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Figure 9 | Molecular Cancer

Figure 9

From: Short-term single treatment of chemotherapy results in the enrichment of ovarian cancer stem cell-like cells leading to an increased tumor burden

Figure 9

Mouse model of chemoresistance and associated recurrence in ovarian cancer. Control untreated and residual HEY cells after treatment with cisplatin or paclitaxel in vitro were injected (ip) into nude mice (n = 18, n = 6/group) and followed for 5–7 weeks. Cisplatin and paclitaxel treated cells enriched in CSC-like markers generated significantly increased tumor burden as well as xenografts with enhanced expression of CD117, Oct4, CA125, Ki67 and E-cadherin compared to tumors derived from non treated HEY cells. This suggests that chemotherapy treatment promotes CSC-dependent enhanced tumor progression in a mouse model of ovarian cancer.

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Molecular Cancer

ISSN: 1476-4598