tumor of | cancer type | tumoral expression | stromal(S)/vascular (V) expression | comments | reference |
---|---|---|---|---|---|
brain | astrocytoma | 0% (grade II), 25% (III), 65% (IV) | high expression in glioma microvasculature | higher expression in recurrent vs. primary tumors; | |
 | meningioma | benign (38%), invasive (86%) |  | invasive tumor: correlation with uPA expression | [134] |
breast | invasive carcinoma, DCIS, LCIS invasive cell lines | 62% | correlates with VEGF, MMP1 and MMP9 expression | prognostic marker for poor prognosis | |
cartilage/bone (jaw) | chondro-sarcoma | 60% | Â | Â | [137] |
 | osteosarcoma | 0% |  |  |  |
cervix | cervical carcinoma | Â | correlates with TMD | correlates with poor prognosis | [127] |
colon/rectum | adenomas | 0–44% |  |  | |
 | colon cancer | 48–84% | 65% (V) correlates with TMD, 28% (S) correlated with lung metastasis | vascular Ets1: linked with LNM and poor prognosis |  |
endometrium | endometrial carcinoma | Â | correlates with TMD | associates with histological grade, detected in cytoplasm | |
esophagus | squamous carcinoma | Â | correlates with VEGF | heterogenous expression, higher at invasive sites | |
liver/biliary tract | hepatocellular carcinoma | 50–100% |  | higher in poorly differentiated tumors | [142] |
 | bile duct carcinoma | 61% |  | higher in well-differentiated tumors | [143] |
 | cholangio-cellular carcinomas | 22% |  |  |  |
lung | pulmonary adeno-carcinoma | Â | Â | linked to LNM | |
lymphoid tissue | T-leukemic cells (T-ALL, ATL) | Â | Â | Â | [132] |
mouth | squamous cell carcinoma | 58% | Â | correlates with tumor stage and LNM | [131] |
ovary | benign cystadenoma | 0% | Â | Â | |
 | carcinoma | 42%, higher when stroma is invaded | 33% (S), correlates with MMP1 and MMP9 expression | associated with poor prognosis |  |
pankreas | adeno-carcinoma | 81% | Â | lower in poorly differentiated carcinoma | [146] |
stomach | adenomas | 0% | Â | Â | |
 | adeno-carcinoma | 64% | correlates with TMD |  |  |
 | mucosal carcinoma | 12% |  |  |  |
thymus | thymoma | Â | Â | higher in higher grade tumors | [149] |
thyroid gland | thyroid carcinoma | 40% (adenomas), 50–98% (carcinoma) |  |  | [150] |
vascular system (skin) | haemangioma | weak | Â | Â | [151] |
 | granuloma pyogenicum | weak |  |  |  |
 | angiosarcoma | strong expression |  | correlates with MMP1 expression |  |