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  1. Pediatric brain tumors may originate from cells endowed with neural stem/precursor cell properties, growing in vitro as neurospheres. We have found that these cells can also be present in adult brain tumors an...

    Authors: Patrizia Tunici, Lorena Bissola, Elena Lualdi, Bianca Pollo, Laura Cajola, Giovanni Broggi, Gabriella Sozzi and Gaetano Finocchiaro

    Citation: Molecular Cancer 2004 3:25

    Content type: Short communication

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  2. Tumors and complex tissues consist of mixtures of communicating cells that differ significantly in their gene expression status. In order to understand how different cell types influence one another's gene exp...

    Authors: Luiz OF Penalva, Michael D Burdick, Simon M Lin, Hedwig Sutterluety and Jack D Keene

    Citation: Molecular Cancer 2004 3:24

    Content type: Research

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  3. The CBFA2T3 locus located on the human chromosome region 16q24.3 is frequently deleted in breast tumors. CBFA2T3 gene expression levels are aberrant in breast tumor cell lines and the CBFA2T3B isoform is a pot...

    Authors: Anthony J Bais, Alison E Gardner, Olivia LD McKenzie, David F Callen, Grant R Sutherland and Gabriel Kremmidiotis

    Citation: Molecular Cancer 2004 3:22

    Content type: Research

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  4. Colorectal cancers displaying high-degree microsatellite instability (MSI-H) have an improved prognosis compared to microsatellite stable (MSS) cancers. The observation of pronounced lymphocytic infiltrates su...

    Authors: Ayan Banerjea, Shafi Ahmed, Rebecca E Hands, Fei Huang, Xia Han, Peter M Shaw, Roger Feakins, Stephen A Bustin and Sina Dorudi

    Citation: Molecular Cancer 2004 3:21

    Content type: Research

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  5. Neurofibromatosis type 1 (NF1) is an autosomal dominant disorder with a complex range of clinical symptoms. The hallmark of NF1 is the onset of heterogeneous (dermal or plexiform) benign neurofibromas. Plexiform ...

    Authors: Pascale Lévy, Dominique Vidaud, Karen Leroy, Ingrid Laurendeau, Janine Wechsler, Giulia Bolasco, Béatrice Parfait, Pierre Wolkenstein, Michel Vidaud and Ivan Bièche

    Citation: Molecular Cancer 2004 3:20

    Content type: Research

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  6. Hypoxia-tolerant human glioma cells reduce oxygen consumption rate in response to oxygen deficit, a defense mechanism that contributes to survival under moderately hypoxic conditions. In contrast, hypoxia-sens...

    Authors: Carrie DeHaan, Bahram Habibi-Nazhad, Elizabeth Yan, Nicole Salloum, Matthew Parliament and Joan Allalunis-Turner

    Citation: Molecular Cancer 2004 3:19

    Content type: Research

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  7. The agouti protein is a paracrine factor that is normally present in the skin of many species of mammals. Agouti regulates the switch between black and yellow hair pigmentation by signalling through the melano...

    Authors: Alexander I Kuklin, Randall L Mynatt, Mitchell L Klebig, Laura L Kiefer, William O Wilkison, Richard P Woychik and Edward J Michaud

    Citation: Molecular Cancer 2004 3:17

    Content type: Research

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  8. Male germ cell tumor (GCT) is a highly curable malignancy, which exhibits exquisite sensitivity to cisplatin treatment. The genetic pathway(s) that determine the chemotherapy sensitivity in GCT remain largely ...

    Authors: Sanjay Koul, James M McKiernan, Gopeshwar Narayan, Jane Houldsworth, Jennifer Bacik, Deborah L Dobrzynski, Adel M Assaad, Mahesh Mansukhani, Victor E Reuter, George J Bosl, Raju SK Chaganti and Vundavalli VVS Murty

    Citation: Molecular Cancer 2004 3:16

    Content type: Research

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  9. The expression of the rodent phosphoinositide-specific phospholipase C δ-4 (PLCδ4) has been found to be elevated upon mitogenic stimulation and expression analysis have linked the upregulation of PLCδ4 express...

    Authors: David W Leung, Chris Tompkins, Jim Brewer, Alexey Ball, Mike Coon, Valerie Morris, David Waggoner and Jack W Singer

    Citation: Molecular Cancer 2004 3:15

    Content type: Research

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  10. CHK2 kinase is a tumor suppressor that plays important role in DNA damage signaling, cell cycle regulation and DNA damage induced apoptosis. CHK2 kinase expression was known to be ubiquitous in mammalian cells...

    Authors: Peilin Zhang, Jie Wang, Weiyi Gao, Bao-Zhu Yuan, John Rogers and Eddie Reed

    Citation: Molecular Cancer 2004 3:14

    Content type: Research

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  11. The cellular retinol binding protein I gene (CRBP) is downregulated in a subset of human breast cancers and in MMTV-Myc induced mouse mammary tumors. Functional studies suggest that CRBP downregulation contribute...

    Authors: Alice Arapshian, Silvina Bertran, Yuvarani S Kuppumbatti, Shigeo Nakajo and Rafael Mira-y-Lopez

    Citation: Molecular Cancer 2004 3:13

    Content type: Research

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  12. Established colorectal cancer cell lines subjected to different 5-fluorouracil (5-FU) treatment protocols are often used as in vitro model systems for investigations of downstream cellular responses to 5-FU and t...

    Authors: Paula M De Angelis, Katherine L Kravik, Siv H Tunheim, Terje Haug and Wenche H Reichelt

    Citation: Molecular Cancer 2004 3:11

    Content type: Research

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  13. Small GTPases of the Rho family are critical regulators of various cellular functions including actin cytoskeleton organization, activation of kinase cascades and mitogenesis. For this reason, a major objectiv...

    Authors: Christina Curtis, Bianca Hemmeryckx, Leena Haataja, Dinithi Senadheera, John Groffen and Nora Heisterkamp

    Citation: Molecular Cancer 2004 3:10

    Content type: Research

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  14. Nuclear factor kappa B (NFκB) is a pro-malignant transcription factor with reciprocal effects on pro-metastatic and anti-metastatic gene expression. Interestingly, NFκB blockade results in the reciprocal induc...

    Authors: Valentine B Andela and Randy N Rosier

    Citation: Molecular Cancer 2004 3:8

    Content type: Research

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  15. Cyclooxygenase-2 (COX-2) has been shown to be highly expressed in a broad series of primary endometrial tumors and its expression may be closely associated with parameters of tumor aggressiveness. In human end...

    Authors: Marie-Eve St-Germain, Veronique Gagnon, Sophie Parent and Eric Asselin

    Citation: Molecular Cancer 2004 3:7

    Content type: Research

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  16. Colorectal cancer (CRC) is one of the most common causes of cancer-related deaths in the Western world, and despite the fact that metastases are usually the ultimate cause of deaths, the knowledge of the genet...

    Authors: Chieu B Diep, Manuel R Teixeira, Lin Thorstensen, Johan N Wiig, Mette Eknæs, Jahn M Nesland, Karl-Erik Giercksky, Bertil Johansson and Ragnhild A Lothe

    Citation: Molecular Cancer 2004 3:6

    Content type: Research

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  17. Probe based detection assays form the mainstay of transcript quantification. Problems with these assays include varying hybridization efficiencies of the probes used for transcript quantification and the expen...

    Authors: Vincenzo Pagliarulo, Ben George, Stephen J Beil, Susan Groshen, Peter W Laird, Jie Cai, James Willey, Richard J Cote and Ram H Datar

    Citation: Molecular Cancer 2004 3:5

    Content type: Research

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  18. The expression of pro-angiogenic cytokines, such as vascular endothelial growth factor (VEGF) and interleukin-8/CXCL8 (IL-8), plays an important role in tumor growth and metastasis. Low oxygen tension within p...

    Authors: Philip L Marjon, Ekaterina V Bobrovnikova-Marjon and Steve F Abcouwer

    Citation: Molecular Cancer 2004 3:4

    Content type: Research

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  19. Cellular senescence is a state in which mammalian cells enter into an irreversible growth arrest and altered biological functions. The senescence response in mammalian cells can be elicited by DNA-damaging age...

    Authors: Aruna S Jaiswal, Asha S Multani, Sen Pathak and Satya Narayan

    Citation: Molecular Cancer 2004 3:3

    Content type: Research

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  20. The chromosomal location of CUL-5 (11q 22-23) is associated with LOH in breast cancer, suggesting that CUL-5 may be a tumor suppressor. The purpose of this research was to determine if there is differential expre...

    Authors: Michael J Fay, Kenneth A Longo, George A Karathanasis, David M Shope, Craig J Mandernach, Jason R Leong, Alfred Hicks, Kenneth Pherson and Amyna Husain

    Citation: Molecular Cancer 2003 2:40

    Content type: Research

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  21. Recognition of pathogens by immune receptors leads to activation of macrophages, dendritic cells, and lymphocytes. Signals are communicated to enhance expression of target molecules such as cytokines and adhes...

    Authors: Martin P Kracklauer and Christian Schmidt

    Citation: Molecular Cancer 2003 2:39

    Content type: Hypothesis

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  22. The TF (Thomson – Friedenreich) blood group antigen behaves as an onco-foetal carcinoma-associated antigen, showing increased expression in malignancies and its detection and quantification can be used in sero...

    Authors: Sankaranarayanan Kannan, Reddi A Lakku, Devaraj Niranjali, Kamala Jayakumar, Arulraj H Steven, Taralakshmi VV, Chandramohan S, Ramathilakam Balakrishnan, Christian Schmidt and Devaraj Halagowder

    Citation: Molecular Cancer 2003 2:38

    Content type: Research

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  23. p8 is a stress-induced protein with multiple functions and biochemically related to the architectural factor HMG-I/Y. We analyzed the expression and function of p8 in pancreatic cancer-derived cells.

    Authors: Cédric Malicet, Nathalie Lesavre, Sophie Vasseur and Juan L Iovanna

    Citation: Molecular Cancer 2003 2:37

    Content type: Research

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  24. In recent years many efforts of researchers and clinicians were made to improve our knowledge of cachexia syndrome. Not only cancer, but also many chronic or end-stage diseases such as AIDS, chronic obstructiv...

    Authors: Marcus E Martignoni, Philipp Kunze and Helmut Friess

    Citation: Molecular Cancer 2003 2:36

    Content type: Editorial

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  25. Ex vivo generated dendritic cells (DC) genetically modified to express secondary lymphoid tissue chemokine (CCL-21/SLC) have been shown to stimulate potent antitumor responses in murine models. When injected intr...

    Authors: Karen Riedl, Felicita Baratelli, Raj K Batra, Seok Chul Yang, Jie Luo, Brian Escuadro, Robert Figlin, Robert Strieter, Sherven Sharma and Steven Dubinett

    Citation: Molecular Cancer 2003 2:35

    Content type: Research

    Published on:

  26. Prostate cancer (PCa) incidences vary with genetic, geographical and ethnic dietary background of patients while angiogenesis is modulated through exquisite interplay of tumor-stromal interactions of biologica...

    Authors: Abhijit G Banerjee, Jie Liu, Yawei Yuan, Velliyur K Gopalakrishnan, Sonny L Johansson, Amit K Dinda, Narmada P Gupta, Lindsey Trevino and Jamboor K Vishwanatha

    Citation: Molecular Cancer 2003 2:34

    Content type: Research

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  27. Transforming growth factor β (TGFβ) plays an important role in animal development and many cellular processes. A variety of cellular functions that are required for tumor metastasis are controlled by integrins...

    Authors: Karsta Luettich and Christian Schmidt

    Citation: Molecular Cancer 2003 2:33

    Content type: Short communication

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    The Retraction Note to this article has been published in Molecular Cancer 2004 3:1

  28. Pancreatic cancer is an aggressive malignancy characterized by low responsiveness to chemotherapy and radiotherapy. This resistance is partly due to the overexpression of several tyrosine kinase receptors and ...

    Authors: Junsheng Li, Jörg Kleeff, Junchao Guo, Lars Fischer, Nathalia Giese, Markus W Büchler and Helmut Friess

    Citation: Molecular Cancer 2003 2:32

    Content type: Research

    Published on:

  29. The hypoxia-inducible factor (HIF) transcription complex, which is activated by low oxygen tension, controls a diverse range of cellular processes including angiogenesis and erythropoiesis. Under normoxic cond...

    Authors: Melanie J Percy, Sharon M Mooney, Mary Frances McMullin, Adrian Flores, Terence RJ Lappin and Frank S Lee

    Citation: Molecular Cancer 2003 2:31

    Content type: Research

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  30. Numerical and structural centrosome abnormalities are detected in various human malignancies and have been implicated in the formation of multipolar mitoses, chromosome missegregation, and chromosomal instabil...

    Authors: Stefan Duensing, Benjamin H Lee, Paola Dal Cin and Karl Münger

    Citation: Molecular Cancer 2003 2:30

    Content type: Short communication

    Published on:

  31. The Ets1 proto-oncoprotein is a member of the Ets family of transcription factors that share a unique DNA binding domain, the Ets domain. The DNA binding activity of Ets1 is controlled by kinases and transcrip...

    Authors: Jürgen Dittmer

    Citation: Molecular Cancer 2003 2:29

    Content type: Review

    Published on:

  32. Transforming growth factor β1 (TGFβ1) is a potent inhibitor of epithelial cell growth, thus playing an important role in tissue homeostasis. Most carcinoma cells exhibit a reduced sensitivity for TGFβ1 mediated g...

    Authors: Martin P Kracklauer, Christian Schmidt and Guido M Sclabas

    Citation: Molecular Cancer 2003 2:28

    Content type: Research

    Published on:

    The Retraction Note to this article has been published in Molecular Cancer 2004 3:2

  33. Cervical cancer (CC), a leading cause of cancer-related deaths in women worldwide, has been causally linked to genital human papillomavirus (HPV) infection. Although a host of genetic alterations have been ide...

    Authors: Gopeshwar Narayan, Hugo Arias-Pulido, Sanjay Koul, Hernan Vargas, Fang F Zhang, Jeannine Villella, Achim Schneider, Mary B Terry, Mahesh Mansukhani and Vundavalli V Murty

    Citation: Molecular Cancer 2003 2:24

    Content type: Research

    Published on:

  34. Highly aggressive, rapidly growing tumors are exposed to hypoxia or even anoxia which occurs as a consequence of inadequate blood supply. Both hypoxia and consecutive hypoxia/reoxygenation exert a variety of i...

    Authors: Manfred Kunz and Saleh M Ibrahim

    Citation: Molecular Cancer 2003 2:23

    Content type: Review

    Published on:

  35. SLC/CCL21, normally expressed in high endothelial venules and in T cell zones of spleen and lymph nodes, strongly attracts T cells and dendritic cells (DC). We have previously shown that SLC/CCL21-mediated ant...

    Authors: Sherven Sharma, Seok-Chul Yang, Sven Hillinger, Li X Zhu, Min Huang, Raj K Batra, Jeff F Lin, Marie D Burdick, Robert M Strieter and Steven M Dubinett

    Citation: Molecular Cancer 2003 2:22

    Content type: Research

    Published on:

  36. Transforming growth factor-β (TGFβ) plays an important role in late-stage carcinogenesis by stimulating invasive behavior of cancer cells, promoting neo-angiogenesis and by helping cancer cells to escape surve...

    Authors: Ralph K Lindemann, Alfred Nordheim and Jürgen Dittmer

    Citation: Molecular Cancer 2003 2:20

    Content type: Research

    Published on:

  37. Ras is an area of intensive biochemical and genetic studies and characterizing downstream components that relay ras-induced signals is clearly important. We used a systematic approach, based on DNA microarray ...

    Authors: Sophie Vasseur, Cédric Malicet, Ezequiel L Calvo, Claude Labrie, Patrice Berthezene, Jean Charles Dagorn and Juan Lucio Iovanna

    Citation: Molecular Cancer 2003 2:19

    Content type: Research

    Published on:

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