Figure 5

miRNA expression profiles of MPs, their donor drug resistant cells, the recipient drug sensitive cells and the cocultures after MP transfer. Hierarchical clustering analysis of the 847 human miRNA signal intensities identified by the Affymetric miRNA microarray detectable in the drug resistant MPs (VLBMP and DXMP), their donor cells (VLB₁₀₀ and DX) and the drug sensitive recipient cells before (CEM and MCF-7) and after MP transfer (CEM + VLBMP and MCF-7 + DXMP) across both leukaemia and breast cancer samples. This shows evidence of the tight correlation between the MPs, cocultured cells and MP donor cells. Vertical bars represent the samples and the horizontal bars represent the miRNA genes. Green bars reflect downregulated genes and red bars upregulated genes