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Figure 6 | Molecular Cancer

Figure 6

From: Targeting the Vav3 oncogene enhances docetaxel-induced apoptosis through the inhibition of androgen receptor phosphorylation in LNCaP prostate cancer cells under chronic hypoxia

Figure 6

Proposed molecular mechanisms of Vav3-mediated signaling pathways in LNCaPH cells. A, following the induction of Vav3 expression under chronic hypoxia, Vav3 can phosphorylate Bad at Ser 112 and AR at Ser 81 through PI3K/Akt and ERK pathways, resulting in cancer cell survival. B, Vav3 siRNA can inhibit Vav3-mediated signaling pathways and docetaxel can phosphorylate Bcl-2 at Ser 70 and dephosphorylate Bad through JNK and PI3K/Akt pathways, respectively, and thus, these two signaling pathways can merge to activate the caspase cascade, resulting in apoptosis.

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Molecular Cancer

ISSN: 1476-4598