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  1. Content type: Review

    Tumour progression is dependent on the interaction between tumour cells and cells of the surrounding microenvironment. The tumour is a dynamic milieu consisting of various cell types such as endothelial cells,...

    Authors: Sarah M. Ridge, Francis J. Sullivan and Sharon A. Glynn

    Citation: Molecular Cancer 2017 16:31

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  2. Content type: Research

    It is widely recognized that inflammation promotes breast cancer invasion and metastasis. Given the complex nature of the breast tumor inflammatory microenvironment, much remains to be understood of the molecu...

    Authors: Stephanie Tsang Mui Chung, Dirk Geerts, Kim Roseman, Ashleigh Renaud and Linda Connelly

    Citation: Molecular Cancer 2017 16:27

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  3. Content type: Research

    ADAM12 is upregulated in human breast cancers and is a predictor of chemoresistance in estrogen receptor-negative tumors. ADAM12 is induced during epithelial-to-mesenchymal transition, a feature associated wit...

    Authors: Sara Duhachek-Muggy, Yue Qi, Randi Wise, Linda Alyahya, Hui Li, Jacob Hodge and Anna Zolkiewska

    Citation: Molecular Cancer 2017 16:32

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  4. Content type: Research

    Contemporary challenges of prostate cancer (PCa) include overdiagnosis and overtreatment, entailing the need for novel clinical tools to improve risk stratification and therapy selection. PCa diagnosis and pro...

    Authors: Jorge Torres-Ferreira, João Ramalho-Carvalho, Antonio Gomez, Francisco Duarte Menezes, Rui Freitas, Jorge Oliveira, Luís Antunes, Maria José Bento, Manel Esteller, Rui Henrique and Carmen Jerónimo

    Citation: Molecular Cancer 2017 16:26

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  5. Content type: Research

    Pilocytic astrocytomas (PAs) are the most common pediatric central nervous system neoplasms. In the majority of cases these tumors are benign and receive favorable prognosis following gross total surgical rese...

    Authors: Guifa Xi, Yuping Derek Li, Gordan Grahovac, Veena Rajaram, Nitin Wadhwani, Tatiana Pundy, Barbara Mania-Farnell, Charles David James and Tadanori Tomita

    Citation: Molecular Cancer 2017 16:21

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  6. Content type: Research

    Colorectal cancer remains one of the most common malignant tumors worldwide. Colorectal cancer initiating cells (CCICs) are a small subpopulation responsible for malignant behaviors of colorectal cancer. Aberr...

    Authors: Zhenzhen Wen, Tianhui Pan, Saisai Yang, Jingwen Liu, Haiying Tao, Yiming Zhao, Dingting Xu, Wei Shao, Jia Wu, Xiyong Liu, Yongjiang Wang, Jianshan Mao and Yongliang Zhu

    Citation: Molecular Cancer 2017 16:20

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  7. Content type: Review

    CircRNAs are a novel type of RNAs. With the newly developed technology of next-generation sequencing (NGS), especially RNA-seq technology, over 30,000 circRNAs have already been found. Owing to their unique st...

    Authors: Yumin Wang, Yongzhen Mo, Zhaojian Gong, Xiang Yang, Mo Yang, Shanshan Zhang, Fang Xiong, Bo Xiang, Ming Zhou, Qianjin Liao, Wenling Zhang, Xiayu Li, Xiaoling Li, Yong Li, Guiyuan Li, Zhaoyang Zeng…

    Citation: Molecular Cancer 2017 16:25

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  8. Content type: Short communication

    Breast cancer is the major cause of cancer-related mortality in women. It is thought that quiescent stem-like cells within solid tumors are responsible for cancer maintenance, progression and eventual metastas...

    Authors: Sarah T. Boyle, Krystyna A. Gieniec, Carly E. Gregor, Jessica W. Faulkner, Shaun R. McColl and Marina Kochetkova

    Citation: Molecular Cancer 2017 16:19

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  9. Content type: Review

    Radiation therapy is one of the major tools of cancer treatment, and is widely used for a variety of malignant tumours. Radiotherapy causes DNA damage directly by ionization or indirectly via the generation of...

    Authors: Su Yeon Lee, Eui Kyong Jeong, Min Kyung Ju, Hyun Min Jeon, Min Young Kim, Cho Hee Kim, Hye Gyeong Park, Song Iy Han and Ho Sung Kang

    Citation: Molecular Cancer 2017 16:10

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  10. Content type: Review

    Epithelial-to-mesenchymal transition (EMT) is associated with metastasis formation as well as with generation and maintenance of cancer stem cells. In this way, EMT contributes to tumor invasion, heterogeneity...

    Authors: Davide Pradella, Chiara Naro, Claudio Sette and Claudia Ghigna

    Citation: Molecular Cancer 2017 16:8

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  11. Content type: Review

    The insulin-like growth factor-I (IGF-I) signaling induces epithelial to mesenchymal transition (EMT) program and contributes to metastasis and drug resistance in several subtypes of tumors. In preclinical stu...

    Authors: Heming Li, Izhar Singh Batth, Xiujuan Qu, Ling Xu, Na Song, Ruoyu Wang and Yunpeng Liu

    Citation: Molecular Cancer 2017 16:6

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  12. Content type: Review

    Epithelial-mesenchymal transition (EMT) and cancer stem-like cells (CSC) are becoming highly relevant targets in anticancer drug discovery. A large body of evidence suggests that epithelial-mesenchymal transit...

    Authors: Fabrizio Marcucci, Pietro Ghezzi and Cristiano Rumio

    Citation: Molecular Cancer 2017 16:3

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  13. Content type: Review

    Liver cancer is an often fatal malignant tumor with a high recurrence rate and chemoresistance. The major malignant phenotypes of cancer, including recurrence, metastasis, and chemoresistance, are related to t...

    Authors: Kouki Nio, Taro Yamashita and Shuichi Kaneko

    Citation: Molecular Cancer 2017 16:4

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  14. Content type: Research

    Dominant-activating mutations in the RET proto-oncogene, a receptor tyrosine kinase, are responsible for the development of medullary thyroid carcinoma (MTC) and causative for multiple endocrine neoplasia (MEN...

    Authors: Alf Spitschak, Claudia Meier, Bhavani Kowtharapu, David Engelmann and Brigitte M. Pützer

    Citation: Molecular Cancer 2017 16:24

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  15. Content type: Research

    Genetic alterations in chromatin modulators such as BRCA-1 associated protein-1 (BAP1) are the most frequent genetic alteration in intrahepatic cholangiocarcinomas (CCA). We evaluated the contribution of BAP1 ...

    Authors: Mansi Parasramka, Irene K. Yan, Xue Wang, Phuong Nguyen, Akiko Matsuda, Sayantan Maji, Catherine Foye, Yan Asmann and Tushar Patel

    Citation: Molecular Cancer 2017 16:22

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  16. Content type: Research

    The development of chemoresistance and metastasis are the leading causes of death for gastric cancer (GC) patients, however, the molecular mechanisms involved remain unclear. Dysregulation of miRNAs is associa...

    Authors: Jia-Xing Zhang, Yi Xu, Ying Gao, Cui Chen, Zhou-San Zheng, Miao Yun, Hui-Wen Weng, Dan Xie and Sheng Ye

    Citation: Molecular Cancer 2017 16:18

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  17. Content type: Research

    Numerous studies have shown that long non-coding RNAs (lncRNAs) behave as a novel class of transcript during multiple cancer processes, such as cell proliferation, apoptosis, migration, and invasion. LINC00152...

    Authors: Qin-nan Chen, Xin Chen, Zhen-yao Chen, Feng-qi Nie, Chen-chen Wei, Hong-wei Ma, Li Wan, Shuai Yan, Sheng-nan Ren and Zhao-xia Wang

    Citation: Molecular Cancer 2017 16:17

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  18. Content type: Review

    The development of childhood solid tumours is tied to early developmental processes. These tumours may be complex and heterogeneous, and elucidating the aberrant mechanisms that alter the early embryonic envir...

    Authors: Anna L. Leichter, Michael J. Sullivan, Michael R. Eccles and Aniruddha Chatterjee

    Citation: Molecular Cancer 2017 16:15

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  19. Content type: Research

    Breast cancer stem cells (CSCs) are small sub-type of the whole cancer cells that drive tumor initiation, progression and metastasis. Recent studies have demonstrated a role for the aryl hydrocarbon receptor (...

    Authors: Abdullah Al-Dhfyan, Ali Alhoshani and Hesham M. Korashy

    Citation: Molecular Cancer 2017 16:14

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    The Erratum to this article has been published in Molecular Cancer 2017 16:69

  20. Content type: Research

    Diffuse large B-cell lymphoma (DLBCL) is an aggressive and complex disease characterized by wide clinical, phenotypic and molecular heterogeneities. The expression pattern and clinical implication of long non-...

    Authors: Meng Zhou, Hengqiang Zhao, Wanying Xu, Siqi Bao, Liang Cheng and Jie Sun

    Citation: Molecular Cancer 2017 16:16

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  21. Content type: Research

    Cancer metastasis is determined by the formation of the metastatic niche and the ability of cancer cells to adapt to microenvironmental stresses. Anoikis resistance is a fundamental feature of metastatic cance...

    Authors: Celia S. L. Mak, Mingo M. H. Yung, Lynn M. N. Hui, Leanne L. Leung, Rui Liang, Kangmei Chen, Stephanie S. Liu, Yiming Qin, Thomas H. Y. Leung, Kai-Fai Lee, Karen K. L. Chan, Hextan Y. S. Ngan and David W. Chan

    Citation: Molecular Cancer 2017 16:11

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  22. Content type: Research

    Despite advancements in the diagnosis and treatment of colorectal cancer (CRC), many patients die because of tumor metastasis or recurrence. Therefore, identifying new prognostic markers and elucidating the me...

    Authors: Senlin Zhao, Hongcheng Sun, Weiliang Jiang, Yushuai Mi, Dongyuan Zhang, Yugang Wen, Dantong Cheng, Huamei Tang, Shaohan Wu, Yang Yu, Xisheng Liu, Weiyingqi Cui, Meng Zhang, Xiaofeng Sun, Zongguang Zhou, Zhihai Peng…

    Citation: Molecular Cancer 2017 16:12

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  23. Content type: Research

    With more than 600,000 mortalities each year, colorectal cancer (CRC) is the third most commonly diagnosed type of cancer worldwide. Recently, mechanisms involving noncoding RNAs have been implicated in the de...

    Authors: Peng Han, Jing-wen Li, Bo-miao Zhang, Jia-chen Lv, Yong-min Li, Xin-yue Gu, Zhi-wei Yu, Yun-he Jia, Xue-feng Bai, Li Li, Yan-long Liu and Bin-bin Cui

    Citation: Molecular Cancer 2017 16:9

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  24. Content type: Research

    Taurine upregulated gene1 (TUG1) as a 7.1-kb lncRNA, has been shown to play an oncogenic role in various cancers. However, the biological functions of lncRNA TUG1 in small cell lung cancer (SCLC) remain unknow...

    Authors: Yuchun Niu, Feng Ma, Weimei Huang, Shun Fang, Man Li, Ting Wei and Linlang Guo

    Citation: Molecular Cancer 2017 16:5

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  25. Content type: Research

    DNA methylation regulates together with other epigenetic mechanisms the transcriptional activity of genes and is involved in the pathogenesis of malignant diseases including lung cancer. In non-small cell lung...

    Authors: Corinna Altenberger, Gerwin Heller, Barbara Ziegler, Erwin Tomasich, Maximilian Marhold, Thais Topakian, Leonhard Müllauer, Petra Heffeter, György Lang, Adelheid End-Pfützenreuter, Balazs Döme, Britt-Madeleine Arns, Walter Klepetko, Christoph C. Zielinski and Sabine Zöchbauer-Müller

    Citation: Molecular Cancer 2017 16:1

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  26. Content type: Review

    Cell lines are still a tool of choice for many fields of biomedical research, including oncology. Although cancer is a very complex disease, many discoveries have been made using monocultures of established ce...

    Authors: Klaudia K. Brodaczewska, Cezary Szczylik, Michal Fiedorowicz, Camillo Porta and Anna M. Czarnecka

    Citation: Molecular Cancer 2016 15:83

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  27. Content type: Research

    Survivin (encoded by the gene BIRC5) plays an important role in the carcinogenesis of bladder cancer. Identifying miRNAs that target Survivin in the setting of bladder cancer will help to develop Survivin-base...

    Authors: Rong Yang, Minghui Liu, Hongwei Liang, Suhan Guo, Xu Guo, Min Yuan, Huibo Lian, Xiang Yan, Shiwei Zhang, Xi Chen, Feng Fang, Hongqian Guo and Chenyu Zhang

    Citation: Molecular Cancer 2016 15:82

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  28. Content type: Research

    SAG (Sensitive to Apoptosis Gene), also known as RBX2, ROC2 or RNF7, is a RING component of CRL (Cullin-RING ligase), required for its activity. Our recent study showed that SAG/RBX2 co-operated with Kras to p...

    Authors: Mingjia Tan, Jie Xu, Javed Siddiqui, Felix Feng and Yi Sun

    Citation: Molecular Cancer 2016 15:81

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  29. Content type: Research

    STAT3 signaling plays the pivotal role in tumorigenesis through EZH2 epigenetic modification, which enhanced STAT3 activity by increased tyrosine phosphorylation of STAT3. Here, another possible feedback mecha...

    Authors: Yuan-Ming Pan, Cheng-Gang Wang, Min Zhu, Rui Xing, Jian-Tao Cui, Wen-Mei Li, De-Dong Yu, Shu-Bin Wang, Wei Zhu, Ying-Jiang Ye, Yun Wu, Shan Wang and You-Yong Lu

    Citation: Molecular Cancer 2016 15:79

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  30. Content type: Review

    Gastric cancer (GC) ranks the most common cancer types and is one of the leading causes of cancer-related death. Due to delayed diagnosis and high metastatic frequency, 5-year survival rate of GC is rather low...

    Authors: Tingting Huang, Yuhang Zhou, Alfred S. L. Cheng, Jun Yu, Ka Fai To and Wei Kang

    Citation: Molecular Cancer 2016 15:80

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  31. Content type: Research

    Blocking the mechanistic target of rapamycin complex-1 (mTORC1) with chemical inhibitors such as rapamycin has shown limited clinical efficacy in cancer. The tumor microenvironment is characterized by an acidi...

    Authors: Seraina Faes, Adrian P. Duval, Anne Planche, Emilie Uldry, Tania Santoro, Catherine Pythoud, Jean-Christophe Stehle, Janine Horlbeck, Igor Letovanec, Nicolo Riggi, Nicolas Demartines and Olivier Dormond

    Citation: Molecular Cancer 2016 15:78

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  32. Content type: Research

    Lipocalin2 (LCN2) is a secretory protein that is aberrantly expressed in several types of cancer and has been involved in metastatic progression. However, neither mechanisms nor the role that LCN2 plays in the...

    Authors: Meibao Feng, Jieqiong Feng, Wuzhen Chen, Wubin Wang, Xuesong Wu, Jing Zhang, Fangying Xu and Maode Lai

    Citation: Molecular Cancer 2016 15:77

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  33. Content type: Research

    Glioblastomas (GBM) continue to remain one of the most dreaded tumours that are highly infiltrative in nature and easily preclude comprehensive surgical resection. GBMs pose an intricate etiology as they are b...

    Authors: Zahid Nawaz, Vikas Patil, Yashna Paul, Alangar S. Hegde, Arimappamagan Arivazhagan, Vani Santosh and Kumaravel Somasundaram

    Citation: Molecular Cancer 2016 15:74

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  34. Content type: Research

    Triple-negative breast cancer (TNBC) has a high risk of relapse and there are few chemotherapy options. Although 5-hydroxytryptamine (5-HT, serotonin) signaling pathways have been suggested as potential target...

    Authors: Jaya Gautam, Suhrid Banskota, Sushil Chandra Regmi, Subi Ahn, Yong Hyun Jeon, Hyunyoung Jeong, Seung Joo Kim, Tae-gyu Nam, Byeong-Seon Jeong and Jung-Ae Kim

    Citation: Molecular Cancer 2016 15:75

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  35. Content type: Review

    Caveolin-1 (CAV1) is an oncogenic membrane protein associated with endocytosis, extracellular matrix organisation, cholesterol distribution, cell migration and signaling. Recent studies reveal that CAV1 is inv...

    Authors: Zeribe Chike Nwosu, Matthias Philip Ebert, Steven Dooley and Christoph Meyer

    Citation: Molecular Cancer 2016 15:71

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  36. Content type: Research

    In many cancers, microRNAs (miRs) contribute to metastatic progression by modulating phenotypic reprogramming processes such as epithelial-mesenchymal plasticity. This can be driven by miRs targeting multiple ...

    Authors: Miles C. Andrews, Joseph Cursons, Daniel G. Hurley, Matthew Anaka, Jonathan S. Cebon, Andreas Behren and Edmund J. Crampin

    Citation: Molecular Cancer 2016 15:72

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  37. Content type: Letter to the Editor

    It is still controversial whether comprehensive genome screening of target molecules by next generation sequencing (NGS) is needed to increase clinical efficacy of investigational drugs or accelerate drug deve...

    Authors: Yuko Tanabe, Hitoshi Ichikawa, Takashi Kohno, Hiroshi Yoshida, Takashi Kubo, Mamoru Kato, Satoru Iwasa, Atsushi Ochiai, Noboru Yamamoto, Yasuhiro Fujiwara and Kenji Tamura

    Citation: Molecular Cancer 2016 15:73

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  38. Content type: Research

    Treatment options for metastatic castrate-resistant prostate cancer (mCRPC) are limited and typically are centered on docetaxel-based chemotherapy. We previously reported that elevated miR-375 levels were sign...

    Authors: Yuan Wang, Rachel Lieberman, Jing Pan, Qi Zhang, Meijun Du, Peng Zhang, Marja Nevalainen, Manish Kohli, Niraj K. Shenoy, Hui Meng, Ming You and Liang Wang

    Citation: Molecular Cancer 2016 15:70

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  39. Content type: Review

    Cancer Stem cells (CSCs) are a unipotent cell population present within the tumour cell mass. CSCs are known to be highly chemo-resistant, and in recent years, they have gained intense interest as key tumour i...

    Authors: Abhijeet Deshmukh, Kedar Deshpande, Frank Arfuso, Philip Newsholme and Arun Dharmarajan

    Citation: Molecular Cancer 2016 15:69

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  40. Content type: Research

    The CXCL12/CXCR4 axis transactivates HER2 and promotes intraosseous tumor growth. To further explore the transactivation of HER2 by CXCL12, we investigated the role of small GTP protein Gαi2 in Src and HER2 phosp...

    Authors: M. Katie Conley-LaComb, Louie Semaan, Rajareddy Singareddy, Yanfeng Li, Elisabeth I. Heath, Seongho Kim, Michael L. Cher and Sreenivasa R. Chinni

    Citation: Molecular Cancer 2016 15:68

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  41. Content type: Review

    Lung cancer is a leading cause of cancer-related deaths worldwide. Lung cancer risk factors, including smoking and exposure to environmental carcinogens, have been linked to chronic inflammation. An integral f...

    Authors: Erin A. Marshall, Kevin W. Ng, Sonia H. Y. Kung, Emma M. Conway, Victor D. Martinez, Elizabeth C. Halvorsen, David A. Rowbotham, Emily A. Vucic, Adam W. Plumb, Daiana D. Becker-Santos, Katey S. S. Enfield, Jennifer Y. Kennett, Kevin L. Bennewith, William W. Lockwood, Stephen Lam, John C. English…

    Citation: Molecular Cancer 2016 15:67

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  42. Content type: Research

    Nearly one-third of serous ovarian cancer (OVCA) patients will not respond to initial treatment with surgery and chemotherapy and die within one year of diagnosis. If patients who are unlikely to respond to cu...

    Authors: Jesus Gonzalez Bosquet, Andreea M. Newtson, Rebecca K. Chung, Kristina W. Thiel, Timothy Ginader, Michael J. Goodheart, Kimberly K. Leslie and Brian J. Smith

    Citation: Molecular Cancer 2016 15:66

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  43. Content type: Research

    Membrane Type-1 Matrix Metalloproteinase (MT1-MMP) is a multifunctional protease implicated in metastatic progression ostensibly due to its ability to degrade extracellular matrix (ECM) components and allow mi...

    Authors: Mario A. Cepeda, Jacob J. H. Pelling, Caitlin L. Evered, Karla C. Williams, Zoey Freedman, Ioana Stan, Jessica A. Willson, Hon S. Leong and Sashko Damjanovski

    Citation: Molecular Cancer 2016 15:65

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  44. Content type: Research

    A handful of studies have exploited antitumor potential of esculetin, a dihydroxy coumarine derivative; the targets to which it binds and the possible downstream mechanism for its cytotoxicity in cancer cells ...

    Authors: Rashi Arora, Sharad Sawney, Vikas Saini, Chris Steffi, Manisha Tiwari and Daman Saluja

    Citation: Molecular Cancer 2016 15:64

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  45. Content type: Research

    Targeted next generation sequencing (tNGS) has become part of molecular pathology diagnostics for determining RAS mutation status in colorectal cancer (CRC) patients as predictive tool for decision on EGFR-tar...

    Authors: Valentina Kovaleva, Anna-Lena Geissler, Lisa Lutz, Ralph Fritsch, Frank Makowiec, Sebastian Wiesemann, Ulrich T. Hopt, Bernward Passlick, Martin Werner and Silke Lassmann

    Citation: Molecular Cancer 2016 15:63

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