Table 1 FGFR3 impact in pancreatic tumour cell lines
From: FGFR3 has tumor suppressor properties in cells with epithelial phenotype
Epithelial-like | Mesenchymal-like | |||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Capan-2 | BxPC-3 | Mia PaCa-2 | PANC-1 | |||||||||||||
Colony formation (Ratio/CT) | Colony area (μm2) | Migration (number of cells) | Senescent cells (%) | Tumour mass (mg) | Colony formation (Ratio/CT) | Colony area (mm2) | Tumour mass (mg) | Colony formation (Ratio/CT) | Colony area (mm2) | Migration (number of cells) | Senescent cells (%) | Tumour mass (mg) | Colony formation (Ratio/CT) | Colony area (mm2) | Tumour mass (mg) | |
CTRL | 1 ± 0.13 | 19.3 ± 5.0 | 997 ± 6 | 24.4 ± 5.3 | 203 ± 37 | 1 ± 0.18 | 24.2 ± 15.1 | 42 ± 0.01 | 1 ± 0.004 | 13.8 ± 4.7 | 98 ± 2 | 8.6 ± 1.9 | 21 ± 3 | 1 ± 0.05 | 9.9 ± 9.2 | 59 ± 39 |
FGFR3-IIIb | 1.38 ± 0.06* | 9.1 ± 1.5* | 1524 ± 26*** | 35.7 ± 3.9** | 110 ± 12* | 0.97 ± 0.10 | 15.9 ± 11.9** | 25 ±0.01* | 1.52 ± 0.18** | 17.0 ± 4.6** | 346 ± 9*** | 4.7 ± 1.9*** | 292 ± 133* | 1.28 ± 0.04* | 21.5 ± 14.1*** | 137 ± 51* |
FGFR3-IIIc | 1.52 ± 0.27* | 6.3 ± 1.5** | 2050 ± 18*** | 32.4 ± 5.5* | 111 ± 14* | 1.37 ± 0.04* | 12.7 ± 9.7*** | 23 ± 0.01* | 1.28 ± 0.17* | 23.7 ± 8.1*** | 515 ± 22*** | 5.0 ± 1*** | 367 ± 113** | 1.23 ± 0.04* | 22.8 ± 14.6*** | 138 ± 39* |
FGFR3-IIIc-KD | 1.21 ± 0.05* | 15.7 ± 11.1 | 1492 ± 10*** | 16.9 ± 3.26* | 212 ± 71 | 1.26 ± 0.04** | 20.9 ± 14.2 | ND | ND | ND | ND | ND | ND | 1.55 ± 0.12* | 15.1 ± 8.7** | ND |