Figure 7

Histogram of p53 and Δp53 relative mRNA expression. Mean and SEM of the relative p53 and Δp53 mRNA expression in a.u. (arbitrary units) for the different mutation classes: missense, in frame, nonsense, frame shift, splice or splice cassette (splice cass). p53 and Δp53 mRNA expression levels are proportion adjusted according to the comparative Ct of 2.64. The number of cases (n) is given by ¹ for p53 and by ² for Δp53, respectively. Differences in case numbers for p53 and Δp53 are due to some mutations which are located inside the area, but removed by the alternative splicing process of Δp53. The expression level for both full-length p53 and Δp53 between the various mutational classes were highly significant (Table 2).