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Table 2 Toxicity to valproate expressed by number of patients suffering the event

From: Histone acetylation and histone deacetylase activity of magnesium valproate in tumor and peripheral blood of patients with cervical cancer. A phase I study

Toxicity

4 patients at each dose level (mg/kg)

 

20

30

40

Depressed level of consciousness*

3 (g2)

3(g2)

1(g1), 3(g2)

Nausea

-

1 (g1), 1(g2)

1 (g2)

Diarrhea

-

-

-

Fatigue

3 (g2)

1(g2)

-

Anorexia

-

1(g2)

-

Dizziness/lightheadedness

-

1(g2)

-

  1. *Grade 2 toxicity. All others were grade 1.
  2. Depressed level of consciousness (g1: somnolence or sedation not interfering with function; g2: somnolence or sedation interfering with function but not interfering with activities of daily living; g3: obtundation or stupor, difficulty to arouse, interfering with daily living; g4) coma.
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Molecular Cancer

ISSN: 1476-4598