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Figure 5 | Molecular Cancer

Figure 5

From: Regulation of angiogenesis and invasion by human Pituitary tumor transforming gene (PTTG) through increased expression and secretion of matrix metalloproteinase-2 (MMP-2)

Figure 5

Cell migration. Medium from HEK293 cells transfected with PTTG cDNA or pcDNA3.1 was used for HUVEC cells plated in 35 mm dishes. A: Wound assay showing the migration of cells in wounded area. B: Graphical representation of data shown in A. A significant increase in HUVEC migration was observed when CM from HEK293 cells transfected with PTTG cDNA was used compared to CM from cell transfected with pcDNA3.1 vector. Addition of MMP-2-specific antibody significantly decreased the cell migration, whereas addition of control mouse IgG to CM was ineffective. Data shown represent mean ± SEM from three independent experiments performed in triplicate. ** = p < 0.05.

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Molecular Cancer

ISSN: 1476-4598