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Molecular Cancer

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  1. Content type: Research

    We have previously shown in pancreatic ductal adenocarcinoma (PDAC) cells that the SRC inhibitors PP2 and PP1 effectively inhibited TGF-β1-mediated cellular responses by blocking the kinase function of the TGF...

    Authors: Tobias Bartscht, Benjamin Rosien, Dirk Rades, Roland Kaufmann, Harald Biersack, Hendrik Lehnert, Frank Gieseler and Hendrik Ungefroren

    Citation: Molecular Cancer 2015 14:199

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  2. Content type: Review

    Survivin, a member of the inhibitor of apoptosis family of proteins (IAPs) that controls cell division, apoptosis, metastasis and angiogenesis, is overexpressed in essentially all human cancers. As a consequen...

    Authors: C. Sanhueza, S. Wehinger, J. Castillo Bennett, M. Valenzuela, G. I. Owen and A. F. G. Quest

    Citation: Molecular Cancer 2015 14:198

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  3. Content type: Letter to the Editor

    The ETV6 gene encodes an ETS family transcription factor that is involved in a myriad of chromosomal rearrangements found in hematological malignancies and other neoplasms. A recurrent ETV6 translocation, previou...

    Authors: Paulo Vidal Campregher, Welbert de Oliveira Pereira, Bianca Lisboa, Renato Puga, Ricardo Helman, Mariana Miyagi, Evelyn Helena Ascendino da Mata, Tarcila Santos Datoguia, Elvira Deolinda Rodrigues Pereira Velloso, Nydia Strachman Bacal, Jeffrey S. Ross, Siraj Ali, Vincent Miller, Fernando Ferreira Costa, Nelson Hamerschlak and Fabio Pires de Souza Santos

    Citation: Molecular Cancer 2015 14:197

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  4. Content type: Research

    Drug resistance hampers the efficient treatment of malignancies, including advanced stage ovarian cancer, which has a 5-year survival rate of only 30 %. The molecular processes underlying resistance have been ...

    Authors: Marijn T. M. van Jaarsveld, Patricia F. van Kuijk, Antonius W. M. Boersma, Jozien Helleman, Wilfred F. van IJcken, Ron H. J. Mathijssen, Joris Pothof, Els M. J. J. Berns, Jaap Verweij and Erik A. C. Wiemer

    Citation: Molecular Cancer 2015 14:196

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  5. Content type: Research

    The therapeutic and prognostic value of the glycolytic enzymes hexokinase, phosphofructokinase, and pyruvate kinase (PK) has been implicated in a variety of cancers, while their roles in treatment of and progn...

    Authors: Guanzhen Yu, Wenlong Yu, Guangzhi Jin, Dongyun Xu, Ying Chen, Tian Xia, Allan Yu, Wenzheng Fang, Xiaoli Zhang, Zhaosheng Li and Keping Xie

    Citation: Molecular Cancer 2015 14:193

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  6. Content type: Research

    MicroRNAs have been identified as potential cancer biomarkers due to their presence and stability in many body fluids including urine and plasma, but the relationship of the pattern of expression of these mess...

    Authors: David A. Armstrong, Benjamin B. Green, John D. Seigne, Alan R. Schned and Carmen J. Marsit

    Citation: Molecular Cancer 2015 14:194

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  7. Content type: Research

    High expression of the long non-coding RNA nuclear-enriched abundant transcript 1 (NEAT1) in whole blood has been reported in colorectal cancer patients; however, its’ clinical significance and origin are uncl...

    Authors: Yuchen Wu, Li Yang, Jiang Zhao, Cong Li, Jia Nie, Fangqi Liu, Changhua Zhuo, Yaxin Zheng, Bin Li, Zhimin Wang and Ye Xu

    Citation: Molecular Cancer 2015 14:191

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  8. Content type: Research

    Ovarian cancer is the most lethal gynecologic malignancy, with limited treatment options for chemoresistant disease. An important link between inflammation and peritoneal spread of ovarian cancer is NF-κB sign...

    Authors: Andrew J. Wilson, Jeanette Saskowski, Whitney Barham, Dineo Khabele and Fiona Yull

    Citation: Molecular Cancer 2015 14:192

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  9. Content type: Research

    Temozolomide (TMZ) is an oral DNA-alkylating agent used for treating patients with glioblastoma. However, therapeutic benefits of TMZ can be compromised by the expression of O6-methylguanine methyltransferase ...

    Authors: Jonathan L. Tso, Shuai Yang, Jimmy C. Menjivar, Kazunari Yamada, Yibei Zhang, Irene Hong, Yvonne Bui, Alexandra Stream, William H. McBride, Linda M. Liau, Stanley F. Nelson, Timothy F. Cloughesy, William H. Yong, Albert Lai and Cho-Lea Tso

    Citation: Molecular Cancer 2015 14:189

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  10. Content type: Research

    MicroRNAs (miR, miRNAs) play pivotal roles in numerous physiological and pathophysiological contexts. We investigated whether miR-362-5p act as an oncogene in chronic myeloid leukaemia (CML) and aimed to under...

    Authors: Peng Yang, Fang Ni, Rui-qing Deng, Guo Qiang, Hua Zhao, Ming-zhen Yang, Xin-yi Wang, You-zhi Xu, Li Chen, Dan-lei Chen, Zhi-jun Chen, Li-xin Kan and Si-Ying Wang

    Citation: Molecular Cancer 2015 14:190

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  11. Content type: Research

    Lung cancer is the leading cause of cancer mortality worldwide, mainly due to late diagnosis, poor prognosis and tumor heterogeneity. Thus, the need for biomarkers that will aid classification, treatment and m...

    Authors: Panagiotis Maragozidis, Eirini Papanastasi, Diana Scutelnic, Athina Totomi, Ioanna Kokkori, Sotirios G. Zarogiannis, Theodora Kerenidi, Konstantinos I. Gourgoulianis and Nikolaos A. A. Balatsos

    Citation: Molecular Cancer 2015 14:187

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  12. Content type: Review

    RNA helicases are a large family of proteins with a distinct motif, referred to as the DEAD/H (Asp-Glu-Ala-Asp/His). The exact functions of all the human DEAD/H box proteins are unknown. However, it has been c...

    Authors: Guus Martinus Bol, Min Xie and Venu Raman

    Citation: Molecular Cancer 2015 14:188

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  13. Content type: Research

    Aberrant expression of A20 has been reported in several human malignancies including hepatocellular carcinoma (HCC). However, its clinical relevance and potential role in HCC remain unknown.

    Authors: Haiyang Chen, Liang Hu, Zaili Luo, Jian Zhang, Cunzhen Zhang, Bijun Qiu, Liwei Dong, Yexiong Tan, Jin Ding, Shanhua Tang, Feng Shen, Zhong Li and Hongyang Wang

    Citation: Molecular Cancer 2015 14:186

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  14. Content type: Research

    BCL-xL is an anti-apoptotic BCL-2 family protein that inhibits apoptosis and is overexpressed in many cancers. We have reported that acquired resistance to the BCL-2 inhibitor ABT-199 (venetoclax) is associate...

    Authors: Sayer Al-harbi, Gaurav S. Choudhary, Jey Sabith Ebron, Brian T. Hill, Nagarajavel Vivekanathan, Angela H. Ting, Tomas Radivoyevitch, Mitchell R. Smith, Girish C. Shukla and Alex Almasan

    Citation: Molecular Cancer 2015 14:185

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  15. Content type: Review

    The imprinted oncofetal long non-coding RNA (lncRNA) H19 is expressed in the embryo, down-regulated at birth and then reappears in tumors. Its role in tumor initiation and progression has long been a subject o...

    Authors: Eli Raveh, Imad J. Matouk, Michal Gilon and Abraham Hochberg

    Citation: Molecular Cancer 2015 14:184

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  16. Content type: Research

    The failure to mount an effective DNA damage response to repair UV induced cyclobutane pyrimidine dimers (CPDs) results in an increased propensity to develop cutaneous squamous cell carcinoma (cSCC). High-risk...

    Authors: Martin Hufbauer, James Cooke, Gijsbertus T. J. van der Horst, Herbert Pfister, Alan Storey and Baki Akgül

    Citation: Molecular Cancer 2015 14:183

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  17. Content type: Research

    Understanding cell signaling pathways that contribute to metastatic colon cancer is critical to risk stratification in the era of personalized therapeutics. Here, we dissect the unique involvement of mitogenic...

    Authors: Jessica Bauer, Ozkan Ozden, Naomi Akagi, Timothy Carroll, Daniel R. Principe, Jonas J. Staudacher, Martina E. Spehlmann, Lars Eckmann, Paul J. Grippo and Barbara Jung

    Citation: Molecular Cancer 2015 14:182

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  18. Content type: Research

    Alcohol consumption is a well-established risk factor for head and neck squamous cell carcinoma (HNSCC); however, the molecular mechanisms by which alcohol promotes HNSCC pathogenesis and progression remain po...

    Authors: Maarouf A. Saad, Selena Z. Kuo, Elham Rahimy, Angela E. Zou, Avinaash Korrapati, Mehran Rahimy, Elizabeth Kim, Hao Zheng, Michael Andrew Yu, Jessica Wang-Rodriguez and Weg M. Ongkeko

    Citation: Molecular Cancer 2015 14:181

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  19. Content type: Research

    Compromised colonic butyrate production resulting from low dietary fiber or altered gut microbiota may promote colon neoplasia. Previous reports indicate these actions are mediated in part by altered levels of...

    Authors: Shien Hu, Lan Liu, Eugene B. Chang, Jian-Ying Wang and Jean-Pierre Raufman

    Citation: Molecular Cancer 2015 14:180

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  20. Content type: Research

    Cancer stem cells (CSCs) are considered responsible for the recurrence and chemoresistance of cancer. Dysregulated autophagy is highly prevalent in many types of cancer including pancreatic cancer and has been...

    Authors: Ming-Chen Yang, Hao-Chen Wang, Ya-Chin Hou, Hui-Ling Tung, Tai-Jan Chiu and Yan-Shen Shan

    Citation: Molecular Cancer 2015 14:179

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  21. Content type: Review

    P-cadherin is a classical cell-to-cell adhesion molecule with a homeostatic function in several normal tissues. However, its behaviour in the malignant setting is notably dependent on the cellular context. In ...

    Authors: André Filipe Vieira and Joana Paredes

    Citation: Molecular Cancer 2015 14:178

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  22. Content type: Research

    Apoptosis-stimulating of p53 protein 2 (ASPP2) is one of the ASPP family members and it has been reported to be associated with human cancer. However, the role of it in pancreatic cancer is still not clear.

    Authors: Bin Song, Qi Bian, Yi-Jie Zhang, Cheng-Hao Shao, Gang Li, An-An Liu, Wei Jing, Rui Liu, Ying-Qi Zhou, Gang Jin and Xian-Gui Hu

    Citation: Molecular Cancer 2015 14:177

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  23. Content type: Short communication

    In multiple myeloma, a long non-coding RNA, KIAA0495 (alias PDAM/TP73-AS1), had been found progressively downregulated from normal plasma cell to benign monoclonal gammopathy of undetermined significance to sympt...

    Authors: Kwan Yeung Wong, Zhenhai Li, Xiaoqin Zhang, Gilberto Ka Kit Leung, Godfrey Chi-fung Chan and Chor Sang Chim

    Citation: Molecular Cancer 2015 14:175

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