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  1. Cyclooxygenase-2 (COX-2) has been shown to be highly expressed in a broad series of primary endometrial tumors and its expression may be closely associated with parameters of tumor aggressiveness. In human end...

    Authors: Marie-Eve St-Germain, Veronique Gagnon, Sophie Parent and Eric Asselin

    Citation: Molecular Cancer 2004 3:7

    Content type: Research

    Published on:

  2. Colorectal cancer (CRC) is one of the most common causes of cancer-related deaths in the Western world, and despite the fact that metastases are usually the ultimate cause of deaths, the knowledge of the genet...

    Authors: Chieu B Diep, Manuel R Teixeira, Lin Thorstensen, Johan N Wiig, Mette Eknæs, Jahn M Nesland, Karl-Erik Giercksky, Bertil Johansson and Ragnhild A Lothe

    Citation: Molecular Cancer 2004 3:6

    Content type: Research

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  3. Probe based detection assays form the mainstay of transcript quantification. Problems with these assays include varying hybridization efficiencies of the probes used for transcript quantification and the expen...

    Authors: Vincenzo Pagliarulo, Ben George, Stephen J Beil, Susan Groshen, Peter W Laird, Jie Cai, James Willey, Richard J Cote and Ram H Datar

    Citation: Molecular Cancer 2004 3:5

    Content type: Research

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  4. The expression of pro-angiogenic cytokines, such as vascular endothelial growth factor (VEGF) and interleukin-8/CXCL8 (IL-8), plays an important role in tumor growth and metastasis. Low oxygen tension within p...

    Authors: Philip L Marjon, Ekaterina V Bobrovnikova-Marjon and Steve F Abcouwer

    Citation: Molecular Cancer 2004 3:4

    Content type: Research

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  5. Cellular senescence is a state in which mammalian cells enter into an irreversible growth arrest and altered biological functions. The senescence response in mammalian cells can be elicited by DNA-damaging age...

    Authors: Aruna S Jaiswal, Asha S Multani, Sen Pathak and Satya Narayan

    Citation: Molecular Cancer 2004 3:3

    Content type: Research

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  6. The chromosomal location of CUL-5 (11q 22-23) is associated with LOH in breast cancer, suggesting that CUL-5 may be a tumor suppressor. The purpose of this research was to determine if there is differential expre...

    Authors: Michael J Fay, Kenneth A Longo, George A Karathanasis, David M Shope, Craig J Mandernach, Jason R Leong, Alfred Hicks, Kenneth Pherson and Amyna Husain

    Citation: Molecular Cancer 2003 2:40

    Content type: Research

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  7. Recognition of pathogens by immune receptors leads to activation of macrophages, dendritic cells, and lymphocytes. Signals are communicated to enhance expression of target molecules such as cytokines and adhes...

    Authors: Martin P Kracklauer and Christian Schmidt

    Citation: Molecular Cancer 2003 2:39

    Content type: Hypothesis

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  8. The TF (Thomson – Friedenreich) blood group antigen behaves as an onco-foetal carcinoma-associated antigen, showing increased expression in malignancies and its detection and quantification can be used in sero...

    Authors: Sankaranarayanan Kannan, Reddi A Lakku, Devaraj Niranjali, Kamala Jayakumar, Arulraj H Steven, Taralakshmi VV, Chandramohan S, Ramathilakam Balakrishnan, Christian Schmidt and Devaraj Halagowder

    Citation: Molecular Cancer 2003 2:38

    Content type: Research

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  9. p8 is a stress-induced protein with multiple functions and biochemically related to the architectural factor HMG-I/Y. We analyzed the expression and function of p8 in pancreatic cancer-derived cells.

    Authors: Cédric Malicet, Nathalie Lesavre, Sophie Vasseur and Juan L Iovanna

    Citation: Molecular Cancer 2003 2:37

    Content type: Research

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  10. In recent years many efforts of researchers and clinicians were made to improve our knowledge of cachexia syndrome. Not only cancer, but also many chronic or end-stage diseases such as AIDS, chronic obstructiv...

    Authors: Marcus E Martignoni, Philipp Kunze and Helmut Friess

    Citation: Molecular Cancer 2003 2:36

    Content type: Editorial

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  11. Ex vivo generated dendritic cells (DC) genetically modified to express secondary lymphoid tissue chemokine (CCL-21/SLC) have been shown to stimulate potent antitumor responses in murine models. When injected intr...

    Authors: Karen Riedl, Felicita Baratelli, Raj K Batra, Seok Chul Yang, Jie Luo, Brian Escuadro, Robert Figlin, Robert Strieter, Sherven Sharma and Steven Dubinett

    Citation: Molecular Cancer 2003 2:35

    Content type: Research

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  12. Prostate cancer (PCa) incidences vary with genetic, geographical and ethnic dietary background of patients while angiogenesis is modulated through exquisite interplay of tumor-stromal interactions of biologica...

    Authors: Abhijit G Banerjee, Jie Liu, Yawei Yuan, Velliyur K Gopalakrishnan, Sonny L Johansson, Amit K Dinda, Narmada P Gupta, Lindsey Trevino and Jamboor K Vishwanatha

    Citation: Molecular Cancer 2003 2:34

    Content type: Research

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  13. Transforming growth factor β (TGFβ) plays an important role in animal development and many cellular processes. A variety of cellular functions that are required for tumor metastasis are controlled by integrins...

    Authors: Karsta Luettich and Christian Schmidt

    Citation: Molecular Cancer 2003 2:33

    Content type: Short communication

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    The Retraction Note to this article has been published in Molecular Cancer 2004 3:1

  14. Pancreatic cancer is an aggressive malignancy characterized by low responsiveness to chemotherapy and radiotherapy. This resistance is partly due to the overexpression of several tyrosine kinase receptors and ...

    Authors: Junsheng Li, Jörg Kleeff, Junchao Guo, Lars Fischer, Nathalia Giese, Markus W Büchler and Helmut Friess

    Citation: Molecular Cancer 2003 2:32

    Content type: Research

    Published on:

  15. The hypoxia-inducible factor (HIF) transcription complex, which is activated by low oxygen tension, controls a diverse range of cellular processes including angiogenesis and erythropoiesis. Under normoxic cond...

    Authors: Melanie J Percy, Sharon M Mooney, Mary Frances McMullin, Adrian Flores, Terence RJ Lappin and Frank S Lee

    Citation: Molecular Cancer 2003 2:31

    Content type: Research

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  16. Numerical and structural centrosome abnormalities are detected in various human malignancies and have been implicated in the formation of multipolar mitoses, chromosome missegregation, and chromosomal instabil...

    Authors: Stefan Duensing, Benjamin H Lee, Paola Dal Cin and Karl Münger

    Citation: Molecular Cancer 2003 2:30

    Content type: Short communication

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  17. The Ets1 proto-oncoprotein is a member of the Ets family of transcription factors that share a unique DNA binding domain, the Ets domain. The DNA binding activity of Ets1 is controlled by kinases and transcrip...

    Authors: Jürgen Dittmer

    Citation: Molecular Cancer 2003 2:29

    Content type: Review

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  18. Transforming growth factor β1 (TGFβ1) is a potent inhibitor of epithelial cell growth, thus playing an important role in tissue homeostasis. Most carcinoma cells exhibit a reduced sensitivity for TGFβ1 mediated g...

    Authors: Martin P Kracklauer, Christian Schmidt and Guido M Sclabas

    Citation: Molecular Cancer 2003 2:28

    Content type: Research

    Published on:

    The Retraction Note to this article has been published in Molecular Cancer 2004 3:2

  19. Cervical cancer (CC), a leading cause of cancer-related deaths in women worldwide, has been causally linked to genital human papillomavirus (HPV) infection. Although a host of genetic alterations have been ide...

    Authors: Gopeshwar Narayan, Hugo Arias-Pulido, Sanjay Koul, Hernan Vargas, Fang F Zhang, Jeannine Villella, Achim Schneider, Mary B Terry, Mahesh Mansukhani and Vundavalli V Murty

    Citation: Molecular Cancer 2003 2:24

    Content type: Research

    Published on:

  20. Highly aggressive, rapidly growing tumors are exposed to hypoxia or even anoxia which occurs as a consequence of inadequate blood supply. Both hypoxia and consecutive hypoxia/reoxygenation exert a variety of i...

    Authors: Manfred Kunz and Saleh M Ibrahim

    Citation: Molecular Cancer 2003 2:23

    Content type: Review

    Published on:

  21. SLC/CCL21, normally expressed in high endothelial venules and in T cell zones of spleen and lymph nodes, strongly attracts T cells and dendritic cells (DC). We have previously shown that SLC/CCL21-mediated ant...

    Authors: Sherven Sharma, Seok-Chul Yang, Sven Hillinger, Li X Zhu, Min Huang, Raj K Batra, Jeff F Lin, Marie D Burdick, Robert M Strieter and Steven M Dubinett

    Citation: Molecular Cancer 2003 2:22

    Content type: Research

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  22. Transforming growth factor-β (TGFβ) plays an important role in late-stage carcinogenesis by stimulating invasive behavior of cancer cells, promoting neo-angiogenesis and by helping cancer cells to escape surve...

    Authors: Ralph K Lindemann, Alfred Nordheim and Jürgen Dittmer

    Citation: Molecular Cancer 2003 2:20

    Content type: Research

    Published on:

  23. Ras is an area of intensive biochemical and genetic studies and characterizing downstream components that relay ras-induced signals is clearly important. We used a systematic approach, based on DNA microarray ...

    Authors: Sophie Vasseur, Cédric Malicet, Ezequiel L Calvo, Claude Labrie, Patrice Berthezene, Jean Charles Dagorn and Juan Lucio Iovanna

    Citation: Molecular Cancer 2003 2:19

    Content type: Research

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  24. p14ARF is a protein product of the alternative reading frame of the human INK4a locus. It functions as a tumor suppressor protein. p14ARF suppresses growth through p53-dependent and p53-independent pathways.

    Authors: Elena Kashuba, Karin Mattsson, George Klein and Laszlo Szekely

    Citation: Molecular Cancer 2003 2:18

    Content type: Research

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  25. Molecular Cancer is as a forum for cutting edge cancer-related papers. This editorial will answer frequently asked question about this open-access and on-line journal as well as its publisher BioMed Central.

    Authors: Karsta Lüttich, Christian Schmidt and Guido M Sclabas

    Citation: Molecular Cancer 2003 2:16

    Content type: Editorial

    Published on:

  26. Cancer of the exocrine pancreas represents the fifth leading cause of cancer death in the Western population with an average survival after diagnosis of 3 to 6 months and a five-year survival rate under 5%. Ou...

    Authors: Gunter Schneider and Roland M Schmid

    Citation: Molecular Cancer 2003 2:15

    Content type: Review

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  27. Pancreatic cancer remains a challenging disease with an overall cumulative 5-year survival rate below 1%. The process of cancer initiation, progression and metastasis is still not understood well. Invasion and...

    Authors: Shereen Keleg, Peter Büchler, Roman Ludwig, Markus W Büchler and Helmut Friess

    Citation: Molecular Cancer 2003 2:14

    Content type: Review

    Published on:

  28. The concept of pancreatic cancer origin is controversial. Acinar, ductal or islet cells have been hypothesized as the cell of origin. The pros and cons of each of these hypotheses are discussed. Based on the w...

    Authors: Parviz M Pour, Krishan K Pandey and Surinder K Batra

    Citation: Molecular Cancer 2003 2:13

    Content type: Review

    Published on:

  29. The incidence and mortality of pancreatic adenocarcinoma are nearly coincident having a five-year survival of less than 5%. Enormous advances have been made in our knowledge of the molecular alterations common...

    Authors: Patrick S Moore, Stefania Beghelli, Giuseppe Zamboni and Aldo Scarpa

    Citation: Molecular Cancer 2003 2:7

    Content type: Review

    Published on:

  30. Pancreatic adenocarcinoma is characterized by poor prognosis, because of late diagnosis and lack of response to chemo- and/or radiation therapies. Resistance to apoptosis mainly causes this insensitivity to co...

    Authors: Sabine Westphal and Holger Kalthoff

    Citation: Molecular Cancer 2003 2:6

    Content type: Review

    Published on:

  31. About 80% of pancreatic cancer patients have glucose intolerance or frank diabetes. This observation has led to the following two hypotheses: i. pancreatic cancer causes the associated diabetes and ii. the condit...

    Authors: Feng Wang, Margery Herrington, Jörgen Larsson and Johan Permert

    Citation: Molecular Cancer 2003 2:4

    Content type: Review

    Published on:

  32. Glucocorticoids inhibit hepatocellular proliferation and modulate the expression of oncogenes and tumor suppressor genes via mechanisms involving the glucocorticoid receptor. Glucocorticoids also produce a recept...

    Authors: Jihan A Youssef and Mostafa Z Badr

    Citation: Molecular Cancer 2003 2:3

    Content type: Research

    Published on:

  33. Rhabdomyosarcoma is a common malignancy in children. There are two major types of rhabdomyosarcomas, the embryonal and the alveolar, differing in cytogenetic and morphologic features. The alveolar type of rhab...

    Authors: Peilin Zhang, Kunjan S Bhakta, Pier Lorenzo Puri, Robert O Newbury, James R Feramisco and Jean Y Wang

    Citation: Molecular Cancer 2003 2:2

    Content type: Research

    Published on:

    The Retraction Note to this article has been published in Molecular Cancer 2003 2:17

  34. Gleevec (aka STI571, Imatinib) is a recently FDA approved anti-tumor drug for chronic myelogenous leukemia. Gleevec binds specifically to BCR-ABL tyrosine kinase and inhibit the tyrosine kinase activity. It cr...

    Authors: Peilin Zhang, Wei Yi Gao, Steven Turner and Barbara S Ducatman

    Citation: Molecular Cancer 2003 2:1

    Content type: Research

    Published on:

  35. Mitochondria play important roles in cellular energy metabolism, free radical generation, and apoptosis. Defects in mitochondrial function have long been suspected to contribute to the development and progress...

    Authors: Jennifer S Carew and Peng Huang

    Citation: Molecular Cancer 2002 1:9

    Content type: Review

    Published on:

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