Expression of full-length p53 and its isoform Δp53 in breast carcinomas in relation to mutation status and clinical parameters

Baumbusch, Lars O; Myhre, Simen; Langerød, Anita; Bergamaschi, Anna; Geisler, Stephanie B; Lønning, Per E; Deppert, Wolfgang; Dornreiter, Irene; Børresen-Dale, Anne-Lise

doi:10.1186/1476-4598-5-47

Molecular Cancer

Table 1 Relationship between p53 and Δp53 mutation status and their correlation to biological and clinical factors

From: Expression of full-length p53 and its isoform Δp53 in breast carcinomas in relation to mutation status and clinical parameters

			Wild type (Wt) Wt Δp53 Wt p53		Mutational hybrid Wt Δp53 M p53		Mutations (MI = MS, IF) MI Δp53 MI p53		Mutations (MII = NS, FS, SP, SC) MII Δp53 MII p53
Characteristic	Total No.		No. of patients	(%)	No. of patients	(%)	No. of patients	(%)	No. of patients	(%)	Groups	p
Lymph node status	88	Node-negative	16	32.0	1	9.1	4	23.5	6	60.0	WtWt-WtM ¹	n.s.
		Node-positive	34	68.0	10	90.9	13	76.5	4	40.0	WtM-MIMI ¹	n.s.
											WtM-MM ¹	n.s. ( p < 0.09)
											WtWt-WtM-MM ²	n.s.
											WtWt-WtM-MIMI-MIIMII ²	n.s. ( p < 0.08)
Estrogen receptor status	88	Negative	10	20.0	3	27.3	8	47.1	3	30.0	WtWt-WtM ¹	n.s.
		Positive	40	80.0	8	72.7	9	52.9	7	70.0	WtM-MIMI ¹	n.s.
											WtM-MM ¹	n.s.
											WtWt-WtM-MM ²	n.s.
											WtWt-WtM-MIMI-MIIMII ²	n.s.
Progesterone receptor status	88	Negative	13	26.0	4	36.4	9	52.9	6	60.0	WtWt-WtM ¹	n.s.
		Positive	37	74.0	7	63.6	8	47.1	4	40.0	WtM-MIMI ¹	n.s.
											WtM-MM ¹	n.s.
											WtWt-WtM-MM ²	p < 0.04
											WtWt-WtM-MIMI-MIIMII ²	n.s. ( p < 0.09)
ERBB2/HER status	60	Negative	29	80.6	5	62.5	10	90.9	1	20.0	WtWt-WtM ¹	n.s.
		Positive	7	19.4	3	37.5	1	9.1	4	80.0	WtM-MIMI ¹	n.s.
											WtM-MM ¹	n.s.
											WtWt-WtM-MM ²	n.s.
											WtWt-WtM-MIMI-MIIMII ²	p < 0.02
Distant metastisis at time of diagnosis	65	Negative	30	90.9	7	77.8	15	100.0	7	87.5	WtWt-WtM ¹	n.s.
		Positive	3	9.1	2	22.2	0	0.0	1	12.5	WtM-MIMI ¹	n.s. ( p < 0.07)
											WtM-MM ¹	n.s.
											WtWt-WtM-MM ²	n.s.
											WtWt-WtM-MIMI-MIIMII ²	n.s.
Grade	88	1	5	10.0	0	0.0	0	0.0	0	0.0	WtWt-WtM ¹	n.s.
		2	24	48.0	4	36.4	4	23.5	4	40.0	WtM-MIMI ¹	n.s.
		3	21	42.0	7	63.6	13	76.5	6	60.0	WtM-MM ¹	n.s.
											WtWt-WtM-MM ²	p < 0.03
											WtWt-WtM-MIMI-MIIMII ²	p < 0.05
Response to chemotherapy	54	Response	24	92.3	8	88.9	9	81.8	5	62.5	WtWt-WtM ¹	n.s.
		None response	2	7.7	1	11.1	2	18.2	3	37.5	WtM-MIMI ¹	n.s.
											WtM-MM ¹	n.s.
											WtWt-WtM-MM ²	n.s.
											WtWt-WtM-MIMI-MIIMII ²	n.s.
Subgroups*	84	Luminal A	25	53.2	2	18.2	2	12.5	0	0.0	WtWt-WtM ¹	n.s. ( p < 0.08)
		Luminal B	6	12.8	2	18.2	4	25.0	3	30.0	WtM-MIMI ¹	n.s.
		ERBB2	7	14.9	3	27.3	4	25.0	4	40.0	WtM-MM ¹	n.s.
		Basal	4	8.5	4	36.4	6	37.5	2	20.0	WtWt-WtM-MM ²	p < 0.008
		Normal-like	5	10.6	0	0.0	0	0.0	1	10.0	WtWt-WtM-MIMI-MIIMII ²	p < 0.02

MS = missense mutations, NS = nonsense mutations, FS = frame shift mutations, IF = in frame mutations, SP = splice mutations, SC = Δp53 splice cassette mutations
M = MI + MII
¹ for WtWt-WtM, WtM-MIMI and WtM-(MIMI+MIIMII) the Mann-Whitney test was performed
² for WtWt-WtM-(MIMI+MIIMII) and WtWt-WtM-MIMI-MIIMII the Kruskal Wallis test was performed
* The tumors have previously been subjected to whole genome microarray analysis and classified into subgroups according to their expression profile (see Material and Methods)

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