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  1. Content type: Research

    The disruption of normal gene regulation due to microRNA dysfunction is a common event in cancer pathogenesis. MicroRNA-27b is an example of an oncogenic miRNA, and it is frequently upregulated in breast cance...

    Authors: Steven C. Eastlack, Shengli Dong, Cristina Ivan and Suresh K. Alahari

    Citation: Molecular Cancer 2018 17:100

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  2. Content type: Research

    Exosomes are extracellular vesicles released by almost all cell types, including cancer cells, into bodily fluids such as saliva, plasma, breast milk, semen, urine, cerebrospinal fluid, amniotic fluid, synovia...

    Authors: Fatima Qadir, Mohammad Arshad Aziz, Chrisdina Puspita Sari, Hong Ma, Haiyan Dai, Xun Wang, Dhiresh Raithatha, Lucas Girotto Lagreca Da Silva, Muhammad Hussain, Seyedeh P. Poorkasreiy, Iain L. Hutchison, Ahmad Waseem and Muy-Teck Teh

    Citation: Molecular Cancer 2018 17:97

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  3. Content type: Research

    Defective autophagy is thought to contribute to the pathogenesis of many diseases, including cancer. Human plasmacytoma variant translocation 1 (PVT1) is an oncogenic long non-coding RNA that has been identifi...

    Authors: Fengting Huang, Wenying Chen, Juanfei Peng, Yuanhua Li, Yanyan Zhuang, Zhe Zhu, Chunkui Shao, Wanling Yang, Herui Yao and Shineng Zhang

    Citation: Molecular Cancer 2018 17:98

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  4. Content type: Research

    A deeper mechanistic understanding of epithelial-to-mesenchymal transition (EMT) regulation is needed to improve current anti-metastasis strategies in ovarian cancer (OvCa). This study was designed to investig...

    Authors: Haihai Liang, Xiaoguang Zhao, Chengyu Wang, Jian Sun, Yingzhun Chen, Guoyuan Wang, Lei Fang, Rui Yang, Mengxue Yu, Yunyan Gu and Hongli Shan

    Citation: Molecular Cancer 2018 17:96

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  5. Content type: Research

    Long noncoding RNA HULC is highly up-regulation in human hepatocellular carcinoma (HCC). However, the functions of HULC in hepatocarcinogenesis remains unclear.

    Authors: Xiaoru Xin, Mengying Wu, Qiuyu Meng, Chen Wang, Yanan Lu, Yuxin Yang, Xiaonan Li, Qidi Zheng, Hu Pu, Xin Gui, Tianming Li, Jiao Li, Song Jia and Dongdong Lu

    Citation: Molecular Cancer 2018 17:94

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  6. Content type: Research

    Dysfunctions of long non-coding RNA (lncRNAs) have been associated with the initiation and progression of hepatocellular carcinoma (HCC), but the clinicopathologic significance and potential role of lncRNA PTT...

    Authors: Jin-lan Huang, Shun-wang Cao, Qi-shui Ou, Bin Yang, Shi-hao Zheng, Jing Tang, Jing Chen, Yan-wei Hu, Lei Zheng and Qian Wang

    Citation: Molecular Cancer 2018 17:93

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  7. Content type: Research

    Mounting evidence indicates that long noncoding RNAs (lncRNAs) could play a pivotal role in cancer biology. However, the role and molecular mechanism and global genes that were mediated by lncRNA AFAP1-AS1 in ...

    Authors: Dandan Yin, Xiyi Lu, Jun Su, Xuezhi He, Wei De, Jinsong Yang, Wei Li, Liang Han and Erbao Zhang

    Citation: Molecular Cancer 2018 17:92

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  8. Content type: Research

    Abnormal metabolism, including abnormal lipid metabolism, is a hallmark of cancer cells. Some studies have demonstrated that the lipogenic pathway might promote the development of hepatocellular carcinoma (HCC...

    Authors: Xirui Liu, Yingjian Liang, Ruipeng Song, Guangchao Yang, Jihua Han, Yaliang Lan, Shangha Pan, Mingxi Zhu, Yao Liu, Yan Wang, Fanzheng Meng, Yifeng Cui, Jiabei Wang, Bo Zhang, Xuan Song, Zhaoyang Lu…

    Citation: Molecular Cancer 2018 17:90

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  9. Content type: Research

    Accumulating evidences indicate that non-coding RNAs (ncRNAs) including long non-coding RNAs (lncRNAs) and microRNAs (miRNAs) acting as crucial regulators in osteosarcoma (OS). Previously, we reported that Rho...

    Authors: Yong Wang, Xiandong Zeng, Ningning Wang, Wei Zhao, Xi Zhang, Songling Teng, Yueyan Zhang and Zhi Lu

    Citation: Molecular Cancer 2018 17:89

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  10. Content type: Research

    Emerging evidence has shown that dysregulation function of long non-coding RNAs (lncRNAs) implicated in gastric cancer (GC). However, the role of the differentially expressed lncRNAs in GC has not fully explai...

    Authors: Gang Zhang, Shuwei Li, Jiafei Lu, Yuqiu Ge, Qiaoyan Wang, Gaoxiang Ma, Qinghong Zhao, Dongdong Wu, Weida Gong, Mulong Du, Haiyan Chu, Meilin Wang, Aihua Zhang and Zhengdong Zhang

    Citation: Molecular Cancer 2018 17:87

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  11. Content type: Letter to the Editor

    Abnormal expression of non-coding circular RNAs (circRNAs) have been reported in many types of tumors. circRNA have been suggested to be an ideal candidate biomarker for diagnostic and therapeutic implications...

    Authors: Cheng Lu, Xi Shi, Amanda Y. Wang, Yuan Tao, Zhenxiao Wang, Chaoping Huang, Yuehua Qiao, Hongyi Hu and Liangfa Liu

    Citation: Molecular Cancer 2018 17:86

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  12. Content type: Research

    Since tumor growth requires reactivation of telomerase (hTERT), this enzyme is a challenging target for drug development. Therefore, it is of great interest to identify telomerase expression and activity regul...

    Authors: Joëlle El Hajj, Eric Nguyen, Qingyuan Liu, Claire Bouyer, Eric Adriaenssens, George Hilal and Evelyne Ségal-Bendirdjian

    Citation: Molecular Cancer 2018 17:85

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  13. Content type: Letter to the Editor

    Conventional tumor markers for non-invasive diagnosis of gastric cancer (GC) exhibit insufficient sensitivity and specificity to facilitate detection of early gastric cancer (EGC). We aimed to identify EGC-spe...

    Authors: Ling-Yun Lin, Li Yang, Qiang Zeng, Lin Wang, Mao-Li Chen, Ze-Hang Zhao, Guo-Dong Ye, Qi-Cong Luo, Pei-Yu Lv, Qi-Wei Guo, Bo-An Li, Jian-Chun Cai and Wang-Yu Cai

    Citation: Molecular Cancer 2018 17:84

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  14. Content type: Research

    Estrogen plays a critical role in breast cancer (BC) progression through estrogen receptor (ER)-mediated gene regulation. Emerging studies suggest that the malignant progress of BC cells is influenced by the c...

    Authors: Cheng-Fei Jiang, Zhu-Mei Shi, Dong-Mei Li, Ying-Chen Qian, Yi Ren, Xiao-Ming Bai, Yun-Xia Xie, Lin Wang, Xin Ge, Wei-Tao Liu, Lin-Lin Zhen, Ling-Zhi Liu and Bing-Hua Jiang

    Citation: Molecular Cancer 2018 17:83

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  15. Content type: Review

    Exosomes are extracellular vesicles released by many cell types and have been attributed for their roles in many diseases including cancer. Exosomes secreted by tumor cells and stromal cells are critical media...

    Authors: Zhenqiang Sun, Shuaixi Yang, Quanbo Zhou, Guixian Wang, Junmin Song, Zhen Li, Zhiyong Zhang, Jizhong Xu, Kunkun Xia, Yuan Chang, Jinbo Liu and Weitang Yuan

    Citation: Molecular Cancer 2018 17:82

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  16. Content type: Letter to the Editor

    Mutations in polymerase ε (POLE) confer favorable prognosis and outcomes in various cancer types, but their role in non-small cell lung cancer (NSCLC) is unknown. Utilizing the data of 513 patients with adenocarc...

    Authors: Liang Liu, Jimmy Ruiz, Stacey S. O’Neill, Stefan C. Grant, W. Jeffrey Petty, Meng Yang, Kexin Chen, Umit Topaloglu, Boris Pasche and Wei Zhang

    Citation: Molecular Cancer 2018 17:81

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  17. Content type: Review

    Circular RNAs (circRNAs) are connected at the 3′ and 5′ ends by exon or intron cyclization, forming a complete ring structure. circRNA is more stable and conservative than linear RNA and abounds in various org...

    Authors: Yaxian Zhong, Yajun Du, Xue Yang, Yongzhen Mo, Chunmei Fan, Fang Xiong, Daixi Ren, Xin Ye, Chunwei Li, Yumin Wang, Fang Wei, Can Guo, Xu Wu, Xiaoling Li, Yong Li, Guiyuan Li…

    Citation: Molecular Cancer 2018 17:79

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  18. Content type: Research

    SALL1 is a multi-zinc finger transcription factor that regulates organogenesis and stem cell development, but the role of SALL1 in tumor biology and tumorigenesis remains largely unknown.

    Authors: Chunling Ma, Fang Wang, Bing Han, Xiaoli Zhong, Fusheng Si, Jian Ye, Eddy C. Hsueh, Lynn Robbins, Susan M. Kiefer, Yanping Zhang, Pamela Hunborg, Mark A. Varvares, Michael Rauchman and Guangyong Peng

    Citation: Molecular Cancer 2018 17:78

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  19. Content type: Review

    Some of the key steps in cancer metastasis are the migration and invasion of tumor cells; these processes require rearrangement of the cytoskeleton. Actin filaments, microtubules, and intermediate filaments in...

    Authors: Yanyan Tang, Yi He, Ping Zhang, Jinpeng Wang, Chunmei Fan, Liting Yang, Fang Xiong, Shanshan Zhang, Zhaojian Gong, Shaolin Nie, Qianjin Liao, Xiayu Li, Xiaoling Li, Yong Li, Guiyuan Li, Zhaoyang Zeng…

    Citation: Molecular Cancer 2018 17:77

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  20. Content type: Letter to the Editor

    DNA damage-specific histone chaperone Aprataxin PNK-like factor (APLF) regulates mesenchymal-to-epithelial transition (MET) during cellular reprogramming. We investigated the role of APLF in epithelial-to-mese...

    Authors: Aditi Majumder, Khaja Moheiddin Syed, Ananda Mukherjee, Manendra Babu Lankadasari, Juberiya Mohammed Azeez, Sreeharshan Sreeja, Kuzhuvelil B. Harikumar, Madhavan Radhakrishna Pillai and Debasree Dutta

    Citation: Molecular Cancer 2018 17:76

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  21. Content type: Review

    Exosomes have emerged as a novel approach for the treatment and diagnosis of cancer after RNA content was discovered in exosomes in 2007. As important meditators of intercellular communication, exosomes have b...

    Authors: Ruihao Zhou, Kaddie Kwok Chen, Jingtao Zhang, Bufan Xiao, Zhaohao Huang, Cheng Ju, Jun Sun, Feifei Zhang, Xiao-Bin Lv and Guofu Huang

    Citation: Molecular Cancer 2018 17:75

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  22. Content type: Letter to the Editor

    Glioblastoma multiforme (GBM) is the most common and aggressive malignant adult primary brain tumor. Despite surgical resection followed by radiotherapy and chemotherapy, the median survival rate is approximat...

    Authors: Sze Kiat Tan, Chiara Pastori, Clara Penas, Ricardo J. Komotar, Michael E. Ivan, Claes Wahlestedt and Nagi G. Ayad

    Citation: Molecular Cancer 2018 17:74

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  23. Content type: Research

    Liver tumor initiating cells (TICs) have self-renewal and differentiation properties, accounting for tumor initiation, metastasis and drug resistance. Long noncoding RNAs are involved in many physiological and...

    Authors: Xiaomin Fu, Xiaoyan Zhu, Fujun Qin, Yong Zhang, Jizhen Lin, Yuechao Ding, Zihe Yang, Yiman Shang, Li Wang, Qinxian Zhang and Quanli Gao

    Citation: Molecular Cancer 2018 17:73

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  24. Content type: Research

    Colorectal cancer (CRC) is one of the most common cancers and causes of cancer-related death worldwide. In patients with CRC, metastasis is a crucial problem that leads to treatment failure and is the primary ...

    Authors: Kuo-Wang Tsai, Yi-Hao Lo, Hsuan Liu, Chung-Yu Yeh, You-Zuo Chen, Chao-Wen Hsu, Wei-Shone Chen and Jui-Ho Wang

    Citation: Molecular Cancer 2018 17:72

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  25. Content type: Letter to the Editor

    Cutaneous melanoma (CM) is a malignancy with increasing occurrence. Its microRNA repertoire has been defined in a number studies, leading to candidates for biological and clinical relevance: miR-200a/b/c, miR-...

    Authors: Marco Galasso, Carl Morrison, Linda Minotti, Fabio Corrà, Carlotta Zerbinati, Chiara Agnoletto, Federica Baldassari, Matteo Fassan, Armando Bartolazzi, Andrea Vecchione, Gerard J. Nuovo, Gianpiero Di Leva, Stefania D’Atri, Ester Alvino, Maurizio Previati, Brian J. Nickoloff…

    Citation: Molecular Cancer 2018 17:71

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  26. Content type: Research

    Metabolic plasticity has been increasingly thought to be a determinant of tumor growth and metastasis. MACC1, a transcriptional regulator of MET, was recognized as an oncogene in gastric cancer (GC); however, ...

    Authors: Yang Zhao, Yajing Liu, Li Lin, Qiong Huang, Wanming He, Shuyi Zhang, Shumin Dong, Zhaowei Wen, Jinjun Rao, Wangjun Liao and Min Shi

    Citation: Molecular Cancer 2018 17:69

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  27. Content type: Research

    Breast cancer is the most common cancer among women worldwide and metastasis is the leading cause of death among patients with breast cancer. The transforming growth factor-β (TGF-β) pathway plays critical rol...

    Authors: Yue Yu, Wei Luo, Zheng-Jun Yang, Jiang-Rui Chi, Yun-Rui Li, Yu Ding, Jie Ge, Xin Wang and Xu-Chen Cao

    Citation: Molecular Cancer 2018 17:70

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  28. Content type: Letter to the Editor

    Long noncoding RNA HOTTIP plays important roles in the generation and progression of human cancers. Exosomes participate in cellular communication by transmitting moleculars between cells and are regarded as s...

    Authors: Rui Zhao, Yanli Zhang, Xin Zhang, Yongmei Yang, Xin Zheng, Xiaohui Li, Yingjie Liu and Yi Zhang

    Citation: Molecular Cancer 2018 17:68

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  29. Content type: Letter to the Editor

    The somatic activation of PI3K/AKT pathway mutations, PIK3CA and AKT1, and ESR1 mutations in plasma cell-free DNA (cfDNA) has been studied as a non-invasive procedure to quickly assess and monitor disease progres...

    Authors: Takashi Takeshita, Yutaka Yamamoto, Mutsuko Yamamoto-Ibusuki, Mai Tomiguchi, Aiko Sueta, Keiichi Murakami and Hirotaka Iwase

    Citation: Molecular Cancer 2018 17:67

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  30. Content type: Review

    Pancreatic ductal adenocarcinoma (PDAC) is unrivalled the deadliest gastrointestinal cancer in the western world. There is substantial evidence implying that insulin and insulin-like growth factor (IGF) signal...

    Authors: Ayse Ceren Mutgan, H. Erdinc Besikcioglu, Shenghan Wang, Helmut Friess, Güralp O. Ceyhan and Ihsan Ekin Demir

    Citation: Molecular Cancer 2018 17:66

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  31. Content type: Letter to the Editor

    Breast cancer stem cells (BCSCs) are thought to be responsible for tumor initiation, metastasis and relapse. Our group and others have described markers useful in isolating BCSCs just as aldehyde dehydrogenase...

    Authors: Mingshan Liu, Yang Liu, Lu Deng, Dong Wang, Xueyan He, Lei Zhou, Max S. Wicha, Fan Bai and Suling Liu

    Citation: Molecular Cancer 2018 17:65

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  32. Content type: Research

    Our previous study has demonstrated that hepatocyte nuclear factor 1α (HNF1α) exerts potent therapeutic effects on hepatocellular carcinoma (HCC). However, the molecular mechanisms by which HNF1α reverses HCC ...

    Authors: Chen-Hong Ding, Chuan Yin, Shi-Jie Chen, Liang-Zhi Wen, Kai Ding, Shu-Juan Lei, Jin-Pei Liu, Jian Wang, Kai-xian Chen, Hua-liang Jiang, Xin Zhang, Cheng Luo and Wei-Fen Xie

    Citation: Molecular Cancer 2018 17:63

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  33. Content type: Review

    Searching for targets that allow pharmacological inhibition of cell proliferation in over-proliferative states, such as cancer, leads us to finely understand the complex mechanisms orchestrating the perfect co...

    Authors: Wagner Ricardo Montor, Andrei Ronaldo Oliveira Silva Escartin Salas and Fabiana Henriques Machado de Melo

    Citation: Molecular Cancer 2018 17:55

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  34. Content type: Review

    The introduction of ABL Tyrosine Kinase Inhibitors (TKIs) has significantly improved the outcome of Chronic Myeloid Leukemia (CML) patients that, in large part, achieve satisfactory hematological, cytogenetic ...

    Authors: Michele Massimino, Stefania Stella, Elena Tirrò, Chiara Romano, Maria Stella Pennisi, Adriana Puma, Livia Manzella, Antonino Zanghì, Fabio Stagno, Francesco Di Raimondo and Paolo Vigneri

    Citation: Molecular Cancer 2018 17:56

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  35. Content type: Research

    ETS variant gene 6 (ETV6) is a putative tumor suppressor and repressed by epidermal growth factor receptor (EGFR) signaling in prostate cancer. Since EGFR antagonists seem ineffective in castration-resistant p...

    Authors: Yuan-Chin Tsai, Tao Zeng, Wassim Abou-Kheir, Hsiu-Lien Yeh, Juan Juan Yin, Yi-Chao Lee, Wei-Yu Chen and Yen-Nien Liu

    Citation: Molecular Cancer 2018 17:42

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  36. Content type: Review

    Acquired T790 M mutation is the commonest cause of resistance for advanced non-small cell lung cancer (NSCLC) epidermal growth factor receptor (EGFR) mutant patients who had progressed after first line EGFR TKI (...

    Authors: Chee-Seng Tan, Nesaretnam Barr Kumarakulasinghe, Yi-Qing Huang, Yvonne Li En Ang, Joan Rou-En Choo, Boon-Cher Goh and Ross A. Soo

    Citation: Molecular Cancer 2018 17:29

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  37. Content type: Research

    Minimal residual disease is the main issue of advanced ovarian cancer treatment. According to the literature and previous results, we hypothesized that Mesenchymal Stromal Cells (MSC) could support this minima...

    Authors: Jennifer Pasquier, Marie Gosset, Caroline Geyl, Jessica Hoarau-Véchot, Audrey Chevrot, Marc Pocard, Massoud Mirshahi, Raphael Lis, Arash Rafii and Cyril Touboul

    Citation: Molecular Cancer 2018 17:47

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  38. Content type: Research

    Both the type I insulin-like growth factor receptor (IGF1R) and Src pathways are associated with the development and progression of numerous types of human cancer, and Src activation confers resistance to anti...

    Authors: Ho Jin Lee, Phuong Chi Pham, Seung Yeob Hyun, Byungyeob Baek, Byungjin Kim, Yunha Kim, Hye-Young Min, Jeeyeon Lee and Ho-Young Lee

    Citation: Molecular Cancer 2018 17:50

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  39. Content type: Review

    Receptor tyrosine kinases (RTKs) play an important role in a variety of cellular processes including growth, motility, differentiation, and metabolism. As such, dysregulation of RTK signaling leads to an assor...

    Authors: Zhenfang Du and Christine M. Lovly

    Citation: Molecular Cancer 2018 17:58

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  40. Content type: Review

    Receptor tyrosine kinase (RTK) pathways serve as frequent oncogene drivers in solid cancers and small molecule and antibody-based inhibitors have been developed as targeted therapeutics for many of these oncog...

    Authors: Emily K. Kleczko and Lynn E. Heasley

    Citation: Molecular Cancer 2018 17:60

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  41. Content type: Review

    c-Met is a receptor tyrosine kinase belonging to the MET (MNNG HOS transforming gene) family, and is expressed on the surfaces of various cells. Hepatocyte growth factor (HGF) is the ligand for this receptor. ...

    Authors: Yazhuo Zhang, Mengfang Xia, Ke Jin, Shufei Wang, Hang Wei, Chunmei Fan, Yingfen Wu, Xiaoling Li, Xiayu Li, Guiyuan Li, Zhaoyang Zeng and Wei Xiong

    Citation: Molecular Cancer 2018 17:45

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