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  1. Aneuploidy and chromosomal instability (CIN) are common abnormalities in human cancer. Alterations of the mitotic spindle checkpoint are likely to contribute to these phenotypes, but little is known about soma...

    Authors: Ivan Bièche, Sophie Vacher, François Lallemand, Sengül Tozlu-Kara, Hind Bennani, Michèle Beuzelin, Keltouma Driouch, Etienne Rouleau, Florence Lerebours, Hugues Ripoche, Géraldine Cizeron-Clairac, Frédérique Spyratos and Rosette Lidereau
    Citation: Molecular Cancer 2011 10:23
  2. Many hypotheses have been postulated to explain the intricate nature of the metastatic process, but none of them completely accounted for the actual biological and clinical observations. Consequently, metastas...

    Authors: Sandra Kraljevic Pavelic, Mirela Sedic, Hrvojka Bosnjak, Sime Spaventi and Kresimir Pavelic
    Citation: Molecular Cancer 2011 10:22
  3. FLASH is a huge nuclear protein involved in various cellular functions such as apoptosis signalling, NF-κB activation, S-phase regulation, processing of histone pre-mRNAs, and co-regulation of transcription. R...

    Authors: Anne Hege Alm-Kristiansen, Petra I Lorenzo, Ann-Kristin Molværsmyr, Vilborg Matre, Marit Ledsaak, Thomas Sæther and Odd S Gabrielsen
    Citation: Molecular Cancer 2011 10:21
  4. As well as inducing direct oncolysis, reovirus treatment of melanoma is associated with activation of innate and adaptive anti-tumour immune responses.

    Authors: Lynette Steele, Fiona Errington, Robin Prestwich, Elizabeth Ilett, Kevin Harrington, Hardev Pandha, Matt Coffey, Peter Selby, Richard Vile and Alan Melcher
    Citation: Molecular Cancer 2011 10:20
  5. Inhibitors of the kinase mTOR, such as rapamycin and everolimus, have been used as cancer therapeutics with limited success since some tumours are resistant. Efforts to establish predictive markers to allow se...

    Authors: Sampoorna Satheesha, Victoria J Cookson, Louise J Coleman, Nicola Ingram, Brijesh Madhok, Andrew M Hanby, Charlotte AB Suleman, Vicky S Sabine, E Jane Macaskill, John MS Bartlett, J Michael Dixon, Jim N McElwaine and Thomas A Hughes
    Citation: Molecular Cancer 2011 10:19
  6. Glioblastoma Multiforme (GBM) is the most common and invasive astrocytic tumor associated with dismal prognosis. Treatment for GBM patients has advanced, but the median survival remains a meager 15 months. In ...

    Authors: Avadhut D Joshi, D Williams Parsons, Victor E Velculescu and Gregory J Riggins
    Citation: Molecular Cancer 2011 10:17
  7. There are limited therapeutic options for hepatocellular carcinoma (HCC), the most common liver malignancy worldwide. Recent studies have identified the Frizzled-7 receptor (FZD7), important for activation of ...

    Authors: Wei Wei, Mei-Sze Chua, Susan Grepper and Samuel K So
    Citation: Molecular Cancer 2011 10:16
  8. The ductal carcinoma in situ (DCIS) of the mammary gland represents an early, pre-invasive stage in the development of invasive breast carcinoma. Since DCIS is a curable disease, it would be highly desirable to i...

    Authors: Céline Kretschmer, Anja Sterner-Kock, Friederike Siedentopf, Winfried Schoenegg, Peter M Schlag and Wolfgang Kemmner
    Citation: Molecular Cancer 2011 10:15
  9. Metastatic colon cancer is one of the leading causes of cancer-related death worldwide, with disease progression and metastatic spread being closely associated with angiogenesis. We investigated whether an ant...

    Authors: Lalitha R Belur, Kelly M Podetz-Pedersen, Brent S Sorenson, Alice H Hsu, Josh B Parker, Cathy S Carlson, Daniel A Saltzman, S Ramakrishnan and R Scott McIvor
    Citation: Molecular Cancer 2011 10:14
  10. Interferon-gamma (IFNγ) is a multifunctional cytokine with antifibrotic and antiproliferative efficiency. We previously found that pancreatic stellate cells (PSC), the main effector cells in cancer-associated ...

    Authors: Falko Lange, Katja Rateitschak, Brit Fitzner, Ralf Pöhland, Olaf Wolkenhauer and Robert Jaster
    Citation: Molecular Cancer 2011 10:13
  11. Curcumin (diferuloylmethane) is a polyphenol derived from the Curcuma longa plant, commonly known as turmeric. Curcumin has been used extensively in Ayurvedic medicine for centuries, as it is nontoxic and has a v...

    Authors: Reason Wilken, Mysore S Veena, Marilene B Wang and Eri S Srivatsan
    Citation: Molecular Cancer 2011 10:12
  12. The importance of the malignant cell environment to its growth and survival is becoming increasingly apparent, with dynamic cross talk between the neoplastic cell, the leukocyte infiltrate and the stroma. Most...

    Authors: Adele Hannigan, Asif M Qureshi, Colin Nixon, Penelope M Tsimbouri, Sarah Jones, Adrian W Philbey and Joanna B Wilson
    Citation: Molecular Cancer 2011 10:11
  13. B-lymphoma Moloney murine leukemia virus insertion region-1 (Bmi-1) acts as an oncogene in various tumors, and its overexpression correlates with a poor outcome in several human cancers. Ectopic expression of ...

    Authors: Bao-Hong Guo, Yan Feng, Rong Zhang, Li-Hua Xu, Man-Zhi Li, Hsiang-Fu Kung, Li-Bing Song and Mu-Sheng Zeng
    Citation: Molecular Cancer 2011 10:10
  14. Despite recent advances in outlining the mechanisms involved in pancreatic carcinogenesis, precise molecular pathways and cellular lineage specification remains incompletely understood.

    Authors: Inamul Haque, Smita Mehta, Monami Majumder, Kakali Dhar, Archana De, Douglas McGregor, Peter J Van Veldhuizen, Sushanta K Banerjee and Snigdha Banerjee
    Citation: Molecular Cancer 2011 10:8
  15. Breast cancer is a disease characterised by both genetic and epigenetic alterations. Epigenetic silencing of tumour suppressor genes is an early event in breast carcinogenesis and reversion of gene silencing b...

    Authors: Cinzia Allegrucci, Michael D Rushton, James E Dixon, Virginie Sottile, Mansi Shah, Rajendra Kumari, Sue Watson, Ramiro Alberio and Andrew D Johnson
    Citation: Molecular Cancer 2011 10:7
  16. LIM kinase 1 (LIMK1) is an actin and microtubule cytoskeleton modulatory protein that is overexpressed in a number of cancerous tissues and cells and also promotes invasion and metastasis of prostate and breas...

    Authors: Tenekua Tapia, Richard Ottman and Ratna Chakrabarti
    Citation: Molecular Cancer 2011 10:6
  17. NEK1, the first mammalian ortholog of the fungal protein kinase never-in-mitosis A (NIMA), is involved early in the DNA damage sensing/repair pathway. A defect in DNA repair in NEK1-deficient cells is suggeste...

    Authors: Yumay Chen, Chi-Fen Chen, Huai-Chin Chiang, Michelle Pena, Rosaria Polci, Randy L Wei, Robert A Edwards, Donna E Hansel, Phang-Lang Chen and Daniel J Riley
    Citation: Molecular Cancer 2011 10:5
  18. Hepatocellular carcinoma has a high mortality rate due to its rate of recurrence. Acyclic retinoid prevents recurrence of hepatocellular carcinoma in patients after surgical removal of their primary tumors by ...

    Authors: Hideki Tatsukawa, Tetsuro Sano, Yayoi Fukaya, Naoto Ishibashi, Makiko Watanabe, Masataka Okuno, Hisataka Moriwaki and Soichi Kojima
    Citation: Molecular Cancer 2011 10:4
  19. SKI and SnoN proteins have been shown to inhibit TGF-β signaling, acting both as transcriptional co-repressors in the cell nucleus, and as sequestrators of SMAD proteins in the cytoplasm. TGF-β, on the other h...

    Authors: Delphine Javelaud, Leon van Kempen, Vasileia I Alexaki, Erwan Le Scolan, Kunxin Luo and Alain Mauviel
    Citation: Molecular Cancer 2011 10:2
  20. MicroRNAs (miRNAs) are involved in cancer development and progression, acting as tumor suppressors or oncogenes. Our previous studies have revealed that miR-148a and miR-152 are significantly down-regulated in...

    Authors: Yong-Xi Song, Zhen-Yu Yue, Zhen-Ning Wang, Ying-Ying Xu, Yang Luo, Hui-Mian Xu, Xue Zhang, Li Jiang, Cheng-Zhong Xing and Yong Zhang
    Citation: Molecular Cancer 2011 10:1
  21. Different isoforms of VEGF-A (mainly VEGF121, VEGF165 and VEGF189) have been shown to display particular angiogenic properties in the generation of a functional tumor vasculature. Recently, a novel class of VEGF-...

    Authors: Raúl Catena, Leyre Larzabal, Marta Larrayoz, Eva Molina, Jose Hermida, Jackeline Agorreta, Ramon Montes, Ruben Pio, Luis M Montuenga and Alfonso Calvo
    Citation: Molecular Cancer 2010 9:320
  22. FBI-1 (f actor that b inds to the i nducer of short transcripts of human immunodeficiency virus-1) is a member of the POK (POZ and Kruppel) family of transcription factors and play important roles in cellular dif...

    Authors: LiLi Jiang, Michelle KY Siu, Oscar GW Wong, Kar Fai Tam, Eric W-F Lam, Hextan YS Ngan, Xiao-Feng Le, Esther SY Wong, Hoi Yan Chan and Annie NY Cheung
    Citation: Molecular Cancer 2010 9:318
  23. Tumor resistance to the selective estrogen receptor modulator tamoxifen remains a serious clinical problem especially in patients with tumors that also overexpress HER2. We have recently demonstrated that the ...

    Authors: Diana M Cittelly, Partha M Das, Nicole S Spoelstra, Susan M Edgerton, Jennifer K Richer, Ann D Thor and Frank E Jones
    Citation: Molecular Cancer 2010 9:317
  24. Lymph node metastasis constitutes a key event in tumor progression. The molecular control of this process is poorly understood. Heparan sulfate is a linear polysaccharide consisting of unique sulfate-modified ...

    Authors: Xin Yin, Jadwiga Truty, Roger Lawrence, Scott C Johns, R Sathish Srinivasan, Tracy M Handel and Mark M Fuster
    Citation: Molecular Cancer 2010 9:316
  25. Perifosine, an alkylphospholipid tested in phase II clinical trials, modulates the extrinsic apoptotic pathway and cooperates with tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) to augment apo...

    Authors: Lei Fu, Yi-Dan Lin, Heath A Elrod, Ping Yue, Youtake Oh, Bo Li, Hui Tao, Georgia Z Chen, Dong M Shin, Fadlo R Khuri and Shi-Yong Sun
    Citation: Molecular Cancer 2010 9:315
  26. Malignant mesotheliomas (MM) have a poor prognosis, largely because of their chemoresistance to anti-cancer drugs such as doxorubicin (Dox). Here we show using human MM lines that Dox activates extracellular s...

    Authors: Arti Shukla, Jedd M Hillegass, Maximilian B MacPherson, Stacie L Beuschel, Pamela M Vacek, Harvey I Pass, Michele Carbone, Joseph R Testa and Brooke T Mossman
    Citation: Molecular Cancer 2010 9:314
  27. Many members of the ETS-domain transcription factor family are important drivers of tumourigenesis. In this context, their activation by Ras-ERK pathway signaling is particularly relevant to the tumourigenic p...

    Authors: Richard Keld, Baoqiang Guo, Paul Downey, Christian Gulmann, Yeng S Ang and Andrew D Sharrocks
    Citation: Molecular Cancer 2010 9:313
  28. MCT-1 oncoprotein accelerates p53 protein degradation via a proteosome pathway. Synergistic promotion of the xenograft tumorigenicity has been demonstrated in circumstance of p53 loss alongside MCT-1 overexpre...

    Authors: Ravi Kasiappan, Hung-Ju Shih, Meng-Hsun Wu, ChikOn Choy, Tai-Du Lin, Linyi Chen and Hsin-Ling Hsu
    Citation: Molecular Cancer 2010 9:311
  29. Beta-catenin is a multifunctional oncogenic protein that contributes fundamentally to cell development and biology. Elevation in expression and activity of β-catenin has been implicated in many cancers and ass...

    Authors: Maher S Saifo, Donald R Rempinski Jr, Youcef M Rustum and Rami G Azrak
    Citation: Molecular Cancer 2010 9:310
  30. Spontaneous interleukin-6 (IL-6) production has been observed in various tumors and implicated in the pathogenesis, progression and drug resistance in cancer. However, the regulation of IL-6 autocrine producti...

    Authors: Wei-Lun Huang, Hsuan-Heng Yeh, Chien-Chung Lin, Wu-Wei Lai, Jang-Yang Chang, Wen-Tsan Chang and Wu-Chou Su
    Citation: Molecular Cancer 2010 9:309
  31. Activation of the RON receptor tyrosine kinase, a member of the c-MET family, regulates tumorigenic phenotypes. The RON extracellular domains are critical in regulating these activities. The objective of this ...

    Authors: Qi Ma, Kun Zhang, Sunny Guin, Yong-Qing Zhou and Ming-Hai Wang
    Citation: Molecular Cancer 2010 9:307
  32. Human serum and other body fluids are rich resources for the identification of novel biomarkers, which can be measured in routine clinical diagnosis. microRNAs are small non-coding RNA molecules, which have an...

    Authors: Jan C Brase, Daniela Wuttig, Ruprecht Kuner and Holger Sültmann
    Citation: Molecular Cancer 2010 9:306
  33. Epigenetic modifications play a key role in the patho-physiology of many tumors and the current use of agents targeting epigenetic changes has become a topic of intense interest in cancer research. DNA methylt...

    Authors: Giovanni L Gravina, Claudio Festuccia, Francesco Marampon, Vladimir M Popov, Richard G Pestell, Bianca M Zani and Vincenzo Tombolini
    Citation: Molecular Cancer 2010 9:305
  34. Neuronal synaptic junction protein δ-catenin (CTNND2) is often overexpressed in prostatic adenocarcinomas but the mechanisms of its activation are unknown. To address this question, we studied the hypothesis that...

    Authors: Jian-Ping Lu, Jiao Zhang, Kwonseop Kim, Thomas C Case, Robert J Matusik, Yan-hua Chen, Michael Wolfe, Jongdee Nopparat and Qun Lu
    Citation: Molecular Cancer 2010 9:304
  35. Sporadic breast cancer like many other cancers is proposed to be a manifestation of abnormal genetic and epigenetic changes. For the past decade our laboratory has identified genes involved in DNA damage respo...

    Authors: Ranjana Pal, Niloo Srivastava, Rupali Chopra, Sailesh Gochhait, Pawan Gupta, Neeraj Prakash, Gaurav Agarwal and Rameshwar NK Bamezai
    Citation: Molecular Cancer 2010 9:303
  36. Human T-cell leukemia virus type I (HTLV-I) has efficiently adapted to its host and establishes a persistent infection characterized by low levels of viral gene expression and slow proliferation of HTLV-I infe...

    Authors: Hicham H Baydoun, Joanna Pancewicz, XueTao Bai and Christophe Nicot
    Citation: Molecular Cancer 2010 9:302
  37. Advanced melanoma is characterized by a pronounced resistance to therapy leading to a limited patient survival of ~6 - 9 months. Here, we report on a novel bifunctional therapeutic fusion protein, designated a...

    Authors: Marco de Bruyn, Anna A Rybczynska, Yunwei Wei, Michael Schwenkert, Georg H Fey, Rudi AJO Dierckx, Aren van Waarde, Wijnand Helfrich and Edwin Bremer
    Citation: Molecular Cancer 2010 9:301
  38. Basal-like carcinoma are aggressive breast cancers that frequently carry p53 inactivating mutations, lack estrogen receptor-α (ERα) and express the cancer stem cell markers CD133 and CD44. These tumors also ov...

    Authors: Laura D'Anello, Pasquale Sansone, Gianluca Storci, Valentina Mitrugno, Gabriele D'Uva, Pasquale Chieco and Massimiliano Bonafé
    Citation: Molecular Cancer 2010 9:300
  39. Live animal imaging is becoming an increasingly common technique for accurate and quantitative assessment of tumor burden over time. Bioluminescence imaging systems rely on a bioluminescent signal from tumor c...

    Authors: Jessamy C Tiffen, Charles G Bailey, Cynthia Ng, John EJ Rasko and Jeff Holst
    Citation: Molecular Cancer 2010 9:299
  40. Sigma-2 receptors are over-expressed in proliferating cancer cells, making an attractive target for the targeted treatment of pancreatic cancer. In this study, we investigated the role of the novel sigma-2 rec...

    Authors: John R Hornick, Jinbin Xu, Suwanna Vangveravong, Zhude Tu, Jonathan B Mitchem, Dirk Spitzer, Peter Goedegebuure, Robert H Mach and William G Hawkins
    Citation: Molecular Cancer 2010 9:298
  41. The non-signalling chemokine receptors, including receptors DARC, D6 and CCX-CKR, have recently been shown to be involved in chemokine clearance and activity regulation. The human chemokine receptor CRAM (also...

    Authors: Julie Catusse, Marion Leick, Mareike Groch, David J Clark, Maike V Buchner, Katja Zirlik and Meike Burger
    Citation: Molecular Cancer 2010 9:297
  42. To identify new and useful candidate biomarkers in head and neck squamous cell carcinoma (HNSCC), we performed a genome-wide survey and found that Myelin and lymphocyte-associated protein (MAL) was a gene that...

    Authors: Wei Cao, Zhi-yuan Zhang, Qin Xu, Qiang Sun, Ming Yan, Jun Zhang, Ping Zhang, Ze-guang Han and Wan-tao Chen
    Citation: Molecular Cancer 2010 9:296
  43. Adult human mesenchymal stem cells (hMSC) have been shown to home to sites of carcinoma and affect biological processes, including tumour growth and metastasis. Previous findings have been conflicting and a cl...

    Authors: Lyndsay V Rhodes, James W Antoon, Shannon E Muir, Steven Elliott, Barbara S Beckman and Matthew E Burow
    Citation: Molecular Cancer 2010 9:295
  44. Parathyroid carcinoma (PC) is a very rare malignancy with a high tendency to recur locally, and recurrent disease is difficult to eradicate. In most western European countries and United States, these malignan...

    Authors: Jessica Svedlund, Maria Aurén, Magnus Sundström, Henning Dralle, Göran Åkerström, Peyman Björklund and Gunnar Westin
    Citation: Molecular Cancer 2010 9:294

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