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  1. Amplification of chromosome 7q21-7q31 is associated with tumor recurrence and multidrug resistance, and several genes in this region are powerful drivers of hepatocellular carcinoma (HCC). We aimed to investig...

    Authors: Xiao-Yong Huang, Peng-Fei Zhang, Chuan-Yuan Wei, Rui Peng, Jia-Cheng Lu, Chao Gao, Jia-Bing Cai, Xuan Yang, Jia Fan, Ai-Wu Ke, Jian Zhou and Guo-Ming Shi

    Citation: Molecular Cancer 2020 19:92

    Content type: Research

    Published on:

  2. N6-methyladenosine (m6A) is the most abundant reversible methylation modification of eukaryotic mRNA, and it plays vital roles in tumourigenesis. This study aimed to explore the role of the m6A demethylase ALK...

    Authors: Xingya Guo, Kai Li, Weiliang Jiang, Yangyang Hu, Wenqin Xiao, Yinshi Huang, Yun Feng, Qin Pan and Rong Wan

    Citation: Molecular Cancer 2020 19:91

    Content type: Research

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  3. Non-small cell lung cancer (NSCLC) patients with activating EGFR mutations initially respond to first-generation EGFR inhibitors; however, the efficacy of these drugs is limited by acquired resistance driven b...

    Authors: Tao Zhang, Rong Qu, Shingpan Chan, Mengzhen Lai, Linjiang Tong, Fang Feng, Hongyu Chen, Tingting Song, Peiran Song, Gang Bai, Yingqiang Liu, Yanan Wang, Yan Li, Yi Su, Yanyan Shen, Yiming Sun…

    Citation: Molecular Cancer 2020 19:90

    Content type: Research

    Published on:

  4. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Tong Liu, Xin Zhang, Lutao Du, Yunshan Wang, Xiaoming Liu, Hui Tian, Lili Wang, Peilong Li, Yinghui Zhao, Weili Duan, Yujiao Xie, Zhaowei Sun and Chuanxin Wang

    Citation: Molecular Cancer 2020 19:89

    Content type: Correction

    Published on:

    The original article was published in Molecular Cancer 2019 18:43

  5. Estrogen receptor-positive (ER+) breast cancers represent approximately two-thirds of all breast cancers and have a sustained risk of late disease recurrence. Cyclin-dependent kinase 4 and 6 (CDK4/6) inhibitor...

    Authors: Xi Jin, Li-Ping Ge, Da-Qiang Li, Zhi-Ming Shao, Gen-Hong Di, Xiao-En Xu and Yi-Zhou Jiang

    Citation: Molecular Cancer 2020 19:87

    Content type: Research

    Published on:

  6. As a novel type of noncoding RNAs, covalently closed circular RNAs (circRNAs) are ubiquitously expressed in eukaryotes. Emerging studies have related dysregulation of circRNAs to tumorigenesis. However, the bi...

    Authors: Zai Luo, Zeyin Rong, Jianming Zhang, Zhonglin Zhu, Zhilong Yu, Tengfei Li, Zhongmao Fu, Zhengjun Qiu and Chen Huang

    Citation: Molecular Cancer 2020 19:86

    Content type: Research

    Published on:

  7. Long noncoding RNAs (lncRNAs) play crucial roles in tumor progression and are aberrantly expressed in various cancers. However, the functional roles of lncRNAs in breast cancer remain largely unknown.

    Authors: Yiran Liang, Xiaojin Song, Yaming Li, Bing Chen, Wenjing Zhao, Lijuan Wang, Hanwen Zhang, Ying Liu, Dianwen Han, Ning Zhang, Tingting Ma, Yajie Wang, Fangzhou Ye, Dan Luo, Xiaoyan Li and Qifeng Yang

    Citation: Molecular Cancer 2020 19:85

    Content type: Research

    Published on:

  8. Circular RNAs (circRNAs) have been reported to have critical regulatory roles in tumor biology. However, their contribution to melanoma remains largely unknown.

    Authors: Chuan-Yuan Wei, Meng-Xuan Zhu, Nan-Hang Lu, Jia-Qi Liu, Yan-Wen Yang, Yong Zhang, Yue-Dong Shi, Zi-Hao Feng, Jia-Xia Li, Fa-Zhi Qi and Jian-Ying Gu

    Citation: Molecular Cancer 2020 19:84

    Content type: Research

    Published on:

  9. Accumulating evidence suggests that circular RNAs (circRNAs) are important participants in cancer progression. However, the biological processes and underlying mechanisms of circRNAs in pancreatic ductal adeno...

    Authors: Xiaofeng Guo, Quanbo Zhou, Dan Su, Yuming Luo, Zhiqiang Fu, Leyi Huang, Zhiguo Li, Decan Jiang, Yao Kong, Zhihua Li, Rufu Chen and Changhao Chen

    Citation: Molecular Cancer 2020 19:83

    Content type: Research

    Published on:

  10. Patients with lymph node (LN)-positive pancreatic ductal adenocarcinoma (PDAC) have extremely poor survival rates. Circular RNAs (circRNAs), a newly discovered type of endogenous noncoding RNAs, have been prop...

    Authors: Yao Kong, Yuting Li, Yuming Luo, Jiang Zhu, Hanhao Zheng, Bowen Gao, Xiaofeng Guo, Zhihua Li, Rufu Chen and Changhao Chen

    Citation: Molecular Cancer 2020 19:82

    Content type: Research

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  11. RNA modifications can be added or removed by a variety of enzymes that catalyse the necessary reactions, and these modifications play roles in essential molecular mechanisms. The prevalent modifications on mRN...

    Authors: Hanhan Shi, Peiwei Chai, Renbing Jia and Xianqun Fan

    Citation: Molecular Cancer 2020 19:78

    Content type: Review

    Published on:

  12. Hepatocellular carcinoma (HCC) is the most frequent subtype of primary liver cancer and one of the leading causes of cancer-related death worldwide. However, the molecular mechanisms underlying HCC pathogenesi...

    Authors: Zhao Huang, Jian-Kang Zhou, Yong Peng, Weifeng He and Canhua Huang

    Citation: Molecular Cancer 2020 19:77

    Content type: Review

    Published on:

  13. Following the publication of the original paper [1], one corresponding author was inadvertently missed.

    Authors: Junxin Chen, Gang Liu, Yizheng Wu, Jianjun Ma, Hongfei Wu, Ziang Xie, Shuai Chen, Yute Yang, Shengyu Wang, Panyang Shen, Yifan Fang, Shunwu Fan, Shuying Shen and Xiangqian Fang

    Citation: Molecular Cancer 2020 19:75

    Content type: Correction

    Published on:

    The original article was published in Molecular Cancer 2019 18:150

  14. Increasing studies have shown that circRNA is closely related to the carcinogenesis and development of many cancers. However, biological functions and the underlying molecular mechanism of circRNAs in triple-n...

    Authors: Xiaying Zheng, Mengge Huang, Lei Xing, Rui Yang, Xiaosong Wang, Rong Jiang, Luyu Zhang and Junxia Chen

    Citation: Molecular Cancer 2020 19:73

    Content type: Research

    Published on:

  15. Epigenetic alterations are involved in various aspects of colorectal carcinogenesis. N6-methyladenosine (m6A) modifications of RNAs are emerging as a new layer of epigenetic regulation. As the most abundant chemi...

    Authors: Chaoqin Shen, Baoqin Xuan, Tingting Yan, Yanru Ma, Pingping Xu, Xianglong Tian, Xinyu Zhang, Yingying Cao, Dan Ma, Xiaoqiang Zhu, Youwei Zhang, Jing-Yuan Fang, Haoyan Chen and Jie Hong

    Citation: Molecular Cancer 2020 19:72

    Content type: Research

    Published on:

  16. Colon cancer (CC) is a common malignant cancer. Recently, circFNDC3B was found to exert biological function in multiple cancers. However, it was unclear whether the potential protein encoded by circFNDC3B is i...

    Authors: Zihao Pan, Jianye Cai, Jiatong Lin, Huinian Zhou, Jingwen Peng, Jinliang Liang, Long Xia, Qi Yin, Baojia Zou, Jun Zheng, Liang Qiao and Lei Zhang

    Citation: Molecular Cancer 2020 19:71

    Content type: Research

    Published on:

  17. Non coding RNAs (ncRNAs) have emerged as regulators of human carcinogenesis by affecting the expression of key tumor suppressor genes and oncogenes. They are divided into short and long ncRNAs, according to th...

    Authors: Martina Ghetti, Ivan Vannini, Clelia Tiziana Storlazzi, Giovanni Martinelli and Giorgia Simonetti

    Citation: Molecular Cancer 2020 19:69

    Content type: Review

    Published on:

  18. Tumor repopulation is a major cause of radiotherapy failure. Previous investigations highlighted that dying tumor cells played vital roles in tumor repopulation through promoting proliferation of the residual ...

    Authors: Ming-jie Jiang, Yi-yun Chen, Juan-juan Dai, Dian-na Gu, Zhu Mei, Fu-rao Liu, Qian Huang and Ling Tian

    Citation: Molecular Cancer 2020 19:68

    Content type: Research

    Published on:

  19. Although both circular RNAs (circRNAs) and autophagy are associated with the function of breast cancer (BC), whether circRNAs regulate BC progression via autophagy remains unknown. In this study, we aim to exp...

    Authors: Gehao Liang, Yun Ling, Maryam Mehrpour, Phei Er Saw, Zihao Liu, Weige Tan, Zhenluan Tian, Wenjing Zhong, Wanyi Lin, Qing Luo, Qun Lin, Qiufang Li, You Zhou, Ahmed Hamai, Patrice Codogno, Jun Li…

    Citation: Molecular Cancer 2020 19:65

    Content type: Research

    Published on:

  20. Empowered by recent advances of sequencing techniques, transcriptome-wide studies have characterized over 150 different types of post-transcriptional chemical modifications of RNA, ranging from methylations of...

    Authors: Xiao Yang, Ming Liu, Mengmeng Li, Sen Zhang, Hong Hiju, Jing Sun, Zhihai Mao, Minhua Zheng and Bo Feng

    Citation: Molecular Cancer 2020 19:64

    Content type: Review

    Published on:

  21. As the most frequently diagnosed non-skin cancer in men and a leading cause of cancer-related death, understanding the molecular mechanisms that drive treatment resistance in prostate cancer poses a significan...

    Authors: Maureen Labbé, Christianne Hoey, Jessica Ray, Vincent Potiron, Stéphane Supiot, Stanley K. Liu and Delphine Fradin

    Citation: Molecular Cancer 2020 19:63

    Content type: Review

    Published on:

  22. Gastric cancer is the fourth most common malignancy and the third leading cause of cancer-related deaths worldwide. Advanced gastric cancer patients can notably benefit from chemotherapy including adriamycin, ...

    Authors: Ling Wei, Jujie Sun, Nasha Zhang, Yan Zheng, Xingwu Wang, Liyan Lv, Jiandong Liu, Yeyang Xu, Yue Shen and Ming Yang

    Citation: Molecular Cancer 2020 19:62

    Content type: Review

    Published on:

  23. Non-coding RNAs are now recognized as fundamental components of the cellular processes. Non-coding RNAs are composed of different classes, including microRNAs (miRNAs) and long non-coding RNAs (lncRNAs). Their...

    Authors: Francesca Crudele, Nicoletta Bianchi, Eva Reali, Marco Galasso, Chiara Agnoletto and Stefano Volinia

    Citation: Molecular Cancer 2020 19:61

    Content type: Review

    Published on:

  24. Metastasis causes the vast majority of colorectal carcinoma (CRC)-related deaths. However, little is known about the specific traits and underlying mechanisms of metastasis-initiating cells in primary CRC. And...

    Authors: Kai Han, Feng-Wei Wang, Chen-Hui Cao, Han Ling, Jie-Wei Chen, Ri-Xin Chen, Zi-Hao Feng, Jie Luo, Xiao-Han Jin, Jin-Ling Duan, Shu-Man Li, Ning-Fang Ma, Jing-Ping Yun, Xin-Yuan Guan, Zhi-Zhong Pan, Ping Lan…

    Citation: Molecular Cancer 2020 19:60

    Content type: Research

    Published on:

  25. Following the publication of article [1], the authors found that the images of Transwell Matrigel invasion (Fig. 7d) are incorrect.

    Authors: Liang-qi Cao, Xue-wei Yang, Yu-bin Chen, Da-wei Zhang, Xiao-Feng Jiang and Ping Xue

    Citation: Molecular Cancer 2020 19:59

    Content type: Correction

    Published on:

    The original article was published in Molecular Cancer 2019 18:148

  26. Circular RNAs (circRNAs), one type of non-coding RNA, were initially misinterpreted as nonfunctional products of pre-mRNA mis-splicing. Currently, circRNAs have been proven to manipulate the functions of diver...

    Authors: Chaochu Cui, Jianbo Yang, Xiao Li, Dongling Liu, Liwu Fu and Xianwei Wang

    Citation: Molecular Cancer 2020 19:58

    Content type: Review

    Published on:

  27. Early-stage detection of leukemia is a critical determinant for successful treatment of the disease and can increase the survival rate of leukemia patients. The factors limiting the current screening approache...

    Authors: Ajaz A. Bhat, Salma N. Younes, Syed Shadab Raza, Lubna Zarif, Sabah Nisar, Ikhlak Ahmed, Rashid Mir, Sachin Kumar, Surender K. Sharawat, Sheema Hashem, Imadeldin Elfaki, Michal Kulinski, Shilpa Kuttikrishnan, Kirti S. Prabhu, Abdul Q. Khan, Santosh K. Yadav…

    Citation: Molecular Cancer 2020 19:57

    Content type: Review

    Published on:

  28. Aberrant expression of circular RNAs contributes to the initiation and progression of cancers, but the underlying mechanism remains elusive.

    Authors: Mengmeng Jie, Yaran Wu, Mengyuan Gao, Xinzhe Li, Cheng Liu, Qin Ouyang, Qingyun Tang, Changyu Shan, Yangfan Lv, Kebin Zhang, Qian Dai, Yang Chen, Shuo Zeng, Chenglin Li, Liting Wang, Fengtian He…

    Citation: Molecular Cancer 2020 19:56

    Content type: Research

    Published on:

  29. Chemoresistance, whether intrinsic or acquired, is a major obstacle in the treatment of cancer. The resistance of cancer cells to chemotherapeutic drugs can result from various mechanisms. Over the last decade...

    Authors: Kaisheng Liu, Lin Gao, Xiaoshi Ma, Juan-Juan Huang, Juan Chen, Leli Zeng, Charles R. Ashby Jr., Chang Zou and Zhe-Sheng Chen

    Citation: Molecular Cancer 2020 19:54

    Content type: Review

    Published on:

  30. The epigenetic regulation of immune response has been demonstrated in recent studies. Nonetheless, potential roles of RNA N6-methyladenosine (m6A) modification in tumor microenvironment (TME) cell infiltration re...

    Authors: Bo Zhang, Qiong Wu, Ben Li, Defeng Wang, Lei Wang and You Lang Zhou

    Citation: Molecular Cancer 2020 19:53

    Content type: Research

    Published on:

  31. Hepatic metastasis develops in ~ 50% of uveal melanoma (UM) patients with no effective treatments. Although GNAQ/GNA11 mutations are believed to confer pathogenesis of UM, the underlying mechanism of liver met...

    Authors: Bei Jin, Ping Zhang, Hailin Zou, Huijing Ye, Yun Wang, Jing Zhang, Huasheng Yang and Jingxuan Pan

    Citation: Molecular Cancer 2020 19:52

    Content type: Research

    Published on:

  32. Long noncoding RNAs (lncRNAs) are emerging as critical regulatory elements and play fundamental roles in the biology of various cancers. However, we are still lack of knowledge about their expression patterns ...

    Authors: Juan Xu, Tingting Shao, Mingxu Song, Yunjin Xie, Jialiang Zhou, Jiaqi Yin, Na Ding, Haozhe Zou, Yongsheng Li and Jiwei Zhang

    Citation: Molecular Cancer 2020 19:51

    Content type: Research

    Published on:

  33. Pancreatic cancer is currently one of the most lethal diseases. In recent years, increasing evidence has shown that reprogrammed metabolism may play a critical role in the carcinogenesis, progression, treatmen...

    Authors: Cheng Qin, Gang Yang, Jinshou Yang, Bo Ren, Huanyu Wang, Guangyu Chen, Fangyu Zhao, Lei You, Weibin Wang and Yupei Zhao

    Citation: Molecular Cancer 2020 19:50

    Content type: Review

    Published on:

  34. Pancreatic cancer is a highly lethal disease with a poor prognosis, and existing therapies offer only limited effectiveness. Mutation gene sequencing has shown several gene associations that may account for it...

    Authors: Heng Zhu, Miaoyan Wei, Jin Xu, Jie Hua, Chen Liang, Qingcai Meng, Yiyin Zhang, Jiang Liu, Bo Zhang, Xianjun Yu and Si Shi

    Citation: Molecular Cancer 2020 19:49

    Content type: Review

    Published on:

  35. As the standard treatments for cancer, chemotherapy and radiotherapy have been widely applied to clinical practice worldwide. However, the resistance to cancer therapies is a major challenge in clinics and sci...

    Authors: Xinyi Zhang, Kai Xie, Honghua Zhou, Yuwei Wu, Chan Li, Yating Liu, Zhaoya Liu, Qian Xu, Shuang Liu, Desheng Xiao and Yongguang Tao

    Citation: Molecular Cancer 2020 19:47

    Content type: Review

    Published on:

  36. N6-methyladenosine (m6A) is the most prevalent RNA epigenetic regulation in eukaryotic cells. However, understanding of m6A in colorectal cancer (CRC) is very limited. We designed this study to investigate the...

    Authors: Xiao Yang, Sen Zhang, Changyu He, Pei Xue, Luyang Zhang, Zirui He, Lu Zang, Bo Feng, Jing Sun and Minhua Zheng

    Citation: Molecular Cancer 2020 19:46

    Content type: Research

    Published on:

  37. Circular RNA (circRNA) has been proven to play a significant role in multiple types of cancer. However, the expression and role of circRNAs in epithelial ovarian cancer (EOC) remains elusive.

    Authors: Xiaoling Gan, Hongtao Zhu, Xingwei Jiang, Samuel C. Obiegbusi, Min Yong, Xingtao Long and Jianguo Hu

    Citation: Molecular Cancer 2020 19:45

    Content type: Research

    Published on:

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