Figure 2
From: Thioredoxin interacting protein (TXNIP) is a novel tumor suppressor in thyroid cancer
TXNIP is expressed in primary DTC tumors but is low or undetectable in ATC tumors. Immunohistochemistry was performed using a TXNIP-specific primary antibody or normal mouse IgG control and a horseradish peroxidase tagged secondary antibody on a panel of 13 PTC and 8 ATC patient specimens. Two representative PTC (A-B) and one ATC (C) specimen stains are shown at 20X and 60X power. Positive staining is indicated by brown coloring, though staining of colloid is nonspecific. Staining was quantitated by a pathologist (S. B. S.), and intensity of staining was scored from absent (0) to high to (3+), followed by percent of tumor positivity.