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  1. Content type: Research

    High toxicity, morbidity and secondary malignancy render chemotherapy of neuroblastoma inefficient, prompting the search for novel compounds. Nanovesicles offer great promise in imaging and treatment of cancer...

    Authors: Mahaboob K Sulaiman, Zhengtao Chu, Victor M Blanco, Subrahmanya D Vallabhapurapu, Robert S Franco and Xiaoyang Qi

    Citation: Molecular Cancer 2015 14:78

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  2. Content type: Research

    Hepatocellular carcinoma (HCC) is characterized by widespread epidemiological and molecular heterogeneity. Previous work showed that in the western part of North Africa, a region of low incidence of HCC, mutat...

    Authors: Khadija Rebbani, Agnès Marchio, Sayeh Ezzikouri, Rajaa Afifi, Mostafa Kandil, Olfa Bahri, Henda Triki, Abdellah Essaid El Feydi, Anne Dejean, Soumaya Benjelloun and Pascal Pineau

    Citation: Molecular Cancer 2015 14:74

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  3. Content type: Research

    Hedgehog acyltransferase (Hhat) catalyzes the transfer of the fatty acid palmitate onto Sonic Hedgehog (Shh), a modification that is essential for Shh signaling activity. The Shh signaling pathway has been imp...

    Authors: Armine Matevossian and Marilyn D Resh

    Citation: Molecular Cancer 2015 14:72

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  4. Content type: Research

    microRNAs are small noncoding RNAs that modulate a variety of cellular processes by regulating multiple targets, which can promote or inhibit the development of malignant behaviors. Accumulating evidence sugge...

    Authors: Dan He, Jun Wang, Chunfang Zhang, Bin Shan, Xiyun Deng, Bin Li, Yanwu Zhou, Wei Chen, Jidong Hong, Yang Gao, Zhuchu Chen and Chaojun Duan

    Citation: Molecular Cancer 2015 14:73

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  5. Content type: Reviewer acknowledgement

    The editors of Molecular Cancer would like to thank all the reviewers who contributed to the journal in Volume 13 (2014) by participating in the review process.

    Authors: Christophe Nicot and Alan Storey

    Citation: Molecular Cancer 2015 14:70

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  6. Content type: Research

    The tumour microenvironment comprises a network of immune response and vascularization factors. From this network, we identified immunological and vascularization gene expression clusters and the correlations ...

    Authors: Simone Punt, Jeanine J Houwing-Duistermaat, Iris A Schulkens, Victor L Thijssen, Elisabeth M Osse, Cornelis D de Kroon, Arjan W Griffioen, Gert Jan Fleuren, Arko Gorter and Ekaterina S Jordanova

    Citation: Molecular Cancer 2015 14:71

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  7. Content type: Research

    It is known that the MDM2 protein is stabilized when it forms a heterodimer with its partner MDM4, but MDM2 protein stability in its homodimer form is not known. The MDM2 protein contains a C-terminal RING dom...

    Authors: Tao Liu, Hailong Zhang, Jing Xiong, Sha Yi, Lubing Gu and Muxiang Zhou

    Citation: Molecular Cancer 2015 14:65

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  8. Content type: Research

    Survival rates for oesophageal adenocarcinoma (OAC) remain disappointingly poor and current conventional treatment modalities have minimal impact on long-term survival. This is partly due to a lack of understa...

    Authors: Elizabeth F Wiseman, Xi Chen, Namshik Han, Aaron Webber, Zongling Ji, Andrew D Sharrocks and Yeng S Ang

    Citation: Molecular Cancer 2015 14:69

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    The Erratum to this article has been published in Molecular Cancer 2016 15:21

  9. Content type: Research

    Gα13 (GNA13) is the α subunit of a heterotrimeric G protein that mediates signaling through specific G protein-coupled receptors (GPCRs). Our recent study showed that control of GNA13 expression by specific mi...

    Authors: Suhail Ahmed Kabeer Rasheed, Cui Rong Teo, Emmanuel Jean Beillard, P Mathijs Voorhoeve, Wei Zhou, Sujoy Ghosh and Patrick J Casey

    Citation: Molecular Cancer 2015 14:67

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  10. Content type: Research

    The incidence of cutaneous malignant melanoma continues to rise, and once the disease metastasizes it is almost inevitably fatal. We recently reported that a large miRNAs cluster on human chromosome 14q32, imp...

    Authors: Liron Zehavi, Hagit Schayek, Jasmine Jacob-Hirsch, Yechezkel Sidi, Raya Leibowitz-Amit and Dror Avni

    Citation: Molecular Cancer 2015 14:68

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  11. Content type: Research

    PinX1 (PIN2/TRF1-interacting telomerase inhibitor 1) was suggested to be correlated with tumor progression. This study was designed to evaluate the role of PinX1 in human breast cancer.

    Authors: Meilin Shi, Menghan Cao, Jun Song, Qinghua Liu, Hailong Li, Fei Meng, Zhenqiang Pan, Jin Bai and Junnian Zheng

    Citation: Molecular Cancer 2015 14:66

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  12. Content type: Research

    TGFβ-induced (TGFBI/βig-H3) is a protein inducible by TGFβ1 and secreted by many types of cells. It binds to collagen, forms part of the extracellular matrix (ECM), and interacts with integrins on cell surface...

    Authors: Bing Han, Haolei Cai, Ying Chen, Bing Hu, Hongyu Luo, Yulian Wu and Jiangping Wu

    Citation: Molecular Cancer 2015 14:64

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  13. Content type: Research

    The Warburg effect describes the increased reliance of tumor cells on glycolysis for ATP generation. Mitochondrial respiratory defect is thought to be an important factor leading to the Warburg effect in some ...

    Authors: Xiang Zhou, Ruohua Chen, Zhenhai Yu, Rui Li, Jiajin Li, Xiaoping Zhao, Shaoli Song, Jianjun Liu and Gang Huang

    Citation: Molecular Cancer 2015 14:63

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  14. Content type: Research

    Patients with high-risk neuroblastoma (NBL) tumors have a high mortality rate. Consequently, there is an urgent need for the development of new treatments for this condition. Targeting death receptor signaling...

    Authors: Koen MO Galenkamp, Paulina Carriba, Jorge Urresti, Laura Planells-Ferrer, Elena Coccia, Joaquín Lopez-Soriano, Bruna Barneda-Zahonero, Rana S Moubarak, Miguel F Segura and Joan X Comella

    Citation: Molecular Cancer 2015 14:62

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  15. Content type: Research

    The calcium sensing receptor (CaSR), a calcium-binding G protein-coupled receptor is expressed also in tissues not directly involved in calcium homeostasis like the colon. We have previously reported that CaSR...

    Authors: Abhishek Aggarwal, Maximilian Prinz-Wohlgenannt, Charlotte Gröschel, Samawansha Tennakoon, Anastasia Meshcheryakova, Wenhan Chang, Edward M Brown, Diana Mechtcheriakova and Enikö Kállay

    Citation: Molecular Cancer 2015 14:61

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  16. Content type: Research

    KCNJ2/Kir2.1, a member of the classical inwardly rectifying potassium channel family, is commonly expressed in a wide range of tissues and cell types. Previous studies indicated that Kir2.1 may be associated w...

    Authors: Huanxin Liu, Jie Huang, Juan Peng, Xiaoxia Wu, Yan Zhang, Weiliang Zhu and Linlang Guo

    Citation: Molecular Cancer 2015 14:59

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  17. Content type: Research

    Patients with hematogenous metastatic lung cancer displayed significantly increased platelet count and aggregation compared to lung cancer patients without hematogenous metastasis. The mechanism underlying the...

    Authors: Hongwei Liang, Xin Yan, Yi Pan, Yongsheng Wang, Nan Wang, Limin Li, Yuan Liu, Xi Chen, Chen-Yu Zhang, Hongwei Gu and Ke Zen

    Citation: Molecular Cancer 2015 14:58

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  18. Content type: Research

    Epithelial ovarian cancer (EOC) is a significant cause of morbidity and mortality. MicroRNAs play important roles in cancer development and progression. The microRNA miR-211 is localized on intron 6 of the Trpm1 ...

    Authors: Bairong Xia, Shanshan Yang, Tianbo Liu and Ge Lou

    Citation: Molecular Cancer 2015 14:57

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  19. Content type: Research

    Acute myeloid leukemia (AML) is initiated and maintained by a subset of self-renewing leukemia stem cells (LSCs), which contribute to the progression, recurrence and therapeutic resistance of leukemia. However...

    Authors: Yi Zhang, Hai-xuan Chen, Shu-yan Zhou, Shao-xiang Wang, Kai Zheng, Dan-dan Xu, Yu-ting Liu, Xiao-yan Wang, Xiao Wang, Hai-zhao Yan, Li Zhang, Qiu-ying Liu, Wan-qun Chen and Yi-fei Wang

    Citation: Molecular Cancer 2015 14:56

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  20. Content type: Research

    Enhancer of zeste homolog 2 (EZH2) is a key epigenetic regulator in cancer cell survival, epithelial-mesenchymal transition, and tumorigenesis. Inhibition of EZH2 has become a promising therapeutic option for ...

    Authors: Pingyu Zhang, Xianbin Yang, Xiaoyan Ma, Davis R Ingram, Alexander J Lazar, Keila E Torres and Raphael E Pollock

    Citation: Molecular Cancer 2015 14:55

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  21. Content type: Short communication

    Squamous cell carcinoma (SCC) is the most common type of tongue and larynx cancer and a common type of lung cancer. In this study, we attempted to specifically evaluate the signaling pathway underlying HGF/Met...

    Authors: Simone Gusenbauer, Emanuele Zanucco, Pjotr Knyazev and Axel Ullrich

    Citation: Molecular Cancer 2015 14:54

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  22. Content type: Research

    The type I insulin-like growth factor receptor (IGF-IR) tyrosine kinase promotes the survival of an aggressive subtype of T-cell lymphoma by interacting with nucleophosmin-anaplastic lymphoma kinase (NPM-ALK) ...

    Authors: Deeksha Vishwamitra, Choladda V Curry, Serhan Alkan, Yao-Hua Song, Gary E Gallick, Ahmed O Kaseb, Ping Shi and Hesham M Amin

    Citation: Molecular Cancer 2015 14:53

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  23. Content type: Research

    MicroRNAs (miRNAs) have been reported to play an important role in tumorigenesis. In this study, the role of miR-15a and miR-16-1 in gastric adenocarcinoma (GAC) was investigated.

    Authors: Wei Kang, Joanna HM Tong, Raymond WM Lung, Yujuan Dong, Junhong Zhao, Qiaoyi Liang, Li Zhang, Yi Pan, Weiqin Yang, Jesse CS Pang, Alfred SL Cheng, Jun Yu and Ka Fai To

    Citation: Molecular Cancer 2015 14:52

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  24. Content type: Research

    Non alcoholic fatty liver disease (NAFLD) is one of the most common liver diseases in the United States and worldwide. Our studies have previously shown an increase in metastatic burden in steatotic vs. normal...

    Authors: Alisha M Mendonsa, Michael N VanSaun, Alessandro Ustione, David W Piston, Barbara M Fingleton and David Lee Gorden

    Citation: Molecular Cancer 2015 14:49

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  25. Content type: Research

    Long noncoding RNAs (lncRNAs) have emerged recently as a new class of genes that regulate cellular processes, such as cell growth and apoptosis. The SPRY4 intronic transcript 1 (SPRY4-IT1) is a 708-bp lncRNA o...

    Authors: Yongguo Shi, Juan Li, Yangchen Liu, Jie Ding, Yingrui Fan, Yun Tian, Li Wang, Yifan Lian, Keming Wang and Yongqian Shu

    Citation: Molecular Cancer 2015 14:51

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  26. Content type: Research

    Metastasis is a process where only a small subset of cells is capable of successfully migrating to and propagating at secondary sites. TGF-β signalling is widely known for its role in cancer metastasis and is ...

    Authors: Rodney B Luwor, Dulani Hakmana, Josephine Iaria, Thao V Nheu, Richard J Simpson and Hong-Jian Zhu

    Citation: Molecular Cancer 2015 14:50

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  27. Content type: Review

    Metastasis is a crucial hallmark of cancer progression, which involves numerous factors including the degradation of the extracellular matrix (ECM), the epithelial-to-mesenchymal transition (EMT), tumor angiog...

    Authors: Zhenyi Su, Zuozhang Yang, Yongqing Xu, Yongbin Chen and Qiang Yu

    Citation: Molecular Cancer 2015 14:48

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  28. Content type: Research

    Recent studies have revealed the potential roles of intelectin 1 (ITLN1) in tumorigenesis. However, its functions and underlying mechanisms in neuroblastoma (NB), the most common extracranial solid tumor in ch...

    Authors: Dan Li, Hong Mei, Jiarui Pu, Xuan Xiang, Xiang Zhao, Hongxia Qu, Kai Huang, Liduan Zheng and Qiangsong Tong

    Citation: Molecular Cancer 2015 14:47

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  29. Content type: Short communication

    Long non-coding RNAs (lncRNAs) can orchestrate oncogenic or tumor-suppressive functions in cancer biology. Accordingly, PCGEM1 and PRNCR1 were implicated in progression of prostate cancer (PCa) as transcriptional...

    Authors: Abhijit Parolia, Francesco Crea, Hui Xue, Yuwei Wang, Fan Mo, Varune Rohan Ramnarine, Hui Hsuan Liu, Dong Lin, Nur Ridzwan Nur Saidy, Pier-Luc Clermont, Hongwei Cheng, Colin Collins, Yuzhuo Wang and Cheryl D Helgason

    Citation: Molecular Cancer 2015 14:46

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  30. Content type: Research

    The VEGF pathway has become an important therapeutic target in lung cancer, where VEGF has long been established as a potent pro-angiogenic growth factor expressed by many types of tumors. While Bevacizumab (A...

    Authors: Martin P Barr, Steven G Gray, Kathy Gately, Emily Hams, Padraic G Fallon, Anthony Mitchell Davies, Derek J Richard, Graham P Pidgeon and Kenneth J O’Byrne

    Citation: Molecular Cancer 2015 14:45

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  31. Content type: Research

    The objective of this study was to investigate the expression and clinical role of 14 genes previously shown to be associated with chemotherapy response and/or progression-free survival in a smaller series of ...

    Authors: Dag Andre Nymoen, Arild Holth, Thea E Hetland Falkenthal, Claes G Tropé and Ben Davidson

    Citation: Molecular Cancer 2015 14:44

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  32. Content type: Research

    Nucleoporins mediate nucleocytoplasmic exchange of macromolecules and several have been assigned active mitotic functions. Nucleoporins can participate in various mitotic functions like spindle assembly, kinet...

    Authors: Sumana Bhattacharjya, Kumar Singha Roy, Abira Ganguly, Shreya Sarkar, Chinmay K Panda, Dibyendu Bhattacharyya, Nitai P Bhattacharyya and Susanta Roychoudhury

    Citation: Molecular Cancer 2015 14:42

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  33. Content type: Research

    Glioblastoma is the most malignant human brain tumor and has a dismal prognosis; however, some patients show long-term survival. The interaction between the costimulatory molecule OX40 and its ligand OX40L gen...

    Authors: Ichiyo Shibahara, Ryuta Saito, Rong Zhang, Masashi Chonan, Takuhiro Shoji, Masayuki Kanamori, Yukihiko Sonoda, Toshihiro Kumabe, Masahiko Kanehira, Toshiaki Kikuchi, Takanori So, Takashi Watanabe, Hiroaki Takahashi, Erina Iwabuchi, Yuetsu Tanaka, Yukiko Shibahara…

    Citation: Molecular Cancer 2015 14:41

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  34. Content type: Review

    IGF-1 is a potent mitogen of major importance in the mammary gland. IGF-1 binding to the cognate receptor, IGF-1R, triggers a signaling cascade leading to proliferative and anti-apoptotic events. Although many...

    Authors: Panagiotis F Christopoulos, Pavlos Msaouel and Michael Koutsilieris

    Citation: Molecular Cancer 2015 14:43

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  35. Content type: Research

    Normal epithelial cells and carcinoma cells can acquire invasiveness by epithelial-to-mesenchymal transition (EMT), a process of considerable cellular remodeling. The endosomal/lysosomal compartment is a princ...

    Authors: Ursula Kern, Vladimir Wischnewski, Martin L Biniossek, Oliver Schilling and Thomas Reinheckel

    Citation: Molecular Cancer 2015 14:39

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  36. Content type: Short Communication

    Cancer cell lines have a prominent role in the initial stages of drug discovery, facilitating high-throughput screening of potential drugs. However, their clinical relevance remains controversial.

    Authors: Samira Jaeger, Miquel Duran-Frigola and Patrick Aloy

    Citation: Molecular Cancer 2015 14:40

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  37. Content type: Short communication

    The metastasis-associated in colon cancer 1 (MACC1) gene has been identified as prognostic biomarker for colorectal cancer (CRC). Here, we aimed at the refinement of risk assessment by separate and combined su...

    Authors: Katharina Ilm, Wolfgang Kemmner, Marc Osterland, Susen Burock, Gudrun Koch, Pia Herrmann, Peter M Schlag and Ulrike Stein

    Citation: Molecular Cancer 2015 14:38

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  38. Content type: Research

    miR-663 is associated with many important biologic processes, such as the evolution, development, viral infection, inflammatory response, and carcinogenesis among vertebrates. However, the molecular function a...

    Authors: Wenqiao Zang, Yuanyuan Wang, Tao Wang, Yuwen Du, Xiaonan Chen, Min Li and Guoqiang Zhao

    Citation: Molecular Cancer 2015 14:37

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  39. Content type: Research

    Inflammatory cytokines and transforming growth factor-β (TGF-β) are mutually inhibitory. However, hyperactivation of nuclear factor-κB (NF-κB) and TGF-β signaling both emerge in glioblastoma. Here, we report m...

    Authors: Hui Wang, Jian-Qing Pan, Lun Luo, Xin-jie Ning, Zhuo-Peng Ye, Zhe Yu and Wen-Sheng Li

    Citation: Molecular Cancer 2015 14:2

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  40. Content type: Research

    MicroRNAs (miRNAs) are short, non-coding RNA molecules that play critical roles in human malignancy. However, the regulatory characteristics of miRNAs in triple-negative breast cancer, a phenotype of breast ca...

    Authors: Yao-Yin Chang, Wen-Hung Kuo, Jui-Hui Hung, Chien-Yueh Lee, Yung-Hua Lee, Ya-Chu Chang, Wen-Chun Lin, Cheng-Ying Shen, Chiun-Sheng Huang, Fon-Jou Hsieh, Liang-Chuan Lai, Mong-Hsun Tsai, King-Jen Chang and Eric Y Chuang

    Citation: Molecular Cancer 2015 14:36

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  41. Content type: Review

    Cancer is an exceedingly complex disease that is orchestrated and driven by a combination of multiple aberrantly regulated processes. The nature and depth of involvement of individual events vary between cance...

    Authors: Anna Maria Rusek, Mohammed Abba, Andrzej Eljaszewicz, Marcin Moniuszko, Jacek Niklinski and Heike Allgayer

    Citation: Molecular Cancer 2015 14:34

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  42. Content type: Research

    In complex with its cofactor UAF1, the USP1 deubiquitinase plays an important role in cellular processes related to cancer, including the response to DNA damage. The USP1/UAF1 complex is emerging as a novel ta...

    Authors: Anne Olazabal-Herrero, Iraia García-Santisteban and Jose Antonio Rodríguez

    Citation: Molecular Cancer 2015 14:33

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  43. Content type: Research

    Migration of breast cancer cells out of a duct or lobule is a prerequisite for invasion and metastasis. However, the factors controlling breast cancer cell migration are not fully elucidated. We previously fou...

    Authors: Erica Maria Pimenta and Betsy J Barnes

    Citation: Molecular Cancer 2015 14:32

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  44. Content type: Research

    An increasing amount of evidence has revealed that microRNAs regulate various biological processes, including cell differentiation, cell proliferation, apoptosis, drug resistance, and fat metabolism. Studies h...

    Authors: Xi Chen, Shuo Chen, Yin-Ling Xiu, Kai-Xuan Sun, Zhi-Hong Zong and Yang Zhao

    Citation: Molecular Cancer 2015 14:31

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  45. Content type: Research

    The poor prognosis and minimally successful treatments of malignant glioma indicate a challenge to identify new therapeutic targets which impact glioma progression. Neurotensin (NTS) and its high affinity rece...

    Authors: Qing Ouyang, Xueyang Gong, Hualiang Xiao, Ji Zhou, Minhui Xu, Yun Dai, Lunshan Xu, Hua Feng, Hongjuan Cui and Liang Yi

    Citation: Molecular Cancer 2015 14:21

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  46. Content type: Research

    Tumor metastasis is responsible for 90% of cancer-related deaths. Recently, a strong link between microRNA dysregulation and human cancers has been established. However, the molecular mechanisms through which ...

    Authors: Rainelli B Koumangoye, Thomas Andl, Kenneth J Taubenslag, Steven T Zilberman, Chase J Taylor, Holli A Loomans and Claudia D Andl

    Citation: Molecular Cancer 2015 14:24

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  47. Content type: Research

    The underlying mechanisms of carcinogenesis and gender disparity in hepatitis B virus (HBV)-induced hepatocellular carcinoma (HCC) remain unclear. Recently, we reported a novel HCC-related W4P/R mutation in th...

    Authors: Seoung-Ae Lee, Hong Kim, You-Sub Won, Seung-Hyeok Seok, YiRang Na, Han-Bo Shin, Kyung-Soo Inn and Bum-Joon Kim

    Citation: Molecular Cancer 2015 14:23

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