Group | Genotype (A-C/EBP | Treatment | Diet during | No. of mice | Body weight | Gross tumor | Â | Histological | lesions | Â | Tumor incidence |
---|---|---|---|---|---|---|---|---|---|---|---|
 | + or -a) |  | 52-62 weeks | examined | (g) | per mouse | Alveolar hyperplasia per mouse | Adenoma per mouse | Carcinoma per mouse | Adenoma and carcinoma per mouse | (%)b |
1 | - | NNK | Dox | 19 | 42.2±1.4d | 2.00 | 0.37 | 1.63 | 0.37e | 2.00 | 95 (17)c |
2 | + | NNK | Dox | 18 | 44.5±1.5d | 2.83 | 0.33 | 2.06 | 0.056f | 2.11 | 83 (15) |
3 | - | NNK | Regular | 18 | 36.2±1.6 | 1.89 | 0.11 | 1.50 | 0.44 | 1.94 | 94 (16) |
4 | + | NNK | Regular | 18 | 38.1±1.6 | 2.22 | 0.17 | 2.00 | 0.44 | 2.44 | 78 (14) |