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  1. Content type: Research

    Cancer metastasis is determined by the formation of the metastatic niche and the ability of cancer cells to adapt to microenvironmental stresses. Anoikis resistance is a fundamental feature of metastatic cance...

    Authors: Celia S. L. Mak, Mingo M. H. Yung, Lynn M. N. Hui, Leanne L. Leung, Rui Liang, Kangmei Chen, Stephanie S. Liu, Yiming Qin, Thomas H. Y. Leung, Kai-Fai Lee, Karen K. L. Chan, Hextan Y. S. Ngan and David W. Chan

    Citation: Molecular Cancer 2017 16:11

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  2. Content type: Research

    With more than 600,000 mortalities each year, colorectal cancer (CRC) is the third most commonly diagnosed type of cancer worldwide. Recently, mechanisms involving noncoding RNAs have been implicated in the de...

    Authors: Peng Han, Jing-wen Li, Bo-miao Zhang, Jia-chen Lv, Yong-min Li, Xin-yue Gu, Zhi-wei Yu, Yun-he Jia, Xue-feng Bai, Li Li, Yan-long Liu and Bin-bin Cui

    Citation: Molecular Cancer 2017 16:9

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  3. Content type: Research

    Taurine upregulated gene1 (TUG1) as a 7.1-kb lncRNA, has been shown to play an oncogenic role in various cancers. However, the biological functions of lncRNA TUG1 in small cell lung cancer (SCLC) remain unknow...

    Authors: Yuchun Niu, Feng Ma, Weimei Huang, Shun Fang, Man Li, Ting Wei and Linlang Guo

    Citation: Molecular Cancer 2017 16:5

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  4. Content type: Research

    DNA methylation regulates together with other epigenetic mechanisms the transcriptional activity of genes and is involved in the pathogenesis of malignant diseases including lung cancer. In non-small cell lung...

    Authors: Corinna Altenberger, Gerwin Heller, Barbara Ziegler, Erwin Tomasich, Maximilian Marhold, Thais Topakian, Leonhard Müllauer, Petra Heffeter, György Lang, Adelheid End-Pfützenreuter, Balazs Döme, Britt-Madeleine Arns, Walter Klepetko, Christoph C. Zielinski and Sabine Zöchbauer-Müller

    Citation: Molecular Cancer 2017 16:1

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  5. Content type: Review

    Cell lines are still a tool of choice for many fields of biomedical research, including oncology. Although cancer is a very complex disease, many discoveries have been made using monocultures of established ce...

    Authors: Klaudia K. Brodaczewska, Cezary Szczylik, Michal Fiedorowicz, Camillo Porta and Anna M. Czarnecka

    Citation: Molecular Cancer 2016 15:83

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  6. Content type: Research

    Survivin (encoded by the gene BIRC5) plays an important role in the carcinogenesis of bladder cancer. Identifying miRNAs that target Survivin in the setting of bladder cancer will help to develop Survivin-base...

    Authors: Rong Yang, Minghui Liu, Hongwei Liang, Suhan Guo, Xu Guo, Min Yuan, Huibo Lian, Xiang Yan, Shiwei Zhang, Xi Chen, Feng Fang, Hongqian Guo and Chenyu Zhang

    Citation: Molecular Cancer 2016 15:82

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  7. Content type: Research

    SAG (Sensitive to Apoptosis Gene), also known as RBX2, ROC2 or RNF7, is a RING component of CRL (Cullin-RING ligase), required for its activity. Our recent study showed that SAG/RBX2 co-operated with Kras to p...

    Authors: Mingjia Tan, Jie Xu, Javed Siddiqui, Felix Feng and Yi Sun

    Citation: Molecular Cancer 2016 15:81

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  8. Content type: Research

    STAT3 signaling plays the pivotal role in tumorigenesis through EZH2 epigenetic modification, which enhanced STAT3 activity by increased tyrosine phosphorylation of STAT3. Here, another possible feedback mecha...

    Authors: Yuan-Ming Pan, Cheng-Gang Wang, Min Zhu, Rui Xing, Jian-Tao Cui, Wen-Mei Li, De-Dong Yu, Shu-Bin Wang, Wei Zhu, Ying-Jiang Ye, Yun Wu, Shan Wang and You-Yong Lu

    Citation: Molecular Cancer 2016 15:79

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  9. Content type: Review

    Gastric cancer (GC) ranks the most common cancer types and is one of the leading causes of cancer-related death. Due to delayed diagnosis and high metastatic frequency, 5-year survival rate of GC is rather low...

    Authors: Tingting Huang, Yuhang Zhou, Alfred S. L. Cheng, Jun Yu, Ka Fai To and Wei Kang

    Citation: Molecular Cancer 2016 15:80

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  10. Content type: Research

    Blocking the mechanistic target of rapamycin complex-1 (mTORC1) with chemical inhibitors such as rapamycin has shown limited clinical efficacy in cancer. The tumor microenvironment is characterized by an acidi...

    Authors: Seraina Faes, Adrian P. Duval, Anne Planche, Emilie Uldry, Tania Santoro, Catherine Pythoud, Jean-Christophe Stehle, Janine Horlbeck, Igor Letovanec, Nicolo Riggi, Nicolas Demartines and Olivier Dormond

    Citation: Molecular Cancer 2016 15:78

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  11. Content type: Research

    Lipocalin2 (LCN2) is a secretory protein that is aberrantly expressed in several types of cancer and has been involved in metastatic progression. However, neither mechanisms nor the role that LCN2 plays in the...

    Authors: Meibao Feng, Jieqiong Feng, Wuzhen Chen, Wubin Wang, Xuesong Wu, Jing Zhang, Fangying Xu and Maode Lai

    Citation: Molecular Cancer 2016 15:77

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  12. Content type: Research

    Glioblastomas (GBM) continue to remain one of the most dreaded tumours that are highly infiltrative in nature and easily preclude comprehensive surgical resection. GBMs pose an intricate etiology as they are b...

    Authors: Zahid Nawaz, Vikas Patil, Yashna Paul, Alangar S. Hegde, Arimappamagan Arivazhagan, Vani Santosh and Kumaravel Somasundaram

    Citation: Molecular Cancer 2016 15:74

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  13. Content type: Research

    Triple-negative breast cancer (TNBC) has a high risk of relapse and there are few chemotherapy options. Although 5-hydroxytryptamine (5-HT, serotonin) signaling pathways have been suggested as potential target...

    Authors: Jaya Gautam, Suhrid Banskota, Sushil Chandra Regmi, Subi Ahn, Yong Hyun Jeon, Hyunyoung Jeong, Seung Joo Kim, Tae-gyu Nam, Byeong-Seon Jeong and Jung-Ae Kim

    Citation: Molecular Cancer 2016 15:75

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  14. Content type: Review

    Caveolin-1 (CAV1) is an oncogenic membrane protein associated with endocytosis, extracellular matrix organisation, cholesterol distribution, cell migration and signaling. Recent studies reveal that CAV1 is inv...

    Authors: Zeribe Chike Nwosu, Matthias Philip Ebert, Steven Dooley and Christoph Meyer

    Citation: Molecular Cancer 2016 15:71

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  15. Content type: Research

    In many cancers, microRNAs (miRs) contribute to metastatic progression by modulating phenotypic reprogramming processes such as epithelial-mesenchymal plasticity. This can be driven by miRs targeting multiple ...

    Authors: Miles C. Andrews, Joseph Cursons, Daniel G. Hurley, Matthew Anaka, Jonathan S. Cebon, Andreas Behren and Edmund J. Crampin

    Citation: Molecular Cancer 2016 15:72

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  16. Content type: Letter to the Editor

    It is still controversial whether comprehensive genome screening of target molecules by next generation sequencing (NGS) is needed to increase clinical efficacy of investigational drugs or accelerate drug deve...

    Authors: Yuko Tanabe, Hitoshi Ichikawa, Takashi Kohno, Hiroshi Yoshida, Takashi Kubo, Mamoru Kato, Satoru Iwasa, Atsushi Ochiai, Noboru Yamamoto, Yasuhiro Fujiwara and Kenji Tamura

    Citation: Molecular Cancer 2016 15:73

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  17. Content type: Research

    Treatment options for metastatic castrate-resistant prostate cancer (mCRPC) are limited and typically are centered on docetaxel-based chemotherapy. We previously reported that elevated miR-375 levels were sign...

    Authors: Yuan Wang, Rachel Lieberman, Jing Pan, Qi Zhang, Meijun Du, Peng Zhang, Marja Nevalainen, Manish Kohli, Niraj K. Shenoy, Hui Meng, Ming You and Liang Wang

    Citation: Molecular Cancer 2016 15:70

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  18. Content type: Review

    Cancer Stem cells (CSCs) are a unipotent cell population present within the tumour cell mass. CSCs are known to be highly chemo-resistant, and in recent years, they have gained intense interest as key tumour i...

    Authors: Abhijeet Deshmukh, Kedar Deshpande, Frank Arfuso, Philip Newsholme and Arun Dharmarajan

    Citation: Molecular Cancer 2016 15:69

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  19. Content type: Research

    The CXCL12/CXCR4 axis transactivates HER2 and promotes intraosseous tumor growth. To further explore the transactivation of HER2 by CXCL12, we investigated the role of small GTP protein Gαi2 in Src and HER2 phosp...

    Authors: M. Katie Conley-LaComb, Louie Semaan, Rajareddy Singareddy, Yanfeng Li, Elisabeth I. Heath, Seongho Kim, Michael L. Cher and Sreenivasa R. Chinni

    Citation: Molecular Cancer 2016 15:68

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  20. Content type: Review

    Lung cancer is a leading cause of cancer-related deaths worldwide. Lung cancer risk factors, including smoking and exposure to environmental carcinogens, have been linked to chronic inflammation. An integral f...

    Authors: Erin A. Marshall, Kevin W. Ng, Sonia H. Y. Kung, Emma M. Conway, Victor D. Martinez, Elizabeth C. Halvorsen, David A. Rowbotham, Emily A. Vucic, Adam W. Plumb, Daiana D. Becker-Santos, Katey S. S. Enfield, Jennifer Y. Kennett, Kevin L. Bennewith, William W. Lockwood, Stephen Lam, John C. English…

    Citation: Molecular Cancer 2016 15:67

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  21. Content type: Research

    Nearly one-third of serous ovarian cancer (OVCA) patients will not respond to initial treatment with surgery and chemotherapy and die within one year of diagnosis. If patients who are unlikely to respond to cu...

    Authors: Jesus Gonzalez Bosquet, Andreea M. Newtson, Rebecca K. Chung, Kristina W. Thiel, Timothy Ginader, Michael J. Goodheart, Kimberly K. Leslie and Brian J. Smith

    Citation: Molecular Cancer 2016 15:66

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  22. Content type: Research

    Membrane Type-1 Matrix Metalloproteinase (MT1-MMP) is a multifunctional protease implicated in metastatic progression ostensibly due to its ability to degrade extracellular matrix (ECM) components and allow mi...

    Authors: Mario A. Cepeda, Jacob J. H. Pelling, Caitlin L. Evered, Karla C. Williams, Zoey Freedman, Ioana Stan, Jessica A. Willson, Hon S. Leong and Sashko Damjanovski

    Citation: Molecular Cancer 2016 15:65

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  23. Content type: Research

    A handful of studies have exploited antitumor potential of esculetin, a dihydroxy coumarine derivative; the targets to which it binds and the possible downstream mechanism for its cytotoxicity in cancer cells ...

    Authors: Rashi Arora, Sharad Sawney, Vikas Saini, Chris Steffi, Manisha Tiwari and Daman Saluja

    Citation: Molecular Cancer 2016 15:64

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  24. Content type: Research

    Targeted next generation sequencing (tNGS) has become part of molecular pathology diagnostics for determining RAS mutation status in colorectal cancer (CRC) patients as predictive tool for decision on EGFR-tar...

    Authors: Valentina Kovaleva, Anna-Lena Geissler, Lisa Lutz, Ralph Fritsch, Frank Makowiec, Sebastian Wiesemann, Ulrich T. Hopt, Bernward Passlick, Martin Werner and Silke Lassmann

    Citation: Molecular Cancer 2016 15:63

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