DUB | Signalling pathway/Process | Substrate |
---|---|---|
USP2a | Fas and p53 | FAS, MDM2, MDMX |
Mitotic progression | Aurora A | |
NF-κB | RIP1, TRAF2, TRAF6 | |
Cell cycle | Cyclin A1 | |
USP4 | Wnt | TCF4 |
p53 | ARF-BP1 | |
NF-κB | TAK1, TRAF2, TRAF6, RIP1 | |
TGF-β and AKT | TβRI | |
Growth factor receptor pathways | PDK1 | |
USP7 | p53 | p53, MDM2, MDMX |
Akt | FOXO4, PTEN | |
USP10 | Transcriptional regulation | H2A.Z |
p53 | p53 | |
USP29 | p53 | p53 |
USP42 | p53 | p53 |
USP8/Ubpy | Endosomal sorting | EGFR |
Wg/Wnt | Frizzled | |
Hedgehog | Smoothened | |
AMSH | Endosomal sorting | EGFR |
Cezanne | NF-κB | TRAF6, RIP1 |
CYLD | NF-κB | TRAF2, TRAF6, TRAF7, TAK1, RIP1 |