Group | Genotype (A-C/EBP | Treatment | Diet | No. of mice | Body weight | Gross tumor | Â | Histological | lesions | Â | Tumor incidence |
---|---|---|---|---|---|---|---|---|---|---|---|
 | + or -a) |  |  | examined | (g) | per mouse | Alveolar hyperplasia per mouse | Adenoma per mouse | Carcinoma per mouse | Adenoma and carcinoma per mouse | (%)b |
1 | - | NNK | Dox | 45 | 46.2±0.8d,e | 1.00 | 0.11g | 1.20h | 0.044 | 1.20h | 76 (34)c |
2 | + | NNK | Dox | 30 | 43.7±0.8e | 1.20 | 0.23 | 1.30h | 0.13 | 1.40h | 83 (25) |
3 | - | Saline | Dox | 24 | 43.7±1.1 | 0.29 | 0.08 | 0.21 | 0 | 0.21 | 21 (5) |
4 | + | Saline | Dox | 23 | 43.4±0.8f | 0.26 | 0.17 | 0.17 | 0 | 0.17 | 13 (3) |
5 | - | NNK | Regular | 44 | 39.8±0.8 | 1.00 | 0.36 | 1.30h | 0 | 1.30h | 71 (31)i |
6 | + | NNK | Regular | 40 | 38.4±0.9 | 1.00 | 0.30 | 1.50h | 0.025 | 1.60h | 88 (35) |
7 | - | Saline | Regular | 38 | 40.8±1.2 | 0.27 | 0.18 | 0.32 | 0 | 0.32 | 26 (10) |
8 | + | Saline | Regular | 31 | 39.9±0.9 | 0.26 | 0.19 | 0.26 | 0 | 0.26 | 19 (6) |