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  1. Intestinal cell kinase (ICK; GeneID 22858) is a conserved MAPK and CDK-like kinase that is widely expressed in human tissues. Data from the Cancer Genome Anatomy Project indicated ICK mRNA is increased in canc...

    Authors: Thomas W Sturgill, Paul B Stoddard, Steven M Cohn and Marty W Mayo
    Citation: Molecular Cancer 2010 9:104
    Content type: Research Published on:

  2. Aberrant expression of cyclin D1 is a common feature in multiple myeloma (MM) and always associated with mantle cell lymphoma (MCL). CCND1 gene is alternatively spliced to produce two cyclin D1 mRNA isoforms whic...

    Authors: Véronique Marsaud, Guergana Tchakarska, Geoffroy Andrieux, Jian-Miao Liu, Doulaye Dembele, Bernard Jost, Joanna Wdzieczak-Bakala, Jack-Michel Renoir and Brigitte Sola
    Citation: Molecular Cancer 2010 9:103
    Content type: Research Published on:

  3. The class 1 carcinogen cadmium (Cd2+) disrupts the E-cadherin/β-catenin complex of epithelial adherens junctions (AJs) and causes renal cancer. Deregulation of E-cadherin adhesion and changes in Wnt/β-catenin sig...

    Authors: Prabir K Chakraborty, Wing-Kee Lee, Malte Molitor, Natascha A Wolff and Frank Thévenod
    Citation: Molecular Cancer 2010 9:102
    Content type: Research Published on:

  4. Breast cancer is one of the most frequently diagnosed cancer and accounts for over 400,000 deaths each year worldwide. It causes premature death in women, despite progress in early detection, treatment, and ad...

    Authors: Mansoor Ahmed and Gopal C Kundu
    Citation: Molecular Cancer 2010 9:101
    Content type: Research Published on:

  5. Estimates suggest that up to 30% of colorectal cancers (CRC) may develop due to an increased genetic risk. The mean age at diagnosis for CRC is about 70 years. Time of disease onset 20 years younger than the m...

    Authors: Marianne Berg, Trude H Ã…gesen, Espen Thiis-Evensen, Marianne A Merok, Manuel R Teixeira, Morten H Vatn, Arild Nesbakken, Rolf I Skotheim and Ragnhild A Lothe
    Citation: Molecular Cancer 2010 9:100
    Content type: Research Published on:

  6. Multidrug resistance (MDR) is a major obstacle in cancer treatment and is often the result of overexpression of the drug efflux protein, P-glycoprotein (P-gp), as a consequence of hyperactivation of NFκB, AP1 ...

    Authors: Wipob Suttana, Samlee Mankhetkorn, Wilart Poompimon, Ajay Palagani, Sergey Zhokhov, Sarah Gerlo, Guy Haegeman and Wim Vanden Berghe
    Citation: Molecular Cancer 2010 9:99
    Content type: Research Published on:

  7. Diminished expression or activity of prostate apoptosis response protein 4 (Par-4) has been demonstrated in a number of cancers, although reports on Par-4 expression during colon cancer progression are lacking...

    Authors: Bi-Dar Wang, Christina Leah B. Kline, Danielle M. Pastor, Thomas L. Olson, Bryan Frank, Truong Luu, Arun K. Sharma, Gavin Robertson, Matthew T. Weirauch, Steven R. Patierno, Joshua M. Stuart, Rosalyn B. Irby and Norman H. Lee
    Citation: Molecular Cancer 2010 9:98
    Content type: Research Published on:

  8. Myc is a well known driver of lymphomagenesis, and Myc-activating chromosomal translocation is the recognized hallmark of Burkitt lymphoma, an aggressive form of non-Hodgkin's lymphoma. We developed a model th...

    Authors: Seong-Su Han, Hwakyung Yun, Dong-Ju Son, Van S. Tompkins, Liangping Peng, Seung-Tae Chung, Joong-Su Kim, Eun-Sung Park and Siegfried Janz
    Citation: Molecular Cancer 2010 9:97
    Content type: Research Published on:

  9. Translational control mediated by non-coding microRNAs (miRNAs) plays a key role in the mechanism of cellular resistance to anti-cancer drug treatment. Dihydrofolate reductase (DHFR) and thymidylate synthase (...

    Authors: Bo Song, Yuan Wang, Matthew A. Titmus, Galina Botchkina, Andrea Formentini, Marko Kornmann and Jingfang Ju
    Citation: Molecular Cancer 2010 9:96
    Content type: Research Published on:

  10. Autophagy is characterized by the sequestration of cytoplasm and organelles into multimembrane vesicles and subsequent degradation by the cell's lysosomal system. It is linked to many physiological functions i...

    Authors: Kathryn G. Eby, Jennifer M. Rosenbluth, Deborah J. Mays, Clayton B. Marshall, Christopher E. Barton, Seema Sinha, Kimberly N. Johnson, Luojia Tang and Jennifer A. Pietenpol
    Citation: Molecular Cancer 2010 9:95
    Content type: Research Published on:

  11. Hepatocellular carcinoma (HCC) is one of the most common cancers worldwide. The molecular mechanisms underlying hepatocarcinogenesis are still poorly understood. Genetically modified mice are powerful tools to...

    Authors: Julia Freimuth, Nikolaus Gassler, Nives Moro, Rolf W. Günther, Christian Trautwein, Christian Liedtke and Gabriele A. Krombach
    Citation: Molecular Cancer 2010 9:94
    Content type: Research Published on:

  12. Tobacco smoke is an important risk factor for various human cancers, including esophageal cancer. How benzo [a]pyrene diol epoxide (BPDE), a carcinogen present in tobacco smoke as well as in environmental polluti...

    Authors: Fei Ye and Xiao-Chun Xu
    Citation: Molecular Cancer 2010 9:93
    Content type: Short communication Published on:

  14. Photodynamic therapy (PDT) has been developed as an anticancer treatment, which is based on the tumor-specific accumulation of a photosensitizer that induces cell death after irradiation of light with a specif...

    Authors: Hong-Tai Ji, Li-Ting Chien, Yu-Hsin Lin, Hsiung-Fei Chien and Chin-Tin Chen
    Citation: Molecular Cancer 2010 9:91
    Content type: Research Published on:

  15. Dendritic cells (DCs) are professional antigen presenting cells that initiate specific immune responses against tumor cells. Transcription factor RBP-J-mediated Notch signaling regulates DC genesis, but whethe...

    Authors: Fan Feng, Yao-Chun Wang, Xing-Bin Hu, Xiao-Wei Liu, Gang Ji, Yun-Ru Chen, Lin Wang, Fei He, Guo-Rui Dou, Liang Liang, Hong-Wei Zhang and Hua Han
    Citation: Molecular Cancer 2010 9:90
    Content type: Research Published on:

  16. Castration resistant prostate cancer (CRPC) develops as a consequence of hormone therapies used to deplete androgens in advanced prostate cancer patients. CRPC cells are able to grow in a low androgen environm...

    Authors: Mengqian Chen, Michael A. Feuerstein, Elina Levina, Prateek S. Baghel, Richard D. Carkner, Matthew J. Tanner, Michael Shtutman, Francis Vacherot, Stéphane Terry, Alexandre de la Taille and Ralph Buttyan
    Citation: Molecular Cancer 2010 9:89
    Content type: Research Published on:

  17. Tissue fibrosis is an integral component of chronic inflammatory (liver and pancreas) diseases and pancreatic cancer. Activated pancreatic- (PSC) and hepatic- (HSC) stellate cells play a key role in fibrogenes...

    Authors: Mert Erkan, Nadine Weis, Zheng Pan, Christian Schwager, Tamar Samkharadze, Xiaohua Jiang, Ute Wirkner, Nathalia A. Giese, Wilhelm Ansorge, Jürgen Debus, Peter E. Huber, Helmut Friess, Amir Abdollahi and Jörg Kleeff
    Citation: Molecular Cancer 2010 9:88
    Content type: Research Published on:

  18. TRAIL is considered as a promising anti-cancer agent, because of its ability to induce apoptosis in cancer but not in most normal cells. However, growing evidence exist that many cancer cells are resistant to ...

    Authors: Alena Vaculova, Vitaliy Kaminskyy, Elham Jalalvand, Olga Surova and Boris Zhivotovsky
    Citation: Molecular Cancer 2010 9:87
    Content type: Research Published on:

  19. Insertional mutagenesis screens in the mouse are an acknowledged approach to identify genes involved in the pathogenesis of cancer. The potential of these screens to identify genes causally involved in tumorig...

    Authors: Magdalena Pyrz, Bruce Wang, Matthias Wabl and Finn Skou Pedersen
    Citation: Molecular Cancer 2010 9:86
    Content type: Research Published on:

  20. Most prostate cancer (PCa)-related deaths are due to metastasis, which is mediated in part by chemokine receptor and corresponding ligand interaction. We have previously shown that PCa tissue and cell lines ex...

    Authors: Christelle P. El Haibi, Praveen K. Sharma, Rajesh Singh, Paul R. Johnson, Jill Suttles, Shailesh Singh and James W. Lillard Jr
    Citation: Molecular Cancer 2010 9:85
    Content type: Research Published on:

  21. RGD-motif acts as a specific integrins-ligand and regulates a variety of cell-functions via extracellular action affecting cell-adhesion properties. However, increasing evidence identifies additional RGDS-func...

    Authors: Maria Simona Aguzzi, Paola Fortugno, Claudia Giampietri, Gianluca Ragone, Maurizio C. Capogrossi and Antonio Facchiano
    Citation: Molecular Cancer 2010 9:84
    Content type: Research Published on:

  22. Neuroblastoma is a paediatric cancer of the sympathetic nervous system. The single most important genetic indicator of poor clinical outcome is amplification of the MYCN transcription factor. One of many down-str...

    Authors: Niamh H. Foley, Isabella M. Bray, Amanda Tivnan, Kenneth Bryan, Derek M. Murphy, Patrick G. Buckley, Jacqueline Ryan, Anne O'Meara, Maureen O'Sullivan and Raymond L. Stallings
    Citation: Molecular Cancer 2010 9:83
    Content type: Research Published on:

  23. Our previous studies showed that the expression of the monocyte-chemoattractant protein (MCP)-1, a chemokine, which triggers the infiltration and activation of cells of the monocyte-macrophage lineage, is abro...

    Authors: Katrin Hacke, Bladimiro Rincon-Orozco, Gilles Buchwalter, Simone Y. Siehler, Bohdan Wasylyk, Lisa Wiesmüller and Frank Rösl
    Citation: Molecular Cancer 2010 9:82
    Content type: Research Published on:

  24. Hepatocellular carcinoma (HCC) is one of the most common malignancies worldwide with poor prognosis due to resistance to conventional chemotherapy and limited efficacy of radiotherapy. There is an urgent need ...

    Authors: Fenglian Ren, Hong Wu, Yunlong Lei, Haiyuan Zhang, Rui Liu, Yong Zhao, Xiancheng Chen, Dequan Zeng, Aiping Tong, Lijuan Chen, Yuquan Wei and Canhua Huang
    Citation: Molecular Cancer 2010 9:81
    Content type: Research Published on:

  25. Pancreatic ductal adenocarcinoma (PDAC) is one of the most malignant tumors with a dismal prognosis and no effective conservative therapeutic strategies. Although it is demonstrated that histone deacetylases (...

    Authors: Susanne Schüler, Petra Fritsche, Sandra Diersch, Alexander Arlt, Roland M. Schmid, Dieter Saur and Günter Schneider
    Citation: Molecular Cancer 2010 9:80
    Content type: Research Published on:

  26. Because some of heat shock protein 90's (HSP90) clients are key cell cycle regulators, HSP90 inhibition can affect the cell cycle. Recently, celastrol is identified both as a novel inhibitor of HSP90 and as a ...

    Authors: Bin Peng, Limin Xu, Fanfan Cao, Tingxuan Wei, Chunxin Yang, Georges Uzan and Denghai Zhang
    Citation: Molecular Cancer 2010 9:79
    Content type: Research Published on:

  27. The aim of the present study was to analyze the expression of eukaryotic translation initiation factor 4 gamma 1 (EIF4G1) in nasopharyngeal carcinoma (NPC) and its correlation with clinicopathologic features, inc...

    Authors: Luxia Tu, Zhen Liu, Xiufang He, Ying He, Huiling Yang, Qingping Jiang, Siming Xie, Guanghui Xiao, Xin Li, Kaitai Yao and Weiyi Fang
    Citation: Molecular Cancer 2010 9:78
    Content type: Research Published on:

  28. Survivin is a dual functioning protein. It inhibits the apoptosis of cancer cells by inhibiting caspases, and also promotes cancer cell growth by stabilizing microtubules during mitosis. Since the molecular ch...

    Authors: Chun Hei Antonio Cheung, Huang-Hui Chen, Li-Ting Cheng, Kevin W. Lyu, Jagat R. Kanwar and Jang-Yang Chang
    Citation: Molecular Cancer 2010 9:77
    Content type: Research Published on:

  29. Protein kinase C (PKC) isoforms are potential targets for breast cancer therapy. This study was designed to evaluate which PKC isoforms might be optimal targets for different breast cancer subtypes.

    Authors: Gry Kalstad Lønne, Louise Cornmark, Iris Omanovic Zahirovic, Göran Landberg, Karin Jirström and Christer Larsson
    Citation: Molecular Cancer 2010 9:76
    Content type: Research Published on:

  31. The goal of this study was to understand gene expression signatures of hepatocellular carcinoma (HCC) recurrence in subjects with hepatitis C virus (HCV) infection. Recurrence-free survival (RFS) following cur...

    Authors: Masato Tsuchiya, Joel S. Parker, Hiroshi Kono, Masanori Matsuda, Hideki Fujii and Ivan Rusyn
    Citation: Molecular Cancer 2010 9:74
    Content type: Research Published on:

  32. Tumor necrosis factor alpha (TNFα) has been used to treat certain tumors in clinic trials. However, the curative effect of TNFα has been undermined by the induced-NF-κB activation in many types of tumor. Masli...

    Authors: Chenghai Li, Zhengfeng Yang, Chunyan Zhai, Wenwei Qiu, Dali Li, Zhengfang Yi, Lei Wang, Jie Tang, Min Qian, Jian Luo and Mingyao Liu
    Citation: Molecular Cancer 2010 9:73
    Content type: Research Published on:

  33. PCBP1 (or alpha CP1 or hnRNP E1), a member of the PCBP family, is widely expressed in many human tissues and involved in regulation of transcription, transportation process, and function of RNA molecules. Howe...

    Authors: Tong Zhang, Xian-Hong Huang, Lan Dong, Deqing Hu, Changhui Ge, Yi-Qun Zhan, Wang-Xiang Xu, Miao Yu, Wei Li, Xiaohui Wang, Liujun Tang, Chang-Yan Li and Xiao-Ming Yang
    Citation: Molecular Cancer 2010 9:72
    Content type: Research Published on:

  34. Autotaxin (ATX) is an extracellular lysophospholipase D that generates lysophosphatidic acid (LPA) from lysophosphatidylcholine (LPC). Both ATX and LPA have been shown to be involved in many cancers. However, ...

    Authors: Jian-Min Wu, Yan Xu, Nicholas J. Skill, Hongmiao Sheng, Zhenwen Zhao, Menggang Yu, Romil Saxena and Mary A. Maluccio
    Citation: Molecular Cancer 2010 9:71
    Content type: Research Published on:

  35. Global hypomethylation and genomic instability are cardinal features of cancers. Recently, we established a method for the detection of DNA methylation levels at sites close to endogenous DNA double strand bre...

    Authors: Narisorn Kongruttanachok, Chutipa Phuangphairoj, Araya Thongnak, Wanpen Ponyeam, Prakasit Rattanatanyong, Wichai Pornthanakasem and Apiwat Mutirangura
    Citation: Molecular Cancer 2010 9:70
    Content type: Research Published on:

  36. The endothelin system is implicated in the pathogenesis of melanoma. We evaluated the effects of bosentan - a dual endothelin receptor antagonist - in patients receiving first-line dacarbazine therapy for stag...

    Authors: Richard F. Kefford, Philip R. Clingan, Benjamin Brady, Andrea Ballmer, Adele Morganti and Peter Hersey
    Citation: Molecular Cancer 2010 9:69
    Content type: Research Published on:

  37. Breast cancer is the most frequent cancer in women and consists of a heterogeneous collection of diseases with distinct histopathological, genetic and epigenetic characteristics. In this study, we aimed to ide...

    Authors: Emelyne Dejeux, Jo Anders Rønneberg, Hiroko Solvang, Ida Bukholm, Stephanie Geisler, Turid Aas, Ivo G. Gut, Anne-Lise Børresen-Dale, Per Eystein Lønning, Vessela N. Kristensen and Jörg Tost
    Citation: Molecular Cancer 2010 9:68
    Content type: Research Published on:

  38. Cells are constantly exposed to stresses from cellular metabolites as well as environmental genotoxins. DNA damage caused by these genotoxins can be efficiently fixed by DNA repair in cooperation with cell cyc...

    Authors: Lu Han, Zhishang Hu, Yuheng Liu, Xiangyuan Wang, Kevin M. Hopkins, Howard B. Lieberman and Haiying Hang
    Citation: Molecular Cancer 2010 9:67
    Content type: Research Published on:

  39. High-resolution magic angle spinning (HRMAS) NMR spectroscopy allows detailed metabolic analysis of whole biopsy samples for investigating tumour biology and tumour classification. Accurate biochemical assignm...

    Authors: Alan J. Wright, Greg A. Fellows, John R. Griffiths, M. Wilson, B. Anthony Bell and Franklyn A. Howe
    Citation: Molecular Cancer 2010 9:66
    Content type: Research Published on:

  40. Functional loss of the tumor suppressor Smad4 is involved in pancreatic and colorectal carcinogenesis and has been associated with the acquisition of invasiveness. We have previously demonstrated that the hete...

    Authors: Dirk Zboralski, Bettina Warscheid, Susanne Klein-Scory, M. Bassel Malas, Heiko Becker, Miriam Böckmann, Helmut E Meyer, Wolff Schmiegel, Patricia Simon-Assmann and Irmgard Schwarte-Waldhoff
    Citation: Molecular Cancer 2010 9:65
    Content type: Research Published on:

  41. Many cancerous cells accumulate β-catenin in the nucleus. We examined the role of epidermal growth factor receptor (EGFR) signaling in the accumulation of β-catenin in the nuclei of oral cancer cells.

    Authors: Chien-Hsing Lee, Hsing-Wen Hung, Pei-Hsin Hung and Yi-Shing Shieh
    Citation: Molecular Cancer 2010 9:64
    Content type: Research Published on:

  42. Both mutational inactivation of the adenomatous polyposis coli (APC) tumor suppressor gene and activation of the KRAS oncogene are implicated in the pathogenesis of colorectal cancer. Mice harboring a germline Ap...

    Authors: Mandayam O. Nandan, Amr M. Ghaleb, Beth B. McConnell, Nilesh V. Patel, Sylvie Robine and Vincent W. Yang
    Citation: Molecular Cancer 2010 9:63
    Content type: Research Published on:

  43. MFSD2A (major facilitator superfamily domain containing 2) gene maps on chromosome 1p34 within a linkage disequilibrium block containing genetic elements associated with progression of lung cancer.

    Authors: Monica Spinola, Felicia S. Falvella, Francesca Colombo, James P. Sullivan, David S. Shames, Luc Girard, Paola Spessotto, John D. Minna and Tommaso A. Dragani
    Citation: Molecular Cancer 2010 9:62
    Content type: Research Published on:

  44. Our understanding of the mechanism regulating pancreatic cancer metastatic phenotype is limited. We analyzed the role of RHOA and PRKCZ in the motility attitude of two subclones of the pancreatic adenocarcinom...

    Authors: Marco Della Peruta, Cinzia Giagulli, Carlo Laudanna, Aldo Scarpa and Claudio Sorio
    Citation: Molecular Cancer 2010 9:61
    Content type: Research Published on:

  45. Epithelial Protein Lost in Neoplasm α is a novel cytoskeleton-associated tumor suppressor whose expression inversely correlates with cell growth, motility, invasion and cancer mortality. Here we show that Epli...

    Authors: Laura Leitner, Dmitry Shaposhnikov, Arnaud Descot, Reinhard Hoffmann and Guido Posern
    Citation: Molecular Cancer 2010 9:60
    Content type: Short communication Published on:

  46. Although an increasing number of histone demethylases have been identified and biochemically characterized, their biological functions largely remain uncharacterized, particularly in the context of human disea...

    Authors: Shinya Hayami, Masanori Yoshimatsu, Abhimanyu Veerakumarasivam, Motoko Unoki, Yukiko Iwai, Tatsuhiko Tsunoda, Helen I. Field, John D Kelly, David E. Neal, Hiroki Yamaue, Bruce A. J. Ponder, Yusuke Nakamura and Ryuji Hamamoto
    Citation: Molecular Cancer 2010 9:59
    Content type: Research Published on:

  47. To understand the role of two interacting proteins LIMD1 and pRB in development of head and neck squamous cell carcinoma (HNSCC), alterations of these genes were analyzed in 25 dysplastic head and neck lesions...

    Authors: Susmita Ghosh, Amlan Ghosh, Guru P Maiti, Nupur Mukherjee, Sankhadeep Dutta, Anup Roy, Susanta Roychoudhury and Chinmay K Panda
    Citation: Molecular Cancer 2010 9:58
    Content type: Research Published on:

  48. The mammalian target of rapamycin (mTOR), which exists in two functionally distinct complexes, mTORC1 and mTORC2 plays an important role in tumor growth. Whereas the role of mTORC1 has been well characterized ...

    Authors: Didier Roulin, Yannick Cerantola, Anne Dormond-Meuwly, Nicolas Demartines and Olivier Dormond
    Citation: Molecular Cancer 2010 9:57
    Content type: Short communication Published on:

  49. We have previously shown that nuclear factor (NF)-κ B activation of mouse Lewis lung carcinoma (LLC) specifically promotes the induction of malignant pleural effusions (MPE) by these cells. In the present studies...

    Authors: Ioannis Psallidas, Sophia P Karabela, Charalampos Moschos, Taylor P Sherrill, Androniki Kollintza, Sophia Magkouta, Panagiota Theodoropoulou, Charis Roussos, Timothy S Blackwell, Ioannis Kalomenidis and Georgios T Stathopoulos
    Citation: Molecular Cancer 2010 9:56
    Content type: Research Published on:

  50. Wnt-11 is a secreted protein that modulates cell growth, differentiation and morphogenesis during development. We previously reported that Wnt-11 expression is elevated in hormone-independent prostate cancer a...

    Authors: Pinar Uysal-Onganer, Yoshiaki Kawano, Mercedes Caro, Marjorie M Walker, Soraya Diez, R Siobhan Darrington, Jonathan Waxman and Robert M Kypta
    Citation: Molecular Cancer 2010 9:55
    Content type: Research Published on:
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Molecular Cancer

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