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  1. Drug resistance is the outcome of multiple-gene interactions in cancer cells under stress of anticancer agents. MDR1 overexpression is most commonly detected in drug-resistant cancers and accompanied with other g...

    Authors: Yong-Yu Liu, Vineet Gupta, Gauri A Patwardhan, Kaustubh Bhinge, Yunfeng Zhao, Jianxiong Bao, Harihara Mehendale, Myles C Cabot, Yu-Teh Li and S Michal Jazwinski
    Citation: Molecular Cancer 2010 9:145
  2. Prostate cancer shows an extremely slow progression, appearing in its metastatic, hormone refractory phenotype mostly in elderly men. The chemopreventive targeting of this tumor could accordingly delay its mal...

    Authors: Roberto Benelli, Stefano Monteghirfo, Roberta Venè, Francesca Tosetti and Nicoletta Ferrari
    Citation: Molecular Cancer 2010 9:142
  3. Solid tumors are often poorly vascularized, with cells that can be 100 μm away from blood vessels. These distant cells get less oxygen and nutrients and are exposed to lower doses of chemotherapeutic agents. A...

    Authors: Sylvine Cottin, Karim Ghani, Pedro Otavio de Campos-Lima and Manuel Caruso
    Citation: Molecular Cancer 2010 9:141
  4. Although the incidence of melanoma in the U.S. is rising faster than any other cancer, the FDA-approved chemotherapies lack efficacy for advanced disease, which results in poor overall survival. Lysophosphatid...

    Authors: Molly K Altman, Vashisht Gopal, Wei Jia, Shuangxing Yu, Hassan Hall, Gordon B Mills, A Cary McGinnis, Michael G Bartlett, Guowei Jiang, Damian Madan, Glenn D Prestwich, Yong Xu, Michael A Davies and Mandi M Murph
    Citation: Molecular Cancer 2010 9:140
  5. Cetuximab, an antibody targeting the epidermal growth factor receptor (EGFR), increases survival in patients with advanced EGFR-positive non-small cell lung cancer when administrated in combination with chemot...

    Authors: Yi-Fan Hsu, Daniel Ajona, Leticia Corrales, Jose M Lopez-Picazo, Alfonso Gurpide, Luis M Montuenga and Ruben Pio
    Citation: Molecular Cancer 2010 9:139
  6. New, more effective strategies are needed to treat highly aggressive neuroblastoma. Our laboratory has previously shown that full-length Secreted Protein Acidic and Rich in Cysteine (SPARC) and a SPARC peptide...

    Authors: Alexandre Chlenski, Lisa J Guerrero, Radhika Peddinti, Jared A Spitz, Payton T Leonhardt, Qiwei Yang, Yufeng Tian, Helen R Salwen and Susan L Cohn
    Citation: Molecular Cancer 2010 9:138
  7. Sharing the common neuroectodermal origin, melanoma and neuroblastoma are tumors widely diffused among adult and children, respectively. Clinical prognosis of aggressive neuroectodermal cancers remains dismal,...

    Authors: Marina Pisano, Gabriella Pagnan, Maria Antonietta Dettori, Sara Cossu, Irene Caffa, Ilaria Sassu, Laura Emionite, Davide Fabbri, Michele Cilli, Fabio Pastorino, Giuseppe Palmieri, Giovanna Delogu, Mirco Ponzoni and Carla Rozzo
    Citation: Molecular Cancer 2010 9:137
  8. In a variety of cancers, altered patterns of microRNA (miRNA) expression are reported and may affect the cell cycle and cell survival. Recent studies suggest that the expression level of miRNAs that act as tum...

    Authors: Akio Iio, Yoshihito Nakagawa, Ichiro Hirata, Tomoki Naoe and Yukihiro Akao
    Citation: Molecular Cancer 2010 9:136
  9. Glioblastoma (GBM) is the most common and malignant primary intracranial human neoplasm. GBMs are characterized by the presence of extensive areas of necrosis and hypoxia. Hypoxia and its master regulator, hyp...

    Authors: Olga Méndez, Jiri Zavadil, Mine Esencay, Yevgeniy Lukyanov, Daniel Santovasi, Shu-Chi Wang, Elizabeth W Newcomb and David Zagzag
    Citation: Molecular Cancer 2010 9:133
  10. Telomerase is activated in oncogenesis, which confers an immortal phenotype to cancer cells. The AAA + ATPase Reptin is required for telomerase biogenesis by maintaining telomerase RNA (hTER) stability and is ...

    Authors: Wenjuan Li, Jiping Zeng, Qiao Li, Li Zhao, Tiantian Liu, Magnus Björkholm, Jihui Jia and Dawei Xu
    Citation: Molecular Cancer 2010 9:132
  11. A maximum entropy approach is proposed to predict the cytotoxic effects of a panel of colchicine derivatives in several human cancer cell lines. Data was obtained from cytotoxicity assays performed with 21 dru...

    Authors: Chih-Yuan Tseng, Jonathan Y Mane, Philip Winter, Lorelei Johnson, Torin Huzil, Elzbieta Izbicka, Richard F Luduena and Jack A Tuszynski
    Citation: Molecular Cancer 2010 9:131
  12. Lung cancer is one of the most prevalent neoplasias in developed countries. Advances in patient survival have been limited and the identification of prognostic molecules is needed. Resistance to treatment is s...

    Authors: Marta Irigoyen, María J Pajares, Jackeline Agorreta, Mariano Ponz-Sarvisé, Elisabeth Salvo, María D Lozano, Ruben Pío, Ignacio Gil-Bazo and Ana Rouzaut
    Citation: Molecular Cancer 2010 9:130
  13. Human mesenchymal stromal cells (MSC) hold a promise for future cell-based therapies due to their immunomodulatory properties and/or secretory activity. Nevertheless non-neoplastic tumor compartment could also...

    Authors: Lucia Kucerova, Miroslava Matuskova, Kristina Hlubinova, Veronika Altanerova and Cestmir Altaner
    Citation: Molecular Cancer 2010 9:129
  14. VHZ is a VH1-like (member Z) dual specific protein phosphatase encoded by DUSP23 gene. Some of the dual specific protein phosphatases (DSPs) play an important role in cell cycle control and have shown to be as...

    Authors: Jing Ping Tang, Cheng Peow Tan, Jie Li, Md Monowarul Siddique, Ke Guo, Siew Wee Chan, Jung Eun Park, Wan Ngee Tay, Zhi Yuan Huang, Wen Cai Li, Jian Chen and Qi Zeng
    Citation: Molecular Cancer 2010 9:128
  15. Inactivation of the Fanconi anemia (FA) pathway through defects in one of 13 FA genes occurs at low frequency in various solid cancer entities among the general population. As FA pathway inactivation confers a...

    Authors: Andreas Palagyi, Kornelia Neveling, Ursula Plinninger, Andreas Ziesch, Bianca-Sabrina Targosz, Gerald U Denk, Stephanie Ochs, Antonia Rizzani, Daniel Meier, Wolfgang E Thasler, Helmut Hanenberg, Enrico N De Toni, Florian Bassermann, Claus Schäfer, Burkhard Göke, Detlev Schindler…
    Citation: Molecular Cancer 2010 9:127
  16. Our previous study showed that, in basal cell carcinoma cells, arecoline reduces levels of the tumor cell survival factor interleukin-6 (IL-6), increases levels of tumor suppressor factor p53, and elicits cell...

    Authors: Hsiao-Ling Cheng, Shu-Jem Su, Li-Wen Huang, Bau-Shan Hsieh, Yu-Chen Hu, Thu-Ching Hung and Kee-Lung Chang
    Citation: Molecular Cancer 2010 9:126
  17. Genome-wide DNA hypomethylation plays a role in genomic instability and carcinogenesis. LINE-1 (L1 retrotransposon) constitutes a substantial portion of the human genome, and LINE-1 methylation correlates with...

    Authors: Yoshifumi Baba, Curtis Huttenhower, Katsuhiko Nosho, Noriko Tanaka, Kaori Shima, Aditi Hazra, Eva S Schernhammer, David J Hunter, Edward L Giovannucci, Charles S Fuchs and Shuji Ogino
    Citation: Molecular Cancer 2010 9:125
  18. Androgen signaling plays a critical role in the development of prostate cancer and its progression. However, androgen-independent prostate cancer cells emerge after hormone ablation therapy, resulting in signi...

    Authors: Young-Rang Kim, Kyung-Jin Oh, Ra-Young Park, Nguyen Thi Xuan, Taek-Won Kang, Dong-Deuk Kwon, Chan Choi, Min Soo Kim, Kwang Il Nam, Kyu Youn Ahn and Chaeyong Jung
    Citation: Molecular Cancer 2010 9:124
  19. Fludarabine, is one of the most active single agents in the treatment of chronic lymphocytic leukemia (CLL). Over time, however, virtually all CLL patients become fludarabine-refractory. To elucidate whether m...

    Authors: Manuela Ferracin, Barbara Zagatti, Lara Rizzotto, Francesco Cavazzini, Angelo Veronese, Maria Ciccone, Elena Saccenti, Laura Lupini, Andrea Grilli, Cristiano De Angeli, Massimo Negrini and Antonio Cuneo
    Citation: Molecular Cancer 2010 9:123
  20. Transforming Growth Factor β (TGF-β) plays an important role in tumor invasion and metastasis. We set out to investigate the possible clinical utility of TGF-β antagonists in a human metastatic basal-like brea...

    Authors: Vidya Ganapathy, Rongrong Ge, Alison Grazioli, Wen Xie, Whitney Banach-Petrosky, Yibin Kang, Scott Lonning, John McPherson, Jonathan M Yingling, Swati Biswas, Gregory R Mundy and Michael Reiss
    Citation: Molecular Cancer 2010 9:122
  21. Gastric cancer is the second leading cause of cancer mortality in the world. The receptor tyrosine kinase MET is constitutively activated in many gastric cancers and its expression is strictly required for sur...

    Authors: Simona Corso, Elena Ghiso, Virna Cepero, J Rafael Sierra, Cristina Migliore, Andrea Bertotti, Livio Trusolino, Paolo M Comoglio and Silvia Giordano
    Citation: Molecular Cancer 2010 9:121
  22. The t(9;22)(q34;q11), generating the Philadelphia (Ph) chromosome, is found in more than 90% of patients with chronic myeloid leukemia (CML). As a result of the translocation, the 3' portion of the ABL1 oncogene ...

    Authors: Francesco Albano, Luisa Anelli, Antonella Zagaria, Nicoletta Coccaro, Paola Casieri, Antonella Russo Rossi, Laura Vicari, Vincenzo Liso, Mariano Rocchi and Giorgina Specchia
    Citation: Molecular Cancer 2010 9:120
  23. Nuclear pore complexes are massive multiprotein channels responsible for traffic between the nucleus and cytoplasm, and are composed of approximately 30 proteins, termed nucleoporins (Nup). Our recent studies ...

    Authors: Chieko Hashizume, Hiroshi Nakano, Kimihisa Yoshida and Richard W Wong
    Citation: Molecular Cancer 2010 9:119
  24. MUC16 is a cell surface mucin expressed at high levels by epithelial ovarian tumors. Following proteolytic cleavage, cell surface MUC16 (csMUC16) is shed in the extracellular milieu and is detected in the seru...

    Authors: Jennifer A Belisle, Sachi Horibata, Gubbels AA Jennifer, Sarah Petrie, Arvinder Kapur, Sabine André, Hans-Joachim Gabius, Claudine Rancourt, Joseph Connor, James C Paulson and Manish S Patankar
    Citation: Molecular Cancer 2010 9:118
  25. Nuclear factor-κB (NF-κB) is constitutively activated in many cancers and plays a key role in promoting cell proliferation, survival, and invasion. Our understanding of NF-κB signaling in thyroid cancer, howev...

    Authors: Kevin T Bauerle, Rebecca E Schweppe and Bryan R Haugen
    Citation: Molecular Cancer 2010 9:117
  26. p27Kip1 (p27) is an important negative regulator of the cell cycle and a putative tumor suppressor. The finding that a spontaneous germline frameshift mutation in Cdkn1b (encoding p27) causes the MENX multiple en...

    Authors: Sara Molatore, Eva Kiermaier, Christian B Jung, Misu Lee, Elke Pulz, Heinz Höfler, Michael J Atkinson and Natalia S Pellegata
    Citation: Molecular Cancer 2010 9:116
  27. Chronic lymphocytic leukemia (CLL) cells are often affected by genomic aberrations targeting key regulatory genes. Although fludarabine is the standard first line therapy to treat CLL, only few data are availa...

    Authors: Etienne Moussay, Valérie Palissot, Laurent Vallar, Hélène A Poirel, Thomas Wenner, Victoria El Khoury, Nasséra Aouali, Kris Van Moer, Bernadette Leners, François Bernardin, Arnaud Muller, Pascale Cornillet-Lefebvre, Alain Delmer, Caroline Duhem, Fernand Ries, Eric van Dyck…
    Citation: Molecular Cancer 2010 9:115
  28. Chemotherapeutic drugs like Adriamycin (ADR) induces apoptosis or senescence in cancer cells but these cells often develop resistance and generate responses of short duration or complete failure. The methylxan...

    Authors: Alejandro Bravo-Cuellar, Pablo C Ortiz-Lazareno, Jose M Lerma-Diaz, Jorge R Dominguez-Rodriguez, Luis F Jave-Suarez, Adriana Aguilar-Lemarroy, Susana del Toro-Arreola, Ruth de Celis-Carrillo, Jose E Sahagun-Flores, Javier E Garcia de Alba-Garcia and Georgina Hernandez-Flores
    Citation: Molecular Cancer 2010 9:114
  29. A recent genome-wide association study (GWAS) has identified a single nucleotide polymorphism (SNP) rs11249433 in the 1p11.2 region as a novel genetic risk factor for breast cancer, and this association was st...

    Authors: Yi-Ping Fu, Hege Edvardsen, Alpana Kaushiva, Juan P Arhancet, Tiffany M Howe, Indu Kohaar, Patricia Porter-Gill, Anushi Shah, Hege Landmark-Høyvik, Sophie D Fosså, Stefan Ambs, Bjørn Naume, Anne-Lise Børresen-Dale, Vessela N Kristensen and Ludmila Prokunina-Olsson
    Citation: Molecular Cancer 2010 9:113
  30. Chronic myelogenous leukemia (CML) is characterized by the chimeric tyrosine kinase Bcr-Abl. Bcr-Abl-T315I is the notorious point mutation that causes resistance to imatinib and the second generation tyrosine ...

    Authors: Zhongzheng Lu, Yanli Jin, Chun Chen, Juan Li, Qi Cao and Jingxuan Pan
    Citation: Molecular Cancer 2010 9:112

    The Correction to this article has been published in Molecular Cancer 2021 20:172

  31. Bortezomib, a proteasome-specific inhibitor, has emerged as a promising cancer therapeutic agent. However, development of resistance to bortezomib may pose a challenge to effective anticancer therapy. Therefor...

    Authors: Lidong Zhang, James E Littlejohn, Yu Cui, Xiaobo Cao, Chander Peddaboina and W Roy Smythe
    Citation: Molecular Cancer 2010 9:110
  32. Klotho was originally characterized as an anti-aging gene that predisposed Klotho-deficient mice to a premature aging-like syndrome. Recently, KLOTHO was reported to function as a secreted Wnt antagonist and as a...

    Authors: Jaehyouk Lee, Dong-Jun Jeong, Jinsun Kim, Soonduck Lee, Jin-Hwa Park, Boogi Chang, Sam-Il Jung, Lisha Yi, Youngsoo Han, Young Yang, Keun Il Kim, Jong-Seok Lim, Inchul Yang, Seob Jeon, Dong Han Bae, Chang-Jin Kim…
    Citation: Molecular Cancer 2010 9:109
  33. In prostate cancer (PCa), the common treatment involving androgen ablation alleviates the disease temporarily, but results in the recurrence of highly aggressive and androgen-independent metastatic cancer. The...

    Authors: Paul Cao, Zhiyong Deng, Meimei Wan, Weiwei Huang, Scott D Cramer, Jianfeng Xu, Ming Lei and Guangchao Sui
    Citation: Molecular Cancer 2010 9:108
  34. The orally active quinoline-3-carboxamide tasquinimod [ABR-215050; CAS number 254964-60-8), which currently is in a phase II-clinical trial in patients against metastatic prostate cancer, exhibits anti-tumor a...

    Authors: Anders Olsson, Anders Björk, Johan Vallon-Christersson, John T Isaacs and Tomas Leanderson
    Citation: Molecular Cancer 2010 9:107
  35. Continuous complete clinical remission in T-cell acute lymphoblastic leukemia (T-ALL) is now approaching 80% due to the implementation of aggressive chemotherapy protocols but patients that relapse continue to...

    Authors: Amanda L Cleaver, Alex H Beesley, Martin J Firth, Nina C Sturges, Rebecca A O'Leary, Stephen P Hunger, David L Baker and Ursula R Kees
    Citation: Molecular Cancer 2010 9:105
  36. Intestinal cell kinase (ICK; GeneID 22858) is a conserved MAPK and CDK-like kinase that is widely expressed in human tissues. Data from the Cancer Genome Anatomy Project indicated ICK mRNA is increased in canc...

    Authors: Thomas W Sturgill, Paul B Stoddard, Steven M Cohn and Marty W Mayo
    Citation: Molecular Cancer 2010 9:104
  37. Aberrant expression of cyclin D1 is a common feature in multiple myeloma (MM) and always associated with mantle cell lymphoma (MCL). CCND1 gene is alternatively spliced to produce two cyclin D1 mRNA isoforms whic...

    Authors: Véronique Marsaud, Guergana Tchakarska, Geoffroy Andrieux, Jian-Miao Liu, Doulaye Dembele, Bernard Jost, Joanna Wdzieczak-Bakala, Jack-Michel Renoir and Brigitte Sola
    Citation: Molecular Cancer 2010 9:103
  38. The class 1 carcinogen cadmium (Cd2+) disrupts the E-cadherin/β-catenin complex of epithelial adherens junctions (AJs) and causes renal cancer. Deregulation of E-cadherin adhesion and changes in Wnt/β-catenin sig...

    Authors: Prabir K Chakraborty, Wing-Kee Lee, Malte Molitor, Natascha A Wolff and Frank Thévenod
    Citation: Molecular Cancer 2010 9:102
  39. Breast cancer is one of the most frequently diagnosed cancer and accounts for over 400,000 deaths each year worldwide. It causes premature death in women, despite progress in early detection, treatment, and ad...

    Authors: Mansoor Ahmed and Gopal C Kundu
    Citation: Molecular Cancer 2010 9:101
  40. Estimates suggest that up to 30% of colorectal cancers (CRC) may develop due to an increased genetic risk. The mean age at diagnosis for CRC is about 70 years. Time of disease onset 20 years younger than the m...

    Authors: Marianne Berg, Trude H Ã…gesen, Espen Thiis-Evensen, Marianne A Merok, Manuel R Teixeira, Morten H Vatn, Arild Nesbakken, Rolf I Skotheim and Ragnhild A Lothe
    Citation: Molecular Cancer 2010 9:100
  41. Multidrug resistance (MDR) is a major obstacle in cancer treatment and is often the result of overexpression of the drug efflux protein, P-glycoprotein (P-gp), as a consequence of hyperactivation of NFκB, AP1 ...

    Authors: Wipob Suttana, Samlee Mankhetkorn, Wilart Poompimon, Ajay Palagani, Sergey Zhokhov, Sarah Gerlo, Guy Haegeman and Wim Vanden Berghe
    Citation: Molecular Cancer 2010 9:99
  42. Diminished expression or activity of prostate apoptosis response protein 4 (Par-4) has been demonstrated in a number of cancers, although reports on Par-4 expression during colon cancer progression are lacking...

    Authors: Bi-Dar Wang, Christina Leah B. Kline, Danielle M. Pastor, Thomas L. Olson, Bryan Frank, Truong Luu, Arun K. Sharma, Gavin Robertson, Matthew T. Weirauch, Steven R. Patierno, Joshua M. Stuart, Rosalyn B. Irby and Norman H. Lee
    Citation: Molecular Cancer 2010 9:98
  43. Myc is a well known driver of lymphomagenesis, and Myc-activating chromosomal translocation is the recognized hallmark of Burkitt lymphoma, an aggressive form of non-Hodgkin's lymphoma. We developed a model th...

    Authors: Seong-Su Han, Hwakyung Yun, Dong-Ju Son, Van S. Tompkins, Liangping Peng, Seung-Tae Chung, Joong-Su Kim, Eun-Sung Park and Siegfried Janz
    Citation: Molecular Cancer 2010 9:97
  44. Translational control mediated by non-coding microRNAs (miRNAs) plays a key role in the mechanism of cellular resistance to anti-cancer drug treatment. Dihydrofolate reductase (DHFR) and thymidylate synthase (...

    Authors: Bo Song, Yuan Wang, Matthew A. Titmus, Galina Botchkina, Andrea Formentini, Marko Kornmann and Jingfang Ju
    Citation: Molecular Cancer 2010 9:96
  45. Autophagy is characterized by the sequestration of cytoplasm and organelles into multimembrane vesicles and subsequent degradation by the cell's lysosomal system. It is linked to many physiological functions i...

    Authors: Kathryn G. Eby, Jennifer M. Rosenbluth, Deborah J. Mays, Clayton B. Marshall, Christopher E. Barton, Seema Sinha, Kimberly N. Johnson, Luojia Tang and Jennifer A. Pietenpol
    Citation: Molecular Cancer 2010 9:95
  46. Hepatocellular carcinoma (HCC) is one of the most common cancers worldwide. The molecular mechanisms underlying hepatocarcinogenesis are still poorly understood. Genetically modified mice are powerful tools to...

    Authors: Julia Freimuth, Nikolaus Gassler, Nives Moro, Rolf W. Günther, Christian Trautwein, Christian Liedtke and Gabriele A. Krombach
    Citation: Molecular Cancer 2010 9:94

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