Figure 8
From: Nectin-2 is a potential target for antibody therapy of breast and ovarian cancers
ADCC of anti-Nectin-2 mAbs against OV-90 cells. OV-90 cells pre-labeled with 51Cr were incubated with anti-Nectin-2 mAbs at a ratio of 1:50 with PBMC effector cells for 4 h at 37°C, followed by the measurement of 51Cr that was released into the culture supernatant. Specific cell lysis was calculated as described in Methods. The numbers in parentheses indicate the epitope bin of each antibody. The results are the mean ± S.D. of triplicate assays.