Expression of full-length p53 and its isoform Δp53 in breast carcinomas in relation to mutation status and clinical parameters

Table 4 p53 or Δp53 mutant classes and their relation to molecular subgroups*

		Wild type (Wt)		Mutation group I (MI) missense and in frame mutations		Mutation group II (MII) nonsense, frame shift and splice mutations
		No. of patients	(%)	No. of patients	(%)	No. of patients	(%)	Groups	p
full-length p53	Luminal A	25	53.2	4	15.4	0	0.0	Wt-MI-MII ¹	p < 0.006
	Luminal B	6	12.8	6	23.1	3	27.3	Wt-MI²	p < 0.02
	ERBB2	7	14.9	7	26.9	4	36.4	Wt-MII²	p < 0.008
	Basal	4	8.5	9	34.6	3	27.3	MI-MII²	n.s.
	Normal-like	5	10.6	0	0.0	1	9.1	Wt-MI&MII²	p < 0.002
Δp53	Luminal A	27	46.6	2	13.3	0	0.0	Wt-MI-MII ¹	p < 0.04
	Luminal B	8	13.8	4	26.7	3	27.3	Wt-MI²	n.s. (p < 0.07)
	ERBB2	10	17.2	3	20.0	5	45.5	Wt-MII²	p < 0.03
	Basal	8	13.8	6	40.0	2	18.2	MI-MII²	n.s.
	Normal-like	5	8.6	0	0.0	1	9.1

¹ for WT-MI-MII the Kruskal Wallis test was performed
² for WT-MI the Mann-Whitney test was performed
* The tumors have previously been subjected to whole genome microarray analysis and classified into subgroups according to their expression profile (see Material and Methods)

ISSN: 1476-4598