Wang, Rongxi Shen, Shuo Zhang, Yurao Tian, Min Li, Daojun Zhu, Anlong Yao, Wei Bao, Qun Zhang, Xingming Tang, Xingyun Wang and Jieshou Li
    Citation: Molecular Cancer 2022 21:133
    Content type: Research Published on:

  34. Crosstalk between neoplastic and stromal cells fosters prostate cancer (PCa) progression and dissemination. Insight in cell-to-cell communication networks provides new therapeutic avenues to mold processes tha...

    Authors: Isabel Heidegger, Georgios Fotakis, Anne Offermann, Jermaine Goveia, Sophia Daum, Stefan Salcher, Asma Noureen, Hetty Timmer-Bosscha, Georg Schäfer, Annemiek Walenkamp, Sven Perner, Aleksandar Beatovic, Matthieu Moisse, Christina Plattner, Anne Krogsdam, Johannes Haybaeck…
    Citation: Molecular Cancer 2022 21:132
    Content type: Research Published on:

  35. This article has been retracted. Please see the Retraction Notice for more detail: https://doi.org/10.1186/s12943-020-01206-5

    Authors: Yiran Liang, Xiaojin Song, Yaming Li, Bing Chen, Wenjing Zhao, Lijuan Wang, Hanwen Zhang, Ying Liu, Dianwen Han, Ning Zhang, Tingting Ma, Yajie Wang, Fangzhou Ye, Dan Luo, Xiaoyan Li and Qifeng Yang
    Citation: Molecular Cancer 2022 21:131
    Content type: Retraction Note Published on:

  36. Authors: Dan Jin, Jiwei Guo, Yan Wu, Lijuan Yang, Xiaohong Wang, Jing Du, Juanjuan Dai, Weiwei Chen, Kaikai Gong, Shuang Miao, Xuelin Li and Hongliang Sun
    Citation: Molecular Cancer 2022 21:130
    Content type: Correction Published on:

    The original article was published in Molecular Cancer 2020 19:40

  37. Early detection can benefit cancer patients with more effective treatments and better prognosis, but existing early screening tests are limited, especially for multi-cancer detection. This study investigated t...

    Authors: Hua Bao, Zheng Wang, Xiaoji Ma, Wei Guo, Xiangyu Zhang, Wanxiangfu Tang, Xin Chen, Xinyu Wang, Yikuan Chen, Shaobo Mo, Naixin Liang, Qianli Ma, Shuyu Wu, Xiuxiu Xu, Shuang Chang, Yulin Wei…
    Citation: Molecular Cancer 2022 21:129
    Content type: Correspondence Published on:

  40. Development of resistance to targeted therapies has tempered initial optimism that precision oncology would improve poor outcomes for cancer patients. Resistance mechanisms, however, can also confer new resist...

    Authors: Mareike Berlak, Elizabeth Tucker, Mathurin Dorel, Annika Winkler, Aleixandria McGearey, Elias Rodriguez-Fos, Barbara Martins da Costa, Karen Barker, Elicia Fyle, Elizabeth Calton, Selma Eising, Kim Ober, Deborah Hughes, Eleni Koutroumanidou, Paul Carter, Reda Stankunaite…
    Citation: Molecular Cancer 2022 21:126
    Content type: Research Published on:

  41. The dynamic epigenome and proteins specialized in the interpretation of epigenetic marks critically contribute to leukemic pathogenesis but also offer alternative therapeutic avenues. Targeting newly discovere...

    Authors: Nunzio Del Gaudio, Antonella Di Costanzo, Ning Qing Liu, Lidio Conte, Carmela Dell’Aversana, Guglielmo Bove, Rosaria Benedetti, Liliana Montella, Fortunato Ciardiello, Vincenzo Carafa, Concetta Ambrosino, Valeria Tucci, Mariarosaria Conte, Joost H. A. Martens, Hendrik G. Stunnenberg, Angela Nebbioso…
    Citation: Molecular Cancer 2022 21:125
    Content type: Research Published on:

  42. Authors: Xin Xia, Xixi Li, Fanying Li, Xujia Wu, Maolei Zhang, Huangkai Zhou, Nunu Huang, Xuesong Yang, Feizhe Xiao, Dawei Liu, Lixuan Yang and Nu Zhang
    Citation: Molecular Cancer 2022 21:124
    Content type: Correction Published on:

    The original article was published in Molecular Cancer 2019 18:131

  43. Multiple lines of evidence have demonstrated that circular RNAs (circRNAs) play oncogenic or tumor-suppressive roles in various human cancers. Nevertheless, the biological functions of circRNAs in small cell l...

    Authors: Jinghan Hua, Xiaolin Wang, Liying Ma, Jingxin Li, Guozhen Cao, Shaobo Zhang and Wenchu Lin
    Citation: Molecular Cancer 2022 21:123
    Content type: Research Published on:

  45. circular RNAs (circRNAs) have been reported to play crucial roles in the biology of different cancers. However, little is known about the function of circSTX6 (hsa_circ_0007905) in pancreatic ductal adenocarci...

    Authors: Lingdong Meng, Yihan Zhang, Pengfei Wu, Danrui Li, Yichao Lu, Peng Shen, Taoyue Yang, Guodong Shi, Qun Chen, Hao Yuan, Wanli Ge, Yi Miao, Min Tu and Kuirong Jiang
    Citation: Molecular Cancer 2022 21:121
    Content type: Research Published on:

  46. AP4 (TFAP4) encodes a basic helix-loop-helix leucine zipper (bHLH-LZ) transcription factor and is a direct target gene of the oncogenic transcription factor c-MYC. Here, we set out to determine the relevance of ...

    Authors: Jinjiang Chou, Markus Kaller, Stephanie Jaeckel, Matjaz Rokavec and Heiko Hermeking
    Citation: Molecular Cancer 2022 21:120
    Content type: Research Published on:

  47. Prostate cancer (PCa) is the most frequently diagnosed malignancy in men, and its mechanism remains poorly understood. Therefore, it is urgent to discover potential novel diagnostic biomarkers and therapeutic ...

    Authors: Bing Yao, Sha Zhu, Xiyi Wei, Ming-Kun Chen, Yangkun Feng, Zhimin Li, Xinyu Xu, Yuwei Zhang, Yang Wang, Jingwan Zhou, Ningyuan Tang, Chengjian Ji, Peng Jiang, Shan-Chao Zhao, Chao Qin and Ninghan Feng
    Citation: Molecular Cancer 2022 21:119
    Content type: Research Published on:

  48. PIK3CA mutation and PTEN suppression lead to tumorigenesis and drug resistance in colorectal cancer (CRC). There is no research on the role of circular RNAs (circRNAs) in regulating PIK3CA mutation and MEK inh...

    Authors: Xiaodan Chong, Jingde Chen, Nanxin Zheng, Zhuqing Zhou, Yanan Hai, Shiqing Chen, Yu Zhang, Qingzhuo Yu, Shijun Yu, Zhiqin Chen, Wenfang Bao, Ming Quan, Zhe-Sheng Chen, Yangyang Zhan and Yong Gao
    Citation: Molecular Cancer 2022 21:118
    Content type: Research Published on:
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Molecular Cancer

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