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Table 1 List of the top 20 PY4.1 genes that were upregulated in response to the presence of 4T1 tumor cells. Genes are classified according to their biological function. Gene expression regulators (GR). Genes involved in metabolism (M). Genes related to cell cycle or cell division (C). Genes encoding structural proteins (S). Other genes (O).

From: RNA-binding proteins to assess gene expression states of co-cultivated cells in response to tumor cells

Name, classification

gbID

fold

P value

biological function

1-Heterogeneous nuclear ribonucleoproteinH1, (G R)

NM_021510

2.6

6.40E-06

RNA binding, RNA processing and modification

2-High mobility group box 1, (G R)

NM_010439

2.7

9.78E-06

DNA binding, nitric oxide biosynthesis, inflammation mediator, cell differentiation

3-Prothymosinalpha, (C)

NM_008972

3.7

1.38E-05

cell proliferation, cell division

4-RIKEN cDNA2610016F04 gene, (G R)

AK009120

2.6

4.59E-05

putative DNA binding, transcritionfactor

5-ATPase, H+ transporting, (M)

NM_024173

1.8

4.92E-05

hydrogen-exporting, ATPaseactivity, phosphorylativemechanism

6-RIKEN cDNA2510010F10 gene, (O)

AF215660

1.8

7.45E-05

described as a carnitinedeficiency-associated gene

7-Stem-loop binding protein, (G R)

NM_009193

2.1

7.88E-05

RNA binding, histonemRNA processing

8-Quaking, (G R)

NM_021881

1.9

7.79E-05

RNA binding, participates in myelination

9-RIKEN cDNA2410004I17 gene, (O)

AK010391

2

8.26E-05

unknown

10-Purinerich element binding protein A, (G R)

NM_008989

2.8

8.95E-05

DNA and RNA binding, association with rough endoplasmic reticulum, postnatal brain development

11-Similar to isopentenyl-diphosphatedelta isomerase, (M)

BC004801

3

9.80E-05

cholesterol biosynthesis, steroid biosynthesis

12-P53 apoptosis effectorrelated to Pmp22, (O)

NM_022032

2.4

1.11E-04

induction of apoptosis

13-Tumor differentially expressed 1, like, (S)

NM_019760

2

1.17E-04

plasma membrane

14-RIKEN cDNA5830409B12 gene, (S)

AK017914

7.6

9.73E-05

putative cytoskeleton associated protein

15-G7e protein, (S)

NM_033075

2

1.42E-04

resembles viral envelope genes

16-Procollagenlysine, 2-oxoglutarate 5-dioxygenase 2, (M)

NM_011961

2.8

1.43E-04

protein metabolism

17-Receptor-like tyrosine kinase, (M)

L21707

1.7

2.08E-04

ATP binding, kinaseactivity

18-RIKEN cDNA4930506D01 gene, (G R)

BC006745

2.8

1.77E-04

putative transcription factor

19-MusmusculusBRUL4 (Brul4) mRNA, (G R)

AF314173

5.8

1.91E-04

RNA binding, translation regulator

20-CyclinI, (C)

NM_017367

2.3

1.67E-04

cell cycle, cyclin-dependent protein kinaseregulator activity

relevant references

    

1-none

 

2-Gastroenterology. 2002. 123:790–802; J LeukocBiol. 2002. 72:1084–1091

 

3-Peptides. 2000. 21:1433–1446; IntJ Biochem Cell Biol. 1999. 31:1243–1248.

 

4-none

 

5-J BiolChem. 2002. 277:36296–36303; Gene. 2003. 302: 147–153.

 

6-Biochim BiophysActa. 2002. 1577:437–444.

 

7-J. Cell Sci. 2002. 115: 4577–4586.

 

8-Neuron. 2002. 36:815–829; Nucleic Acids Res. 2003.31:4616–4624

 

9-none

 

10-J BiolChem. 2002.277:37804–37810; Mol Cell Biol. 2003. 23:6857–6875

 

11-J Mol Evol. 2003. 57: 282–291.

 

12-Genes Dev. 2000. 14: 704–718.

 

13-J Exp Biol. 2000. 203:447–457.

 

14-none

 

15-Genomics. 1996. 15:5–12

 

16-J BiolChem. 2003. 278:40967–40972.

 

17-none

 

18-J Immunol. 1995. 154:1157–1166; Proc NatlAcadSciU S A. 1992. 89:11818–11822.

 

19-CytogenetGenome Res. 2002.97:254–260.

 

20-Gene. 2000. 256: 59–67.

 
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Molecular Cancer

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