Table 5 Relationships between the prognostic (+/- relapses) and the mRNA levels of BRCA2, DNMT3B and CCNE1 in 104 ERα-positive postmenopausal breast tumors

GENES	Tumors without relapses (n = 73)	Tumors with relapses (n = 31)	P ^a	ROC-AUC^b
BRCA2	4.7 (1.0–23.6^c	7.5 (1.4–38.4)	0.0018	0.694 (0.58–0.80)^d
DNMT3B	3.6 (1.0–27.8)	6.2 (2.3–74.1)	0.00052	0.716 (0.61–0.82)
CCNE1	6.4 (1.0–46.2)	9.0 (1.3–62.8)	0.028	0.636 (0.51–0.76)

^a:P value, Mann-Whitney U test.
^b:ROC (Receiver Operating Characteristics) – AUC (Area Under Curve) analysis
^c:Median (range) of gene mRNA levels
^d:AUC value (95% confidence interval)

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