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Table 5 Genes significantly decreased in tumors.

From: Global gene expression in neuroendocrine tumors from patients with the MEN1 syndrome

GeneBank Accession

Gene Description

Symbol

Normal Mean

Tumor Mean

Fold Change

P value

 

Cell Growth/Division

     

D17291

regenerating protein I beta

REG1B

6286

13

-499.46

0.000095

X67318

carboxypeptidase A1

CPA1

3928

121

-32.57

0.003205

AI763065

regenerating islet-derived 1 alpha

REG1A

5641

334

-16.88

0.000001

D29990

solute carrier family 7, member 2

SLC7A2

2988

445

-6.72

0.002204

AB017430

kinesin-like 4

KIFF22

1223

316

-3.87

0.000177

Z25884

chloride channel 1

CLCN1

2511

655

-3.84

0.00013

X81438

amphiphysin

AMPH

2686

752

-3.57

0.000002

L03785

myosin, light polypeptide 5

MYL5

207

59

-3.51

0.000233

W28062

guanine nucleotide-exch. Prot. 2

ARFGEF2

66

19

-3.46

0.003602

X52486

uracil-DNA glycosylase 2

UNG2

2555

756

-3.38

0.000514

M81933

cell division cycle 25A

CDC25A

312

96

-3.25

0.000005

M69136

chymase 1

CMA1

360

115

-3.13

0.004413

U90543

butyrophilin

BTN2A1

685

226

-3.04

0.000023

X69086

utrophin

UTRN

1325

457

-2.90

0.000011

AF039241

histone deacetylase 5

HDAC5

1124

393

-2.86

0.000319

U49392

allograft inflammatory factor 1

AIF1

165

58

-2.82

0.000105

U81992

pleiomorphic adenoma gene-like 1

PLAGL1

330

118

-2.80

0.004717

L26336

heat shock 70kD protein 2

HSPA2

90

32

-2.79

0.000689

F27891

cytochrome c oxidase subunit VIa

COX6A2

872

313

-2.79

0.000342

D87673

heat shock transcription factor 4

HSF4

1964

721

-2.73

0.000453

X97795

RAD54-like

RAD54L

392

144

-2.72

0.001345

X92689

UDP-N-acetyl-alpha-D-galactosamine

GALNT3

80

32

-2.50

0.000243

Y08683

carnitine palmitoyltransferase I

CPT1B

1038

420

-2.47

0.000573

U40622

X-ray repair complementing defective repair 4

XRCC4

177

72

-2.45

0.000678

U64315

excision repair, complementation group 4

ERCC4

2122

868

-2.44

0.000045

AB020337

beta 1,3-galactosyltransferase

B3GALT5

1489

635

-2.34

0.002613

U40152

origin recognition complex

ORC1L

3671

1702

-2.16

0.001425

M10943

metallothionein 1F

MT1F

5691

2653

-2.14

0.001707

X79882

major vault protein

MVP

758

376

-2.02

0.001719

AF035960

transglutaminase 5

TGM5

3097

1542

-2.01

0.002951

 

Cell Death/Apoptosis

     

S81914

immediate early response 3

IER3

2209

480

-4.60

0.000307

D80007

programmed cell death 11

PDCD11

457

129

-3.55

0.002358

AF013956

chromobox homolog 4

CBX4

1599

492

-3.25

0.00034

U33284

protein tyrosine kinase 2 beta

PTK2B

693

237

-2.93

0.000763

U90919

likely partner of ARF1

APA1

2687

1021

-2.63

0.000015

X57110

Cas-Br-M retroviral transforming

CBL

1889

784

-2.41

0.000033

AL050161

pro-oncosis receptor

PORIMIN

1178

497

-2.37

0.00031

U40380

presenilin 1

PSEN1

1301

569

-2.29

0.00012

D83699

harakiri, BCL2 interacting protein

HRK

768

338

-2.27

0.001321

U07563

v-abl viral oncogene homolog 1

ABL1

1415

631

-2.24

0.000248

M95712

v-raf oncogene homolog B1

BRAF

338

157

-2.16

0.004207

M16441

lymphotoxin alpha

LTA

2106

985

-2.14

0.000239

AF035444

pleckstrin homology-like domain, family A, member 2

PHLDA2

334

166

-2.01

0.001759