Table 1 Frequencies of KRAS mutations in 1267 colorectal cancer cases

Any

Any

Any

Any

505

40%

12

Any

Any

Any

344

27%

13

Any

Any

Any

115

9.1%

61

Any

Any

Any

19

1.5%

146

Any

Any

Any

40

3.2%

Mutations identified in only one of codons 12, 13, 61 and 146

12

c.34G>A

p.G12S

GGT>AGT

12

1.0%

12

c.34G>C

p.G12R

GGT>CGT

7

0.6%

12

c.34G>T

p.G12C

GGT>TGT

43

3.4%

12

c.35G>A

p.G12D

GGT>GAT

157

12%

12

c.35G>C

p.G12A

GGT>GCT

20

1.6%

12

c.35G>T

p.G12V

GGT>GTT

93

7.3%

12

c.35_36delinsCA

p.G12A

GGT>GCA

1

0.1%

13

c.37G>C

p.G13R

GGC>CGC

1

0.1%

13

c.37G>T

p.G13C

GGC>TGC

2

0.2%

13

c.38G>A

p.G13D

GGC>GAC

103

8.1%

13

c.38G>T

p.G13V

GGC>GTC

2

0.2%

61

c.182A>G

p.Q61R

CAA>CGA

2

0.2%

61

c.182A>T

p.Q61L

CAA>CTA

4

0.3%

61

c.183A>C

p.Q61H

CAA>CAC

7

0.6%

60, 61

c.180_181delinsAA

p.Q61K

GGT + CAA>GGA + AAA

4

0.3%

146

c.436G>A

p.A146T

GCA>ACA

21

1.7%

146

c.436G>C

p.A146P

GCA>CCA

3

0.2%

146

c.437C>T

p.A146V

GCA>GTA

11

0.9%

Mutations identified in two or more of codons 12, 13, 61 and 146

12, 13

c.35G>A, c.38G>A

p.G12D, p.G13D

GGT>GAT, GGC>GAC

4

0.3%

12, 13

c.35G>T, c.37G>T

p.G12V, p.G13C

GGT>GTT, GGC>TGC

1

0.1%

12,

c.35G>T,

p.G12V,

GGT>GTT, GGT + CAA>GGA + AAA

1

0.1%

60, 61

c.180_181delinsAA

p.Q61K

12, 146

c.34G>C, c.436G>A

p.G12R, p.A146T

GGT>CGT, GCA>ACA

1

0.1%

12, 146

c.34G>T, c.436G>A

p.G12C, p.A146T

GGT>TGT, GCA>ACA

1

0.1%

12, 146

c.34G>T, c.437C>T

p.G12C, p.A146V

GGT>TGT, GCA>GTA

1

0.1%

12, 146

c.35G>T, c.436G>A

p.G12V, p.A146T

GGT>GTT, GCA>ACA

1

0.1%

13, 146

c.38G>A, c.436G>A

p.G13D, p.A146T

GGC>GAC, GCA>ACA

1

0.1%

12, 13, 61

c.35G>A, c.38G>A, c.183A>T

p.G12D, p.G13D, p.Q61H

GGT>GAT, GGC>GAC, CAA>CAT

1

0.1%