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  1. Content type: Research

    Activating mutations in KRAS are prevalent in lung cancer and have been causally linked to the oncogenic process. However, therapies targeted to oncogenic RAS have been ineffective to date and identification o...

    Authors: Edmilson Ozorio dos Santos, Tatiana Correa Carneiro-Lobo, Mateus Nobrega Aoki, Elena Levantini and Daniela Sanchez Bassères

    Citation: Molecular Cancer 2016 15:12

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  2. Content type: Research

    NF-κB signaling pathway plays an important role in gastric carcinogenesis. The basic expression and functional role of NFKB1 and RELA (components of canonical NF-κB pathway) in gastric cancer (GC) have not bee...

    Authors: Tingting Huang, Wei Kang, Bin Zhang, Feng Wu, Yujuan Dong, Joanna H. M. Tong, Weiqin Yang, Yuhang Zhou, Li Zhang, Alfred S. L. Cheng, Jun Yu and Ka Fai To

    Citation: Molecular Cancer 2016 15:9

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  3. Content type: Research

    Detachment of epithelial cells from the extracellular matrix initiates programmed cell death by a process termed anoikis. Malignant cells must acquire anoikis resistance to leave the primary tumour and metasta...

    Authors: Brendan C. Luey and Felicity E. B. May

    Citation: Molecular Cancer 2016 15:8

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  4. Content type: Research

    Cancer associated fibroblasts (CAF) play important roles in tumor growth that involves inflammation and epithelial cell differentiation. Early studies suggested that estrogen receptor alpha (ERα) was expressed...

    Authors: Chiuan-Ren Yeh, Spencer Slavin, Jun Da, Iawen Hsu, Jie Luo, Guang-Qian Xiao, Jie Ding, Fu-Ju Chou and Shuyuan Yeh

    Citation: Molecular Cancer 2016 15:7

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  5. Content type: Review

    PIWI-interacting RNAs (piRNAs) are emerging players in cancer genomics. Originally described in the germline, there are over 20,000 piRNA genes in the human genome. In contrast to microRNAs, piRNAs interact wi...

    Authors: Kevin W. Ng, Christine Anderson, Erin A. Marshall, Brenda C. Minatel, Katey S. S. Enfield, Heather L. Saprunoff, Wan L. Lam and Victor D. Martinez

    Citation: Molecular Cancer 2016 15:5

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  6. Content type: Research

    Circadian disruption and deranged molecular clockworks are involved in carcinogenesis. The cryptochrome genes (CRY1 and CRY2) encode circadian proteins important for the functioning of biological oscillators. The...

    Authors: Gianluigi Mazzoccoli, Tommaso Colangelo, Anna Panza, Rosa Rubino, Angelo De Cata, Cristiana Tiberio, Maria Rosa Valvano, Valerio Pazienza, Giuseppe Merla, Bartolomeo Augello, Domenico Trombetta, Clelia Tiziana Storlazzi, Gemma Macchia, Annamaria Gentile, Francesca Tavano, Manlio Vinciguerra…

    Citation: Molecular Cancer 2016 15:6

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  7. Content type: Review

    As our knowledge of cancer metabolism has increased, it has become apparent that cancer metabolic processes are extremely heterogeneous. The reasons behind this heterogeneity include genetic diversity, the exi...

    Authors: Debanti Sengupta and Guillem Pratx

    Citation: Molecular Cancer 2016 15:4

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  8. Content type: Research

    Initially identified as a molecule that regulates the final step of glycolysis, the M2 isoform of pyruvate kinase (PKM2) was recently reported to have a central role in the metabolic reprogramming of cancer ce...

    Authors: Ninel Azoitei, Alexander Becher, Konrad Steinestel, Arefeh Rouhi, Kristina Diepold, Felicitas Genze, Thomas Simmet and Thomas Seufferlein

    Citation: Molecular Cancer 2016 15:3

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  9. Content type: Research

    Zinc (Zn) hyper-accumulates in breast tumors and malignant cell lines compared to normal mammary epithelium. The mechanisms responsible for Zn accumulation and the consequence of Zn dysregulation are poorly un...

    Authors: Paige Chandler, Bose S. Kochupurakkal, Samina Alam, Andrea L. Richardson, David I. Soybel and Shannon L. Kelleher

    Citation: Molecular Cancer 2016 15:2

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  10. Content type: Research

    Neuroblastoma is a malignant embryonal tumor occurring in young children, consisting of undifferentiated neuroectodermal cells derived from the neural crest. Current therapies for high-risk neuroblastoma are i...

    Authors: Constanza L. Cortes, Sonia R. Veiga, Eugènia Almacellas, Javier Hernández-Losa, Joan C. Ferreres, Sara C. Kozma, Santiago Ambrosio, George Thomas and Albert Tauler

    Citation: Molecular Cancer 2016 15:1

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  11. Content type: Research

    A new class of non-coding RNAs, known as long non-coding RNAs (lncRNAs), has been recently described. These lncRNAs are implicated to play pivotal roles in various molecular processes, including development an...

    Authors: Norma I. Rodríguez-Malavé, Thilini R. Fernando, Parth C. Patel, Jorge R. Contreras, Jayanth Kumar Palanichamy, Tiffany M. Tran, Jaime Anguiano, Michael J. Davoren, Michael O. Alberti, Kimanh T. Pioli, Salemiz Sandoval, Gay M. Crooks and Dinesh S. Rao

    Citation: Molecular Cancer 2015 14:214

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  12. Content type: Research

    Abnormal activation of STAT3 and miR-21 plays a vital role in progression and invasion of solid tumors. The cyclin-dependent kinase 5 (CDK5) is reported to contribute to cancer metastasis by regulating epithel...

    Authors: Shan-Shan Sun, Xuan Zhou, Yuan-Yuan Huang, Ling-Ping Kong, Mei Mei, Wen-Yu Guo, Ming-Hui Zhao, Yu Ren, Qiang Shen and Lun Zhang

    Citation: Molecular Cancer 2015 14:213

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  13. Content type: Research

    Pancreatic acinar cell carcinoma (ACC) is a rare tumor entity with an unfavorable prognosis. Recent whole-exome sequencing identified p53 mutations in a subset of human ACC. Activation of the mammalian target ...

    Authors: Bo Kong, Tao Cheng, Chengjia Qian, Weiwei Wu, Katja Steiger, Jing Cao, Anna Melissa Schlitter, Ivonne Regel, Susanne Raulefs, Helmut Friess, Mert Erkan, Irene Esposito, Jörg Kleeff and Christoph W. Michalski

    Citation: Molecular Cancer 2015 14:212

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  14. Content type: Research

    The limited efficacy of current treatments against pancreatic cancer has prompted the search of new alternatives such as virotherapy. Activation of the immune response against cancer cells is emerging as one o...

    Authors: Estanislao Nistal-Villan, Maria Bunuales, Joanna Poutou, Manuela Gonzalez-Aparicio, Carlos Bravo-Perez, Jose I. Quetglas, Beatriz Carte, Gloria Gonzalez-Aseguinolaza, Jesus Prieto, Esther Larrea and Ruben Hernandez-Alcoceba

    Citation: Molecular Cancer 2015 14:210

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  15. Content type: Letter to the Editor

    Through a combined approach integrating RNA-Seq, SNP-array, FISH and PCR techniques, we identified two novel t(15;21) translocations leading to the inactivation of RUNX1 and its partners SIN3A and TCF12. One is a...

    Authors: Alberto L’Abbate, Doron Tolomeo, Francesca De Astis, Angelo Lonoce, Crocifissa Lo Cunsolo, Dominique Mühlematter, Jacqueline Schoumans, Peter Vandenberghe, Achilles Van Hoof, Orazio Palumbo, Massimo Carella, Tommaso Mazza and Clelia Tiziana Storlazzi

    Citation: Molecular Cancer 2015 14:211

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  16. Content type: Research

    Tamoxifen (TAM) and fulvestrant (FUL) are the major drugs for patients with estrogen receptor-positive (ER+) breast cancers. However, the development of endocrine resistance is the impediment for successful treat...

    Authors: Xinfeng Yu, Aiping Luo, Yicong Liu, Shuqing Wang, Ye Li, Wenna Shi, Zhihua Liu and Xianjun Qu

    Citation: Molecular Cancer 2015 14:208

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  17. Content type: Research

    The clinical application of TRAIL receptor agonists as a novel cancer therapy has been tempered by heterogeneity in tumour responses. This is illustrated in breast cancer, where TRAIL is cytotoxic in cell line...

    Authors: Rhiannon French, Olivia Hayward, Samuel Jones, William Yang and Richard Clarkson

    Citation: Molecular Cancer 2015 14:209

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  18. Content type: Review

    Diffuse large B-cell lymphoma (DLBCL) is a clinically heterogeneous lymphoid malignancy and the most common subtype of non-Hodgkin’s lymphoma in adults, with one of the highest mortality rates in most develope...

    Authors: Rosalba Camicia, Hans C. Winkler and Paul O. Hassa

    Citation: Molecular Cancer 2015 14:207

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  19. Content type: Research

    Wnt/β-catenin signaling is often portrayed as a simple pathway that is initiated by Wnt ligand at the cell surface leading, via linear series of interactions between ‘core pathway’ members, to the induction of...

    Authors: Jamie Freeman, David Smith, Branko Latinkic, Ken Ewan, Lee Samuel, Massimo Zollo, Natascia Marino, Lorraine Tyas, Nick Jones and Trevor C. Dale

    Citation: Molecular Cancer 2015 14:206

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  20. Content type: Research

    A promising therapeutic approach for aggressive B-cell Non-Hodgkin lymphoma (NHL), including diffuse large B-cell lymphoma (DLBCL), and Burkitt lymphoma (BL) is to target kinases involved in signal transductio...

    Authors: S. Kreuz, K. B. Holmes, R. M. Tooze and P. F. Lefevre

    Citation: Molecular Cancer 2015 14:205

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  21. Content type: Research

    An inverse correlation between expression of the aldehyde dehydrogenase 1 subfamily A2 (ALDH1A2) and gene promoter methylation has been identified as a common feature of oropharyngeal squamous cell carcinoma (...

    Authors: Katharina Seidensaal, Andre Nollert, Agnes Hiou Feige, Marie Muller, Thomas Fleming, Nikolas Gunkel, Karim Zaoui, Niels Grabe, Wilko Weichert, Klaus-Josef Weber, Peter Plinkert, Christian Simon and Jochen Hess

    Citation: Molecular Cancer 2015 14:204

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  22. Content type: Research

    Pancreatic ductal adenocarcinoma (PDAC) is presently one of the cancers with the worst survival rates and least effective treatments. Moreover, total deaths due to PDAC are predicted to increase in the next 15...

    Authors: Andrea Giannuzzo, Stine Falsig Pedersen and Ivana Novak

    Citation: Molecular Cancer 2015 14:203

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  23. Content type: Research

    Despite the declining incidence of gastric cancer, mortality rate remains high due to late presentation. We aimed to evaluate the sensitivity of miRNA as a diagnostic marker for gastric cancer in the circulation.

    Authors: Vivian Yvonne Shin, Enders K. O. Ng, Vivian W. Chan, Ava Kwong and Kent-Man Chu

    Citation: Molecular Cancer 2015 14:202

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