Figure 7
From: In vivo gene transfer targeting in pancreatic adenocarcinoma with cell surface antigens
Oncotargeted transduction of lentiviruses is efficient only in pancreases bearing tumors. Ten μg of p24 lentiviruses carrying the luciferase reporter gene packaged into the VSV-G-containing envelope (A lateral view, B ventral view) or anti-MUC4-conjugated lentiviruses (C lateral view) were directly injected in the pancreas of tumor free animals (n = 3 animals in each group). Luciferase signal was visualized after one week. Luciferase signal intensity was quantified and is reported as mean of Ph/sr/s ± SEM (D). Increased luciferase signal is shown after 16 days in the same animals (E, F: VSV-G and G: MUC4), with signal quantification (H).