Nedd4-1 is an exceptional prognostic biomarker for gastric cardia adenocarcinoma and functionally associated with metastasis

Table 3 Association of Nedd4-1 expression with pathological categories of gastric cardia tumors

Pathological category		Case number	Nedd4-1 Positive	%	p
Age	< = 60	108	88	81.5	0.631
Age	>60	106	89	84	0.631
Gender	Male	157	128	81.5	0.448
Gender	Female	57	49	86	0.448
Tumor size	<=6 cm	166	135	81.3	0.319
Tumor size	>6 cm	48	42	87.5	0.319
T category	T1/T2	63	43	68.3	0.001
T category	T3/T4	151	134	88.7	0.001
N category	N0	73	50	68.5	< 0.001
N category	N1-3	141	127	90.1	< 0.001
Differentiation^a	Well/Mod	130	103	79.2	0.066
Differentiation^a	Poor/Undiff	84	74	88.1	0.066
TNM stage	I	44	28	63.6
	II	39	28	71.8	I/II vs III/IV
	III	98	89	90.8	<0.001
	IV	33	32	97.0

^aIn differentiation category, “Well” stands for well differentiated, “Mod” for moderately differentiated, “Poor” for poorly differentiated, “Undiff” for undifferentiated.

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