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Molecular Cancer

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  1. Content type: Research

    Triple negative breast cancer (TNBC) is a highly heterogeneous and aggressive type of cancer that lacks effective targeted therapy. Despite detailed molecular profiling, no targeted therapy has been establishe...

    Authors: Prson Gautam, Leena Karhinen, Agnieszka Szwajda, Sawan Kumar Jha, Bhagwan Yadav, Tero Aittokallio and Krister Wennerberg

    Citation: Molecular Cancer 2016 15:34

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  2. Content type: Review

    Unlike normal cells, cancer cells express high levels of phosphatidylserine on the extracellular leaflet of their cell membrane. Exploiting this characteristic, our lab developed a therapeutic agent that consi...

    Authors: Harold W. Davis, Nida Hussain and Xiaoyang Qi

    Citation: Molecular Cancer 2016 15:33

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  3. Content type: Research

    Pancreatic ductal adenocarcinoma (PDAC) is one of the most aggressive neoplastic diseases, associated with a remarkably poor prognosis. However, the molecular mechanisms underlying the development of PDAC rema...

    Authors: Hiroto Fukushima, Makiko Yasumoto, Sachiko Ogasawara, Jun Akiba, Yuhei Kitasato, Masamichi Nakayama, Yoshiki Naito, Yusuke Ishida, Yoshinobu Okabe, Masafumi Yasunaga, Hiroyuki Horiuchi, Etsuko Sakamoto, Hiraku Itadani, Shinji Mizuarai, Shinji Oie and Hirohisa Yano

    Citation: Molecular Cancer 2016 15:32

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  4. Content type: Research

    While hepatitis B and C viral infection have been suppressed, non-B non-C hepatocellular carcinoma (NBNC-HCC) is considered to be rising in incidence terms in some developed countries where prevalence of those...

    Authors: Masanori Nojima, Takeshi Matsui, Akihiro Tamori, Shoji Kubo, Ken Shirabe, Koichi Kimura, Mitsuo Shimada, Tohru Utsunomiya, Yasuteru Kondo, Etsuko Iio, Yutaka Naito, Takahiro Ochiya and Yasuhito Tanaka

    Citation: Molecular Cancer 2016 15:31

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  5. Content type: Research

    Tissue inhibitor of metalloproteinases-1 (TIMP-1) is a multifunctional protein that can directly regulate apoptosis and metastasis. In this study, we investigated the functional and molecular mechanisms by whi...

    Authors: Guangcun Cheng, Xuemei Fan, Mingang Hao, Jinglong Wang, Xiaoming Zhou and Xueqing Sun

    Citation: Molecular Cancer 2016 15:30

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  6. Content type: Research

    Cathepsin S has been implicated in a variety of malignancies with genetic ablation studies demonstrating a key role in tumor invasion and neo-angiogenesis. Thus, the application of cathepsin S inhibitors may h...

    Authors: Richard D. A. Wilkinson, Andrew Young, Roberta E. Burden, Rich Williams and Christopher J. Scott

    Citation: Molecular Cancer 2016 15:29

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  7. Content type: Research

    The advantages and utility of microRNAs (miRNAs) as diagnostic and prognostic cancer markers is at the vanguard in recent years. In this study, we attempted to identify and validate the differential expression...

    Authors: Mayakannan Manikandan, Arungiri Kuha Deva Magendhra Rao, Ganesan Arunkumar, Meenakshisundaram Manickavasagam, Kottayasamy Seenivasagam Rajkumar, Ramamurthy Rajaraman and Arasambattu Kannan Munirajan

    Citation: Molecular Cancer 2016 15:28

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  8. Content type: Research

    Bone morphogenetic proteins (BMP) are embryonic proteins that are part of the transforming growth factor (TGFβ) superfamily, which are aberrantly expressed in many carcinomas. Inhibition of BMP receptors with ...

    Authors: Dave J. Augeri, Elaine Langenfeld, Monica Castle, John A. Gilleran and John Langenfeld

    Citation: Molecular Cancer 2016 15:27

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  9. Content type: Research

    Hypoxia-inducible factors (HIFs) are well-established mediators of tumor growth, the epithelial to mesenchymal transition (EMT) and metastasis. In several types of solid tumors, including breast cancers, the H...

    Authors: Danielle L. Peacock Brooks, Luciana P. Schwab, Raisa Krutilina, Deanna N. Parke, Aarti Sethuraman, David Hoogewijs, Alexandra Schörg, Lauren Gotwald, Meiyun Fan, Roland H. Wenger and Tiffany N. Seagroves

    Citation: Molecular Cancer 2016 15:26

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  10. Content type: Review

    Cancer poses a serious health problem in society and is increasingly surpassing cardiovascular disease as the leading cause of mortality in the United States. Current therapeutic strategies for cancer are extr...

    Authors: Ann Hanna and Lalita A. Shevde

    Citation: Molecular Cancer 2016 15:24

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    The Erratum to this article has been published in Molecular Cancer 2016 15:35

  11. Content type: Research

    There is growing evidence that Bit1 exerts different roles in the development and progression of human cancers. Although Bit1 was highly exhibited in ESCC tissues in our previous study, its roles and molecular...

    Authors: Tianli Fan, Jing Chen, Lirong Zhang, Pan Gao, Yiran Hui, Peirong Xu, Xiaqing Zhang and Hongtao Liu

    Citation: Molecular Cancer 2016 15:23

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  12. Content type: Research

    p53 is a tumour suppressor protein that plays a key role in many steps of apoptosis, and malfunctioning of this transcription factor leads to tumorigenesis. Prognosis of many tumours also depends upon the p53 ...

    Authors: Reshma Thamkachy, Rohith Kumar, K. N. Rajasekharan and Suparna Sengupta

    Citation: Molecular Cancer 2016 15:22

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  13. Content type: Review

    The epithelial to mesenchymal transition (EMT) is a biological process in which a non-motile epithelial cell changes to a mesenchymal phenotype with invasive capacities. This phenomenon has been well documente...

    Authors: Silvia Juliana Serrano-Gomez, Mazvita Maziveyi and Suresh K. Alahari

    Citation: Molecular Cancer 2016 15:18

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  14. Content type: Research

    The identification of signaling pathways that affect the cancer stem-like phenotype may provide insights into therapeutic targets for combating embryonal rhabdomyosarcoma. The aim of this study was to investig...

    Authors: Carmela Ciccarelli, Francesca Vulcano, Luisa Milazzo, Giovanni Luca Gravina, Francesco Marampon, Giampiero Macioce, Adele Giampaolo, Vincenzo Tombolini, Virginia Di Paolo, Hamisa Jane Hassan and Bianca Maria Zani

    Citation: Molecular Cancer 2016 15:16

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  15. Content type: Research

    Several studies have found that Cathepsin B (CTSB) is up-regulated in many tumor types and facilitates tumor progression. However, the role of CTSB in hepatocellular carcinoma (HCC) progression remains unclear...

    Authors: Jian Ruan, Haiyan Zheng, Xiaodong Rong, Xiaomin Rong, Junyi Zhang, Weijia Fang, Peng Zhao and Rongcheng Luo

    Citation: Molecular Cancer 2016 15:17

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  16. Content type: Research

    Epigenetic regulators play a critical role in the maintenance of specific chromatin domains in an active or repressed state. Disruption of epigenetic regulatory mechanisms is widespread in cancer cells and lar...

    Authors: Chien-Hung Yeh, Xue Tao Bai, Ramona Moles, Lee Ratner, Thomas A. Waldmann, Toshiki Watanabe and Christophe Nicot

    Citation: Molecular Cancer 2016 15:15

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    The Erratum to this article has been published in Molecular Cancer 2016 15:20

  17. Content type: Research

    Ovarian cancer is mostly associated with pathologically regulated permeability of peritoneal vessels, leading to ascites. Here, we investigated the molecular regulation of endothelial permeability by the vascu...

    Authors: Inga Bekes, Thomas W. P. Friedl, Tanja Köhler, Volker Möbus, Wolfgang Janni, Achim Wöckel and Christine Wulff

    Citation: Molecular Cancer 2016 15:13

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  18. Content type: Research

    Activating mutations in KRAS are prevalent in lung cancer and have been causally linked to the oncogenic process. However, therapies targeted to oncogenic RAS have been ineffective to date and identification o...

    Authors: Edmilson Ozorio dos Santos, Tatiana Correa Carneiro-Lobo, Mateus Nobrega Aoki, Elena Levantini and Daniela Sanchez Bassères

    Citation: Molecular Cancer 2016 15:12

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