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  1. Research

    MicroRNA-29c functions as a tumor suppressor by targeting VEGFA in lung adenocarcinoma

    Lung adenocarcinoma (LAD) is considered to be a highly aggressive disease with heterogeneous prognosis and the molecular mechanisms underlying tumor progression remain elusive. Growing evidence demonstrates th...

    Lipin Liu, Nan Bi, Lihong Wu, Xiao Ding, Yu Men, Wei Zhou, Lin Li, Weimin Zhang, Susheng Shi, Yongmei Song and Luhua Wang

    Molecular Cancer 2017 16:50

    Published on: 28 February 2017

  2. Letter to the Editor

    Mitochondrial DNA sequencing demonstrates clonality of peritoneal implants of borderline ovarian tumors

    Borderline ovarian tumors are rare low malignant potential neoplasms characterized by the absence of stromal invasion, whose main prognostic factors are stage and type of peritoneal implants. The latter are de...

    Giulia Girolimetti, Pierandrea De Iaco, Martina Procaccini, Riccardo Panzacchi, Ivana Kurelac, Laura Benedetta Amato, Giulia Dondi, Giacomo Caprara, Claudio Ceccarelli, Donatella Santini, Anna Maria Porcelli, Anna Myriam Perrone and Giuseppe Gasparre

    Molecular Cancer 2017 16:47

    Published on: 27 February 2017

  3. Research

    MicroRNA-30d promotes angiogenesis and tumor growth via MYPT1/c-JUN/VEGFA pathway and predicts aggressive outcome in prostate cancer

    Even though aberrant expression of microRNA (miR)-30d has been reported in prostate cancer (PCa), its associations with cancer progression remain contradictory. The aim of this study was to investigate clinica...

    Zhuo-yuan Lin, Guo Chen, Yan-qiong Zhang, Hui-chan He, Yu-xiang Liang, Jian-heng Ye, Ying-ke Liang, Ru-jun Mo, Jian-ming Lu, Yang-jia Zhuo, Yu Zheng, Fu-neng Jiang, Zhao-dong Han, Shu-lin Wu, Wei-de Zhong and Chin-Lee Wu

    Molecular Cancer 2017 16:48

    Published on: 27 February 2017

  4. Research

    Mechanistic added value of a trans-Sulfonamide-Platinum-Complex in human melanoma cell lines and synergism with cis-Platin

    Cisplatin is a potent antitumor agent. However, toxicity and primary and secondary resistance are major limitations of cisplatin-based chemotherapy, leading to therapeutic failure. We have previously reported ...

    Alba Agudo-López, Elena Prieto-García, José Alemán, Carlos Pérez, C. Vanesa Díaz-García, Lucía Parrilla-Rubio, Silvia Cabrera, Carmen Navarro-Ranninger, Hernán Cortés-Funes, José A. López-Martín and M. Teresa Agulló-Ortuño

    Molecular Cancer 2017 16:45

    Published on: 23 February 2017

  5. Research

    ITIH5 mediates epigenetic reprogramming of breast cancer cells

    Extracellular matrix (ECM) is known to maintain epithelial integrity. In carcinogenesis ECM degradation triggers metastasis by controlling migration and differentiation including cancer stem cell (CSC) charact...

    Michael Rose, Vera Kloten, Erik Noetzel, Lukas Gola, Josef Ehling, Timon Heide, Steffen K. Meurer, Aljona Gaiko-Shcherbak, Antonio S. Sechi, Sebastian Huth, Ralf Weiskirchen, Oliver Klaas, Wiebke Antonopoulos, Qiong Lin, Wolfgang Wagner, Jürgen Veeck…

    Molecular Cancer 2017 16:44

    Published on: 23 February 2017

  6. Research

    KCNMA1 cooperating with PTK2 is a novel tumor suppressor in gastric cancer and is associated with disease outcome

    Inactivation of tumor suppressor genes by promoter hypermethylation plays a key role in the tumorgenesis. It is necessary to uncover the detailed pattern of whole genome-wide abnormal DNA methylation during th...

    Gaoxiang Ma, Hanting Liu, Qiuhan Hua, Meilin Wang, Mulong Du, Yadi Lin, Yuqiu Ge, Weida Gong, Qinghong Zhao, Fulin Qiang, Guoquan Tao, Zhengdong Zhang and Haiyan Chu

    Molecular Cancer 2017 16:46

    Published on: 23 February 2017

  7. Review

    Linking long non-coding RNAs and SWI/SNF complexes to chromatin remodeling in cancer

    Chromatin remodeling controls gene expression and signaling pathway activation, and aberrant chromatin structure and gene dysregulation are primary characteristics of human cancer progression. Recent reports h...

    Yanyan Tang, Jinpeng Wang, Yu Lian, Chunmei Fan, Ping Zhang, Yingfen Wu, Xiayu Li, Fang Xiong, Xiaoling Li, Guiyuan Li, Wei Xiong and Zhaoyang Zeng

    Molecular Cancer 2017 16:42

    Published on: 17 February 2017

  8. Review

    Intra-tumor heterogeneity from a cancer stem cell perspective

    Tumor heterogeneity represents an ongoing challenge in the field of cancer therapy. Heterogeneity is evident between cancers from different patients (inter-tumor heterogeneity) and within a single tumor (intra...

    Pramudita R. Prasetyanti and Jan Paul Medema

    Molecular Cancer 2017 16:41

    Published on: 16 February 2017

  9. Research

    LincRNAFEZF1-AS1 represses p21 expression to promote gastric cancer proliferation through LSD1-Mediated H3K4me2 demethylation

    Although the prognosis of gastric cancer patients have a favorable progression, there are some patients with unusual patterns of locoregional and systemic recurrence. Therefore, a better understanding of early...

    Yan-wen Liu, Rui Xia, Kai Lu, Min Xie, Fen Yang, Ming Sun, Wei De, Cailian Wang and Guozhong Ji

    Molecular Cancer 2017 16:39

    Published on: 16 February 2017

  10. Research

    Doxycycline attenuates breast cancer related inflammation by decreasing plasma lysophosphatidate concentrations and inhibiting NF-κB activation

    We previously discovered that tetracyclines increase the expression of lipid phosphate phosphatases at the surface of cells. These enzymes degrade circulating lysophosphatidate and therefore doxycycline increa...

    Xiaoyun Tang, Xianyan Wang, Yuan Y. Zhao, Jonathan M. Curtis and David N. Brindley

    Molecular Cancer 2017 16:36

    Published on: 8 February 2017

  11. Research

    CD73/NT5E is a target of miR-30a-5p and plays an important role in the pathogenesis of non-small cell lung cancer

    CD73 (ecto-5′-nucleotidase) is implicated in the development of many types of cancer. CD73 inhibitors are currently being tested in clinical trials for the treatment of cancer. Understanding the molecular and ...

    Jianjie Zhu, Yuanyuan Zeng, Wei Li, Hualong Qin, Zhe Lei, Dan Shen, Dongmei Gu, Jian-an Huang and Zeyi Liu

    Molecular Cancer 2017 16:34

    Published on: 3 February 2017

  12. Research

    Targeting MUC1-C inhibits the AKT-S6K1-elF4A pathway regulating TIGAR translation in colorectal cancer

    Colorectal cancer is third most common malignancy and is the second most common cause of cancer-related death. The MUC1 heterodimeric protein is aberrantly overexpressed in colorectal cancer and has been linke...

    Rehan Ahmad, Maroof Alam, Masanori Hasegawa, Yasumitsu Uchida, Omar Al-Obaid, Surender Kharbanda and Donald Kufe

    Molecular Cancer 2017 16:33

    Published on: 2 February 2017

  13. Research

    Dclk1, a tumor stem cell marker, regulates pro-survival signaling and self-renewal of intestinal tumor cells

    More than 80% of intestinal neoplasia is associated with the adenomatous polyposis coli (APC) mutation. Doublecortin-like kinase 1 (Dclk1), a kinase protein, is overexpressed in colorectal cancer and specifically...

    Parthasarathy Chandrakesan, Jiannan Yao, Dongfeng Qu, Randal May, Nathaniel Weygant, Yang Ge, Naushad Ali, Sripathi M. Sureban, Modhi Gude, Kenneth Vega, Eddie Bannerman-Menson, Lijun Xia, Michael Bronze, Guangyu An and Courtney W. Houchen

    Molecular Cancer 2017 16:30

    Published on: 1 February 2017

  14. Review

    Epigenetics in cancer stem cells

    Compelling evidence have demonstrated that bulk tumors can arise from a unique subset of cells commonly termed “cancer stem cells” that has been proposed to be a strong driving force of tumorigenesis and a key...

    Tan Boon Toh, Jhin Jieh Lim and Edward Kai-Hua Chow

    Molecular Cancer 2017 16:29

    Published on: 1 February 2017

  15. Review

    Cancer stem cell niche models and contribution by mesenchymal stroma/stem cells

    The initiation and progression of malignant tumors is driven by distinct subsets of tumor-initiating or cancer stem-like cells (CSCs) which develop therapy/apoptosis resistance and self-renewal capacity. In or...

    Catharina Melzer, Juliane von der Ohe, Hendrik Lehnert, Hendrik Ungefroren and Ralf Hass

    Molecular Cancer 2017 16:28

    Published on: 1 February 2017

  16. Research

    Metalloprotease-disintegrin ADAM12 actively promotes the stem cell-like phenotype in claudin-low breast cancer

    ADAM12 is upregulated in human breast cancers and is a predictor of chemoresistance in estrogen receptor-negative tumors. ADAM12 is induced during epithelial-to-mesenchymal transition, a feature associated wit...

    Sara Duhachek-Muggy, Yue Qi, Randi Wise, Linda Alyahya, Hui Li, Jacob Hodge and Anna Zolkiewska

    Molecular Cancer 2017 16:32

    Published on: 1 February 2017

  17. Review

    Mesenchymal stem cells: key players in cancer progression

    Tumour progression is dependent on the interaction between tumour cells and cells of the surrounding microenvironment. The tumour is a dynamic milieu consisting of various cell types such as endothelial cells,...

    Sarah M. Ridge, Francis J. Sullivan and Sharon A. Glynn

    Molecular Cancer 2017 16:31

    Published on: 1 February 2017

  18. Short communication

    Interplay between CCR7 and Notch1 axes promotes stemness in MMTV-PyMT mammary cancer cells

    Breast cancer is the major cause of cancer-related mortality in women. It is thought that quiescent stem-like cells within solid tumors are responsible for cancer maintenance, progression and eventual metastas...

    Sarah T. Boyle, Krystyna A. Gieniec, Carly E. Gregor, Jessica W. Faulkner, Shaun R. McColl and Marina Kochetkova

    Molecular Cancer 2017 16:19

    Published on: 31 January 2017

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