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Table 3 Relationship between mRNA levels of 20 markedly upregulated genes and breast cancer progression

From: Expression analysis of mitotic spindle checkpoint genes in breast carcinoma: role of NDC80/HEC1 in early breast tumorigenicity, and a two-gene signature for aneuploidy

Genes

Normal breast tissues

(n = 9)

Benign breast tumors

(n = 14)

pa

DCIS of the breast

(n = 14)

pb

Invasive grade I breast tumors

(n = 11)

pc

Invasive grade III breast tumors

(n = 12)

pd

NDC80

1,0 (0,00-1,39)

3,64 (1,32-17,79) e

< 0,01

14,55 (4,10-24,20)

0,0009

7,11 (1,38-13,55)

NS

15,22 (4,76-54,69)

0,01

BUB1

1,0 (0,00-1,38)

2,97 (1,52-14,03)

< 0,01

15,37 (1,59-94,35)

0,001

6,59 (0,00-94,35)

NS

17,54 (5,46-57,28)

0,004

BUB1B

1,0 (0,24-2,97)

2,72 (1,01-9,38)

< 0,01

14,54 (3,53-39,95)

0,0002

6,11 (0,00-11,31)

NS

18,66 (2,39-105,05)

0,004

CCNB1

1,0 (0,00-3,14)

2,51 (1,01-6,82)

< 0,01

6,82 (1,71-15,24)

0,002

4,23 (1,33-5,90)

NS

9,05(3,51-41,64)

0,007

TACC3

1,0 (0,00-1,35)

1,70 (0,78-6,18)

< 0,01

7,21 (1,77-13,67)

0,0003

5,31 (1,11-11,24)

0,02

17,04 (4,98-74,03)

0,0006

TPX2

1,0 (0,31-4,23)

2,84 (0,82-10,73)

< 0,05

16,99 (4,70-35,59)

0,00009

6,51 (1,67-19,74)

NS

23,84 (6,15-315,17)

0,0009

CCNA2

1,0 (0,05-1,45)

2,19 (0,20-7,19)

< 0,05

10,56 (1,70-17,21)

0,0006

3,36 (1,04-8,34)

NS

11,38 (1,64-104,33)

0,008

CDC2

1,0 (0,00-2,11)

1,76 (0,76-7,36)

< 0,05

10,16 (2,56-20,87)

0,00008

6,01 (1,06-10,78)

NS

10,99 (3,32-56,75)

0,006

CDC20

1,0 (0,06-1,28)

1,67 (0,63-3,54)

< 0,05

3,90 (1,49-14,09)

0,0001

1,65 (1,76-3,00)

NS

6,14 (1,76-142,68)

0,0002

NEK2

1,0 (0,16-2,87)

1,17 (0,41-3,78)

NS

10,44 (2,03-26,23)

0,00004

2,67 (1,15-11,88)

0,008

14,83 (3,60-115,09)

0,0006

AURKA

1,0 (0,30-2,58)

1,12 (0,33-2,32)

NS

6,04 (1,27-21,01)

0,00002

2,54 (1,25-7,16)

0,002

7,82 (2,04-58,89)

0,003

PLK1

1,0 (0,30-2,08)

0,80 (0,34-1,99)

NS

3,83 (1,09-11,37)

0,00003

1,91 (0,20-5,66)

0,04

7,09 (1,92-117,27)

0,0009

TTK

1,0 (0,01-7,32)

2,43 (0,00-11,29)

NS

9,85 (2,59-32,07)

0,0003

2,32 (0,00-5,68)

NS

8,59 (4,14-55,84)

0,0002

AURKB

1,0 (0,00-3,24)

2,07 (0,22-7,41)

NS

5,97 (0,99-26,91)

0,02

4,24 (1,05-10,06)

NS

16,26 (5,70-210,84)

0,0003

BIRC5

1,0 (0,46-3,40)

1,37 (0,39-6,06)

NS

7,86 (1,68-40,50)

0,00008

3,51 -0,54-7,29)

NS

12,20 (3,14-128,0)

0,0007

ZWINT

1,0 (0,00-3,71)

1,98 (0,39-4,53)

NS

5,70 (2,45-15,74)

0,0002

3,59 (0,89-6,09)

NS

10,95 (2,70-55,46)

0,001

CCNB2

1,0 (0,31-1,93)

1,43 (0,70-5,98)

NS

8,98 (1,57-23,43)

0,0002

3,31 (0,03-7,31)

NS

12,28 (1,53-52,35)

0,005

CENPE

1,0 (0,03-4,58)

0,96 (0,33-6,15)

NS

3,61 (1,11-8,34)

0,002

2,00 (0,33-5,57)

NS

2,98 (0,84-10,15)

0,04

UBD

1,0 (0,00-3,07)

1,49 (0,34-4,66)

NS

3,19 (0,43-4,66)

0,04

2,92 (0,19-14,72)

NS

5,30 (1,16-32,37)

NS

CCNB3

1,0 (0,00-6,11)

2,52 (0,53-5,82)

NS

1,36 (0,00-8,94)

NS

3,24 (0,63-8,54)

NS

2,71 (0,00-8,54)

NS

MKI67

1,0 (0,03-2,87)

2,63 (0,47-12,70)

NS

14,92 (2,12-33,98)

0,0007

5,21 (0,13-12,15)

NS

14,09 (2,45-189,14)

0,009

  1. aMann et Whitney's U Test: Benign breast tumors vs Normal breast tissues. NS, not significant.
  2. bDuctal Carcinoma In Situ (DCIS) of the breast vs Benign breast tumors.
  3. cInvasive grade I breast tumors vs Benign breast tumors.
  4. dInvasive grade III breast tumors vs Invasive grade I breast tumors.
  5. eMedian (range) of gene mRNA levels. The mRNA levels of the tumor samples were normalized such that the median of the 9 normal breast tissues mRNA levels was 1.
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Molecular Cancer

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