Skip to main content

Articles

Page 44 of 65

  1. Gastric cancer is the second most common cause of cancer-related death in the world. Inflammatory signals originating from gastric cancer cells are important for recruiting inflammatory cells and regulation of...

    Authors: Stephanie Geisler Crone, Anders Jacobsen, Birgitte Federspiel, Linda Bardram, Anders Krogh, Anders H Lund and Lennart Friis-Hansen
    Citation: Molecular Cancer 2012 11:71
  2. Non–small-cell lung cancer (NSCLC) is categorized into various histologic subtypes that play an important role in prognosis and treatment outcome. We investigated the antitumor activity of motesanib, a selecti...

    Authors: Angela Coxon, Beth Ziegler, Stephen Kaufman, Man Xu, Hongyu Wang, Dawn Weishuhn, Joanna Schmidt, Heather Sweet, Charlie Starnes, Douglas Saffran and Anthony Polverino
    Citation: Molecular Cancer 2012 11:70
  3. The role of the tumor necrosis factor receptor associated protein 1 (TRAP1) – supposed to be involved in protection of cells from apoptosis and oxidative stress – has just started to be investigated in ovarian...

    Authors: Stefanie Aust, Anna Bachmayr-Heyda, Petra Pateisky, Dan Tong, Silvia Darb-Esfahani, Carsten Denkert, Radoslav Chekerov, Jalid Sehouli, Sven Mahner, Toon Van Gorp, Ignace Vergote, Paul Speiser, Reinhard Horvat, Robert Zeillinger and Dietmar Pils
    Citation: Molecular Cancer 2012 11:69
  4. Coronins are a family of highly evolutionary conserved proteins reportedly involved in the regulation of actin cytoskeletal dynamics, although only coronin 3 has been shown to be related to cancer cell migrati...

    Authors: Gui Ren, Qifei Tian, Yanxin An, Bin Feng, Yuanyuan Lu, Jie Liang, Kai Li, Yulong Shang, Yongzhan Nie, Xin Wang and Daiming Fan
    Citation: Molecular Cancer 2012 11:67

    The Correction to this article has been published in Molecular Cancer 2022 21:203

  5. Bone loss and pathological fractures are common skeletal complications associated with androgen deprivation therapy and bone metastases in prostate cancer patients. We have previously demonstrated that prostat...

    Authors: Aditi Gupta, Wei Cao and Meenakshi A Chellaiah
    Citation: Molecular Cancer 2012 11:66
  6. The invasion of glioblastoma cells into regions of the normal brain is a critical factor that limits current therapies for malignant astrocytomas. Previous work has identified roles for the Rho family guanine ...

    Authors: Aneta Kwiatkowska, Sebastien Didier, Shannon Fortin, Yayu Chuang, Timothy White, Michael E Berens, Elisabeth Rushing, Jennifer Eschbacher, Nhan L Tran, Amanda Chan and Marc Symons
    Citation: Molecular Cancer 2012 11:65
  7. Hepatocyte growth factor (HGF) induced c-Met activation is known as the main stimulus for hepatocyte proliferation and is essential for liver development and regeneration. Activation of HGF/c-Met signaling has...

    Authors: Giray Bozkaya, Peyda Korhan, Murat Çokaklı, Esra Erdal, Özgül Sağol, Sedat Karademir, Christopher Korch and Neşe Atabey
    Citation: Molecular Cancer 2012 11:64
  8. Rab proteins constitute a large family of monomeric GTP-binding proteins that regulate intracellular vesicle transport. Several Rab proteins, including rab31, have been shown to affect cancer progression and a...

    Authors: Bettina Grismayer, Susanne Sölch, Bastian Seubert, Thomas Kirchner, Sonja Schäfer, Gustavo Baretton, Manfred Schmitt, Thomas Luther, Achim Krüger, Matthias Kotzsch and Viktor Magdolen
    Citation: Molecular Cancer 2012 11:62
  9. The oncogenic roles contributed by the Akt/PKB kinase family remain controversial and presumably depend on cell context, but are perceived to be modulated by an interplay and net balance between various isofor...

    Authors: Zhengang Peng, Jennifer Chao Weber, Zhaosheng Han, Rulong Shen, Wenchao Zhou, James R Scott, Michael WY Chan and Huey-Jen L Lin
    Citation: Molecular Cancer 2012 11:61
  10. Constitutive activation of Ras in immortalized bronchial epithelial cells increases electron transport chain activity, oxygen consumption and tricarboxylic acid cycling through unknown mechanisms. We hypothesi...

    Authors: Sucheta Telang, Kristin K Nelson, Deanna L Siow, Abdullah Yalcin, Joshua M Thornburg, Yoannis Imbert-Fernandez, Alden C Klarer, Hanan Farghaly, Brian F Clem, John W Eaton and Jason Chesney
    Citation: Molecular Cancer 2012 11:60
  11. Heat-shock protein 90 (Hsp90) is vital to cell survival under conditions of stress, and binds client proteins to assist in protein stabilization, translocation of polypeptides across cell membranes, and recove...

    Authors: Tomohisa Horibe, Aya Torisawa, Masayuki Kohno and Koji Kawakami
    Citation: Molecular Cancer 2012 11:59
  12. Colony stimulating factor-1 (CSF-1) plays an important role in ovarian cancer biology and as a prognostic factor in ovarian cancer. Elevated levels of CSF-1 promote progression of ovarian cancer, by binding to...

    Authors: Ho-Hyung Woo, Csaba F László, Stephen Greco and Setsuko K Chambers
    Citation: Molecular Cancer 2012 11:58
  13. Recent evidence has accumulated that MicroRNA (miRNA) dysregulation occurs in the majority of human malignancies including acute myeloid leukemia (AML) and may contribute to onco-/leukemo-genesis.

    Authors: Xiaolu Zhang, Jiping Zeng, Minran Zhou, Bingnan Li, Yuanyuan Zhang, Tao Huang, Lixiang Wang, Jihui Jia and Chunyan Chen
    Citation: Molecular Cancer 2012 11:56
  14. Multiple activations of individual genes during embryonic liver and HCC development have repeatedly prompted speculations about conserved embryonic signatures driving cancer development. Recently, the emerging...

    Authors: Diana Becker, Ioannis Sfakianakis, Markus Krupp, Frank Staib, Aslihan Gerhold-Ay, Anja Victor, Harald Binder, Maria Blettner, Thorsten Maass, Snorri Thorgeirsson, Peter R Galle and Andreas Teufel
    Citation: Molecular Cancer 2012 11:55
  15. Our previous work demonstrated that ectopic expression of interferon regulatory factor 4 binding protein (IBP) was correlated with the malignant behaviour of human breast cancer cells. The mechanisms controlli...

    Authors: Mingzhen Yang, Fang Yuan, Peng Li, Zhongjiao Chen, An Chen, Shuhui Li and Chuanmin Hu
    Citation: Molecular Cancer 2012 11:54
  16. This study is to analyze promoter methylation of various tumor suppressor genes in different types of ovarian carcinoma and to identify potential therapeutic targets of ovarian clear cell adenocarcinoma (OCCA).

    Authors: Chih-Ming Ho, Chi-Jung Huang, Chia-Yen Huang, Yih-Yiing Wu, Shwu-Fen Chang and Wen-Fang Cheng
    Citation: Molecular Cancer 2012 11:53
  17. Early prostate cancer (PCa) is generally treatable and associated with good prognosis. After a variable time, PCa evolves into a highly metastatic and treatment-refractory disease: castration-resistant PCa (CR...

    Authors: Francesco Crea, Lei Sun, Antonello Mai, Yan Ting Chiang, William L Farrar, Romano Danesi and Cheryl D Helgason
    Citation: Molecular Cancer 2012 11:52
  18. The enhancer of zeste homolog 2 (EZH2) was found to be overexpressed and associated with tumor metastasis in esophageal squamous cell carcinoma (ESCC). On the other hand, it was reported that miR-26a, miR-98, ...

    Authors: Sheng-Dong Huang, Yang Yuan, Chong-Wen Zhuang, Bai-Ling Li, De-Jun Gong, Shu-Gang Wang, Zhi-Yong Zeng and He-Zhong Cheng
    Citation: Molecular Cancer 2012 11:51
  19. Many human cancer cells express filamin A (FLNA), an actin-binding structural protein that interacts with a diverse set of cell signaling proteins, but little is known about the biological importance of FLNA i...

    Authors: Rajesh K Nallapalli, Mohamed X Ibrahim, Alex X Zhou, Sashidar Bandaru, Sai Naresh Sunkara, Björn Redfors, David Pazooki, Yin Zhang, Jan Borén, Yihai Cao, Martin O Bergo and Levent M Akyürek
    Citation: Molecular Cancer 2012 11:50
  20. Colorectal cancer is one of the main cancers in the Western world. About 90% of the deaths arise from formation of distant metastasis. The expression of the newly identified gene metastasis associated in colon...

    Authors: Felicitas Schmid, Susen Burock, Konrad Klockmeier, Peter M Schlag and Ulrike Stein
    Citation: Molecular Cancer 2012 11:49
  21. Cell death induced by poly(ADP-ribose) (PAR) and mediated by apoptosis-inducing factor (AIF) is well-characterized in models of ischemic tissue injury, but their roles in cancer cell death after chemotherapy a...

    Authors: Xiaoxing Feng, Yiran Zhou, Alicia M Proctor, Mandi M Hopkins, Mengwei Liu and David W Koh
    Citation: Molecular Cancer 2012 11:48
  22. Successful treatment of solid tumors relies on the ability of drugs to penetrate into the tumor tissue.

    Authors: Daniel J Freeman, Kevin McDorman, Selam Ogbagabriel, Carl Kozlosky, Bing-Bing Yang, Sameer Doshi, Juan Jose Perez-Ruxio, William Fanslow, Charlie Starnes and Robert Radinsky
    Citation: Molecular Cancer 2012 11:47
  23. We previously established a three-dimensional (3-D) colonic crypt model using HKe3 cells which are human colorectal cancer (CRC) HCT116 cells with a disruption in oncogenic KRAS, and revealed the crucial roles of...

    Authors: Toshiyuki Tsunoda, Takeharu Ota, Takahiro Fujimoto, Keiko Doi, Yoko Tanaka, Yasuhiro Yoshida, Masahiro Ogawa, Hiroshi Matsuzaki, Masato Hamabashiri, Darren R Tyson, Masahide Kuroki, Shingo Miyamoto and Senji Shirasawa
    Citation: Molecular Cancer 2012 11:46
  24. Platinum-containing anti-cancer drugs such as cisplatin are widely used for patients with various types of cancers, however, resistance to cisplatin is observed in some cases. Whereas we have recently reported...

    Authors: Junji Kawaguchi, Seiji Adachi, Ichiro Yasuda, Takahiro Yamauchi, Masanori Nakashima, Tomohiko Ohno, Masahito Shimizu, Takashi Yoshioka, Masahiko Itani, Osamu Kozawa and Hisataka Moriwaki
    Citation: Molecular Cancer 2012 11:45
  25. Metastatic melanoma is a devastating disease with limited therapeutic options. MicroRNAs (miRNAs) are small non coding RNA molecules with important roles in post-transcriptional gene expression regulation, who...

    Authors: Liron Zehavi, Roi Avraham, Aviv Barzilai, Dalia Bar-Ilan, Roy Navon, Yechezkel Sidi, Dror Avni and Raya Leibowitz-Amit
    Citation: Molecular Cancer 2012 11:44
  26. CD24 expression is associated with human colorectal cancer (CRC). Our previous data indicated that CD24 promoted the proliferation and invasion of colorectal cancer cells through the activation of ERK1/2. Sinc...

    Authors: Ning Su, Liang Peng, Bingqing Xia, Yingying Zhao, Angao Xu, Jing Wang, Xinying Wang and Bo Jiang
    Citation: Molecular Cancer 2012 11:43

    The Erratum to this article has been published in Molecular Cancer 2012 11:68

  27. Treatment of Philadelphia chromosome-positive acute lymphoblastic leukemias (Ph-positive ALL) with clinically approved inhibitors of the Bcr/Abl tyrosine kinase frequently results in the emergence of a leukemi...

    Authors: Fei Fei, Min Lim, Sabine Schmidhuber, Jürgen Moll, John Groffen and Nora Heisterkamp
    Citation: Molecular Cancer 2012 11:42
  28. Lapatinib, a tyrosine kinase inhibitor of HER2 and EGFR and is approved, in combination with capecitabine, for the treatment of trastuzumab-refractory metastatic breast cancer. In order to establish a possible...

    Authors: Fiona O’Neill, Stephen F Madden, Sinead T Aherne, Martin Clynes, John Crown, Padraig Doolan and Robert O’Connor
    Citation: Molecular Cancer 2012 11:41
  29. The Runt-related transcription factor Runx2 is essential for bone development but is also implicated in progression of several cancers of breast, prostate and bone, where it activates cancer-related genes and ...

    Authors: Manish Tandon, Karthiga Gokul, Syed A Ali, Zujian Chen, Jane Lian, Gary S Stein and Jitesh Pratap
    Citation: Molecular Cancer 2012 11:27
  30. Hypermethylation of promotor CpG islands is a common mechanism that inactivates tumor suppressor genes in cancer. Genes belonging to the RASSF gene family have frequently been reported as epigenetically silenced ...

    Authors: Anna Djos, Tommy Martinsson, Per Kogner and Helena Carén
    Citation: Molecular Cancer 2012 11:40
  31. Hepatocellular carcinoma (HCC) is the fifth most common cancer worldwide. Frequent tumor recurrence after surgery is related to its poor prognosis. Although gene expression signatures have been associated with...

    Authors: Li Weng, Juan Du, Qinghui Zhou, Binbin Cheng, Jun Li, Denghai Zhang and Changquan Ling
    Citation: Molecular Cancer 2012 11:39
  32. Tri- and tetra-nucleotide repeats in mammalian genomes can induce formation of alternative non-B DNA structures such as triplexes and guanine (G)-quadruplexes. These structures can induce mutagenesis, chromoso...

    Authors: Laura D Nelson, Christian Bender, Heiko Mannsperger, Daniel Buergy, Patryk Kambakamba, Giridhar Mudduluru, Ulrike Korf, Dennis Hughes, Michael W Van Dyke and Heike Allgayer
    Citation: Molecular Cancer 2012 11:38
  33. Microparticles (MPs) are membrane vesicles which are released from normal and malignant cells following a process of budding and detachment from donor cells. MPs contain surface antigens, proteins and genetic ...

    Authors: Ritu Jaiswal, Frederick Luk, Joyce Gong, Jean-Marie Mathys, Georges Emile Raymond Grau and Mary Bebawy
    Citation: Molecular Cancer 2012 11:37
  34. The extracellular matrix (ECM) has a key role in facilitating the progression of ovarian cancer and we have shown recently that the secreted ECM protein TGFBI modulates the response of ovarian cancer to paclit...

    Authors: David A Tumbarello, Jillian Temple and James D Brenton
    Citation: Molecular Cancer 2012 11:36
  35. Increased consumption of plant-based diets has been linked to the presence of certain phytochemicals, including polyphenols such as flavonoids. Several of these compounds exert their protective effect via inhi...

    Authors: Sofia Bellou, Evdoxia Karali, Eleni Bagli, Nawaf Al-Maharik, Lucia Morbidelli, Marina Ziche, Herman Adlercreutz, Carol Murphy and Theodore Fotsis
    Citation: Molecular Cancer 2012 11:35
  36. 2,4-Dimethoxyphenyl-E-4-arylidene-3-isochromanone (IK11) was previously described to induce apoptotic death of A431 tumor cells. In this report, we investigated the molecular action of IK11 in the HepG2 human hep...

    Authors: Balazs Radnai, Csenge Antus, Boglarka Racz, Peter Engelmann, Janos Krisztian Priber, Zsuzsanna Tucsek, Balazs Veres, Zsuzsanna Turi, Tamas Lorand, Balazs Sumegi and Ferenc Gallyas Jr
    Citation: Molecular Cancer 2012 11:34
  37. Toll-like receptor 4 (TLR4) is expressed on immune cells as a sensor that recognizes lipopolysaccharide (LPS), a microbial conserved component. It has recently been determined that the expression of TLR4 is al...

    Authors: Zujun Sun, Qingqiong Luo, Dongxia Ye, Wantao Chen and Fuxiang Chen
    Citation: Molecular Cancer 2012 11:33
  38. High-grade gliomas, including glioblastomas (GBMs), are recalcitrant to local therapy in part because of their ability to invade the normal brain parenchyma surrounding these tumors. Animal models capable of r...

    Authors: L Gerard Toussaint III, Allan E Nilson, Jennie M Goble, Karla V Ballman, C David James, Florence Lefranc, Robert Kiss and Joon H Uhm
    Citation: Molecular Cancer 2012 11:32
  39. Hepatocellular carcinoma (HCC) has a dismal 5-year-survival rate of 10%, so novel strategies are warranted. IL-24 mediates anti-tumor activity reducing STAT3 expression, which suggests that interferon (IFN) al...

    Authors: Cong-Jun Wang, Chao-Wen Xiao, Tian-Geng You, Ya-Xin Zheng, Wei Gao, Zhu-Qing Zhou, Jun Chen, Xin-Bo Xue, Jia Fan and Hui Zhang
    Citation: Molecular Cancer 2012 11:31
  40. Induction of osteoblast differentiation by paracrine Sonic hedgehog (Shh) signaling may be a mechanism through which Shh-expressing prostate cancer cells initiate changes in the bone microenvironment and promo...

    Authors: Samantha M Zunich, Maria Valdovinos, Taneka Douglas, David Walterhouse, Philip Iannaccone and Marilyn L G Lamm
    Citation: Molecular Cancer 2012 11:30
  41. CADM1 encodes an immunoglobulin superfamily (IGSF) cell adhesion molecule. Inactivation of CADM1, either by promoter hypermethylation or loss of heterozygosity, has been reported in a wide variety of tumor types,...

    Authors: Louise van der Weyden, Mark J Arends, Alistair G Rust, George Poulogiannis, Rebecca E McIntyre and David J Adams
    Citation: Molecular Cancer 2012 11:29
  42. Cellular senescence represents a tumor suppressive response to a variety of aberrant and oncogenic insults. We have previously described a transgenic mouse model of Cyclin D1-driven senescence in pineal cells ...

    Authors: Hasan Zalzali, Mohamad Harajly, Lina Abdul-Latif, Nader El-Chaar, Ghassan Dbaibo, Stephen X Skapek and Raya Saab
    Citation: Molecular Cancer 2012 11:28
  43. Platinum compounds such as cisplatin and carboplatin are DNA crosslinking agents widely used for cancer chemotherapy. However, the effectiveness of platinum compounds is often tempered by the acquisition of ce...

    Authors: Céline Jacquemont, Julian A Simon, Alan D D'Andrea and Toshiyasu Taniguchi
    Citation: Molecular Cancer 2012 11:26
  44. Metastatic melanoma is a lethal skin cancer and its incidence is rising every year. It represents a challenge for oncologist, as the current treatment options are non-curative in the majority of cases; therefo...

    Authors: Aitziber Buqué, Jangi Sh Muhialdin, Alberto Muñoz, Begoña Calvo, Sergio Carrera, Unai Aresti, Aintzane Sancho, Itziar Rubio and Guillermo López-Vivanco
    Citation: Molecular Cancer 2012 11:25
  45. The membrane-bound mucins are thought to play an important biological role in cell–cell and cell–matrix interactions, in cell signaling and in modulating biological properties of cancer cell. MUC4, a transmemb...

    Authors: Sateesh Kunigal, Moorthy P Ponnusamy, Navneet Momi, Surinder K Batra and Srikumar P Chellappan
    Citation: Molecular Cancer 2012 11:24
  46. MicroRNAs (miRNAs) have been suggested to play a vital role in tumor initiation and progression by negatively regulating oncogenes and tumor suppressors. Quite recently, studies have identified some miRNAs ope...

    Authors: Yu Zhang, Zhongqiu Wang, Min Chen, Liang Peng, Xinying Wang, Qunying Ma, Fengli Ma and Bo Jiang
    Citation: Molecular Cancer 2012 11:23
  47. TAK733 is a novel allosteric, non-ATP-binding, inhibitor of the BRAF substrates MEK-1/2.

    Authors: Erika von Euw, Mohammad Atefi, Narsis Attar, Connie Chu, Sybil Zachariah, Barry L Burgess, Stephen Mok, Charles Ng, Deborah JL Wong, Bartosz Chmielowski, David I Lichter, Richard C Koya, Tara A McCannel, Elena Izmailova and Antoni Ribas
    Citation: Molecular Cancer 2012 11:22

Annual Journal Metrics

  • 2022 Citation Impact
    37.3 - 2-year Impact Factor
    33.1 - 5-year Impact Factor
    5.740 - SNIP (Source Normalized Impact per Paper)
    8.703 - SJR (SCImago Journal Rank)

    2023 Speed
    5 days submission to first editorial decision for all manuscripts (Median)
    91 days submission to accept (Median)

    2023 Usage 
    3,569,666 downloads
    2,070 Altmetric mentions