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  1. Activating KRAS mutations are important for cancer initiation and progression; and have recently been shown to cause primary resistance to therapies targeting the epidermal growth factor receptor. Therefore, stra...

    Authors: Sang Y Chun, Craig Johnson, Joseph G Washburn, Marcia R Cruz-Correa, Duyen T Dang and Long H Dang
    Citation: Molecular Cancer 2010 9:293
  2. Activating mutations of the FLT3 gene mediate leukemogenesis, at least in part, through activation of PI3K/AKT. The mammalian target of rapamycin (mTOR)-Raptor signaling pathway is known to act downstream of AKT....

    Authors: Weina Chen, Elias Drakos, Ioannis Grammatikakis, Ellen J Schlette, Jiang Li, Vasiliki Leventaki, Efi Staikou-Drakopoulou, Efstratios Patsouris, Panayiotis Panayiotidis, L Jeffrey Medeiros and George Z Rassidakis
    Citation: Molecular Cancer 2010 9:292
  3. ZNF217 is a candidate oncogene located at 20q13, a chromosomal region frequently amplified in breast cancers. The precise mechanisms involved in ZNF217 pro-survival function are currently unknown, and utmost i...

    Authors: Aurélie Thollet, Julie A Vendrell, Léa Payen, Sandra E Ghayad, Sabrina Ben Larbi, Evelyne Grisard, Colin Collins, Marie Villedieu and Pascale A Cohen
    Citation: Molecular Cancer 2010 9:291
  4. We hypothesised that differences in microRNA expression profiles contribute to the contrasting natural history and clinical outcome of the two most common types of malignant germ cell tumour (GCT), yolk sac tu...

    Authors: Matthew J Murray, Harpreet K Saini, Stijn van Dongen, Roger D Palmer, Balaji Muralidhar, Mark R Pett, Matias Piipari, Claire M Thornton, James C Nicholson, Anton J Enright and Nicholas Coleman
    Citation: Molecular Cancer 2010 9:290
  5. A critical therapeutic challenge in epithelial ovarian carcinoma is the development of chemoresistance among tumor cells following exposure to first line chemotherapeutics. The molecular and genetic changes th...

    Authors: Shelley B Hooks, Phillip Callihan, Molly K Altman, Jillian H Hurst, Mourad W Ali and Mandi M Murph
    Citation: Molecular Cancer 2010 9:289
  6. Cancer cells are believed to arise primarily from stem cells. CD44+/CD24- have been identified as markers for human breast cancer stem cells. Although, HER2 is a well known breast cancer oncogene, the mechanisms ...

    Authors: Kai-Hung Wang, An-Pei Kao, Chia-Cheng Chang, Jau-Nan Lee, Ming-Feng Hou, Cheng-Yu Long, Hung-Sheng Chen and Eing-Mei Tsai
    Citation: Molecular Cancer 2010 9:288
  7. Podoplanin, a mucin-like transmembrane glycoprotein, is reportedly expressed in a variety of malignant cells and is generally regarded as a factor for promoting tumor progression in conventional studies. By co...

    Authors: Hanako Suzuki, Mitsuho Onimaru, Yoshikazu Yonemitsu, Yoshihiko Maehara, Seiji Nakamura and Katsuo Sueishi
    Citation: Molecular Cancer 2010 9:287
  8. Ethanol is a tumor promoter. Both epidemiological and experimental studies suggest that ethanol may enhance the metastasis of breast cancer cells. We have previously demonstrated that ethanol increased the mig...

    Authors: Mei Xu, Kimberly A Bower, Siying Wang, Jacqueline A Frank, Gang Chen, Min Ding, Shiow Wang, Xianglin Shi, Zunji Ke and Jia Luo
    Citation: Molecular Cancer 2010 9:285
  9. Rearrangement of the mixed-lineage leukemia gene (MLL) is found in 80% of infant acute lymphoblastic leukemia (ALL) and is associated with poor prognosis and resistance to glucocorticoids (GCs). We have recently ...

    Authors: Alex H Beesley, Janelle L Rampellini, Misty-Lee Palmer, Jasmin YS Heng, Amy L Samuels, Martin J Firth, Jette Ford and Ursula R Kees
    Citation: Molecular Cancer 2010 9:284
  10. Head and neck squamous cell carcinoma (HNSCC) is a highly lethal cancer that contains cellular and functional heterogeneity. Previously, we enriched a subpopulation of highly tumorigenic head and neck cancer i...

    Authors: Meng-Ju Wu, Chia-Ing Jan, Yeou-Guang Tsay, Yau-Hua Yu, Chih-Yang Huang, Shu-Chun Lin, Chung-Ji Liu, Yu-Syuan Chen, Jeng-Fan Lo and Cheng-Chia Yu
    Citation: Molecular Cancer 2010 9:283
  11. Recent observations indicate potential role of transcription factor STAT3 in cervical cancer development but its role specifically with respect to HPV infection is not known. Present study has been designed to...

    Authors: Shirish Shukla, Gauri Shishodia, Sutapa Mahata, Suresh Hedau, Arvind Pandey, Suresh Bhambhani, Swaraj Batra, Seemi F Basir, Bhudev C Das and Alok C Bharti
    Citation: Molecular Cancer 2010 9:282
  12. Metastatic melanoma is an aggressive malignancy that is resistant to therapy and has a poor prognosis. The progression of primary melanoma to metastatic disease is a multi-step process that requires dynamic re...

    Authors: Srinivas Vinod Saladi, Bridget Keenen, Himangi G Marathe, Huiling Qi, Khew-Voon Chin and Ivana L de la Serna
    Citation: Molecular Cancer 2010 9:280
  13. Pim family kinases are small constitutively active serine/threonine-specific kinases, elevated levels of which have been detected in human hematopoietic malignancies as well as in solid tumours. While we and o...

    Authors: Niina M Santio, Riitta L Vahakoski, Eeva-Marja Rainio, Jouko A Sandholm, Sanna S Virtanen, Michelle Prudhomme, Fabrice Anizon, Pascale Moreau and Päivi J Koskinen
    Citation: Molecular Cancer 2010 9:279
  14. TPC-1 is a papillary thyroid carcinoma (PTC)-derived cell line that spontaneously expresses the oncogene RET/PTC1. TPC-1 treated with the RET/PTC1 inhibitor RPI-1 displayed a cytostatic and reversible inhibition ...

    Authors: Dario Caccia, Francesca Miccichè, Giuliana Cassinelli, Piera Mondellini, Patrizia Casalini and Italia Bongarzone
    Citation: Molecular Cancer 2010 9:278
  15. The chromodomain, helicase DNA-binding protein 5 (CHD5) is a potential tumor suppressor gene located on chromosome 1p36, a region recurrently deleted in high risk neuroblastoma (NB). Previous data have shown t...

    Authors: Idoia Garcia, Gemma Mayol, Eva Rodríguez, Mariona Suñol, Timothy R Gershon, José Ríos, Nai-Kong V Cheung, Mark W Kieran, Rani E George, Antonio R Perez-Atayde, Carla Casala, Patricia Galván, Carmen de Torres, Jaume Mora and Cinzia Lavarino
    Citation: Molecular Cancer 2010 9:277
  16. Neuropilin is a transmembrane receptor for vascular endothelial growth factor (VEGF) and is expressed in normal endothelial cells and upregulated in cancer cells. Neuropilin-1 (NRP-1) has been shown to promote...

    Authors: Danny CW Yu, Jennifer S Waby, Haridasan Chirakkal, Carolyn A Staton and Bernard M Corfe
    Citation: Molecular Cancer 2010 9:276
  17. Butyrate, a known histone deacetylase inhibitor (HDACi) and product of fibre fermentation, is postulated to mediate the protective effect of dietary fibre against colon cancer. The transcription factor Sp1 is ...

    Authors: Jennifer S Waby, Haridasan Chirakkal, ChenWei Yu, Gareth J Griffiths, Roderick SP Benson, Colin D Bingle and Bernard M Corfe
    Citation: Molecular Cancer 2010 9:275
  18. The status of estrogen receptor-α (ERα) is critical to the clinical prognosis and therapeutic approach in breast cancer. ERα-negative breast cancer is clinically aggressive and has a poor prognosis because of ...

    Authors: Yuanyuan Li, Yih-Ying Yuan, Syed M Meeran and Trygve O Tollefsbol
    Citation: Molecular Cancer 2010 9:274
  19. Increased numbers of tumour-associated macrophages correlate with shortened survival in some cancers. The molecular bases of this correlation are not thoroughly understood. Events triggered by CXCL12 may play ...

    Authors: Antonella Rigo, Michele Gottardi, Alberto Zamò, Pierluigi Mauri, Massimiliano Bonifacio, Mauro Krampera, Ernesto Damiani, Giovanni Pizzolo and Fabrizio Vinante
    Citation: Molecular Cancer 2010 9:273
  20. We previously identified that Ran protein, a member of the Ras GTPase family, is highly expressed in high grade and high stage serous epithelial ovarian cancers, and that its overexpression is associated with ...

    Authors: Véronique Barrès, Véronique Ouellet, Julie Lafontaine, Patricia N Tonin, Diane M Provencher and Anne-Marie Mes-Masson
    Citation: Molecular Cancer 2010 9:272
  21. Among the most harmful of all genetic abnormalities that appear in colorectal cancer (CRC) development are mutations of KRAS and its downstream effector BRAF as they result in abnormal extracellular signal-rel...

    Authors: Sébastien Bergeron, Etienne Lemieux, Véronique Durand, Sébastien Cagnol, Julie C Carrier, Jacques G Lussier, Marie-Josée Boucher and Nathalie Rivard
    Citation: Molecular Cancer 2010 9:271
  22. Glioblastoma multiforme is the most malignant cancer of the brain and is notoriously difficult to treat due to the highly proliferative and infiltrative nature of the cells. Herein, we explored the combination...

    Authors: Ivy A Ho, Wai H Ng and Paula Y Lam
    Citation: Molecular Cancer 2010 9:270
  23. Stress, anxiety and depression can cause complex physiological and neuroendocrine changes, resulting in increased level of stress related hormone catecholamine, which may constitute a primary mechanism by whic...

    Authors: Ming Shi, Dan Liu, Huijun Duan, Caili Han, Bo Wei, Lu Qian, Changguo Chen, Liang Guo, Meiru Hu, Ming Yu, Lun Song, Beifen Shen and Ning Guo
    Citation: Molecular Cancer 2010 9:269
  24. Hypoxia-inducible factor-1α (HIF-1α), a critical transcription factor to reduced O2 availability, has been demonstrated to be extensively involved in tumor survival, aggressive progression, drug resistance and an...

    Authors: Zhao-Li Zhou, Zhi-Guo Luo, Bing Yu, Yi Jiang, Yi Chen, Jian-Ming Feng, Mei Dai, Lin-Jiang Tong, Zheng Li, Yuan-Chao Li, Jian Ding and Ze-Hong Miao
    Citation: Molecular Cancer 2010 9:268
  25. Activated leukocyte cell adhesion molecule (ALCAM) is implicated in the prognosis of multiple cancers with low level expression associated with metastasis and early death in breast cancer. Despite this signifi...

    Authors: Judy A King, Fang Tan, Flaubert Mbeunkui, Zachariah Chambers, Sarah Cantrell, Hairu Chen, Diego Alvarez, Lalita A Shevde and Solomon F Ofori-Acquah
    Citation: Molecular Cancer 2010 9:266
  26. Polycomb group (PcG) proteins are crucial for neural cancer stem cell (NCSC) self-renewal. However, the relative expression levels of PcG genes in different subtypes of brain tumors, their prognostic role and ...

    Authors: Francesco Crea, Elaine M Hurt and William L Farrar
    Citation: Molecular Cancer 2010 9:265
  27. The Ras association domain family (RASSF) encodes for distinct tumor suppressors and several members are frequently silenced in human cancer. In our study, we analyzed the role of RASSF2, RASSF3, RASSF4, RASSF...

    Authors: Undraga Schagdarsurengin, Antje M Richter, Juliane Hornung, Cornelia Lange, Katrin Steinmann and Reinhard H Dammann
    Citation: Molecular Cancer 2010 9:264
  28. Sin3A is an evolutionarily conserved transcriptional repressor which regulates gene expression as part of the multi-protein Sin3 repressive complex. It functions as a scaffold upon which proteins with enzymati...

    Authors: Stephanie J Ellison-Zelski and Elaine T Alarid
    Citation: Molecular Cancer 2010 9:263
  29. Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL; apo2 ligand) induces apoptosis in cancer cells but has little effect on normal cells. However, many cancer cell types are resistant to TRAI...

    Authors: Ji-Young Jang, Yoon-Kyung Jeon, Yun Choi and Chul-Woo Kim
    Citation: Molecular Cancer 2010 9:262
  30. Stress has been shown to be a tumor promoting factor. Both clinical and laboratory studies have shown that chronic stress is associated with tumor growth in several types of cancer. Corticotropin Releasing Fac...

    Authors: Alicia Arranz, Maria Venihaki, Berber Mol, Ariadne Androulidaki, Erini Dermitzaki, Olga Rassouli, Jorge Ripoll, Efstathios N Stathopoulos, Rosa P Gomariz, Andrew N Margioris and Christos Tsatsanis
    Citation: Molecular Cancer 2010 9:261
  31. Drug resistance is one of the major obstacles limiting the activity of anticancer agents. Activation of DNA repair mechanism often accounts for increase resistance to cancer chemotherapy.

    Authors: Maria Antonietta Sabatino, Mirko Marabese, Monica Ganzinelli, Elisa Caiola, Cristina Geroni and Massimo Broggini
    Citation: Molecular Cancer 2010 9:259
  32. Prostate cancer (PCa) cells preferentially metastasize to bone at least in part by acquiring osteomimetic properties. Runx2, an osteoblast master transcription factor, is aberrantly expressed in PCa cells, and...

    Authors: Sanjeev K Baniwal, Omar Khalid, Yankel Gabet, Ruchir R Shah, Daniel J Purcell, Deepak Mav, Alice E Kohn-Gabet, Yunfan Shi, Gerhard A Coetzee and Baruch Frenkel
    Citation: Molecular Cancer 2010 9:258
  33. Myxoid liposarcoma is a relatively common malignant soft tissue tumor, characterized by a (12;16) translocation resulting in a FUS-DDIT3 fusion gene playing a pivotal role in its tumorigenesis. Treatment optio...

    Authors: Stefan M Willems, Yvonne M Schrage, Inge H Briaire-de Bruijn, Karoly Szuhai, Pancras CW Hogendoorn and Judith VMG Bovée
    Citation: Molecular Cancer 2010 9:257
  34. Dysregulation of epidermal growth factor and insulin-like growth factor signaling play important roles in human hepatocellular carcinoma (HCC), leading to frequent activation of their downstream targets, the r...

    Authors: Nicolas Charette, Christine De Saeger, Valérie Lannoy, Yves Horsmans, Isabelle Leclercq and Peter Stärkel
    Citation: Molecular Cancer 2010 9:256
  35. Malignant transformation of melanocytes is frequently attended by a switch in cadherin expression profile as shown for E- and N-cadherin. For P-cadherin, downregulation in metastasizing melanoma has been demon...

    Authors: Koen Jacobs, Mireille Van Gele, Ramses Forsyth, Lieve Brochez, Barbara Vanhoecke, Olivier De Wever and Marc Bracke
    Citation: Molecular Cancer 2010 9:255
  36. Cancer arises from normal cells through the stepwise accumulation of genetic alterations. Cancer development can be studied by direct genetic manipulation within experimental models of tumorigenesis. Thereby, ...

    Authors: Stephanie M Pütz, Fotini Vogiatzi, Thorsten Stiewe and Albert Sickmann
    Citation: Molecular Cancer 2010 9:254
  37. β-catenin, a key factor in the Wnt signaling pathway, has essential functions in the regulation of cell growth and differentiation. Aberrant β-catenin signaling has been linked to various disease pathologies, ...

    Authors: Kai Huang, Jun-Xia Zhang, Lei Han, Yong-Ping You, Tao Jiang, Pei-Yu Pu and Chun-Sheng Kang
    Citation: Molecular Cancer 2010 9:252
  38. Sema4D, also known as CD100, is a protein belonging to class IV semaphorin. Its physiologic roles in the immune and nervous systems have been extensively explored. However, the roles of Sema4D have extended be...

    Authors: Ewe Seng Ch'ng and Atsushi Kumanogoh
    Citation: Molecular Cancer 2010 9:251
  39. A growing body of work implicates chemokines, in particular CXCL12 and its receptors, in the progression and site-specific metastasis of various cancers, including breast cancer. Various agents have been used ...

    Authors: Sharon A Williams, Yuka Harata-Lee, Iain Comerford, Robin L Anderson, Mark J Smyth and Shaun R McColl
    Citation: Molecular Cancer 2010 9:250
  40. Colorectal cancer (CRC) has long been associated with bacteremia and/or endocarditis by Streptococcus gallolyticus member bacteria (SGMB) but the direct colonization of SGMB along with its molecular carcinogenic ...

    Authors: Ahmed S Abdulamir, Rand R Hafidh and Fatimah Abu Bakar
    Citation: Molecular Cancer 2010 9:249
  41. Cisplatin based chemotherapy cures over 80% of metastatic testicular germ cell tumours (TGCT). In contrast, almost all other solid cancers in adults are incurable once they have spread beyond the primary site....

    Authors: Svetlana Usanova, Andrea Piée-Staffa, Ulrike Sied, Jürgen Thomale, Astrid Schneider, Bernd Kaina and Beate Köberle
    Citation: Molecular Cancer 2010 9:248
  42. The canonical Wnt signaling is concurrently important for osteoblast differentiation and myeloma cell proliferation. Its activation in myeloma cells and its inhibition in osteoblasts and their progenitors have...

    Authors: Xiaoyi Dun, Hua Jiang, Jianfeng Zou, Jun Shi, Lili Zhou, Rong Zhu and Jian Hou
    Citation: Molecular Cancer 2010 9:247
  43. The HOX11/TLX1 (hereafter referred to as HOX11) homeobox gene was originally identified at a t(10;14)(q24;q11) translocation breakpoint, a chromosomal abnormality observed in 5-7% of T cell acute lymphoblastic...

    Authors: Edwin Chen, Xiaoyong Huang, Yanzhen Zheng, You-Jun Li, Alden Chesney, Yaacov Ben-David, Eric Yang and Margaret R Hough
    Citation: Molecular Cancer 2010 9:246
  44. Differentiation-inducing factor-1 (DIF-1) is a putative morphogen that induces cell differentiation in Dictyostelium discoideum. DIF-1 inhibits proliferation of various mammalian tumor cells by suppressing the ca...

    Authors: Tatsuya Yoshihara, Fumi Takahashi-Yanaga, Fumie Shiraishi, Sachio Morimoto, Yutaka Watanabe, Masato Hirata, Sumio Hoka and Toshiyuki Sasaguri
    Citation: Molecular Cancer 2010 9:245
  45. Frequent mutations of p53 in human cancers exemplify its crucial role as a tumor suppressor transcription factor, and p21, a transcriptional target of p53, plays a central role in surveillance of cell-cycle ch...

    Authors: Xifeng Zhang, Qian Zhang, Jun Zhang, Li Qiu, Shuang-shuang Yan, Juling Feng, Yan Sun, Xingxu Huang, Karen H Lu and Zheng Li
    Citation: Molecular Cancer 2010 9:244

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