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  1. Approximate 25% HER2-positive (HER2+) breast cancer (BC) patients treated with trastuzumab recurred rapidly. However, the mechanisms underlying trastuzumab resistance remained largely unclear.

    Authors: Yun Ling, Gehao Liang, Qun Lin, Xiaolin Fang, Qing Luo, Yinghuan Cen, Maryam Mehrpour, Ahmed Hamai, Zihao Liu, Yu Shi, Juanmei Li, Wanyi Lin, Shijie Jia, Wenqian Yang, Qiang Liu, Erwei Song…
    Citation: Molecular Cancer 2022 21:8
  2. Dysregulation of long noncoding RNAs (lncRNAs) has been linked to various human cancers. Bcr-Abl oncogene that results from a reciprocal translocation between human chromosome 9 and 22, is associated with several...

    Authors: Yun Ma, Guijie Guo, Tingting Li, Faxin Wen, Jianling Yang, Biao Chen, Xuefei Wang and Ji-Long Chen
    Citation: Molecular Cancer 2022 21:5
  3. Camrelizumab plus chemotherapy significantly prolonged progression-free survival (PFS) and overall survival (OS) compared to chemotherapy alone as first-line treatment in advanced lung squamous cell carcinoma ...

    Authors: Tao Jiang, Jianhua Chen, Xingxiang Xu, Ying Cheng, Gongyan Chen, Yueyin Pan, Yong Fang, Qiming Wang, Yunchao Huang, Wenxiu Yao, Rui Wang, Xingya Li, Wei Zhang, Yanjun Zhang, Sheng Hu, Renhua Guo…
    Citation: Molecular Cancer 2022 21:4
  4. In recent years, the application of functional genetic immuno-oncology screens has showcased the striking ability to identify potential regulators engaged in tumor-immune interactions. Although these screens h...

    Authors: Yan Li, Chen Yang, Zhicheng Liu, Shangce Du, Susan Can, Hailin Zhang, Linmeng Zhang, Xiaowen Huang, Zhenyu Xiao, Xiaobo Li, Jingyuan Fang, Wenxin Qin, Chong Sun, Cun Wang, Jun Chen and Huimin Chen
    Citation: Molecular Cancer 2022 21:2
  5. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Zhongzheng Lu, Yanli Jin, Chun Chen, Juan Li, Qi Cao and Jingxuan Pan
    Citation: Molecular Cancer 2021 20:172

    The original article was published in Molecular Cancer 2010 9:112

  6. Epigenetic mechanisms play vital roles not only in cancer initiation and progression, but also in the activation, differentiation and effector function(s) of immune cells. In this review, we summarize current ...

    Authors: Enyong Dai, Zhi Zhu, Shudipto Wahed, Zhaoxia Qu, Walter J. Storkus and Zong Sheng Guo
    Citation: Molecular Cancer 2021 20:171
  7. Recent studies have revealed the significant dysregulation of m6A level in peripheral blood in several cancer types and its value in diagnosis. Nonetheless, a biomarker for accurate screening of multiple cancer t...

    Authors: Bo Zhang, Zhenmei Chen, Baorui Tao, Chenhe Yi, Zhifei Lin, Yitong Li, Weiqing Shao, Jing Lin and Jinhong Chen
    Citation: Molecular Cancer 2021 20:170
  8. Circular RNAs (circRNAs) have been indicated as potentially critical mediators in various types of tumor progression, generally acting as microRNA (miRNA) sponges to regulate downstream gene expression. Howeve...

    Authors: Cheng-Peng Gui, Bing Liao, Cheng-Gong Luo, Yu-Hang Chen, Lei Tan, Yi-Ming Tang, Jia-Ying Li, Yi Hou, Hong-De Song, Hai-Shan Lin, Quan-Hui Xu, Gao-Sheng Yao, Hao-Hua Yao, Xi-Liu, Jun-Hang Luo, Jia-Zheng Cao…
    Citation: Molecular Cancer 2021 20:169
  9. Craniopharyngioma (CP) is rare histologically benign but clinically challenging tumor because of its intimate relationship with the critical structure in the central brain. CP can be divided into two major his...

    Authors: Juan He, Zhen Zeng, Yuelong Wang, Jiaojiao Deng, Xin Tang, Fujun Liu, Jianhan Huang, Hongxu Chen, Ruichao Liang, Xin Zan, Zhiyong Liu, Aiping Tong, Gang Guo, Jianguo Xu, Xiaofeng Zhu, Liangxue Zhou…
    Citation: Molecular Cancer 2021 20:168
  10. Accumulating studies have revealed that aberrant expression of circular RNAs (circRNAs) is widely involved in the tumorigenesis and progression of malignant cancers, including colorectal cancer (CRC). Neverthe...

    Authors: Tao Jiang, Hongyu Wang, Lianyu Liu, Hu Song, Yi Zhang, Jiaqi Wang, Lei Liu, Teng Xu, Ruizhi Fan, Yixin Xu, Shuai Wang, Linsen Shi, Li Zheng, Renhao Wang and Jun Song
    Citation: Molecular Cancer 2021 20:167
  11. Dysregulation of circular RNAs (circRNAs) plays an important role in the development of gastric cancer; thus, revealing the biological and molecular mechanisms of abnormally expressed circRNAs is critical for ...

    Authors: Dong-Liang Chen, Hui Sheng, Dong-Sheng Zhang, Ying Jin, Bai-Tian Zhao, Nuo Chen, Kang Song and Rui-Hua Xu
    Citation: Molecular Cancer 2021 20:166
  12. Stem Cell leukemia/lymphoma syndrome (SCLL) presents as a myeloproliferative disease which can progress to acute myeloid leukemia and is associated with the coincident development of B-cell and T-cell lymphoma...

    Authors: Baohuan Cai, Yun Liu, Yating Chong, Hualei Zhang, Atsuko Matsunaga, Xuexiu Fang, Rafal Pacholczyk, Gang Zhou, John K. Cowell and Tianxiang Hu
    Citation: Molecular Cancer 2021 20:165
  13. Clinically, prophylactic anti-recurrence treatments for hepatocellular carcinoma (HCC) patients after radical surgery are extremely limited. Neoantigen based vaccine can generate robust anti-tumor immune respo...

    Authors: Zhixiong Cai, Xiaoping Su, Liman Qiu, Zhenli Li, Xiaolou Li, Xiuqing Dong, Fuqun Wei, Yang Zhou, Liuping Luo, Geng Chen, Hengkai Chen, Yingchao Wang, Yongyi Zeng and Xiaolong Liu
    Citation: Molecular Cancer 2021 20:164
  14. Autophagy is a highly conserved catabolic process seen in eukaryotes and is essentially a lysosome-dependent protein degradation pathway. The dysregulation of autophagy is often associated with the pathogenesi...

    Authors: Yu Wang, Jiang Du, Xuemei Wu, Ahmed Abdelrehem, Yu Ren, Chao Liu, Xuan Zhou and Sinan Wang
    Citation: Molecular Cancer 2021 20:163
  15. Cis-diamminedichloro-platinum (CDDP)-based chemotherapy regimens are the most predominant treatment strategies for patients with esophageal squamous cell carcinoma (ESCC). Dysregulated long non-coding RNAs (ln...

    Authors: Yunlong Jia, Cong Tian, Hongyan Wang, Fan Yu, Wei Lv, Yuqing Duan, Zishuo Cheng, Xuexiao Wang, Yu Wang, Tianxu Liu, Jiali Wang and Lihua Liu
    Citation: Molecular Cancer 2021 20:162
  16. Circular RNAs (circRNAs), a class of noncoding RNAs (ncRNAs), may modulate gene expression by binding to miRNAs. Additionally, recent studies show that circRNAs participate in some pathological processes. Howe...

    Authors: Shenglong Li, Fei Liu, Ke Zheng, Wei Wang, Enduo Qiu, Yi Pei, Shuang Wang, Jiaming Zhang and Xiaojing Zhang
    Citation: Molecular Cancer 2021 20:161
  17. Prostate adenocarcinoma (PRAD) is a leading cause of death among men. Messenger ribonucleic acid (mRNA) vaccine presents an attractive approach to achieve satisfactory outcomes; however, tumor antigen screenin...

    Authors: Xiaonan Zheng, Hang Xu, Xianyanling Yi, Tianyi Zhang, Qiang Wei, Hong Li and Jianzhong Ai
    Citation: Molecular Cancer 2021 20:160
  18. Current treatment strategy for kidney renal clear cell carcinoma (KIRC) is limited. Tumor-associated antigens, especially neoantigen-based personalized mRNA vaccines represent new strategies and manifest clini...

    Authors: Hang Xu, Xiaonan Zheng, Shiyu Zhang, Xianyanling Yi, Tianyi Zhang, Qiang Wei, Hong Li and Jianzhong Ai
    Citation: Molecular Cancer 2021 20:159
  19. Circular RNA (circRNA), a subclass of non-coding RNA, plays a critical role in cancer tumorigenesis and metastasis. It has been suggested that circRNA acts as a microRNA sponge or a scaffold to interact with p...

    Authors: Yin Peng, Yidan Xu, Xiaojing Zhang, Shiqi Deng, Yuan Yuan, Xiaonuan Luo, Md Tofazzal Hossain, Xiaohui Zhu, Kaining Du, Fan Hu, Yang Chen, Shanshan Chang, Xianling Feng, Xinmin Fan, Hassan Ashktorab, Duane Smoot…
    Citation: Molecular Cancer 2021 20:158
  20. Non-small cell lung cancer (NSCLC) is the most common type of human lung cancers, which has diverse pathological features. Although many signaling pathways and therapeutic targets have been defined to play imp...

    Authors: Yaomei He, Xiulin Jiang, Lincan Duan, Qiuxia Xiong, Yixiao Yuan, Peishen Liu, Liping Jiang, Qiushuo Shen, Song Zhao, Cuiping Yang and Yongbin Chen
    Citation: Molecular Cancer 2021 20:156
  21. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Weipu Mao, Keyi Wang, Bin Xu, Hui Zhang, Si Sun, Qiang Hu, Lei Zhang, Chunhui Liu, Shuqiu Chen, Jianping Wu, Ming Chen, Wei Li and Bo Peng
    Citation: Molecular Cancer 2021 20:155

    The original article was published in Molecular Cancer 2021 20:142

  22. To identify novel cancer therapies, the tumor microenvironment (TME) has received a lot of attention in recent years in particular with the advent of clinical successes achieved by targeting immune checkpoint ...

    Authors: Chao Li, Adilson Fonseca Teixeira, Hong-Jian Zhu and Peter ten Dijke
    Citation: Molecular Cancer 2021 20:154
  23. Epstein-Barr virus (EBV) represents an important pathogenic factor of lymphoma and is significantly associated with poor clinical outcome of diffuse large B-cell lymphoma (DLBCL). Circular RNAs (circRNAs) play...

    Authors: Chen-xing Zhao, Zi-xun Yan, Jing-jing Wen, Di Fu, Peng-peng Xu, Li Wang, Shu Cheng, Jian-da Hu and Wei-li Zhao
    Citation: Molecular Cancer 2021 20:153
  24. Authors: Matteo Allegretti, Alessandra Fabi, Elena Giordani, Cristiana Ercolani, Paolo Romania, Cecilia Nisticò, Simona Gasparro, Vittoria Barberi, Maria Ciolina, Edoardo Pescarmona, Diana Giannarelli, Gennaro Ciliberto, Francesco Cognetti and Patrizio Giacomini
    Citation: Molecular Cancer 2021 20:151
  25. Accumulation of Foxp3+ regulatory T (Treg) cells in the tumor often represents an important mechanism for cancer immune evasion and a critical barrier to anti-tumor immunity and immunotherapy. Many tumor-infiltra...

    Authors: Michael L. Dixon, Lin Luo, Sadashib Ghosh, Jeffrey M. Grimes, Jonathan D. Leavenworth and Jianmei W. Leavenworth
    Citation: Molecular Cancer 2021 20:150
  26. Although mechanistic studies clarifying the molecular underpinnings of AML have facilitated the development of several novel targeted therapeutics, most AML patients still relapse. Thus, overcoming the inheren...

    Authors: Vijendra Singh, Mohammed Hafiz Uddin, Jeffrey A. Zonder, Asfar S. Azmi and Suresh Kumar Balasubramanian
    Citation: Molecular Cancer 2021 20:149
  27. The Drug Response Gene Expression Associated Map, also referred as “DREAM” (http://​bio-big-data.​cn:​8080/​DREAM), is a manually curated database of experimentally su...

    Authors: Shupeng Li, Lulu Li, Xiangqi Meng, Penggang Sun, Yi Liu, Yuntang Song, Sijia Zhang, Chuanlu Jiang, Jinquan Cai and Zheng Zhao
    Citation: Molecular Cancer 2021 20:148
  28. Authors: Bonan Chen, Wai Nok Chan, Chun Wai Mui, Xiaoli Liu, Jinglin Zhang, Yifei Wang, Alvin H. K. Cheung, Aden K. Y. Chan, Ronald C. K. Chan, Kam Tong Leung, Yujuan Dong, Yi Pan, Huixing Ke, Li Liang, Zhaocai Zhou, Chi Chun Wong…
    Citation: Molecular Cancer 2021 20:147
  29. CD8+ T cells play a critical role in the innate antitumour immune response. Recently, CD8+ T cell dysfunction has been verified in various malignant cancers, including non-small cell lung cancer (NSCLC). However,...

    Authors: Shi-Wei Chen, Shu-Qiang Zhu, Xu Pei, Bai-Quan Qiu, Dian Xiong, Xiang Long, Kun Lin, Feng Lu, Jian-Jun Xu and Yong-Bing Wu
    Citation: Molecular Cancer 2021 20:144
  30. Circular RNAs are a new class of non-coding RNAs that have been shown to play critical roles in the development and progression of renal cell carcinoma (RCC). However, little is known about the functional mech...

    Authors: Weipu Mao, Keyi Wang, Bin Xu, Hui Zhang, Si Sun, Qiang Hu, Lei Zhang, Chunhui Liu, Shuqiu Chen, Jianping Wu, Ming Chen, Wei Li and Bo Peng
    Citation: Molecular Cancer 2021 20:142

    The Correction to this article has been published in Molecular Cancer 2021 20:155

  31. DLC1, a tumor suppressor gene that is downregulated in many cancer types by genetic and nongenetic mechanisms, encodes a protein whose RhoGAP and scaffolding activities contribute to its tumor suppressor functio...

    Authors: Beatriz Sanchez-Solana, Dunrui Wang, Xiaolan Qian, Parthibane Velayoudame, Dhirendra K. Simanshu, Jairaj K. Acharya and Douglas R. Lowy
    Citation: Molecular Cancer 2021 20:141
  32. Autophagy is best known for its role in organelle and protein turnover, cell quality control, and metabolism. The autophagic machinery has, however, also adapted to enable protein trafficking and unconventiona...

    Authors: Martina Raudenska, Jan Balvan and Michal Masarik
    Citation: Molecular Cancer 2021 20:140
  33. Circular RNAs (circRNAs) constitute a family of transcripts with unique structures and have been confirmed to be critical in tumorigenesis and to be potential biomarkers or therapeutic targets. However, only a...

    Authors: Xiaodan Liu, Xiaoping Liu, Mansi Cai, Ailing Luo, Yingyi He, Sha Liu, Xiaohong Zhang, Xu Yang, Ling Xu and Hua Jiang
    Citation: Molecular Cancer 2021 20:139
  34. Emerging studies have revealed the potent functions of circRNAs in breast cancer tumorigenesis. However, the biogenesis, biofunction and mechanism of circRNAs in triple-negative breast cancer (TNBC) are largel...

    Authors: Jie Li, Xinya Gao, Zhanqiang Zhang, Yuanhui Lai, Xunxun Lin, Bo Lin, Maoguang Ma, Xiaoli Liang, Xixi Li, Weiming Lv, Ying Lin and Nu Zhang
    Citation: Molecular Cancer 2021 20:138
  35. Authors: Mathias Dahlmann, Guido Gambara, Bernadette Brzezicha, Oliver Popp, Eva Pachmayr, Lena Wedeken, Alina Pflaume, Margarita Mokritzkij, Safak Gül-Klein, Andreas Brandl, Caroline Schweiger-Eisbacher, Philipp Mertins, Jens Hoffmann, Ulrich Keilholz, Wolfgang Walther, Christian Regenbrecht…
    Citation: Molecular Cancer 2021 20:129
  36. Renal Cell Carcinoma (RCC) is difficult to treat with 5-year survival rate of 10% in metastatic patients. Main reasons of therapy failure are lack of validated biomarkers and scarce knowledge of the biological...

    Authors: Lindsay S. Cooley, Justine Rudewicz, Wilfried Souleyreau, Andrea Emanuelli, Arturo Alvarez-Arenas, Kim Clarke, Francesco Falciani, Maeva Dufies, Diether Lambrechts, Elodie Modave, Domitille Chalopin-Fillot, Raphael Pineau, Damien Ambrosetti, Jean-Christophe Bernhard, Alain Ravaud, Sylvie Négrier…
    Citation: Molecular Cancer 2021 20:136
  37. Authors: Atish Kizhakeyil, Nurmahirah Binte Mohammed Zaini, Zhi Sheng Poh, Brandon Han Siang Wong, Xinpeng Loh, Aik Seng Ng, Zun Siong Low, Praseetha Prasannan, Chun Gong, Michelle Guet Khim Tan, Chandramouli Nagarajan, Dachuan Huang, Pang Wan Lu, Jing Quan Lim, Sharon Barrans, Choon Kiat Ong…
    Citation: Molecular Cancer 2021 20:134
  38. AMP-activated protein kinase (AMPK) is a metabolic sensor that maintains energy homeostasis. AMPK functions as a tumor suppressor in different cancers; however, its role in regulating antitumor immunity, parti...

    Authors: Ram Hari Pokhrel, Suman Acharya, Jae-Hee Ahn, Ye Gu, Mahesh Pandit, Jong-Oh Kim, Yun-Yong Park, Ben Kang, Hyun-Jeong Ko and Jae-Hoon Chang
    Citation: Molecular Cancer 2021 20:133
  39. Hepatocellular carcinoma (HCC) is one of the most intractable tumors in the world due to its high rate of recurrence and heterogeneity. Liver cancer initiating cells also called cancer stem cells (CSCs) play a...

    Authors: Yang Gu, Yanying Wang, Luyun He, Jiahang Zhang, Xiaoxiao Zhu, Nian Liu, Jianyi Wang, Tiankun Lu, Lei He, Yong Tian and Zusen Fan
    Citation: Molecular Cancer 2021 20:132
  40. Cancer-associated fibroblasts (CAFs), a stromal cell population with cell-of-origin, phenotypic and functional heterogeneity, are the most essential components of the tumor microenvironment (TME). Through mult...

    Authors: Xiaoqi Mao, Jin Xu, Wei Wang, Chen Liang, Jie Hua, Jiang Liu, Bo Zhang, Qingcai Meng, Xianjun Yu and Si Shi
    Citation: Molecular Cancer 2021 20:131
  41. Authors: Odile Berthier-Vergnes, Laetitia Barbollat-Boutrand, Roxane M. Pommier, Arnaud de la Fouchardière, Patrick Combemale, Maxime Grimont, Noémie Lopez-Ramirez, Julie Caramel, Stéphane Dalle, Jean-Luc Perrot, Caroline Gaudy-Marqueste, Nicolas Macagno, Sandrine Mansard, Fanny Bouquet and Ingrid Masse
    Citation: Molecular Cancer 2021 20:127

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