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Figure 7 | Molecular Cancer

Figure 7

From: Sodium glucose cotransporter 1 ligand BLF501 as a novel tool for management of gastrointestinal mucositis

Figure 7

Hypothetical cellular pathways activated by BLF501-mediated SGLT-1 engagement. MAPKAPK-2/AKT-2 activation induces GSK-3 phosphorylation and consequent inhibition of p53–mediated caspase-3 cleavage. P-GSK-3 also preserves the cytoplasmic pool of beta-catenin involved in cellular proliferation mechanisms. Akt-2 is a key effector involved in tight junction management via ERM complex modulation.

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Molecular Cancer

ISSN: 1476-4598