Table 1 Top 10 functions and diseases annotation given by IPA, based on the number of proteins related to the network in Figure 4
From: ADAM17 mediates OSCC development in an orthotopic murine model
Function | Function annotation | p-value | Molecules | # Molecules |
|---|---|---|---|---|
Cancer | Cancer | 1.57E-06 | ACADVL, APEX1, ATP2A1, ATP2A2, CYCS, DHX9, DPYSL2, DSC3, DSG1, DSG3, DSP, FABP5, FGB, FGG, FLII, G6PD, GOT1, HNRNPA1, HNRNPK, HSPA8, LAMA3, LAMB3, LRPPRC, MCM3, PARVA, PCNA, PGK1, PKM, RAN, RPS4X, RPS9, SFN, SOD2, STIP1, STK24, STMN1, TPM1, TPM2, TUBB2A | 39 |
Solid tumor | Solid tumor | 4.61E-06 | APEX1, ATP2A1, ATP2A2, DHX9, DPYSL2, DSC3, DSG1, DSG3, DSP, FABP5, FGB, FGG, FLII, G6PD, HNRNPA1, HNRNPK, HSPA8, LAMA3, LAMB3, LRPPRC, MCM3, PARVA, PCNA, PGK1, PKM, RPS9, SFN, SOD2, STIP1, STK24, STMN1, TPM1, TPM2, TUBB2A | 34 |
Carcinoma | Carcinoma | 9.78E-06 | APEX1, ATP2A1, ATP2A2, DHX9, DPYSL2, DSC3, DSG1, DSG3, DSP, FABP5, FGB, FGG, FLII, G6PD, HNRNPA1, HNRNPK, HSPA8, LAMA3, LAMB3, LRPPRC, MCM3, PARVA, PCNA, PGK1, PKM, RPS9, SFN, SOD2, STIP1, STMN1, TPM1, TPM2, TUBB2A | 33 |
Proliferation | Proliferation of cells | 2.00E-07 | ACTN1, APEX1, ATP2A2, DECR1, DSG3, DSP, FABP5, G6PD, HADHB, HNRNPA1, HNRNPF, HNRNPK, HSPA8, LAMA3, MCM3, PCNA, PDCD10, PGK1, PKM, PKP1, PRPS2, RAN, RPS3A, RPS4X, RPS9, SFN, SOD2, STK24, STMN1, TPM1, TPM2, TUBB2A | 32 |
Cell death | Cell death | 6.36E-05 | APEX1, ATP2A1, ATP2A2, CYCS, DECR1, DHX9, DSG1, DSG3, DSP, G6PD, HNRNPA1, HNRNPK, HSPA8, LAMA3, MSN, PARVA, PCNA, PDCD10, PKM, RAN, RPS3A, RUVBL2, SFN, SOD2, STIP1, STK24, STMN1, TPM1 | 28 |
Apoptosis | Apoptosis | 6.07E-06 | APEX1, ATP2A1, CYCS, DECR1, DHX9, DSG1, DSG3, DSP, G6PD, HNRNPA1, HNRNPK, HSPA8, LAMA3, MSN, PARVA, PCNA, PDCD10, PKM, RPS3A, RUVBL2, SFN, SOD2, STIP1, STK24, STMN1, TPM1 | 26 |
Necrosis | Necrosis | 1.96E-04 | APEX1, ATP2A1, ATP2A2, CYCS, DECR1, DSG1, DSG3, DSP, G6PD, HNRNPA1, HNRNPK, HSPA8, LAMA3, MSN, PARVA, PCNA, PKM, RAN, RPS3A, SFN, SOD2, STMN1, TPM1 | 23 |
Adenocarcinoma | Adenocarcinoma | 7.94E-03 | ATP2A1, DHX9, DSC3, DSG1, DSG3, DSP, FGB, FLII, HNRNPA1, HNRNPK, HSPA8, LAMA3, LAMB3, LRPPRC, PCNA, PGK1, PKM, RPS9, SOD2, TUBB2A | 20 |
Carcinoma | Carcinoma in lung | 7.96E-03 | APEX1, ATP2A1, DHX9, DSC3, DSG1, DSG3, DSP, FGB, FGG, HNRNPA1, HNRNPK, HSPA8, LAMA3, LRPPRC, PCNA, SOD2, STMN1, TUBB2A | 18 |
Carcinoma | Carcinoma in lung | 7.96E-03 | APEX1, ATP2A1, DHX9, DSC3, DSG1, DSG3, DSP, FGB, FGG, HNRNPA1, HNRNPK, HSPA8, LAMA3, LRPPRC, PCNA, SOD2, STMN1, TUBB2A | 18 |