Figure 1From: Trop-2-targeting tetrakis-ranpirnase has potent antitumor activity against triple-negative breast cancerSchematic of expression cassettes and cartoon structures of C H 3-AD2-IgG (or X), C k 3-AD2-IgG (or X*), Rap-DDD2, (Rap) 2 , (Rap) 2 -X-(Rap) 2 , and (Rap) 2 -X*-(Rap) 2 . DDD2 and AD2 are shown in blue and red, respectively. SH, V, C, G, L, and 6H represent sulfhydryl groups, variable domain (green), constant region (gray), hinge, linker (GSGGGGSGG), and His tag (HHHHHH), respectively.Back to article page