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  1. Content type: Research

    The epithelial–mesenchymal transition (EMT) is crucial for the invasion and metastasis of breast cancer. However, how Notch signaling regulates the EMT process and invasion in breast cancer remains largely unk...

    Authors: Shan Shao, Xiaoai Zhao, Xiaojin Zhang, Minna Luo, Xiaoxiao Zuo, Shangke Huang, Ying Wang, Shanzhi Gu and Xinhan Zhao

    Citation: Molecular Cancer 2015 14:28

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  2. Content type: Research

    Zebrafish have been used as a vertebrate model to study human cancers such as melanoma, rhabdomyosarcoma, liver cancer, and leukemia as well as for high-throughput screening of small molecules of therapeutic v...

    Authors: Bensheng Ju, Wenbiao Chen, Brent A Orr, Jan M Spitsbergen, Sujuan Jia, Christopher J Eden, Hannah E Henson and Michael R Taylor

    Citation: Molecular Cancer 2015 14:18

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  3. Content type: Short communication

    The Wnt/beta-catenin and the Hedgehog (Hh) pathway interact in various cell types while eliciting opposing or synergistic cellular effects. Both pathways are known as exclusive drivers of two distinct molecula...

    Authors: Jenny Zinke, Fabian T Schneider, Patrick N Harter, Sonja Thom, Nicole Ziegler, Rune Toftgård, Karl H Plate and Stefan Liebner

    Citation: Molecular Cancer 2015 14:17

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  4. Content type: Research

    Receptor protein tyrosine phosphatase beta/zeta (RPTPβ/ζ) is a chondroitin sulphate (CS) transmembrane protein tyrosine phosphatase and is a receptor for pleiotrophin (PTN). RPTPβ/ζ interacts with ανβ3 on the cel...

    Authors: Marina Koutsioumpa, Evangelia Poimenidi, Evangelia Pantazaka, Christina Theodoropoulou, Angeliki Skoura, Vasileios Megalooikonomou, Nelly Kieffer, Jose Courty, Shuji Mizumoto, Kazuyuki Sugahara and Evangelia Papadimitriou

    Citation: Molecular Cancer 2015 14:19

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  5. Content type: Research

    Kruppel-like factor 4 (KLF4) induces tumorigenesis or suppresses tumor growth in a tissue-dependent manner. However, the roles of KLF4 in hematological malignancies and the mechanisms of action are not fully u...

    Authors: Wei Li, Zhiwu Jiang, Tianzhong Li, Xinru Wei, Yi Zheng, Donghai Wu, Lijian Yang, Shaohua Chen, Bing Xu, Mei Zhong, Jue Jiang, Yufeng Hu, Hexiu Su, Minjie Zhang, Xiaojun Huang, Suxia Geng…

    Citation: Molecular Cancer 2015 14:26

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  6. Content type: Research

    Members of the inhibitor of DNA-binding (ID) family of helix-loop-helix proteins have been causally implicated in the pathogenesis of several types of B-cell lineage malignancy, either on the basis of mutation...

    Authors: Sarah Weiler, Jolaolu A Ademokun and John D Norton

    Citation: Molecular Cancer 2015 14:30

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  7. Content type: Research

    Several clinical and pathological factors have an impact on the prognosis of colorectal cancer (CRC), but they are not yet adequate for risk assessment. We aimed to identify a molecular signature that can reli...

    Authors: Lisha Wang, Xiaohan Shen, Zhimin Wang, Xiuying Xiao, Ping Wei, Qifeng Wang, Fei Ren, Yiqin Wang, Zebing Liu, Weiqi Sheng, Wei Huang, Xiaoyan Zhou and Xiang Du

    Citation: Molecular Cancer 2015 14:22

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  8. Content type: Research

    The study aims to evaluate the expression and activity of glycogen synthase kinase 3 isoforms α/β (GSK3α/β) and to assess their oncogenic potential through a correlation with the expression of cyclin D1 and p5...

    Authors: Rajakishore Mishra, Siddavaram Nagini and Ajay Rana

    Citation: Molecular Cancer 2015 14:20

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  9. Content type: Research

    Approximately 20% of melanomas contain a mutation in NRAS. However no direct inhibitor of NRAS is available. One of the main signaling pathways downstream of NRAS is the MAPK pathway. In this study we investig...

    Authors: Mohammad Atefi, Bjoern Titz, Earl Avramis, Charles Ng, Deborah JL Wong, Amanda Lassen, Michael Cerniglia, Helena Escuin-Ordinas, David Foulad, Begonya Comin-Anduix, Thomas G Graeber and Antoni Ribas

    Citation: Molecular Cancer 2015 14:27

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  10. Content type: Research

    B cell precursor acute lymphoblastic leukaemia (BCP-ALL) is the most common paediatric cancer. BCP-ALL blasts typically retain wild type p53, and are therefore assumed to rely on indirect measures to suppress ...

    Authors: Elin Hallan Naderi, Seham Skah, Hege Ugland, Ola Myklebost, Dagny Lise Sandnes, Maria Lyngaas Torgersen, Dag Josefsen, Ellen Ruud, Soheil Naderi and Heidi Kiil Blomhoff

    Citation: Molecular Cancer 2015 14:14

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  11. Content type: Research

    Hepatocellular carcinoma (HCC), the most common form of primary liver cancer, is the third leading cause of cancer-related death in human. Alcohol is a known risk factor for HCC. However it is still unclear wh...

    Authors: Fei Wang, Jin-Lian Yang, Ke-ke Yu, Mei Xu, You-zhi Xu, Li Chen, Yan-min Lu, Hao-shu Fang, Xin-yi Wang, Zhong-qian Hu, Fei-fei Li, Lixin Kan, Jia Luo and Si-Ying Wang

    Citation: Molecular Cancer 2015 14:10

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  12. Content type: Research

    Gallbladder cancer (GBC) is a leading cause of cancer-related death worldwide, and its prognosis remains poor, with 5-year survival of approximately 5%. In this study, we analyzed the involvement of a novel pr...

    Authors: Yi-Jun Shu, Hao Weng, Yuan-Yuan Ye, Yun-Ping Hu, Run-Fa Bao, Yang Cao, Xu-An Wang, Fei Zhang, Shan-Shan Xiang, Huai-Feng Li, Xiang-Song Wu, Mao-Lan Li, Lin Jiang, Wei Lu, Bao-San Han, Zhi-Gang Jie…

    Citation: Molecular Cancer 2015 14:12

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  13. Content type: Research

    Ubiquitination is a highly dynamic and reversible process with a central role in cell homeostasis. Deregulation of several deubiquitinating enzymes has been linked to tumor development but their specific role ...

    Authors: Diego Iglesias-Gato, Yin-Choy Chuan, Ning Jiang, Charlotte Svensson, Jing Bao, Indranil Paul, Lars Egevad, Benedikt M Kessler, Pernilla Wikström, Yuanjie Niu and Amilcar Flores-Morales

    Citation: Molecular Cancer 2015 14:8

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    The Erratum to this article has been published in Molecular Cancer 2015 14:88

  14. Content type: Research

    High-grade gliomas are one of the most invasive and therapy-resistant cancers. We have recently shown that noncanonical NF-κB/RelB signaling is a potent driver of tumorigenesis and invasion in the aggressive, ...

    Authors: Evan M Cherry, Dong W Lee, Ji-Ung Jung and Raquel Sitcheran

    Citation: Molecular Cancer 2015 14:9

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  15. Content type: Research

    S100A7 (Psoriasin) is an inflammatory protein known to be upregulated in breast cancer. However, the role of S100A7 in breast cancer has been elusive, since both pro- and anti-proliferative roles have been rep...

    Authors: Helong Zhao, Tasha Wilkie, Yadwinder Deol, Amita Sneh, Akaansha Ganju, Mustafa Basree, Mohd W Nasser and Ramesh K Ganju

    Citation: Molecular Cancer 2015 14:11

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    The Erratum to this article has been published in Molecular Cancer 2015 14:195

  16. Content type: Short communication

    Voltage-gated Na+ channels (VGSCs) are heteromeric protein complexes containing pore-forming α subunits and smaller, non-pore-forming β subunits. VGSCs are classically expressed in electrically excitable cells, e...

    Authors: Michaela Nelson, Ming Yang, Adam A Dowle, Jerry R Thomas and William J Brackenbury

    Citation: Molecular Cancer 2015 14:13

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  17. Content type: Research

    TR4 nuclear receptor 4 (TR4) plays an important role in macrophages-associated foam cell formation of cardiovascular diseases and infiltrating macrophages are critical for prostate cancer (PCa) progression. Ho...

    Authors: Xianfan Ding, Dong-Rong Yang, Liqun Xia, Bide Chen, Shicheng Yu, Yuanjie Niu, Mingchao Wang, Gonghui Li and Chawnshang Chang

    Citation: Molecular Cancer 2015 14:16

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  18. Content type: Research

    Core Binding Factor acute myeloid leukemia (CBF-AML) with t(8;21) RUNX1-MTG8 or inv(16) CBFB-MYH11 fusion proteins often show upregulation of wild type or mutated KIT receptor. However, also non-CBF-AML freque...

    Authors: John Adams Fischer, Stefano Rossetti, Arani Datta, Kevin Hasegawa Eng, Alessandro Beghini and Nicoletta Sacchi

    Citation: Molecular Cancer 2015 14:7

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  19. Content type: Research

    Growing evidence indicates that miR-146a is involved in carcinogenesis and tumor progression in several human malignancies. However, the molecular details underlying miR-146a mediated regulation of its target ...

    Authors: Zheng Zhang, Yang Zhang, Xiu-Xuan Sun, Xi Ma and Zhi-Nan Chen

    Citation: Molecular Cancer 2015 14:5

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  20. Content type: Research

    Recent studies have demonstrated that long non-coding RNAs (lncRNAs) were present in the blood of cancer patients and have shown great potential as powerful and non-invasive tumor markers. However, little is k...

    Authors: Yu-Suo Tong, Xiao-Wei Wang, Xi-Lei Zhou, Zi-Hao Liu, Tong-Xin Yang, Wei-Hong Shi, Hai-Wei Xie, Jin Lv, Qing-Quan Wu and Xiu-Feng Cao

    Citation: Molecular Cancer 2015 14:3

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  21. Content type: Research

    While angiogenesis inhibitors represent a viable cancer therapy, there is preclinical and clinical data to suggest that many tumors develop resistance to such treatments. Moreover, previous studies have reveal...

    Authors: Anup S Pathania, Zahoor A Wani, Santosh K Guru, Suresh Kumar, Shashi Bhushan, Hasan Korkaya, Darren F Seals, Ajay Kumar, Dilip M Mondhe, Zabeer Ahmed, Bal K Chandan and Fayaz Malik

    Citation: Molecular Cancer 2015 14:6

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  22. Content type: Research

    Lung cancer is one of the most frequent cancer types and the leading cause of cancer death worldwide. Cisplatin is a widely used chemotherapeutic for non-small cell lung carcinoma (NSCLC), however, its positiv...

    Authors: Carina Fischer, Katharina Leithner, Christoph Wohlkoenig, Franz Quehenberger, Alexandra Bertsch, Andrea Olschewski, Horst Olschewski and Andelko Hrzenjak

    Citation: Molecular Cancer 2015 14:4

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  23. Content type: Research

    Nodular melanoma is one of the most life threatening tumors with still poor therapeutic outcome. Similarly to other tumors, permissive microenvironment is essential for melanoma progression. Features of this m...

    Authors: Ondřej Kodet, Lukáš Lacina, Eliška Krejčí, Barbora Dvořánková, Miloš Grim, Jiří Štork, Daniela Kodetová, Čestmír Vlček, Jana Šáchová, Michal Kolář, Hynek Strnad and Karel Smetana

    Citation: Molecular Cancer 2015 14:1

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  24. Content type: Review

    LRRC4/NGL-2 (Leucine rich repeat containing 4/Netrin-G ligand-2), a relatively specific expressed gene in brain tissue, is a member of the LRRC4/ NGL (netrin-G ligand) family and belongs to the superfamily of ...

    Authors: Peiyao Li, Gang Xu, Guiyuan Li and Minghua Wu

    Citation: Molecular Cancer 2014 13:266

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  25. Content type: Research

    Anti-resorptive bisphosphonates (BP) are used for the treatment of osteoporosis and bone metastases. Clinical studies indicated a benefit in survival and tumor relapse in subpopulations of breast cancer patien...

    Authors: Regina Ebert, Jutta Meissner-Weigl, Sabine Zeck, Jorma Määttä, Seppo Auriola, Sofia Coimbra de Sousa, Birgit Mentrup, Stephanie Graser, Tilman D Rachner, Lorenz C Hofbauer and Franz Jakob

    Citation: Molecular Cancer 2014 13:265

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  26. Content type: Research

    Loss of cell-cell adhesion is important for the development of cancer invasion and metastasis. Vinculin, a key adhesion-related protein, can affect metastasis and prognosis in several tumours. Here, we determi...

    Authors: Ting Li, Hanqing Guo, Ying Song, Xiaodi Zhao, Yongquan Shi, Yuanyuan Lu, Sijun Hu, Yongzhan Nie, Daiming Fan and Kaichun Wu

    Citation: Molecular Cancer 2014 13:263

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  27. Content type: Review

    Despite decades of research, ovarian cancer is still associated with unacceptably high mortality rates, which must be addressed by novel therapeutic approaches. One avenue through which this may be achieved is...

    Authors: Brendan Ffrench, Claudia Gasch, John J O’Leary and Michael F Gallagher

    Citation: Molecular Cancer 2014 13:262

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  28. Content type: Short communication

    NaV1.5 voltage-gated sodium channels are abnormally expressed in breast tumours and their expression level is associated with metastatic occurrence and patients’ death. In breast cancer cells, NaV1.5 activity pro...

    Authors: Virginie Driffort, Ludovic Gillet, Emeline Bon, Séverine Marionneau-Lambot, Thibauld Oullier, Virginie Joulin, Christine Collin, Jean-Christophe Pagès, Marie-Lise Jourdan, Stéphan Chevalier, Philippe Bougnoux, Jean-Yves Le Guennec, Pierre Besson and Sébastien Roger

    Citation: Molecular Cancer 2014 13:264

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  29. Content type: Research

    Wnt/β-catenin signaling pathway plays important roles in human cancer progression. Better understanding the mechanism underlying regulation of Wnt/β-catenin signaling pathway might provide novel therapeutic ta...

    Authors: Xian-Cheng Zeng, Fo-Qiu Liu, Rong Yan, Hui-Min Yi, Tong Zhang, Guo-Ying Wang, Yang Li and Nan Jiang

    Citation: Molecular Cancer 2014 13:261

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  30. Content type: Research

    Bone morphogenetic protein (BMP) signaling is thought to play key roles in regulating the survival and maintenance of cancer stem cells (CSCs), which contribute to disease recurrences and treatment failures in...

    Authors: Ali Khammanivong, Raj Gopalakrishnan and Erin B Dickerson

    Citation: Molecular Cancer 2014 13:260

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  31. Content type: Research

    Lung cancer is the major cause of cancer-related deaths and many cases of Non Small Cell Lung Cancer (NSCLC), a common type of lung cancer, have frequent genetic/oncogenic activation of EGFR, KRAS, PIK3CA, BRAF, ...

    Authors: Venkatasubbaiah A Venkatesha, Asavari Joshi, Magesh Venkataraman, Vinay Sonawane, Dimple Bhatia, Prashant Tannu, Julie Bose, Sarika Choudhari, Ankita Srivastava, Prashant Kumar Pandey, Vaibhavi J Lad, Ramachandra Sangana, Tausif Ahmed, Anagha Damre, Vijaykumar Deore, Bichismita Sahu…

    Citation: Molecular Cancer 2014 13:259

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  32. Content type: Research

    OTUB1 (OTU deubiquitinase, ubiquitin aldehyde binding 1) is a deubiquitinating enzyme (DUB) that belongs to the OTU (ovarian tumor) superfamily. The aim of this study was to clarify the role of OTUB1 in colore...

    Authors: Yi Zhou, Jiangxue Wu, Xiang Fu, Wuying Du, Ling Zhou, Xiangqi Meng, Hongyan Yu, Jiaxin Lin, Wen Ye, Jiani Liu, Hui Peng, Ran-yi Liu, Changchuan Pan and Wenlin Huang

    Citation: Molecular Cancer 2014 13:258

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  33. Content type: Research

    Aberrant activation of the Wnt/β-catenin signaling pathway is an important factor in the development of nasopharyngeal carcinoma (NPC). Previous studies have demonstrated that the developmental gene sex-determ...

    Authors: Zhong Guan, Jialiang Zhang, Jing Wang, Hefei Wang, Feimeng Zheng, Jieren Peng, Yaodong Xu, Min Yan, Bing Liu, Bai Cui, Ying Huang and Quentin Liu

    Citation: Molecular Cancer 2014 13:257

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  34. Content type: Research

    TRAIL and IFNγ are promising anti-cancer cytokines and it has been shown that IFNγ may sensitize cancer cells to TRAIL. Adipose derived mesenchymal stem cells (ADSCs) are attractive vehicles for delivering ant...

    Authors: Vahid Bahrambeigi, Nafiseh Ahmadi, Stefan Moisyadi, Johann Urschitz, Rasoul Salehi and Shaghayegh Haghjooy Javanmard

    Citation: Molecular Cancer 2014 13:255

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  35. Content type: Research

    Our previous study identified AKT1, AKT2 and AKT3 as unfavorable prognostic factors for patients with hepatocellular carcinoma (HCC). However, limited data are available on their exact mechanisms in HCC. Since...

    Authors: Yanqiong Zhang, Xiaodong Guo, Lu Xiong, Lingxiang Yu, Zhiwei Li, Qiuyan Guo, Zhiyan Li, Boan Li and Na Lin

    Citation: Molecular Cancer 2014 13:253

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  36. Content type: Research

    The epithelial-to-mesenchymal transition (EMT) process results in a loss of cell-cell adhesion, increased cell mobility, and is crucial for enabling the metastasis of cancer cells. Recently, the enzyme SIRT1 h...

    Authors: I-Chieh Chen, Wei-Fan Chiang, Hsin-Hsiu Huang, Pei-Fen Chen, Ying-Ying Shen and Hung-Che Chiang

    Citation: Molecular Cancer 2014 13:254

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  37. Content type: Research

    CUL4A has been proposed as oncogene in several types of human cancer, but its clinical significance and functional role in human non-small cell lung cancer (NSCLC) remain unclear.

    Authors: Yunshan Wang, Pengju Zhang, Ziming Liu, Qin Wang, Mingxin Wen, Yuli Wang, Hongtu Yuan, Jian-Hua Mao and Guangwei Wei

    Citation: Molecular Cancer 2014 13:252

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  38. Content type: Research

    Arsenic trioxide (As2O3) is highly effective in treating acute promyelocytic leukemia (APL), but shows more variable therapeutic efficacy for other types of hematological malignancies. Previously, we reported tha...

    Authors: Mohcine Benbijja, Amine Mellouk and Pierre Bobé

    Citation: Molecular Cancer 2014 13:251

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  39. Content type: Research

    MicroRNAs (miRNAs) are crucial molecules that regulate gene expression and hence pathways that are key to prostate cancer progression. These non-coding RNAs are highly deregulated in prostate cancer thus facil...

    Authors: Smrithi Rajendiran, Anil V Parwani, Richard J Hare, Subhamoy Dasgupta, Rhonda K Roby and Jamboor K Vishwanatha

    Citation: Molecular Cancer 2014 13:250

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  40. Content type: Review

    Chromosomal translocations are a major cause of cancer. At the same time, the mechanisms that lead to specific chromosomal translocations that associate different gene regions remain largely unknown. Transloca...

    Authors: Olga V Iarovaia, Mikhail Rubtsov, Elena Ioudinkova, Tatiana Tsfasman, Sergey V Razin and Yegor S Vassetzky

    Citation: Molecular Cancer 2014 13:249

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  41. Content type: Research

    Gastric cardia adenocarcinoma (GCA) is the most aggressive subtype of gastric carcinoma. New molecular markers and therapeutic targets are needed for diagnosis, prognosis and treatment of GCA. This study is to...

    Authors: Aiqin Sun, Guanzhen Yu, Xiaoyan Dou, Xiaowei Yan, Wannian Yang and Qiong Lin

    Citation: Molecular Cancer 2014 13:248

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  42. Content type: Research

    Cancer stem cells (CSC) represent a rare fraction of cancer cells characterized by resistance to chemotherapy and radiation, therefore nowadays there is great need to develop new targeted therapies for brain t...

    Authors: Carlo Cenciarelli, Hany ES Marei, Manuela Zonfrillo, Pasquale Pierimarchi, Emanuela Paldino, Patrizia Casalbore, Armando Felsani, Angelo Luigi Vescovi, Giulio Maira and Annunziato Mangiola

    Citation: Molecular Cancer 2014 13:247

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  43. Content type: Research

    Although tumor invasion and metastasis are both classical hallmarks of cancer malignancy and the major causes of poor clinical outcomes among cancer patients, the underlying master regulators of invasion and m...

    Authors: Min-Xia Liu, Ke-Cheng Zhou and Yi Cao

    Citation: Molecular Cancer 2014 13:245

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  44. Content type: Research

    A KIT gain of function mutation is present in 70% of gastrointestinal stromal tumors (GISTs) and the wild-type (WT) allele is deleted in 5 to 15% of these cases. The WT KIT is probably deleted during GIST progres...

    Authors: Nelson Lourenço, Zofia Hélias-Rodzewicz, Jean-Baptiste Bachet, Sabrina Brahimi-Adouane, Fabrice Jardin, Jeanne Tran van Nhieu, Frédérique Peschaud, Emmanuel Martin, Alain Beauchet, Frédéric Chibon and Jean-François Emile

    Citation: Molecular Cancer 2014 13:246

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  45. Content type: Research

    For long, natural killer (NK) cells have been suspected to play a critical role in suppressing the development of spontaneous metastases in cancer patients. Despite a wide range of studies it remains unclear s...

    Authors: Tobias Brodbeck, Nina Nehmann, Anja Bethge, Gero Wedemann and Udo Schumacher

    Citation: Molecular Cancer 2014 13:244

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