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  1. Content type: Research

    Increasing evidence suggests long non-coding RNAs (lncRNAs) are frequently aberrantly expressed in cancers, however, few related lncRNA signatures have been established for prediction of cancer prognosis. We a...

    Authors: Xiaoqiang Zhu, Xianglong Tian, Chenyang Yu, Chaoqin Shen, Tingting Yan, Jie Hong, Zheng Wang, Jing-Yuan Fang and Haoyan Chen

    Citation: Molecular Cancer 2016 15:60

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  2. Content type: Research

    The mechanisms involved in lung cancer (LC) progression are poorly understood making discovery of successful therapies difficult. Adaptor proteins play a crucial role in cancer as they link cell surface recept...

    Authors: Niranjan Jeganathan, Dan Predescu, Jin Zhang, Fei Sha, Cristina Bardita, Monal Patel, Stephen Wood, Jeffrey A. Borgia, Robert A. Balk and Sanda Predescu

    Citation: Molecular Cancer 2016 15:59

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  3. Content type: Research

    Ovarian cancer (OC) ascites consist in a proinflammatory tumor environment that is characterized by the presence of various cytokines, chemokines and growth factors. The presence of these inflammatory-related ...

    Authors: Denis Lane, Isabelle Matte, Claude Laplante, Perrine Garde-Granger, Alex Carignan, Paul Bessette, Claudine Rancourt and Alain Piché

    Citation: Molecular Cancer 2016 15:58

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  4. Content type: Research

    Liver cancer is one of the main causes of cancer-related death in human. HOXA7 has been proved to be related with several cancers.

    Authors: Bo Tang, Guangying Qi, Xiaoyu Sun, Fang Tang, Shengguang Yuan, Zhenran Wang, Xingsi Liang, Bo Li, Shuiping Yu, Jie Liu, Qi Huang, Yangchao Wei, Run Zhai, Biao Lei, Xinjin Guo and Songqing He

    Citation: Molecular Cancer 2016 15:57

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  5. Content type: Review

    Over the past few years, microRNAs (miRNAs) have not only emerged as integral regulators of gene expression at the post-transcriptional level but also respond to signalling molecules to affect cell function(s)...

    Authors: Emenike K. Onyido, Eloise Sweeney and Abdolrahman Shams Nateri

    Citation: Molecular Cancer 2016 15:56

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  6. Content type: Research

    Colorectal cancer (CRC) is 3rd most commonly diagnosed cancer in males and the second in females. PD-1/PD-L1 axis, as an immune checkpoint, is up-regulated in many tumors and their microenvironment. However, t...

    Authors: Yaqi Li, Lei Liang, Weixing Dai, Guoxiang Cai, Ye Xu, Xinxiang Li, Qingguo Li and Sanjun Cai

    Citation: Molecular Cancer 2016 15:55

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  7. Content type: Research

    Previous studies have established that proteinase-activated receptor 2 (PAR2) promotes migration and invasion of hepatocellular carcinoma (HCC) cells, suggesting a role in HCC progression. Here, we assessed the i...

    Authors: Franziska Mußbach, Hendrik Ungefroren, Bernd Günther, Kathrin Katenkamp, Petra Henklein, Martin Westermann, Utz Settmacher, Lennart Lenk, Susanne Sebens, Jörg P. Müller, Frank-Dietmar Böhmer and Roland Kaufmann

    Citation: Molecular Cancer 2016 15:54

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  8. Content type: Research

    Cutaneous squamous cell carcinoma (cSCC) is the second most common skin cancer and frequently progresses from an actinic keratosis (AK), a sun-induced keratinocyte intraepithelial neoplasia (KIN). Epigenetic m...

    Authors: Agustí Toll, Rocío Salgado, Blanca Espinet, Angel Díaz-Lagares, Eugenia Hernández-Ruiz, Evelyn Andrades, Juan Sandoval, Manel Esteller, Ramón M Pujol and Inmaculada Hernández-Muñoz

    Citation: Molecular Cancer 2016 15:53

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  9. Content type: Research

    Both epidemiological and experimental studies suggest that excessive alcohol exposure increases the risk for breast cancer and enhances metastasis/recurrence. We have previously demonstrated that alcohol enhan...

    Authors: Mei Xu, Zhenhua Ren, Xin Wang, Ashley Comer, Jacqueline A. Frank, Zun-ji Ke, Yi Huang, Zhuo Zhang, Xianglin Shi, Siying Wang and Jia Luo

    Citation: Molecular Cancer 2016 15:52

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  10. Content type: Research

    Dysregulation of microRNAs (miRNAs) have been demonstrated to contribute to carcinogenesis. MiR-143-3p has been identified to function as a tumor suppressor in several tumors, but the role of miR-143-3p in eso...

    Authors: Zhenyue He, Jun Yi, Xiaolong Liu, Jing Chen, Siqi Han, Li Jin, Longbang Chen and Haizhu Song

    Citation: Molecular Cancer 2016 15:51

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  11. Content type: Review

    Expression of various long noncoding RNAs (lncRNAs) may affect cancer prognosis. Here, we aim to gather and examine all evidence on the potential role of lncRNAs as novel predictors of survival in human cancer.

    Authors: Stylianos Serghiou, Aikaterini Kyriakopoulou and John P. A. Ioannidis

    Citation: Molecular Cancer 2016 15:50

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  12. Content type: Research

    Pancreatic cancer is one of the most lethal malignancies. The innovative treatments are required and now the cancer stem cells (CSCs) are expected to be an effective target for novel therapies. Therefore we in...

    Authors: Yumi Miyazaki, Shyuichirou Matsubara, Qiang Ding, Koichiro Tsukasa, Makoto Yoshimitsu, Ken-ichiro Kosai and Sonshin Takao

    Citation: Molecular Cancer 2016 15:49

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  13. Content type: Review

    Ovarian cancer is the leading cause of death among gynecologic malignancies. Since ovarian cancer develops asymptomatically, it is often diagnosed at an advanced and incurable stage. Despite many years of rese...

    Authors: Koji Nakamura, Kenjiro Sawada, Akihiko Yoshimura, Yasuto Kinose, Erika Nakatsuka and Tadashi Kimura

    Citation: Molecular Cancer 2016 15:48

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  14. Content type: Research

    Fusion proteins have unique oncogenic properties and their identification can be useful either as diagnostic or therapeutic targets. Next generation sequencing data have previously shown a fusion gene formed b...

    Authors: Arjun Kalvala, Li Gao, Brittany Aguila, Kathleen Dotts, Mohammad Rahman, Serge P. Nana-Sinkam, Xiaoping Zhou, Qi-En Wang, Joseph Amann, Gregory A. Otterson, Miguel A. Villalona-Calero and Wenrui Duan

    Citation: Molecular Cancer 2016 15:47

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  15. Content type: Research

    Triple-negative breast cancer (TNBC) is the most aggressive and invasive of the breast cancer subtypes. TNBC is a challenging disease that lacks targets for treatment. Histone deacetylase inhibitors (HDACi) ar...

    Authors: Hui-Wen Chiu, Ya-Ling Yeh, Yi-Ching Wang, Wei-Jan Huang, Sheng-Yow Ho, Pinpin Lin and Ying-Jan Wang

    Citation: Molecular Cancer 2016 15:46

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  16. Content type: Research

    The 3-dimensional (3D) microenvironment of breast carcinomas is characterized by profoundly altered pH homeostasis, reflecting increased metabolic acid production and a confined extracellular space characteriz...

    Authors: Anne Poder Andersen, Mette Flinck, Eva Kjer Oernbo, Nis Borbye Pedersen, Birgitte Martine Viuff and Stine Falsig Pedersen

    Citation: Molecular Cancer 2016 15:45

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  17. Content type: Research

    Malignant pleural mesothelioma (MPM) is an aggressive, locally invasive, cancer elicited by asbestos exposure and almost invariably a fatal diagnosis. To date, we are one of the leading laboratory that compare...

    Authors: Yuen Yee Cheng, Casey M. Wright, Michaela B. Kirschner, Marissa Williams, Kadir H. Sarun, Vladimir Sytnyk, Iryna Leshchynska, J. James Edelman, Michael P. Vallely, Brian C. McCaughan, Sonja Klebe, Nico van Zandwijk, Ruby C. Y. Lin and Glen Reid

    Citation: Molecular Cancer 2016 15:44

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  18. Content type: Review

    Prostate cancer, the second most frequently diagnosed cancer in males worldwide, is estimated to be diagnosed in 1.1 million men per year. Introduction of PSA testing substantially improved early detection of ...

    Authors: Edgars Endzeliņš, Vita Melne, Zane Kalniņa, Vilnis Lietuvietis, Una Riekstiņa, Alicia Llorente and Aija Linē

    Citation: Molecular Cancer 2016 15:41

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  19. Content type: Research

    Recent studies have suggested that cancer cells contain subpopulations that can initiate tumor growth, self-renew, and maintain tumor cell growth. However, for esophageal cancer cells, the relationship between...

    Authors: Dan-dan Xu, Peng-jun Zhou, Ying Wang, Li Zhang, Wu-yu Fu, Bi-bo Ruan, Hai-peng Xu, Chao-zhi Hu, Lu Tian, Jin-hong Qin, Sheng Wang, Xiao Wang, Yi-cheng Li, Qiu-ying Liu, Zhe Ren, Rong Zhang…

    Citation: Molecular Cancer 2016 15:40

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  20. Content type: Research

    Sorafenib, a kinase inhibitor active against various solid tumours, induces oxidative stress and ferroptosis, a new form of oxidative necrosis, in some cancer cells. Clinically-applicable biomarkers that refle...

    Authors: Aline Houessinon, Catherine François, Chloé Sauzay, Christophe Louandre, Gaelle Mongelard, Corinne Godin, Sandra Bodeau, Shinichiro Takahashi, Zuzana Saidak, Laurent Gutierrez, Jean-Marc Régimbeau, Nathalie Barget, Jean-Claude Barbare, Nathalie Ganne, Bruno Chauffert, Romain Coriat…

    Citation: Molecular Cancer 2016 15:38

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  21. Content type: Letter to the Editor

    The early detection of lung cancer can reduce the mortality. However, there is no effective means in clinical settings for noninvasively detecting lung cancer. We previously developed 3 sputum miRNA biomarkers...

    Authors: Yun Su, Maria A. Guarnera, HongBin Fang and Feng Jiang

    Citation: Molecular Cancer 2016 15:36

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  22. Content type: Research

    Triple negative breast cancer (TNBC) is a highly heterogeneous and aggressive type of cancer that lacks effective targeted therapy. Despite detailed molecular profiling, no targeted therapy has been establishe...

    Authors: Prson Gautam, Leena Karhinen, Agnieszka Szwajda, Sawan Kumar Jha, Bhagwan Yadav, Tero Aittokallio and Krister Wennerberg

    Citation: Molecular Cancer 2016 15:34

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  23. Content type: Review

    Unlike normal cells, cancer cells express high levels of phosphatidylserine on the extracellular leaflet of their cell membrane. Exploiting this characteristic, our lab developed a therapeutic agent that consi...

    Authors: Harold W. Davis, Nida Hussain and Xiaoyang Qi

    Citation: Molecular Cancer 2016 15:33

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  24. Content type: Research

    Pancreatic ductal adenocarcinoma (PDAC) is one of the most aggressive neoplastic diseases, associated with a remarkably poor prognosis. However, the molecular mechanisms underlying the development of PDAC rema...

    Authors: Hiroto Fukushima, Makiko Yasumoto, Sachiko Ogasawara, Jun Akiba, Yuhei Kitasato, Masamichi Nakayama, Yoshiki Naito, Yusuke Ishida, Yoshinobu Okabe, Masafumi Yasunaga, Hiroyuki Horiuchi, Etsuko Sakamoto, Hiraku Itadani, Shinji Mizuarai, Shinji Oie and Hirohisa Yano

    Citation: Molecular Cancer 2016 15:32

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  25. Content type: Research

    While hepatitis B and C viral infection have been suppressed, non-B non-C hepatocellular carcinoma (NBNC-HCC) is considered to be rising in incidence terms in some developed countries where prevalence of those...

    Authors: Masanori Nojima, Takeshi Matsui, Akihiro Tamori, Shoji Kubo, Ken Shirabe, Koichi Kimura, Mitsuo Shimada, Tohru Utsunomiya, Yasuteru Kondo, Etsuko Iio, Yutaka Naito, Takahiro Ochiya and Yasuhito Tanaka

    Citation: Molecular Cancer 2016 15:31

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  26. Content type: Research

    Tissue inhibitor of metalloproteinases-1 (TIMP-1) is a multifunctional protein that can directly regulate apoptosis and metastasis. In this study, we investigated the functional and molecular mechanisms by whi...

    Authors: Guangcun Cheng, Xuemei Fan, Mingang Hao, Jinglong Wang, Xiaoming Zhou and Xueqing Sun

    Citation: Molecular Cancer 2016 15:30

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  27. Content type: Research

    Cathepsin S has been implicated in a variety of malignancies with genetic ablation studies demonstrating a key role in tumor invasion and neo-angiogenesis. Thus, the application of cathepsin S inhibitors may h...

    Authors: Richard D. A. Wilkinson, Andrew Young, Roberta E. Burden, Rich Williams and Christopher J. Scott

    Citation: Molecular Cancer 2016 15:29

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  28. Content type: Research

    The advantages and utility of microRNAs (miRNAs) as diagnostic and prognostic cancer markers is at the vanguard in recent years. In this study, we attempted to identify and validate the differential expression...

    Authors: Mayakannan Manikandan, Arungiri Kuha Deva Magendhra Rao, Ganesan Arunkumar, Meenakshisundaram Manickavasagam, Kottayasamy Seenivasagam Rajkumar, Ramamurthy Rajaraman and Arasambattu Kannan Munirajan

    Citation: Molecular Cancer 2016 15:28

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  29. Content type: Research

    Bone morphogenetic proteins (BMP) are embryonic proteins that are part of the transforming growth factor (TGFβ) superfamily, which are aberrantly expressed in many carcinomas. Inhibition of BMP receptors with ...

    Authors: Dave J. Augeri, Elaine Langenfeld, Monica Castle, John A. Gilleran and John Langenfeld

    Citation: Molecular Cancer 2016 15:27

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  30. Content type: Research

    Hypoxia-inducible factors (HIFs) are well-established mediators of tumor growth, the epithelial to mesenchymal transition (EMT) and metastasis. In several types of solid tumors, including breast cancers, the H...

    Authors: Danielle L. Peacock Brooks, Luciana P. Schwab, Raisa Krutilina, Deanna N. Parke, Aarti Sethuraman, David Hoogewijs, Alexandra Schörg, Lauren Gotwald, Meiyun Fan, Roland H. Wenger and Tiffany N. Seagroves

    Citation: Molecular Cancer 2016 15:26

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  31. Content type: Review

    Cancer poses a serious health problem in society and is increasingly surpassing cardiovascular disease as the leading cause of mortality in the United States. Current therapeutic strategies for cancer are extr...

    Authors: Ann Hanna and Lalita A. Shevde

    Citation: Molecular Cancer 2016 15:24

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    The Erratum to this article has been published in Molecular Cancer 2016 15:35

  32. Content type: Research

    There is growing evidence that Bit1 exerts different roles in the development and progression of human cancers. Although Bit1 was highly exhibited in ESCC tissues in our previous study, its roles and molecular...

    Authors: Tianli Fan, Jing Chen, Lirong Zhang, Pan Gao, Yiran Hui, Peirong Xu, Xiaqing Zhang and Hongtao Liu

    Citation: Molecular Cancer 2016 15:23

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  33. Content type: Research

    p53 is a tumour suppressor protein that plays a key role in many steps of apoptosis, and malfunctioning of this transcription factor leads to tumorigenesis. Prognosis of many tumours also depends upon the p53 ...

    Authors: Reshma Thamkachy, Rohith Kumar, K. N. Rajasekharan and Suparna Sengupta

    Citation: Molecular Cancer 2016 15:22

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  34. Content type: Review

    The epithelial to mesenchymal transition (EMT) is a biological process in which a non-motile epithelial cell changes to a mesenchymal phenotype with invasive capacities. This phenomenon has been well documente...

    Authors: Silvia Juliana Serrano-Gomez, Mazvita Maziveyi and Suresh K. Alahari

    Citation: Molecular Cancer 2016 15:18

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  35. Content type: Research

    The identification of signaling pathways that affect the cancer stem-like phenotype may provide insights into therapeutic targets for combating embryonal rhabdomyosarcoma. The aim of this study was to investig...

    Authors: Carmela Ciccarelli, Francesca Vulcano, Luisa Milazzo, Giovanni Luca Gravina, Francesco Marampon, Giampiero Macioce, Adele Giampaolo, Vincenzo Tombolini, Virginia Di Paolo, Hamisa Jane Hassan and Bianca Maria Zani

    Citation: Molecular Cancer 2016 15:16

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  36. Content type: Research

    Several studies have found that Cathepsin B (CTSB) is up-regulated in many tumor types and facilitates tumor progression. However, the role of CTSB in hepatocellular carcinoma (HCC) progression remains unclear...

    Authors: Jian Ruan, Haiyan Zheng, Xiaodong Rong, Xiaomin Rong, Junyi Zhang, Weijia Fang, Peng Zhao and Rongcheng Luo

    Citation: Molecular Cancer 2016 15:17

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  37. Content type: Research

    Epigenetic regulators play a critical role in the maintenance of specific chromatin domains in an active or repressed state. Disruption of epigenetic regulatory mechanisms is widespread in cancer cells and lar...

    Authors: Chien-Hung Yeh, Xue Tao Bai, Ramona Moles, Lee Ratner, Thomas A. Waldmann, Toshiki Watanabe and Christophe Nicot

    Citation: Molecular Cancer 2016 15:15

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    The Erratum to this article has been published in Molecular Cancer 2016 15:20

  38. Content type: Research

    Ovarian cancer is mostly associated with pathologically regulated permeability of peritoneal vessels, leading to ascites. Here, we investigated the molecular regulation of endothelial permeability by the vascu...

    Authors: Inga Bekes, Thomas W. P. Friedl, Tanja Köhler, Volker Möbus, Wolfgang Janni, Achim Wöckel and Christine Wulff

    Citation: Molecular Cancer 2016 15:13

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